cell surface engineering of mesenchymal stem cells

... Regulation of stemness and stem cell niche of mesenchymal stem cells: implications in tumorigenesis and metastasis J Cell Physiol 2010, 222:268-277 Ohishi M, Schipani E: Bone marrow mesenchymal stem cells ... Grünwald-Giemsa staining (Figure 1B) of HPBAML-I cells revealed that this cell line is composed of round-polygonal and spindle-like cells Unlike the round-polygonal cells, HPB-AML-I cells with the spindle-like ... decreased after passage of round-polygonal cells Normal cells are known to have the property of contact inhibition, which is lost in transformed cells Therefore, cellto -cell contact might induce...

Ngày tải lên: 10/08/2014, 10:20

... delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells Stem Cells 2007, 25(7):1618-26 12 Komarova S, Kawakami Y, Stoff-Khalili MA, Curiel DT, Pereboeva L: Mesenchymal progenitor cells ... the level of cells that home to tumors or other sites The tumor homing behavior of MSCs was demonstrated by the mere presence of these cells in the sites of interest and/or lack of such cells in ... phenomenon of MSCs was confirmed in different experimental systems [2,12] Other cell types, such as umbilical cord matrix stem cells (UCMS) [14], neural stem cells [15,16] and endothelial progenitor cells...

Ngày tải lên: 20/06/2014, 07:20

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Ngày tải lên: 07/08/2014, 18:21

... accelerated degeneration of the treated IVD [18-24] An alternative cell source are adult stem cells, in particular, bone-marrow-derived mesenchymal stem cells (MSCs) The use of these cells would allow ... Intervertebral disc cell- mediated mesenchymal stem cell differentiation Stem Cells 2006, 24:707-716 27 Richardson SM, Hughes N, Hunt JA, Freemont AJ, Hoyland JA: Human mesenchymal stem cell differentiation ... E, Bertram H, Abel R, Chen B, Winter A, Richter W: Induction of intervertebral disc-like cells from adult mesenchymal stem cells Stem Cells 2005, 23:403-411 44 Risbud MV, Albert TJ, Guttapalli...

Ngày tải lên: 09/08/2014, 01:22

... L-selectin)/lymphohematopoietic stem and progenitor cells, small-vessel endothelial cells, embryonic fibroblasts Augments B responses/ plasma cells Growth, differentiation, and isotype-switching of B cells/ B cells Ligand ... marrow-derived mesenchymal stem cells and neural progenitor cells Haematologica 2003, 88:126-133 Reyes M, Verfaillie CM: Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal ... Ligand for CD28 and CD152 (CTLA-4)/B cells Growth factor receptor/haemopoietic stem and progenitor cells, mast cells Function unknown/haematopoietic stem cells and precursors [67] [67,68] [67]...

Ngày tải lên: 09/08/2014, 08:23

... Expression levels of ADAM and adhesion molecules during chondrogenic differentiation of mesenchymal stem cells (MSCs) The gene-expression (MSCs) profile of mesenchymal stem cells (MSCs; n = 2) ... Page of 12 (page number not for citation purposes) Arthritis Research & Therapy Vol No Djouad et al Figure stem cells of the expression of cell- surface proteins on mesenchymal Modulation(MSCs) stem ... 39 40 41 42 43 44 45 46 47 48 49 characterization of mesenchymal stem cells Stem Cells 2006, 24:475-481 Charo IF, Ransohoff RM: The many roles of chemokines and chemokine receptors in inflammation...

Ngày tải lên: 09/08/2014, 10:20

... migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells Stem Cells 2007, 25:520-528 Reya T, Morrison SJ, Clarke MF, et al: Stem cells, cancer, and cancer stem cells ... ratio of MSCs to cancer cells, nature of tumour cells and cancer stem cells, integrity of immune system, number of stem cell passages and site of injection; all can affect the outcome of MSCs ... relationship between stem cells and tumor cells Qiao and coworkers reported that human mesenchymal stem cells (hMSCs) can home to tumor sites and inhibit the growth of tumor cells[ 8] Furthermore,...

