cellular senescence and cancer

... Apoptosis, Senescence, and Cancer Cancer Drug Discovery and Development Beverly A Teicher, Series Editor Apoptosis, Senescence, and Cancer, edited by David A Gewirtz, Shawn E Holt and Steven ... Kelland and Nicholas P Farrell, 2000 Apoptosis and Cancer Chemotherapy, edited by John A Hickman and Caroline Dive, 1999 Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and ... phagocytes (2) From: Cancer Drug Discovery and Development Apoptosis, Senescence, and Cancer Edited by: D A Gewirtz, S E Holt and S Grant © Humana Press Inc., Totowa, NJ Part I / Apoptosis and Alternative...

Ngày tải lên: 29/06/2014, 06:20

... Leukocyte Antigen System .19 1.1.9 Cellular Senescence .20 1.1.10 Cellular Senescence and Age Related Diseases .24 1.1.11 Senescence and the Kidney 27 1.1.12 Biomarkers ... research and writing of this thesis To my family and my children Nick and Andy who brought smiles and joy during those difficult moments Lastly, to Nicky BC (1982-2009) whose courage and strength ... Figure 1.1 Diagram depicting primary causes and consequences of cellular senescence It has become increasingly clear that cellular senescence is a crucial anticancer mechanism that prevents the growth...

Ngày tải lên: 22/12/2014, 21:25

... the granule are released remains debated, and there are arguments supporting both total and transient fusion as described by 'fuse -and- collapse' and 'kiss -and- run' mechanisms, respectively Visual ... combined physical and chemical approach may yield a better understanding into cell functionality and mechanics Artifacts in the form of bubbles caught trapped between the cell and polymer and ripping ... caused by cancer mutations, which act to deform and distort the cell structure in several ways [25,26], and often result in complex and varying cellular forms Even considering the potential artifacts...

Ngày tải lên: 11/08/2014, 00:22

... PTS1- and PTS2-containing proteins (Wendland and Subramani, 1993; Legakis and Terlecky, 2001) It was established, through a variety of assay permutations, that Hsp70 and Hsp40, as well as Pex5p and ... cytosol and the peroxisome, giving rise to the model of a shuttling receptor (Marzioch et al., 1994; Dodt and Gould, 1996) Once complexed, the receptor and ligand move to the peroxisome membrane and ... Fransen et al., 1998), and PTS2 import (Legakis and Terlecky 2001), and that Pex5p and Pex14p play a 18 role in PTS1 import (Wiemer et al., 1995; Fransen et al., 1998; Legakis and Terlecky, 2001)...

Ngày tải lên: 14/11/2014, 13:16

... between NS1 and PARP Since PARP is active at the site of single strand DNA breaks, and single-strand nicking is a known activity of NS1 protein, it is likely that NS1 is nicking the cellular DNA, ... cause double strand breaks through the simple mechanism of nicking both DNA strands a short distance apart Nicking and binding to the DNA end would not only create broken strands, but adducts ... in a covalent manner, and that both DNA-helix distorting and single strand nick forms of DNA damage are important pathways to apoptosis upon expression of NS1 Materials and Methods Transfection...

Ngày tải lên: 25/10/2012, 11:18

... frequent types of cancer diagnosed in the United States in decreasing incidence are breast cancer, prostate cancer, lung cancer and colon cancer; yet lung cancer is the deadliest form of cancer in the ... Cdc28 and classes of vertebrate cyclins (D- and E-type cyclins in G1 and A -and B-type cyclins in G2/M) that control a family of Cdks (cyclindependent kinases) greatly enhanced our understanding ... 1997; Zachariae and Nasmyth 1999) These studies and others demonstrated the universality of the cell Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231 cycle, and strongly suggested...

