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Considering mechanistic data to assess mode of action or human relevance

Considering mechanistic data to assess mode of action or human relevance

Ngày tải lên : 15/04/2015, 09:16
... epidemiological study – “Strength” of evidence – Judgment on the reliability of a given data set supporting a toxicological effect • Quality of the studies and methodology McLaughlin Centre University ... systematic assimilation) – Comprehensive, integrated judgment of all relevant information supporting conclusions regarding a toxicological effect, including human relevance • Consistency, specificity, ... What does the chemical to the body? McLaughlin Centre University of Ottawa 11 Exposure-Response Continuum Mode of Action involves identification of several key events between exposure and effect...
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labor market transitions of involuntary part-time workers how hard is it to get back to full-time jobs

labor market transitions of involuntary part-time workers how hard is it to get back to full-time jobs

Ngày tải lên : 03/06/2014, 02:05
... research has estimated multinomial logit models Since multinomial probit models allow for correlated error terms across alternatives and unequal error term variances, computing each alternative is ... work choices of an individual constrained by continuous budget line reflecting a wage work scenario (no self-employment) When there are no discontinuities (no rationing) individuals may choose ... parameters such as spouse-specific resources and non-labor (exogenous) income Therefore, departing from existing literature that often uses an individual utility maximization theoretical framework,...
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Internet Payment Processing Introduction What is online payment processing? How hard is it ppt

Internet Payment Processing Introduction What is online payment processing? How hard is it ppt

Ngày tải lên : 28/06/2014, 12:20
... implement online payment processing on my website? If you have an existing website that currently displays your products, incorporating online processing may not be too difficult or costly Every online ... to avoiding • Understand what existing technical measures are already in place to reduce fraud by your payment gateway chargebacks should be applicable to preventing • Retain and require documentation ... processing? When researching online payment processing options for your site, try to leverage any existing relationship with your bank by seeing what they can provide for you Online payment processing...
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báo cáo khoa học: "Why don’t hospital staff activate the rapid response system (RRS)? How frequently is it needed and can the process be improved?" potx

báo cáo khoa học: "Why don’t hospital staff activate the rapid response system (RRS)? How frequently is it needed and can the process be improved?" potx

Ngày tải lên : 10/08/2014, 10:23
... The situation awareness model has three distinct parts: perception, comprehension, and projection Perception Perception of the vital signs of a deteriorating patient typically means that the observations ... should trigger them to call for assistance Page of Intra-professional barriers Pre-existing pathways to activating the RRS may be based in the culture of the profession [21] It has been established ... political barriers preventing them from calling for help These barriers may occur between professional groups, within professional groups, or as a result of a group identity existing such as within...
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Báo cáo y học: "Variability science in intensive care – how relevant is it" docx

Báo cáo y học: "Variability science in intensive care – how relevant is it" docx

Ngày tải lên : 12/08/2014, 20:20
... useful and widely accepted prognostic tool for the clinician Competing interests The author(s) declare that they have no competing interests References Seely A, Macklem PT: Complex systems and ... heart rate variability in healthy young men Clin Neurophysiol 2003, 114:2146-2155 Another interesting field of research that employs techniques very close to those presented by Seely and Macklem ... Degaute JP: Arterial baroreflex control of the sinus node during dobutamine exercise stress testing Hypertension 1999, 33:987-991 La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A, Schwartz PJ:...
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Bài giảng môn tiếng anh 7: Unit 4: Set 4: How long is it?

Bài giảng môn tiếng anh 7: Unit 4: Set 4: How long is it?

Ngày tải lên : 21/08/2015, 09:39
... sampleListen and brainstorming sentence by using pictures Introduce the system ofListen and distinguish the English measurement difference between English and Vietnamese system Give instruction...
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Software Design and Development (A guide) is help you how to managed IT Project. Especially for Design and Develop software project.

Software Design and Development (A guide) is help you how to managed IT Project. Especially for Design and Develop software project.

Ngày tải lên : 15/10/2013, 23:13
... solid design Applicable to creation of new design and to the modification of existing design Day - Software Design Creating the design - reused design Reusing previously created & proven designs is ... representing various software & development skills People outside the organization possessing special expertise may be invited Day - Software Design Reviewing the design - how In a group setting ... Scrutinize the list of planned activities and test activities to ascertain whether any changes or additions are needed The design may have revealed the need for modifying the development & testing...
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Service-Oriented Architecture: What Is It and How Can It Help Your Business?

Service-Oriented Architecture: What Is It and How Can It Help Your Business?

