cellular physiology of the honey bee brain

... describe the linkage map of the honey bee and its anchorage on the sequenced-based physical map We also draw out the emerging properties of the honey bee meioses and compare them to those of some ... honeygenotyped honey bee, forcontaining sequencesize andinthename,map of colA PDFandKosambithe a microsatellite-basedthethe scaffolds ,the Additionallinesscaffolds ,the4 .0),areof theThecoordinates markers, the ... physical unit of 22 cM/Mb, the average for the whole genome of the honey bee is 20 times greater than that of humans [42], 1.0 cM/Mb As the females of the two species have about the same genetic...

Ngày tải lên: 14/08/2014, 07:21

... quantification of a virus genome and antigenome in vivo using the honey bee as a model This permitted the specific identification of an important honey bee virus (DWV) replication sites in the honey bee ... Bee Culture 2000, 128:1-15 Allen M, Ball B: The incidence and world distribution of honey bee viruses Bee World 1996, 77:141-162 Ellis JD, Munn PA: The worldwide health status of honey bees Bee ... transmission of DWV and suggested that the lining of the digestive tract was likely the primary site of the DWV infection via food-borne transmission, with the virus spreading to secondary sites from the...

Ngày tải lên: 20/12/2015, 08:30

... abolished the internalization of the GFP-fused Tat protein but did not alter the uptake of the Tat CPP These biochemical evidences con®rmed a pathway for the entry of the Tat peptide unrelated to the ... rightward shift of the signal was observed signifying a reduction of the uptake of the Tat peptide at low temperature Likewise, a threefold reduction of the uptake at °C has been reported for the Antennapedia ... concentration of lgámL)1 in the presence of 100 lM chloroquine in the cell culture medium For FACS analysis, the concentration of the recombinant protein was increased to lgámL)1 The internalization of the...

Ngày tải lên: 21/02/2014, 03:20

... Although the effect of ecdysone on neurons of the central nervous system has been extensively studied in Drosophila and Manduca, little information is available on the role of EcR expression in the brain ... pattern of expression RpL32 expression did not differ between the two parts of the brain Cell-specific expression of EcR isoforms as revealed by in situ hybridization The spatial specificity of EcR-A ... distribution of gene expression (C) RT-PCR analysis of EcR expression using RNA from the anterior (A) and posterior (P) part of the brains The number of PCR cycles is indicated above the panel 3862...

Ngày tải lên: 16/03/2014, 13:20

... likely in the CIITA-NF-YB molecular complex, is at the basis of the functional inactivation of Tax-2 leading to the inhibition of HTLV-2 retrovirus replication Further studies of subcellular localization ... distribution of Tax-2 molecules was analyzed in the presence and in the absence of CIITA In the absence of CIITA, Tax-2 localizes both and in the cytoplasm and in the nucleus of 293T cells often with ... region of CIITA Furthermore, these results strongly suggest that interaction between the N-terminal, but not the C-terminal, part of CIITA, and Tax-2 is responsible of the biological effect of CIITA...

Ngày tải lên: 18/06/2014, 22:20

... likely in the CIITA-NF-YB molecular complex, is at the basis of the functional inactivation of Tax-2 leading to the inhibition of HTLV-2 retrovirus replication Further studies of subcellular localization ... distribution of Tax-2 molecules was analyzed in the presence and in the absence of CIITA In the absence of CIITA, Tax-2 localizes both and in the cytoplasm and in the nucleus of 293T cells often with ... region of CIITA Furthermore, these results strongly suggest that interaction between the N-terminal, but not the C-terminal, part of CIITA, and Tax-2 is responsible of the biological effect of CIITA...

Ngày tải lên: 20/06/2014, 04:20

... deeper into the latest science of the modern middle-aged brain, I found not bad news but good As it turns out, the brain in middle age has another story to tell that’s quite the opposite of the one ... our brains, they are neither as uniform nor as drastic as we feared Indeed, even the long-held view that our brains lose millions of brain cells through the years has now been discounted Using brain ... people who knew what they were doing These were people, also in the thick of middle age, who, despite not remembering the name of the restaurant they just ate in or the book they just read, were...

Ngày tải lên: 05/07/2014, 07:39

... every bee experiment at each distance Therefore, we suggest that the lack of enrichment for these same GO slim terms in the bee experiment may reflect the lack of a complete gene list in honey bee, ... support of the postulated role of miRNAs in regulating the alternative developmental trajectories associated with caste differentiation, we examined the functional role of honey bee official ... in honey bees Some of these novel miRNAs appear to have been overlooked in analyses of the well-studied insect Drosophila melanogaster and other genomes Results Computational identification of...

Ngày tải lên: 14/08/2014, 07:21

... Franklin Neither this thesis, nor the man I am today, would be possible without the heroic effort of Professor Too Heng-Phon, whose philosophy of mentoring is a true embodiment of the quote Professor ... this thesis is my original work and it has been written by me in its entirety I have duly acknowledged all the sources of information which have been used in the thesis This thesis has also not been ... provided conflicting results of the physiological role of this pathway in the maintenance of adult neurons No obvious differences in the morphology or biochemical properties of the dopaminergic nigrostriatal...

Ngày tải lên: 09/09/2015, 10:13

... disruption of the association of these proteins could represent a potential therapeutic strategy for the treatment of AD Here, we used GST fusion proteins of Fyn-SH2 and FynSH3 to further investigate the ... whether the tyrosine phosphorylation status of tau also affects the binding of tau to Fyn-SH3, CHO cells were cotransfected with Fyn together with either wild-type or the YF mutant forms of tau ... The SH3 domain of Fyn binds to proline-rich motifs within the sequence PXXP in interacting proteins Seven such motifs are present in the proline-rich domain of the longest isoform of tau in the...

