... vitamins including B12112 and riboflavin113 have been reported Folic acid and vitamins B6 and B12 are important co-factors in metabolism ofthe sulphurcontaining amino acid homocysteine, and deficiencies ... Many of these changes were found to be less pronounced and inconsistent in children, and some investigators considered this appearance in SCD to be an exaggeration ofthe normal characteristics of ... occurs early in life Booker et al.25 reported weight deceleration starting at about 4–6 months of age, coinciding with the onset of crises and infections and continuing during the 1st years of life...
... associations indicate the importance of further consideration of internalizing symptoms and particularly parenting stress inthe assessment of HRQOL andin efforts to improve functioning of youth ... Critical issues and needs in health- related quality of life assessment ofchildrenandadolescents with chronic health conditions In Measuring Health- related Quality of Life inChildrenand Adolescents: ... contributed tothe conception and design ofthe study, acquisition of data, analysis and interpretation of data, and drafting and revision ofthe manuscript She has given final approval of this version...
... of SCD, such as hypoxia, hypovolemia, hypothermia and hyperviscosity, were prevented by monitoring his vital signs and maintaining them within tight ranges Anaesthesia from the beginning up to ... beginning up tothe end of surgery lasted 80 minutes Postoperative care, including fluid management and weaning off the respirator with extubation on the day ofthe surgery, was provided by the hospital’s ... of SCD For that reason, it is essential to maintain normovolemia, normothermia and normoxemia during anaesthesia andthe perioperative period [5,6] The clinical symptoms of SCD, which start in...
... status, and employment Healthcare professionals working with the SCD population need to be aware of these factors They need to ensure continuing education ofthe patients, and hence increase further ... enable us to gain understanding into mechanisms of depression in this disease population and how these may vary among different genotypes The main limitations of this study relate tothe instrument ... were also included on their utilization ofthe clinic (SCU) services, frequency of painful crises, and whether they had leg ulceration as a result of their sickle cell disease Pain was defined as...
... determined by high performance liquid chromatography and isoelectric focusing analysis and grouped into phenotypes of hemoglobin SS or hemoglobin SC Children were included inthe asthma group if they ... sickle hemoglobin to gel, inducing red blood cell sickling and vaso-occlusion within pulmonary blood vessels Asthma is the most common chronic disease of childhood occurring in 6% ofthe general ... complications of sickle cell disease including acute chest syndrome and cerebral vascular accidents compared tochildren with sickle cell disease alone The significance of these findings relates to the...
... purpose ofthe study and assured them of confidentiality of privileged information and a feedback after the study as told to them inthe last meeting Then the researchers requested for volunteers in ... members ofthe fathers and mothers Interestingly, his/her present state he/she picked it from them and whatever he/she becomes is the handiwork ofthe parents as family is said to be the cradle ofthe ... facilities since mostly mothers stay with their childreninthe hospitals or accompany them tothe hospitals, most mothers are more caring than fathers regardless ofthe diagnoses of their children...
... maintained (NIH, 2009a) The remaining 99% ofthe body’s calcium is stored inthe bones and teeth where it supports their structure There is constant reabsorption and deposition of calcium into ... that in spite of chronic disease, growth is the number one indicator ofthe overall healthand well-being of a child The medical team must be able to recognize the onset of growth disturbances in ... the SCD population; however, this finding supports the benefit of increasing fat, protein, and carbohydrate intake It is the role of both the registered nurse and advanced practice nurse to carefully...
... represents the efforts of those who have dedicated their professional careers tothecareof individuals with sickle cell disease The names ofthe authors, their affiliations, and their e-mail addresses ... entitled tothe information and can benefit from knowing the child’s carrier status, in part because the information may influence their reproductive decision-making Therefore, parents of infants ... do?” Since counseling goals are based entirely upon the principle of self-determination, and are not intended to be preventive, the counselor’s success is not determined by a decline inthe incidence...
... barriers tothe use of pain medications We also identified one study that investigated the impact of an intervention to improve receipt of routine healthcare and, partly because ofthe strength ofthe ... leading tothe development of anemia andthe release of free hemoglobin into the circulation, a phenomenon that is also injurious tothe endothelium The term sickle cell anemia refers tothe ... between the data abstracted andthe data appearing inthe article, this discrepancy was brought tothe attention ofthe investigator in charge ofthe specific data set, andthe data were corrected in...
... clarithromycin or clindamycin * Other antibiotics used in other centres include amoxicillin and erythromycin-sulfamethoxazole In making the recommendations above the Child Health Network have weighed the ... documented inthehealth record to confirm the patient’s location should thehealthcare team need to contact them Assessment and Treatment: Outpatient Antimicrobial Therapy: Following the initial ... pain, fever or respiratory symptoms) Encourage the patient to drink, monitor intake and output Initiate an IV (if febrile, dehydrated or in moderate to severe pain) For mild to moderate pain...