Ngày tải lên : 16/10/2013, 12:15
... forge a solid understanding of service-oriented architecture from which you can jump off to implementing this technology within your business Defining Service-Oriented Architectures Essentially, a ... different purposes And a service-oriented architecture gives your business the ability to leverage existing services easily while also leaving the option to write new services to fulfill specific purposes ... enables developers to define their own specific structure of data However, one major benefit of setting up a service-oriented architecture is that it doesn’t matter which language or protocol is...
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Tài liệu Service-Oriented Architecture: What Is It and How Can It Help Your Business? pdf

Tài liệu Service-Oriented Architecture: What Is It and How Can It Help Your Business? pdf

Ngày tải lên : 21/12/2013, 06:18
... forge a solid understanding of service-oriented architecture from which you can jump off to implementing this technology within your business Defining Service-Oriented Architectures Essentially, a ... different purposes And a service-oriented architecture gives your business the ability to leverage existing services easily while also leaving the option to write new services to fulfill specific purposes ... enables developers to define their own specific structure of data However, one major benefit of setting up a service-oriented architecture is that it doesn’t matter which language or protocol is...
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Nano means one billionth  major aspects of nanotechnology  what is it  how did it come about  what are the social implications

Nano means one billionth major aspects of nanotechnology what is it how did it come about what are the social implications

Ngày tải lên : 15/03/2014, 22:13
... Nanotechnology - Deals with moleculues between one and one hundred nanometers in diameter Manipulating individual atoms and manufacturing from the bottom up Major Aspects of Nanotechnology •What ... manufacturing at top left (F) shows two atoms in the protein, (G) reveals the nucleus of the atom as a tiny speck Below: 35 xenon atoms spell out a familiar logo A demonstration on the molecular level...
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Báo cáo y học: " Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively" docx

Báo cáo y học: " Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively" docx

Ngày tải lên : 11/08/2014, 08:22
... cranio-caudal length (the optically maximal transversal dimension intercepting one of the two poles) were measured; the resulting values were then averaged, since the two measurements not always ... respectively, not so far from previous observations, [17] HOMA was assessed by the formula: fasting insulin (μU/ mL) × fasting glucose (mg/dL)/405 [18] Analytes Serum concentrations of alanine aminotransferase ... alanine aminotransferase; (SD): standard deviation 14 15 16 17 Competing interests The authors declare that they have no competing interests 18 Authors' contributions CP conceived of the study,...
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Báo cáo y học: "Remission in psoriatic arthritis: is it possible and how can it be predicted" pdf

Báo cáo y học: "Remission in psoriatic arthritis: is it possible and how can it be predicted" pdf

Ngày tải lên : 12/08/2014, 14:21
... have no competing interests Authors' contributions TPS was responsible for author conception, design, acquisition of data, analysis and interpretation of data, and also for drafting of the manuscript ... interpretation of data, and also for drafting of the manuscript DJV was responsible for conception, design, acquisition of data, analysis and interpretation of data and drafting of the manuscript Acknowledgements ... (P < 0.001) Discussion In this study, we show a significant response to anti-TNF therapy in routine clinical practise with DAS28 remission in 58% PsA patients compared to 44% of RA patients There...
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Báo cáo y học: "Host immune response in sepsis due to ventilator-associated pneumonia: how is it different" pot

Báo cáo y học: "Host immune response in sepsis due to ventilator-associated pneumonia: how is it different" pot

Ngày tải lên : 13/08/2014, 20:21
... work is needed before those changes are attributed solely to VAP Competing interests The author declares that they have no competing interests References Pelekanou A, Tsagkaris I, Kotsaki A, Karagianni ... that of endotoxin tolerance [12], the authors attempted to mimic VAP pathogenesis by using augmenting concentrations of Gram-negative bacteria to sequentially stimulate ex vivo peripheral blood ... Critical Care Vol 13 No Christaki implications of endotoxin tolerance continue to be elusive [4] Although endotoxin tolerance has been implicated in increased susceptibility...
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sloan - don't blame the shorts; why short sellers are always blamed for market crashes and how history is repeating itself (2010)

sloan - don't blame the shorts; why short sellers are always blamed for market crashes and how history is repeating itself (2010)

Ngày tải lên : 03/11/2014, 18:31
... about fraud or faulty accounting But most shorting is done to offset the risk of holding a convertible bond, of betting on the spread of a merger arbitrage, or of isolating the interest rate risk ... the stock market continued to fall, this move led to an outright ban on shorting financial shares (As of this writing, short sellers are coming under even more federal scrutiny After reversing ... considerable amount • DON’T BLAME THE SHORTS of risk Shorting is not selling those stocks that are overpriced, and getting the gearing and position weighting right The short must endure many days, sometimes...
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BitLocker: Is It Really Secure?

