cell gene expression signatures in inflammatory breast cancer

... breast cancer gene expression profiling-based assays are now available in the U.S These assays investigate the expression of specific panels of genes by measuring their RNA levels in breast cancer ... required for use in diagnostic or predictive testing In recent years, gene expression profiling has been successfully used in breast cancer research For instance, distinct subtypes of breast tumors ... http://www.ahrq.gov/clinic/tp/brcgenetp.htm 21 gene expression profiling We used a systematic approach for searching the literature to minimize the risk of bias in selecting articles for inclusion in the review In...

Ngày tải lên: 06/03/2014, 01:20

... clinically distinct subsets One report has described microarray findings in MS brain lesions using autopsy samples from human subjects [8] This study highlighted several genes, including some involved ... others encoding proteins involved in cell cycling A second report generated using MS patients is the only one that has examined longitudinal specimens from patients enrolled in a clinical trial [13] ... other groups (working in MS and SLE) by including patients with RA and IDDM, and by offering direct comparisons between them The similar gene expression findings in these clinically diverse conditions...

Ngày tải lên: 09/08/2014, 01:23

... differential gene expression will be examined in those cells that are important in RA pathogenesis In the present study we conducted a global analysis of coordinated gene expression in injured tissue ... [18] Interestingly, most of the genes exhibiting the greatest fold increase in gene expression (Delta > 5) on days -13.8, -13 or were involved in chemotaxis These included several CC chemokine ... analyzed gene expression profiles in rat joints with SCW-induced arthritis using RAE230A GeneChip® oligonucleotide microarray (Affymetrix Inc.) We chose to profile gene expression in whole ankle joint...

Ngày tải lên: 09/08/2014, 06:22

... in breast cancer tumorigenesis and malignant progression Breast Cancer Res 2001, 3:289-293 Rimm DL, Sinard JH, Morrow JS: Reduced alpha-catenin and Ecadherin expression in breast cancer Lab Invest ... carcinoma cases with cytoplasmic staining were included in the general category of reduced expression of E-cadherin staining Competing interests In conclusion, using real time quantitative PCR we ... e-cadherin in a high-risk breast- cancer population Int J Clin Oncol 2004, 9:154-160 Kleer CG, van Golen KL, Braun T, Merajver SD: Persistent E-cadherin expression in inflammatory breast cancer...

Ngày tải lên: 09/08/2014, 07:21

... biological processes involved at RA onset Conversely, genes involved in the cell cycle, apoptosis inhibition, and granulocyte-mediated immunity were upregulated in LS RA, suggesting the involvement of ... activation, endothelin signaling pathway, hypoxia response, and plasminogen-activating cascade In cluster 2, 216 genes were expressed significantly more in LS than early RA The main biological processes ... corresponding genes were significantly upregulated during early RA (Table S3 in Additional data file 3) Many pathways involved in this gene cluster were also significantly recognized (P < 0.05): T-cell...

Ngày tải lên: 09/08/2014, 14:22

... mapping to a gene in an individual, divided by the length of the gene In the methylation to gene expression comparisons we split genes into quantiles based on the mean Page 10 of 13 gene expression ... predominantly near transcription start sites However, not much is known about the precise mechanisms by which genetic variants modify gene- expression Combining genetic, epigenetic, and gene expression ... [20,22] and RNA sequencing [23,24], as well as smaller studies of variation in chromatin accessibility and PolII binding [25,26] Finally, one of the HapMap cell lines is now being intensely studied...

Ngày tải lên: 09/08/2014, 22:23

Ngày tải lên: 09/08/2014, 23:20

... categories: no staining, or weak staining in fewer than 10% of the tumor cells (0); weak staining in part of the membrane in more than 10% of the tumor cells (1+); complete staining of the membrane ... positive staining of p53 in a representative case of high-grade (G3) ductal carcinoma Immunostaining shows a clear and wide nuclear staining in an high grade (G3) invasive ductal carcinoma Original ... of cancer and the second leading cause of cancer death in women in the USA [1] and its incidence is increasing in many countries, including Italy [2] thus representing a major health problem To...

Ngày tải lên: 10/08/2014, 10:21

... erythropoiesis [31] by inducing hepatic expression of hepcidin and subsequent decreased intestinal absorption of iron and by inducing ferritin expression in monocytes/macrophages, causing iron sequestration ... wholegenome gene- expression analysis technology has allowed the discovery of sJIA-specific gene- expression signatures, opening a window into disease pathogenesis and diagnosis [14,21,22] In a previous ... Clustering of gene- expression profiles from purified cells by using the erythropoiesis signature The file contains a heat map showing clustering of RNA samples from purified cell populations Expression...

Ngày tải lên: 12/08/2014, 14:22

... stromal cells Localizing expression of interferon-response genes to breast cancer cell lines We investigated in which cell the interferon-response genes were induced in response to heterotypic interaction ... following response in two types of breast cancer cell lines Induction of interferon page) Induction of interferon response in two types of breast cancer cell lines (a) MDA-MB231 cells were incubated ... heterotypic interaction effects As a model for investigating the gene expression program in response to heterotypic cell- cell interaction in normal breast and in breast cancer, we examined cells representing...

Ngày tải lên: 14/08/2014, 08:20

... PTL induces apoptosis in primitive cancer cells PTL induces apoptosis in primitive cancer cells Percent viability of prostate cancer cells and cells from a patient with BPH treated with increasing ... found in vivo [29] This suggests that the use of feeder cells in our cultures of cancer stem cells is likely to be important for maintaining gene expression patterns similar to cancer stem cells in ... Distinctive stem cell and tumor signatures are found in human prostate cancers containing a minimum Gleason score pathology Distinctive stem cell and tumor signatures are found in human prostate cancers...

