cell cell adhesion and communication the discovery of toposome

... the design and coordination of the study MM, HI, and RS participated in the design of the study and the maintenance of the animals KM provided the animals and gave final approval of the version ... first measured the number of Tregs in the spleen by flow cytometry The percentages of CD4+CD25+ T cells among spleen cells and of CD25+ cells among CD4+ T cells were not different Page of 11 (page ... with that when they were actively immunized, these results nevertheless support a regulatory role of RP105 in the development of arthritis induced by TLR ligands On the other hand, these in vivo...

Ngày tải lên: 09/08/2014, 13:22

... increases the growth rate and shortens the duration of the cell cycle is the polymer-inherent isosterism of the carboxylates with the array of phosphates in nucleic acids and, consequently, the competition ... changes in the levels of PMLA in cytoplasm and nuclei, we injected 400 lg of the polymer into M3CVII and LU887 plasmodia (weights of 150 mg) and measured the PMLA contents of nuclear and cytoplasmic ... the mechanism(s) underlying the increase in the growth rate and the shortening of the cell cycle might be related to the ability of PMLA to form complexes with nucleic acid binding proteins and...

Ngày tải lên: 16/03/2014, 18:20

... majority of BMSCs (97%) showed remarkable DiI-Ac-LDL and OVA-FITC endocytosis, and VCAM-1 expression Of these, 48% expressed von Willebrand antigen, suggesting their endothelial cell phenotype The other ... (A375M) cells constitutively expressed COX-2 (100% of the cell population) and VLA-4 (50% of the cell population) [32] Therefore, A375M cells were similarly pre-incubated with untreated and LPS-treated ... compared to the adhesion of basal medium-treated B16M cells Therefore, soluble factors from untreated and LPS-treated BMSCs induced the adhesive phenotype in certain B16M cells enlarging the cellular...

Ngày tải lên: 18/06/2014, 22:20

... in the percentage of cells in the G2/M phase of the cell cycle Since Page of 12 the G2/M phase of the cell cycle is one of the most sensitive to radiation [17], this could explain some of the ... dividing the density of the released DNA band by the density of the total DNA in the lane (the released DNA band plus the unreleased DNA remaining in the well) Page of 12 Cell Cycle Analysis The effect ... Chk1 leading to accumulation of cells in G2/M phase of the cell cycle Our data suggest that other parts of the cell cycle are also affected since the percentage of cells in G2/M never increased...

Ngày tải lên: 09/08/2014, 10:20

... applied to the cell and the design of the 18 adhesion assay The research on cell adhesion strength has been conducted from two aspects The first is to relate the macroscopic tensions to the cell- substrate ... constant volume The ligands on the substrate are Figure 3.2 Schematic of vesicle adhesion mediated by the diffusion of the receptors and the binding of the receptor-ligand pairs; n is the surface ... mediated by the diffusion of the receptors and the binding of the receptor-ligand pairs 35 Figure 3.3 Variation of receptor density caused by diffusion of the receptors on the cell surface...

Ngày tải lên: 10/09/2015, 15:48

... Island They would then cross another thirty-two miles of ocean to the southern flank of San Clemente Island, a naval base and artillery range populated by unexploded ordnance and a dwindling herd of ... had seen from the air and set a course that soon put them within earshot of what seemed the loneliest bell on the face of the planet The tiny man-made island was laden with guano and inhabited ... breakfast into the deep blue sea The buoys stayed anchored, offering the surfers a point of reference and a measure of relief When the next set of four or five waves broke, they showed that the surf...

Ngày tải lên: 17/02/2014, 05:20

... and the convergence of the biological with the mechanical all reflect and stimulate shifts in the understanding of the nature of life Although the cultural practices of breeding and the use of ... reconsideration of human communication processes as a result of what has been learned about cellular and biochemical communications, and legal and cultural implications of the merging of the digital and ... computing and communication technologies together is just one in a series of types of convergence of communication with other materials and social processes There have been four: The convergence of...

Ngày tải lên: 08/04/2014, 12:47

... absence of complement; (1) In the presence of Alemtuzumab and heat inactivated sera, the majority of VLC are viable Annexin V (-) and PI (-) cells In contrast, in the presence of Alemtuzumab and ... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans ... angiogenesis based on the elimination of VLC, Alemtuzumab may also inhibit angiogenesis via the elimination of B cells and mast cells from the tumor microenvironment; both of these cell types have...

Ngày tải lên: 18/06/2014, 15:20

... disciplines, the testing of new ideas in the research laboratory and in animal models, the development of new cellular therapies and GMP methods to produce these therapies, and the testing of new adoptive ... the field of adoptive cellular therapy of cancer The growing clinical applications and success of adoptive cellular therapy of cancer has been due to the rapid evolution of immunology, gene therapy ... across these diverse disciplines, the testing of new ideas in the research laboratory and in animal models, the development of new cellular therapies and GMP methods to produce these therapies, and...

Ngày tải lên: 20/06/2014, 04:20

... washing the cells with PBS and adding the nanoparticle-containing medium After the exposure time, the cells were analyzed microscopically The total number of cells and the number of fluorescent cells ... in their fabrication, and wrote the main parts of the manuscript GO carried out the transfection of the reporter cell line and was involved in the preparation of the manuscript AS fabricated the ... between the individual cell responses Analysis of the biocompatibility of the MCC Figure The miniaturized cell culture chamber (a) Work flow of the fabrication (b) Design of the MCC The MCC contains...