Ngày tải lên: 14/02/2014, 14:20

... addition of DA (Fig 5) Discussion Degeneration of the dopaminergic neurons of the substantia nigra pars compacta is responsible for the major motor symptoms of PD The neurotransmitter DA has been ... counter Values are the mean of six replicates The specific uptake was determined by subtracting the uptake counts in the absence of inhibitor from the uptake counts in the presence of cocaine or S-citalopram, ... total concentration of DA and the y axis shows the DA uptake after 10 The y axis demonstrates specific uptake, defined as total uptake subtracted the uptake in the presence of the DAT inhibitor cocaine...

Ngày tải lên: 14/02/2014, 21:20

... roles of GIF within the brain Further studies are required to determine the function of GIF within the normal, injured and neurodegenerative brain, and to establish the therapeutic potential of the ... brain injury or neurodegenerative disease Synthesis and secretion of GIF in the brain Cellular and temporal localization of GIF synthesis Whilst the MT1 and MT2 isoforms are ubiquitously synthesized ... conditions [22] In the traumatically injured brain, however, the synthesis of MT1 and MT2, as well as the synthesis of GIF, are up-regulated by reactive astrocytes in the vicinity of the lesion [23]...

Ngày tải lên: 16/02/2014, 15:20

... through the extracellular matrix with the help of matrix metalloproteinase [82] The consequent event of brain macrophages is one of the most important defense mechanisms used by the brain However, ... and barriergenesis fers according to the size of the vessels In the brain, pial arteries invade the brain parenchyma and reduce the width of arterioles, then form deep branches that become small ... In particular, the concept of a ‘neurovascular unit’ that encompasses neurons, vessels and other types of cells located at their interface has become one of the main themes of brain science [43,44]...

Ngày tải lên: 18/02/2014, 11:20

... Physiology and pathophysiology of the SREBP family H Shimano at G1 [19] In particular, p21 is a direct target of SREBP [20] The role of SREBP-1a in the regulation of cell growth and the cell cycle ... H Shimano Physiology and pathophysiology of the SREBP family SREBP-1c and lipogenesis The SREBP family consists of three isoforms: SREBP1a, SREBP-1c, and SREBP-2 Each isoform has a different ... resistance [48] The exact roles of SREBP-1c ⁄ ADD1 are not yet fully defined SREBP and parasympathetic function in heart Parasympathetic stimulation of the heart involves activation of GIRK1 ⁄ 4,...

Ngày tải lên: 18/02/2014, 13:20

... [17,18] In several of the ARTs, the replacement of this second glutamate abolishes the ability of these transferases to use arginine as acceptors, thus further supporting the hypothesis that this ... Despite the low similarity at the level of their amino-acid sequences, there are common structural features that characterize this family of mammalian ARTs [15,16] The catalytic domain of these ... needs to be clarified is the occurrence of the extracellular NAD+ that is required to sustain the ADP-ribosylation reaction The steadystate concentration of NAD+ in the serum of healthy individuals...

Ngày tải lên: 20/02/2014, 02:21

Ngày tải lên: 28/02/2014, 20:18

... world!" "Snakes of the Santo!" Friday gasped, the whites of his eyes showing all around "Then we must be on an asteroid!" They were From the far side of the dome ahead of them the asteroid stretched ... acceptance of the astounding fact; he was too busy to make comment He was observing the buildings, the nature of them, the exits from the dome, how they could best be reached T HEY stood on the roof of ... In the middle of that night, when the pleasures of Porno were in full stride, there emerged suddenly, from one of the dark, crooked byways that angled off the Street of the Sailors, a squad of...

Ngày tải lên: 06/03/2014, 17:20

... investigated the cellular localization of GFPtagged versions of these proteins, as well as their ability to support growth Besides clarifying the relative importance of different regions of the Lsm1 ... (Fig 1B) [32] The Lsm1 and Lsm8 polypeptides are most similar in the regions of the Sm1 and Sm2 motifs These motifs form the Sm-fold, the hallmark of the Sm-like proteins, consisting of a five-stranded ... for the localization and function of these complexes In budding yeast, only one form of the homologous Sm complex exists; it forms the core of non-U6 spliceosomal snRNPs and accumulates in the...

Ngày tải lên: 07/03/2014, 02:20

... level over the time period of the experiments as conducted here As shown below, alterations in the levels of the differentially glycosylated forms of GC-C regulate the cellular response to the ST-peptide, ... thought they were able to bind the ST peptide (Fig 2) Therefore, there appeared to be a correlation between the presence of the 145 kDa form of GC-C, which represents the mature glycosylated form of ... amount of 130 kDa protein was localized on the surface of The studies described in this report suggest that regulation of the glycosylation of GC-C can act as a means of controlling the ability of...

Ngày tải lên: 08/03/2014, 08:20

... 77 FIVE The Mommy Brain 95 SIX Emotion: The Feeling Brain 117 SEVEN The Mature Female Brain 135 EPILOGUE The Future of the Female Brain 159 vii C o n t e n ts APPENDIX ONE: The Female Brain and ... displays of status They often express agreement with a partner’s suggestions And when they have ideas of their own, they’ll put them in the form of questions, such as “I’ll be the teacher, okay?” Their ... created The boys pushed the girls around, refused to take turns, and would ignore a girl’s request to stop or give the toy back By the end of the morning, Leila had retreated to the other end of the...

Ngày tải lên: 08/03/2014, 23:20