Ngày tải lên: 14/08/2014, 08:21

... the expression of miR-519b was 8-fold greater in hES cells than in EB cells and it was not even detected in adult cells The expression of miR-520b was 26-fold greater in hES cells then in EB cells ... different cell lines tested or the different technical platforms used in assessing miRNA expression Gene expression profiling We assessed global hES gene expression profiles on separate passages of cells ... reported in human [16,17] and mouse embryonic stem cells [18-20] The unique patterns of miRNA expression in embryonic stem cells suggest they are involved in maintaining "stemness" Identifying mRNAs...

Ngày tải lên: 18/06/2014, 15:20

... of staining and the proportion of positive staining carcinoma cells within the entire slide: “0”, no immunostaining was observed within carcinoma cells; “+”, less than 10% of carcinoma cells ... 16 17 18 19 20 21 22 of cell- of-origin breast tumor subtypes in inflammatory breast cancer by gene expression profiling Breast Cancer Res Treat 2006, 95:243-255 Alberini JL, Lerebours F, Wartski ... KL: Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer Breast Cancer Res Treat 2006, 95:219-228 Mohamed MM, Sloane BF: Cysteine cathepsins: multifunctional...

Ngày tải lên: 18/06/2014, 16:20

... delta7-reductase gene expression in cumulus cells during meiotic resumption of porcine oocytes Endocrinology 2005, 146:186-194 Shimada M, Anas MKI, Terada T: Effects of phosphotidylinositol 3-kinase inhibitors, ... by FSH in granulosa cells Mol Endocrinol 2000, 14:1283-1300 Qin L, Partridge NC: Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase ... TACE/ADAM17 expression in cumulus cells cultured with FSH and/or LH have remained unclear during in vitro maturation of porcine COCs http://www.ovarianresearch.com/content/2/1/20 The binding of FSH...

Ngày tải lên: 20/06/2014, 07:20

... expressed in cultured bovine granulosa cells and involved in the maintenance of cell differentiation [30] The activity of this enzyme is increased in rabbit ovarian follicles after hCG-induced ... panel) and mean gene expression intensities (right panel) of detected and undetected genes in gene arrays The number of undetected genes was higher than that of detected genes in all arrays (left ... oxidizes peptidyl lysine to peptidyl aldehyde residues within collagen and elastin, initiating formation of the covalent cross- linkages that insolubilize these extracellular proteins [34] This enzyme...

Ngày tải lên: 20/06/2014, 07:20

... made in Spain on HRQL in Breast Cancer patients In brief, there is clearly insufficient information available on the HRQL of Spanish women with breast cancer Since HRQL is one of the principal ... despite the general recommendation to include HRQL as an outcome in clinical studies involving breast cancer patients [49], and the fact that HRQL questionnaires are routinely used in clinical research ... Breast Neoplasm” AND “Spain” in PubMed, EMBASE and PsycINFO, with Breast Cancer also being used as a key word; “Quality of life” AND Breast cancer in Dialnet; “quality” AND “life” AND cancer ...

Ngày tải lên: 20/06/2014, 15:20

... recent changes in lifestyle will increase the incidence of breast cancer in carrier families In conclusion, our findings suggest that the norms of accepting breast cancer cases for BRCA analysis ... does it relate to breast cancer in African-American women? Cancer, 2005, 103(8): 1540-1550 Collaborative Group on Hormonal Factors in Breast Cancer Breast cancer and breastfeeding: collaborative ... proportion of breast cancer overall We therefore set out to determine the contribution of mutations in the BRCA1 gene to breast cancer in Algeria This was a pilot study to determine inclusion criterea...

Ngày tải lên: 08/08/2014, 17:20

... obvious as being truly regulated A different cellular composition resulting from infiltration is inherent in the inflammatory processes analysed in rheumatology Parameters that reflect this cellular ... the investigators could not identify genes that distinguished between different autoimmune diseases Their candidates were predominantly genes involved in apoptosis, cell cycle progression, cell ... groups [6–9] have independently identified an interferon signature by analysing PBMCs One group [7] confirmed these findings by comparing the patients’ profiles with in vitro-induced interferon (IFN)-α,...

Ngày tải lên: 09/08/2014, 01:23

... antiinflammatory cascade [51] Thus, gene expression related to pro -inflammatory and anti -inflammatory events can be detected even before the migration of inflammatory leukocytes into the joints ... http://arthritis-research.com/content/7/2/R196 Figure genes in inflamed joints were those involved in immune responses: 51 genes in AA and 25 genes in CA These genes were upregulated as much as 31-fold (group average) in acute arthritis ... preinflamed joints, in paws normal paws of naive BALB/cSCID comparison Fold gene expression in with genes and chronic arthritis, in mice inflamed joints, in paws with acute and chronic arthritis, in comparison...

Ngày tải lên: 09/08/2014, 06:22

... tumour characteristics including stage distribution [17] are detailed in table Pathology reports revealed in 80.7% invasiv ductal and in 9.2% invasiv lobular carcinoma; in 3.7% a DCIS was found ... was also involved in the clinical patient management KE participated in the study development especially by helping to define the Page of study endpoints KE was also actively involved in the data ... Clinical assessment of breast anatomy and marking Volume, CTV) Organs at risk were the lung and the contralateral breast In nodal negative breast cancer patients the axillar region was defined...

Ngày tải lên: 09/08/2014, 09:20