Ngày tải lên: 21/06/2014, 00:20

... trị ligand amino acid đặc trưng protein thụ thể Sự gắn ligand làm cho thụ thể biến dạng Ligand không tiếp tục tham gia vào đường Các receptor gắn ligand theo quy luật tác động khối (law of mass ... đa tế bào với ligand đặc biệt nói chung xảy nồng độ ligand hầu hết receptor chưa bị choán chỗ Các ligand Ligand (phối tử) phân tử tín hiệu gắn vào thụ thể Các receptor gắn ligand với tính đặc ... nghịch Nồng độ ligand làm phân nửa receptor bị choán chỗ gắn kết với ligand, Kd, xác định thực nghiệm biểu thị lực ligand với receptor Các tác nhân ức chế gắn vào chỗ gắn ligand phân tử receptor...

Ngày tải lên: 29/07/2014, 10:20

... the scientific community Users of ConSite can either provide an existing alignment of two orthologous sequences or input just the sequences alone and the program will generate the alignment The ... alignment of orthologous sequences; then, automated computer programs were developed to assist the process In this issue of Journal of Biology, Lenhard, Sandelin and colleagues describe their most ... positions in the two aligned sequences, are selected and reported in the output The remainder of the sites, which are not conserved between the two species, are considered to be false positives and are...

Ngày tải lên: 06/08/2014, 18:20

... These cells fail to express the CD68 antigen and are not believed to be of hematopoietic origin The association of the fibroblastic cells with the bone surface and the ex vivo demonstration that they ... the enzymes that are expressed in these cells and contribute to the resorption of the extracellular matrix component of bone [5-7] Although the expressions of these genes have served as useful ... prosthesis Of importance, in our studies we observed that the levels of expression of both cathepsin K and TRAP were much higher in the cells associated with the bone surface compared with the...

Ngày tải lên: 09/08/2014, 07:20

... activities The residual cost (Table 1) is the difference between the cost of null hypothesis and the total cost The larger the difference between the cost of the null hypothesis and total cost, the ... %Y, the percentage of known actives in the hit list (recall); Ht, the number of hits retrieved; D, the number of compounds in the Page of 13 database; E, the enrichment of the concentration of ... decamethonium [10] and donepezil [19] extend to the mouth of the gorge, the opening of the hydrophobic pocket Page of 13 The drug discovery process is both time-consuming and expensive [20] yet...

Ngày tải lên: 10/08/2014, 05:21

... established within the plane of the epithelium and promotes the rearrangement of the cytoskeletal components of the cell [97] Although the asymmetric localization of some of the PCP factors has ... arrangement of these PCP core components, appearing to be highly sensitive to the orientation of the cell s sides with respect to the global axis of the epithelium, allows the polarity of the cell to ... mutated embryos, the polarity of the ommatidia of the compound eye and the hairs of the wing and thorax are disrupted, such that rather than pointing in the same direction, they point in multiple...

Ngày tải lên: 10/08/2014, 10:20

... kinetics, distribution and stability of HGFCNP in the blood circulation Whether HGF released from the CNP causes the stem cell differentiation or apoptosis of myofibroflasts or both of these functions ... Suppression of inflammatory cytokines could reduce the activation of hepatic stellate cells Inhibition of the proliferation of T cells thereby modulating the pro-inflammatory cytokines such as TNF-a and ... in the knockout model [37] or the fibrolysis of ECM content [38] For better understanding we have compared the contribution of either HSC or MSC in the process of reversal of cirrhosis in the...

Ngày tải lên: 11/08/2014, 00:23

... while cultured in the RVW Expression and Organization of Cellular Tight Junction and Polarity Markers in 3-D Huh7 Aggregates While the effect of HCV on cell polarity and TJs (and viceversa) cannot ... expression and organization of the HCV receptors (CD81 and SR-B1), cell adhesion molecules (E-Cadherin and β-Catenin), cellular TJ proteins (CLDN1, ZO-1 and Occuldin-1) and the polarity marker (CD26) ... 4B shows that the majority of Huh7 cells were positive for the HCV E2 glycoprotein and that the entire aggregate was permissive for HCV infection rather than just the cells at the periphery,...

Ngày tải lên: 12/08/2014, 04:21

... while cultured in the RVW Expression and Organization of Cellular Tight Junction and Polarity Markers in 3-D Huh7 Aggregates While the effect of HCV on cell polarity and TJs (and viceversa) cannot ... expression and organization of the HCV receptors (CD81 and SR-B1), cell adhesion molecules (E-Cadherin and β-Catenin), cellular TJ proteins (CLDN1, ZO-1 and Occuldin-1) and the polarity marker (CD26) ... 4B shows that the majority of Huh7 cells were positive for the HCV E2 glycoprotein and that the entire aggregate was permissive for HCV infection rather than just the cells at the periphery,...

Ngày tải lên: 12/08/2014, 04:22

... primary blood cells, but not with the systems of Sachs and Metcalf These methylcellulose colonies of leukocytes provided too few cells and growth of these cells were limited in number and in time ... Instead, they used the technique previously applied to virus transformed cells of cell growth on a methylcellulose solid surface in the form of cell colonies However, growth was transient and the ... 2) Discoveries of HTLV-1 and HTLV-2 The first detection and isolation of HTLV-1 was in 1979, and the first detection came from the analysis of a T cell line established by J Minna and A Gazdar...

Ngày tải lên: 13/08/2014, 09:21