cell cycle transcription regulation
Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... p53. Cell cycle arrest can be medi-ated by p53 downregulating the transcription of central cell cycle regulators such as cyclin B, Cks1, Cdc2 and Cdc25C.CDE ⁄ CHR-dependent cell cycle- gene transcription ... RegulatedDuring the Cell Cycle by a CDE ⁄ CHR TandemElement and is Downregulated by p53 but not by p63or p73. Cell Cycle 6, 853–862.37 Yoshida K (2005) Cell- cycle- dependent regulation ofthe ... found to play only a limited role in cell cycle- dependent transcription [4]. Later, this finding on theCDE was confirmed and the major cell cycle- depen-dent regulation was attributed to a novel...
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cell cycle regulation - Ebook USA ( biotechnology)
... TransductionofDNADamageSignals 744 Regulation of Downstream Cellular Processes . . . . . . . . 764.1 RegulationoftheCellCycle 774.2 RegulationofDNAReplicationForks 784.3 RegulationofDNARepair 794.4 RegulationofTelomeres ... restriction point of the cell cycle. Cell Cycle 1:103–110Buchkovich K, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylatedduring specific phases of the cell cycle. Cell 58:1097–1105Burdon ... ofcritical cell cycle machinery.2.3 Cell Cycle MachineryRecognition that specific protein catalysts are responsible for diverse cellu-lar processes such as fermentation (late 1800s) suggested that cell...
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Cell Cycle Regulation in Mammalian Germ Cells
... Probl Cell Differ (42)P. Kaldis: Cell Cycle Regulation DOI 10.1007/003/Published online: 20 December 2005© Springer-Verlag Berlin Heidelberg 2005 Cell Cycle Regulation in Mammalian Germ CellsChanganamkandath ... female Cell Cycle Regulation in Mammalian Germ Cells 347Table 1 (continued)Gene Protein Name Effect on germ cell development Refs.B. Transcriptional and Translational FactorsAhch Dax1 A transcriptional ... metaphase stage in knockouts. Cell Cycle Regulation in Mammalian Germ Cells 351Table 1 (continued)Gene Protein Name Effect on germ cell development Refs.E. Prophase-I Regulation Atm Ataxia A nuclear...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
... critical regulator of most cell cycle responses. While each single pocket protein can mediate cell cycle arrest upon cell- cell contact, pRb is the critical mediator of cell cycle arrestupon growth ... roles in controlling cell cycle exit upon growth-inhibiting signals. Only ablation of all pocket proteins fullyalleviated a cell cycle arrest upon serum withdrawal, cell- cell contact inhi-bition, ... pro-teins at these specific stages of the cell cycle. 4.4pRb Family Mediated Regulation of E2F by Cellular LocalizationAnother level of control of the E2F transcriptional activity is added by the...
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Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
... tangles contain the antigenic profile of many cell cycle markers, re-flecting a re-entry into the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is an early and ... suppression of the cell cycle and cell survival instead of apoptosis and their presence may be a neuroprotective factor to prolong the life of the cell after re-entry into the cell cycle, pro-tecting ... dividing neuronal cells during development, and is present in smaller amounts in fully differentiated cells [13]. BRCA1 is known to regulate transcription, regulate cell cycle progression,...
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Báo cáo y học: "Cell Cycle Arrest by a Natural Product via G2/M Checkpoint"
... of cell cycle arrest and apoptosis. We have investigated its effects on cell cycle regulation using a gastric cancer cell line, AGS. The effects of CKBM on cell proliferation, cell cycle regulation ... cell line. CKBM is found to inhibit cell proliferation through the induction of apoptosis and G2/M cell cycle arrest. To further elucidate the mechanism of CKBM on apoptosis and G2/M cell cycle ... AGS cells were seeded in a 6-well plate at a density of 1.2 x 106 cells/well. After 2, 4 or 6 hr of CKBM treatment at a concentration of 5, 10 or 15 % v/v, cells were trypsinized. Then cells...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
... Nature 343:665–669Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231 cycle, and strongly suggested that deregulation of the mechanisms controlling cell cycle progression could ... coordinate cell cycle exit with the induction of differentiationthat confers upon pRB its tumor suppressor function.230 L. Yamasaki2The Universality of the Cell Cycle The discovery of the cell cycle ... progression.Results Probl Cell Differ (42)P. Kaldis: Cell Cycle Regulation DOI 10.1007/b136682/Published online: 1 September 2005© Springer-Verlag Berlin Heidelberg 2005Modeling Cell Cycle Control and...