Ngày tải lên: 25/10/2013, 21:20

... Ras and the telomerase catalytic subunit (hTERT) can transform HDFs and human keratinocytes (Hahn et al 1999) T-Ag inactivates the p53- and Rb-dependent senescence- inducing pathways and hTERT Senescence ... tumor-suppressor pathways and cell cycle control during cellular senescence Role of the p53 Pathway in Senescence The tumor-suppressor p53 plays a key role in induction of senescence as evidenced ... determination between senescence and immortalization These proteins bind to the E2F family transcription factors and maintain the repressor function of E2F (Hatakeyama and Weinberg 1995; Stevaux and Dyson...

Ngày tải lên: 25/10/2013, 21:20

... Early Cancer and Cancer Risk Hepatocellular Carcinoma/Primary Liver Cancer Primary hepatocellular carcinoma (HCC) is fifth in cancer incidence worldwide and the third leading cause of cancer ... Texas M D Anderson Cancer Center Colorectal and Other Gastrointestinal Cancers 35 Colorectal Cancer Colon cancer is the third most frequently diagnosed cancer in the United States and the third ... cancers, gastrointestinal and other associated cancers, lung and upper aerodigestive cancers and prostate and urologic cancers, each have biomarkers in prevalidation and validation phases in which...

Ngày tải lên: 14/02/2014, 21:20

... bioassays and are carcinogenic (Gold et al., 1997b) Dehydroepiandrosterone (DHEA) and DHEA sulfate are the major secretion products of adrenal glands in humans and are precursors of androgenic and ... Stofberg and Grundschober (1987) 800 Stofberg and Grundschober (1987), Lorenz and Maga (1972) Stofberg and Grundschober (1987), Arkima (1968) (7300) TAS (1989), Nelson and Hoff (1969), Kazeniac and ... Stofberg and Grundschober (1987), Blauch and Tarka (1983), Nagata and Sakai (1985), IARC (1991) EPA (1989a), Risch and Herrmann (1988) TAS (1989), Eltayeb and Roddick (1984) 4100 Stofberg and Grundschober...

Ngày tải lên: 14/02/2014, 22:20

... with cancer of the mouth, larynx, pharynx and esophagus, and heavy beer drinking is associated with cancer of the rectum Cancer can develop anywhere along the gastrointestinal tract, but colon cancer ... Nutrition and Health, stomach cancer has been found among populations who eat lots of pickled vegetables (Japan), salted fish (Norway) and smoked trout and mutton (Ireland) Esophageal cancer is ... certain types of cancer, especially if you drink and smoke Choose high-fiber foods Besides fresh fruits and vegetables, add more whole grain breads and cereals and legumes (dried peas and beans) to...

Ngày tải lên: 15/02/2014, 04:20

... mortality and YLL, and the transition towards cancer In more recent years, the highest burdens of disease came from cancers in men and from cardiovascular diseases in women Keywords Cancer, Cardiovascular ... rates and numbers of deaths were performed for all ages and by age groups (0–14, 15–34, 35–54, 55–74 and ≥75 years) The YLL due to premature mortality for each cause (CVD and cancer) , gender and ... 1980 and 2010, the burden of CVD was much higher compared to cancer and, in 2010, CVD were responsible for 10,000 deaths more than cancers Among men, the YLL from cancer increased between 1980 and...

Ngày tải lên: 15/02/2014, 04:20

... The Bone and Cancer Foundation is to: • Provide information to cancer patients and family member on the causes and current treatment of cancer that involves the bone • Provide information and serve ... information can be found in the Bone and Cancer Foundation publication “Osteonecrosis of the Jaw – Information for Cancer Patients” available online at www.boneandcancerfoundation.org or by calling ... percent of people with lung cancer will have their cancer spread, or metastasize, to bone When lung cancer metastasizes, tumor cells from the original cancer break off and travel through the blood...

Ngày tải lên: 15/02/2014, 05:20

... for skin cancer, colon cancer, and lung cancer is the same for women and men (trans or not) Trans people should have the same screening as anyone else for these kinds of cancers Some cancer protocols ... detection and treatment of cancer The rest of this booklet focuses on trans-specific protocols for cancer screening Trans-Specific Cancer Screening Recommendations The earlier cancer is detected and ... spread Cancer of the uterus” usually refers to cancer of the lining of the uterus (endometrium) Endometrial cancer is the fourth most common type of cancer in BC and is the most common cancer...