... suffering to them CBT can be offered to patients with SCD individually or in groups There is some evidence to suggest that CBT helps to reduce health service utilization in both childrenandadolescents ... status andhealth service utilization seem to make only a limited contribution to understanding the pattern of poor quality of life, suggesting that haematologists should examine other factors ... result of frequent pain, hospitalizations and loss of schooling (in children) and employment (in adults) These accounts could indicate depressive symptoms and should not be ignored by haematologists...
... functioning The total score is comprised ofthe average of all items inthe questionnaire The psychosocial summary score is comprised ofthe average ofthe items inthe emotional, social, and school ... score, and family functioning summary score The total score is comprised ofthe average ofthe responses to all items inthe questionnaire The parent HRQL summary score is determined by averaging the ... proxy-reporting of their child's HRQL inchildren with sickle cell disease In a study of healthy children, parents' HRQL was shown to correlate with their proxy reporting ofthe child's HRQL [11] The...
... further study of their possible weaknesses and strengths Therefore, the specific aims of this study are to: i) assess the properties of WHOQOL-BREF in SCD; and ii) compare the properties ofthe ... groups experiencing different frequencies of painful crises Pain is a major indicator of health- seeking and hospitalization in these patients [38,39,42-45], and those with frequent painful crises ... values of 70 and over were deemed acceptable [37] The floor and ceiling effects were measured for the scales and their domains with floor effect being the percentage of subjects with the lowest...
... notification network, the investigators were informed of any case of SCA presenting during the study period, and each patient was then evaluated by one ofthe investigators using the standardized format ... inthe study population with 84 (71.2%) occurring inthe lower limbs, 33 (28.0%) in upper limbs and (0.8%) inthe spine An analysis ofthe pattern of regional anatomic involvement according to ... musculo-skeletal presentation of SCA and occurs predominantly in patients below the age of 10 years The predominant presentation inadolescents is AVN, with majority of them presenting inthe late stage Multiple...
... performed inthe United States of America As the healthcare system andthe origins ofthe patient population inthe USA differ from Western Europe, findings from these studies cannot be generalized to ... SCD using a self-report measure and a control group of healthy siblings In general, the HRQoL ofchildren with SCD appeared similar tothe HRQoL of healthy siblings, with the exception of lower ... HRQoL ofchildren with SCD While interpreting the results of this study, strengths and limitations should be taken into account Findings of this study are strengthened by the use of a well-standardized...
... further study of their possible weaknesses and strengths Therefore, the specific aims of this study are to: i) assess the properties of WHOQOL-BREF in SCD; and ii) compare the properties ofthe ... groups experiencing different frequencies of painful crises Pain is a major indicator of health- seeking and hospitalization in these patients [38,39,42-45], and those with frequent painful crises ... values of 70 and over were deemed acceptable [37] The floor and ceiling effects were measured for the scales and their domains with floor effect being the percentage of subjects with the lowest...
... (GFR) These parameters decrease with age as well as with administration of prostaglandin inhibitors Proteinuria, a common finding in adults with SCD, may progress tothe nephrotic syndrome Proteinuria, ... effacement in approximately 10 glomeruli Immunofluorescence staining was negative for immunoglobulin G (IgG), IgA, IgM, C1q, C3, fibrin, albumin andand l chains A diagnosis of CG was considered and ... stain to highlight the basement membranes of glomerular capillary loops and tubular epithelium The capillary loops of this normal glomerulus are well defined and thin Ramidi et al Journal of...
... lipids, resulting inchangesin fluidity ofthe bilayer Additionally, there is increased ion permeability, inactivation of membrane enzymes and receptors, and covalent cross-linking of lipid Once ... transfer of electrons between Fe and O2, leading tothe production of O2– Auto-oxidation of hemoglobin, which occurs to a small extent physiologically, leads tothe production of methemoglobin and ... oxidant/antioxidant profile of SCD patients at baseline and during VOCs, including ACS, andto examine the clinical effect of pharmacologic intervention to reduce oxidant production in SCD This will...
... collaboration using the models of consultation and liaison services among psychiatrists and other healthcare professionals in managing childrenandadolescents with SCD Treating psychotic symptoms in this ... duration being longer than the first episode The acute and transient nature of psychotic symptoms in this adolescent would point to a fleeting precipitating factor Conclusion Considering the diagnostic ... his insurance work required frequent traveling O.J and his siblings spent most part of their time with the house-help and their stepmother None ofthe patient's siblings suffered from SCD, but the...
... single-ringed pyrimidines and double-ringed purines The purines are adenine (A) and guanine (G) The pyrimidines are cytosine (C), thymine (T), and uracil (U) Thymine is found primarily in DNA and ... turns inthe rest ofthe DNA, making it energetically favorable to continue unwinding the strands To unwind the DNA, positive superhelical turns have to be removed by cutting the DNA and allowing ... dissolves, and a spindle of microtubules forms from one pole ofthe cell tothe other During metaphase, the chromosomes line up inthe center ofthe spindle At anaphase, the two chromatids of each...