Ngày tải lên: 10/08/2014, 10:21

... invasion of mesenchymal stem cells J Mol Cell Cardiol 2008, 44:1072-1084 30 Estrada R, Li N, Sarojini H, An J, Lee MJ, Wang E: Secretome from mesenchymal stem cells induces angiogenesis via Cyr61 J Cell ... et al.: The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities Stem Cells 2007, 25:1737-1745 24 Segers VF, ... early activation of MSC: specifically, an increase in the mobility of these stem cells and in their adhesion to endothelial cells Moreover, it was also found that the serum of apneic rats improved...

Ngày tải lên: 12/08/2014, 11:22

... Characterisation of canine adipose tissue derived mesenchymal stem cells In order to demonstrate that the cells isolated from the canine adipose tissue (Figure 1A) are indeed mesenchymal stem cells (MSCs) ... morphological features of apoptotic cell death was determined by scoring 100 cells from 30 different microscopic fields per culture and the number of apoptotic cells expressed as an indicator of MSC culture ... the biofunctions and biotransformations of curcumin Biofactors 2000, 13:153-158 19 Conget PA, Minguell JJ: Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells...

Ngày tải lên: 12/08/2014, 14:22

... Figure Mesenchymal stem cells used during this study Mesenchymal stem cells used during this study Typical morphological aspects of mesenchymal stem cells observed through culture flask (A) Mesenchymal ... distribution of mesenchymal stem cells in vivo Figure Early dynamic distribution of mesenchymal stem cells in vivo Sequential whole body scintigraphies after infusion of indium-111 labeled mesenchymal stem ... perspective of cellular therapy by intravenous stem cells infusion The participation of stem cells in several vascular diseases pathogenesis was first proved with haematopoietic stem cells (HSCs)...

Ngày tải lên: 12/08/2014, 18:20

... interventions28 Mesenchymal Stem Cells In The Treatment Of Acute Myocardial Infarction With the emergence of stem cells as potential regenerative medicine, attempts to use stem cells to reduce ... 2004 Mesenchymal stem cells and their potential as cardiac therapeutics Circ Res 95, 9–20 Quesenberry, P.J., Aliotta, J.M., 2008 The paradoxical dynamism of marrow stem cells: considerations of stem ... transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Nat Cell Biol 9, 654–659 Zimmet, J.M., Hare, J.M., 2005 Emerging role for bone marrow derived mesenchymal stem cells...

Ngày tải lên: 10/09/2015, 08:42

... Making use of multiple pathways, in vitro expanded MSCs have been shown to suppress the function of a broad range of immune cells, including T cells, B cells, NK cells and antigen-presenting cells ... differentiation of bone marrow mesenchymal stem cells Society for Neuroscience 35th Annual Meeting, Washington DC, USA Chao YX, He BP, Tay SSW (2006) Immune Potential of Mesenchymal Stem Cells Society for ... Genetic background of stem cells in stem cell transplantation……………93 3.1.1 Characterization of in vitro cultured MSCs……………… …………94 3.1.2 Effect of NFL knockout on the proliferation of MSCs……… …… 95...

Ngày tải lên: 11/09/2015, 09:05

... Human Adult Mesenchymal Stem Cells HfMSC Human Fetal Mesenchymal Stem Cells HSC Hematopoietic stem cells HUVEC Human Umbilical Vein Endothelial Cells ICAM-1 Inter-cellular cell adhesion molecule IFN-β ... Vascular cell adhesion molecule VLA4 Very Late Antigen (α4β1 integrin) ix Introduction 1.1 Mesenchymal stem cells Mesenchymal stem cells (MSC), otherwise known as bone marrow stromal cells, was ... full of love i Table of Contents Introduction .1 1.1 Mesenchymal stem cells 1.1.1 MSC of fetal origin 1.1.2 Potential applications of MSC 1.1.3 Mode of...

Ngày tải lên: 13/10/2015, 15:54

... x List of Abbreviations and acronyms xii Introduction 1.1 Mesenchymal stem cells (MSC) 1.1.1 Definition of stem cells 1.1.2 Criteria of being stem cells ... microlitres xvii INTRODUCTION 1 Introduction 1.1 Mesenchymal stem cells (MSC) 1.1.1 Definition of stem cells Stem cells (SC) are defined functionally as cells that have the capacity to self-renew and ... the stem cell pool There are two schools of thought for stem cells regeneration (Watt & Hogan, 2000) One, known as invariant asymmetric division, involves a stem cell undergoing asymmetric cell...