BitLocker: Is It Really Secure?

Ngày tải lên : 16/10/2013, 12:15
... Migrating to Server 2008 Updating Your Active Directory Technology Skills to Windows Server 2008 (Beta 3) Updating Your Application Platform Technology Skills to Windows Server 2008 (Beta 3) Updating ... operating system, while Windows Server 2008 can additionally encrypt other volumes By design, BitLocker encrypts the entire Windows operating system volume on the hard-drive, including the operating ... achieve this by implementing a Static Root of Trust Measurement, which is a methodology specified by the Trusted Computing Group (http://en.wikipedia.org/wiki/Trusted_Computing_Group) User authentication...
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HOW GOOD IS THE EVIDENCE - INTUITION, PERSONAL EXPERIENCE, TESTIMONIALS, AND APPEALS TO AUTHORITY

HOW GOOD IS THE EVIDENCE - INTUITION, PERSONAL EXPERIENCE, TESTIMONIALS, AND APPEALS TO AUTHORITY

Ngày tải lên : 25/10/2013, 15:20
... claim here is the statistic reporting "an increase in the number of gun-related crimes over the last 10 years" and it functions as a reason 106 Chapter supporting a prescriptive conclusion In ... a position to have especially good access to pertinent facts? ? Is there good reason to believe that the authority is relatively free of distorting influences? ? Has the authority developed a ... chips Not to mention the price! When will these things stop costing so much?" George Z., truck driver: "I like nothing better than eating a box of crackers and drinking pop while on the road Yet,...
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HOW GOOD IS THE EVIDENCE - PERSONAL OBSERVATION, RESEARCH STUDIES, CASE EXAMPLES, AND ANALOGIES

HOW GOOD IS THE EVIDENCE - PERSONAL OBSERVATION, RESEARCH STUDIES, CASE EXAMPLES, AND ANALOGIES

Ngày tải lên : 25/10/2013, 15:20
... involve testing people's reasoning processes The researchers are trying to figure out why people make certain decisions when confronted with different scenarios However, we should ask, "Is sitting ... an equal chance of getting sampled; they try to avoid a biased sample Major polls, like the Gallop poll, for example, always try to sample randomly This keeps them from getting groups of events ... Thus, single research studies presented out of the context of the family of research studies thatinvestigate the question often provide misleading conclusions Research findings that most deserve...
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Style - It’s Not What They Say but How They Say It

Style - It’s Not What They Say but How They Say It

Ngày tải lên : 25/10/2013, 17:20
... distinctive way of writing or speaking or doing something; the manner in which something is done Which version uses complex sentences? a version A b version B What Is Style? Style, in writing, ... innovative, must also be cutting-edge Therefore, the definition of innovative must be similar to cutting-edge, so the likely choice is inventive – WORD POWER: PUTTING IT ALL TOGETHER – c The ... writer and reader In business, as in most writing, the audience usually determines the writer’s style The writer of letter A is probably capable of writing in the style of letter B, but because...
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The BMATT course - What is it

The BMATT course - What is it

Ngày tải lên : 25/10/2013, 18:20
... evaluate the resources they have, formulate a training plan including formulating their aims and activities and then implementing the training programme they have put together Answer the following ... The BAYONET is shaped to provide good thrust penetration It has a cutting edge, blade channels and a ribbed portion for rope cutting A slot at the forward end is for use with the scabbard when used ... Bayonet and Scabbard The design of the bayonet for hand-to-hand fighting is based on combat experience The bayonet also serves as a fighting knife and a general purpose tool and is made from one piece...
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Agile Testing What is it? Can it work?

Agile Testing What is it? Can it work?

Ngày tải lên : 29/10/2013, 06:15
... more." www.agilemanifesto.org What is Agile Testing? Testing practice that follows the agile manifesto, treating development as the customer of testing  In this light the context-driven manifesto ... Refactoring “User Stories" Acceptance Testing The Role of Testing Testing is the headlights of the project  Where are you now? Where you headed? Testing provides information to the team  This ... excuse for hacking I think that XP is exciting and will improve the practice of testing in the industry    XP developers are writing unit tests and unit testing tools Kent Beck’s next book is Test-Driven...
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