Ngày tải lên: 15/02/2014, 05:20

... 303 EGFR and cancer T Mitsudomi and Y Yatabe Fig Distribution and frequency of EGFR mutations occurring in the kinase domain in lung cancer (upper part of the figure) [12] and in the extracellular ... 3-kinase, and thus is a preferred dimerization partner EGFR and cancer EGFR overexpression and cancer EGFR is expressed in a variety of human tumors, including those in the lung, head and neck, ... to ERBB3 and ERBB4 NRG1 and NRG2 bind to both ERBB3 and ERBB4, whereas NRG3 and NRG4 only bind to ERBB4 [3] Although these ligands show redundancy, heparinbinding-EGF is the only ligand whose...

Ngày tải lên: 16/02/2014, 09:20

... subcellular location and molecular function (Fig 3) To better understand the probable roles of the membrane proteomes in terms of their biological functions, the subcellular localization and ... because of their low concentration and high hydrophobicity New tools and strategies are needed so that membrane fractions from cancer cells can be screened for candidate biomarkers In this study, ... Overexpression of CLDN3, HLA-A1, TAPBP and SLC25A4 in colorectal cancer has not been prominently reported, and there is interest in developing these proteins as diagnostic and prognostic markers for this...

Ngày tải lên: 16/02/2014, 15:20

... groups and demonstrated the important differences between VTE in adults and pediatric patients and called for evidencebased guidelines for management and prevention of VTE in neonates and children ... patient lives” and issued a call for action stating that DVT and PE constitute major health problem in the USA and more people die of PE than motor vehicle accidents, breast cancer or AIDS, and physicians, ... Pselectin and thrombospondin all of which help promote thrombosis (Jy, et al 2007) 3.1.3 Microparticles, VTE and cancer In contrast to the above discussion for idiopathic VTE – thrombosis, cancer and...

Ngày tải lên: 19/02/2014, 23:20

... Double-Stranded RNA and Activation of Innate Immunity by RIG-I-Like Receptors Mitsutoshi Yoneyama and Takashi Fujita 51 Innate Immune Signaling and Negative Regulators in Cancer Helen Y Wang and ... of cancer Parts of the Book Part I of the book discusses innate immune signaling and inflammatory responses to pathogens and cancer Chapters and introduce innate lymphocytes, including NKT and ... cells and their roles in innate immune response to cancer Chapters and offer an overview of TLR- and RLR-mediated innate immune signaling and their role in detecting invading pathogens and initiating...

Ngày tải lên: 05/03/2014, 23:20

... example PET and MR and ultrasound and MR, there will be a need to have standardization in order to follow longitudinal studies of response to therapy Cancer is a multi-factorial disease and imaging ... detection of small cancers and depicts significantly more cancers and at smaller size and lower stage than does a physical examination, which detects independently extremely few cancers Mammographic ... head and neck cancer and non-small cell lung cancer (Eschmann et al., 2005) Slow specific accumulation and clearance from normoxic tissues will limit the clinical use of 18F-MISO 18F-FAZA and 18...

Ngày tải lên: 06/03/2014, 00:22

... Children and Cancer CHILDHOOD CANCER OBJECTIVES To discuss childhood cancer To address the links between childhood environments and adult onset of cancer To present current knowledge of causation and ... To discuss cancer clusters To present educational and preventive measures Children and Cancer OVERVIEW INCIDENCE AND TYPES OF CHILDHOOD CANCER CAUSES, RISK FACTORS AND HYPOTHESES ... DC Children and Cancer OVERVIEW INCIDENCE AND TYPES OF CHILDHOOD CANCER CAUSES, RISK FACTORS AND HYPOTHESES BIOLOGICAL PROCESSES LEADING TO CANCER DEVELOPMENT EXPOSURE ASSESSMENT AND ITS CHALLENGES...

Ngày tải lên: 06/03/2014, 01:20