Ngày tải lên: 16/10/2015, 15:35

... promise for the future of tissue engineering and regeneration [134] Mesenchymal stem cells versus embryonic stem cells Embryonic stem (ES) cells are derived from the inner cell mass of the embryonic ... the use of ES cells Future of mesenchymal stem cells To seriously consider the applications of MSCs for regeneration and tissue engineering, two key fundamental questions regarding these cells ... which is often used for either hematopoietic or mesenchymal stem cells, the central nervous system stem cell, the hepatic stem cell, etc.? If many stem cells are found circulating, not only the specific...

Ngày tải lên: 09/08/2014, 01:21

... functionality of cell surface molecules on human mesenchymal stem cells J Biomed Sci 2003, 10:228-241 Reyes M, Verfaillie CM: Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal ... characterization of size-sieved stem cells from human bone marrow Stem Cells 2002, 20:249-258 Shur I, Marom R, Lokiec F, Socher R, Benayahu D: Identification of cultured progenitor cells from human ... cytometry analysis of cells Either isolated cells from OC were directly used for flow cytometric analysis or cells were used after adherence and cultivation, as described above Cells were washed...

Ngày tải lên: 09/08/2014, 01:23

... of 11 Mesenchymal stem cell treatment has no effect on the development of collagen-induced arthritis Figure Mesenchymal stem cells (MSCs) inhibit the anti-CD3induced proliferation of CD4+ T cells ... Page of 11 Figure Mesenchymal stem cells (MSCs) inhibit the proliferation of CD4 + T cells in vitro by induction of nitric oxide and prostaglandin E2 (PGE2) (a) CD4+ T cells, in the presence of ... activity of human bone marrow mesenchymal stem cells Stem Cells 2006, 24:386-398 Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D: Human bone marrow stromal cells inhibit allogeneic T-cell...

Ngày tải lên: 12/08/2014, 11:23

... .44 2.8.2 Cellular Sources 46 2.8.2.1 Osteogenic Cells 46 2.8.2.2 Mesenchymal Stem Cells 48 2.8.2.3 Mesenchymal Stem Cells in Bone Tissue Engineering .49 ... choice of cells, scaffolds, bioreactor and microenvironment oxygen tensions Low O2 MSC + EPC Stem Cells Scaffold Bioreactor BTE Component Coculture of Honeycomb mesenchymal stem macroporous cells ... Proposed Cell Type – Human Fetal Mesenchymal Stem Cells 50 2.8.2.5 Endothelial Cell Types 51 2.8.2.6 Endothelial Progenitor Cells 52 2.8.2.7 Endothelial Progenitor Cells in...

Ngày tải lên: 09/09/2015, 10:16

... improvement of blood circulation in the necrotic femoral head and surrounding tissues [4] Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types ... Treatment of Femoral Head Necrosis with Arterial Perfusion of Marrow Stem Cells Chin J Integr Trad West Med 2004,24(11):999-1002 Yan Z, Hang D, Guo C, Chen Z Fate of mesenchymal stem cells transplanted ... to human Stem Cells Dev,2006,15(3):349-357 Devine SM, Bartholomew AM, Mahmud N, et al Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion...

Ngày tải lên: 25/10/2012, 11:18

... Kitamura S & Nagaya N (2007) Effect of hypoxia on gene expression of bone marrowderived mesenchymal stem cells and mononuclear cells Stem Cells 25, 1166–1177 Li L, Zhang S, Zhang Y, Yu B, Xu Y & Guan ... DR (1999) Multilineage potential of adult human mesenchymal stem cells Science 284, 143–147 Porada CD, Zanjani ED & Almeida-Porad G (2006) Adult mesenchymal stem cells: a pluripotent population ... effect of transplanted mesenchymal stem cells in a rat model of global heart failure Mol Biol Rep 36, 725–731 Li L, Zhang Y, Li Y, Yu B, Xu Y, Zhao S & Guan Z (2008) Mesenchymal stem cell transplantation...

Ngày tải lên: 18/02/2014, 04:20