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MouseModels of Cell Cycle Regulators - New Paradigms
... mammalswithin certain cell types such as trophoblast giant cells of the placenta andmegakaryocytes, but it can also be observed in cells due to a defect in the cell cycle regulation of these cells. For ... principal cell cycle inhibitor in β cells, as it accumu-latesinthenucleusofβ cells from obese mice, inhibiting compensatory β cell expansion (Uchida et al. 2005).Mouse Models of Cell Cycle Regulators: ... one round of cell division, every cell in metazoans hasto decide whether it will re-enter the cell cycle, exit the cell cycle and en-ter a quiescence state, and every quiescent cell has to similarly...
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Senescence and Cell Cycle Control
... RA (1995) The role of Rb in cell cycle control. Prog Cell Cycle Res 1:9–19Senescence and Cell Cycle Control 259eliminates telomere-mediated signaling, allowing cells to undergo transform-ation ... ofretinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424:223–228Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell- cycle controlcausing specific inhibition of ... and cell mortality. Cell 85:27–37Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokespremature cell senescence associated with accumulation of p53 and p16INK4a .Cell 88:593–602Sharpless...
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The ubiquitin-proteasome pathway in cell cycle control
... a transcription factor that is activated in response tovariety of cellular stresses, evokes a number of responses ranging from cell cycle arrest to programmed cell death, depending on the cell ... Probl Cell Differ (42)P. Kaldis: Cell Cycle Regulation DOI 10.1007/b136681/Published online: 6 July 2005© Springer-Verlag Berlin Heidelberg 2005The ubiquitin-proteasome pathway in cell cycle ... from studies on the early embryonic cell cycles ofTable 1 Cell cycle targets of the anaphase promoting complexSubstrate Organism Specificity factor Cell cycle functionSecurin S. cerevisiae...
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Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
... phase of the cell- division cycle. Therefore, we tested,using light microscopy and after DAPI staining, whetherthe slow growth yields a cell- cycle phenotype. Cells ofthe logarithmically ... asynchronouscells. To test whether phosphorylated Rio1p is, in fact,degraded at a certain stage of the cell- division cycle, whereas the unphosphorylated form is not, we per-formed cell- cycle arrest ... observeda cell- cycle phenotype with this mutant. Cytologicalapproaches investigating cell- cycle stages reveal thatthis mutant yeast strain accumulates G1cells, whereasthe number of S phase cells...
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Báo cáo khoa học: MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-jB1 ppt
... ES-2 cells and cell growth activity was detected using a MTT assay. It wasindicated that knockdown of NF-jB1 suppressed cell growth in a time-dependent manner. A significant reduc-tion in cell ... whether overexpression of miR-9 in ES-2 cellscould affect cell growth. In a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay,cells transfected with miR-9 expression ... miR-9 in ES-2 cells caused a 20%reduction in cell proliferation at 72 h after transfection(Fig. 2C). These results indicated that the expressionlevel of miR-9 had an influence on cell growth....
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Báo cáo khoa học: 3 Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines potx
... upon cell cycle exit. To this effect, HFF cells weredeprived of serum f or 48 h to induce cell cycle exit. Serumwas th en r e-added a nd samples taken as cells progressedinto the cell cycle. ... [13]. When cells exit the cell cycle, licensing in lost, a nd is est ablished again a s cells prepare t oreenter the cell cycle. While a previous study did not detect asignificant down -regulation ... in quiescent cells, suggesting that i n contrast to their regulation during the cell cycle [13], upon exit and entry tothe cell cycle both genes are controlled, at least in part,transcriptionally.Cdt1...
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Báo cáo khoa học: A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis doc
... staining cells. Scale bars = 200 lm. (F) Quantification of binucle-ated cells in control and Grx3-KD cells. Total 600 cells counted for control cells and 360 cells counted for Grx3-KD cells. The ... finish cell cycle back to G1phase. Cells were harvested at 2-h intervals.Half of cells were stained with propidium iodide, and analyzed by FACS. Another half of cells were prepared for cell ... Given the complexity of cell cycle regulation and the numerous intracellular compo-nents responding to oxidative stress, it is not surprisingthat Grx3-mediated cell cycle control may be depen-dent...
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Báo cáo khoa học: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex doc
... (a) cellspulse treated (1 h) with cycloheximide early in the cell cycle (before RP) immediately suffer a long delay inthe cell division cycle; (b) cells treated late in the divi-sion cycle ... asthe emergent RP in the mammalian cell cycle) in termsof the multitude of reaction steps and interactionsbetween the cell s molecular parts (e.g. cell cycle pro-teins) [18]. Numerous studies ... restrictionpoint of the cell cycle. Cell Cycle 1, 103–110.4 Yao G & Lee TJ, Mori S, Nevins JR & You L (2008)A bistable Rb-E2F switch underlies the restrictionpoint. Nat Cell Biol 10, 476–482.5...
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