celldeath in the central nervoussystem
báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... expressing CCR1, CCR2 or CCR5 mRNA within and around inflammatory foci in the spinal cord of rats with EAE, thus identifying potential determinants for trafficking of these cells to the CNS These findings ... immunization) of EAE show extensive inflammation involving the white and grey matter (D), with marked demyelination in the inflammatory areas (F) The majority of the infiltrating inflammatory cells are macrophages, ... rats in the acute phase (day 13) revealed marked inflammatory lesions in the white and grey matter of the spinal cord (Fig 3D) Within the inflammatory infiltrates, numerous actively phagocytosing...
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Báo cáo sinh học: "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system" doc
... was a 2.5-fold increase in apoptosis in the subventricular zone (SVZ) and a 4-fold increase in the dentate gyrus of the hippocampus (DG) The increased cell death persisted in the SVZ and DG for ... F4/80 staining was markedly increased at day in one of the ten mice treated with 5-FU (Figure 11a,b) In this animal, there was diffuse microglial activation throughout the brain, including the primary ... by the body’s reaction to the presence of a tumor In addition, the roles of ongoing inflammation or damage to the vasculature in inducing such delayed CNS damage are wholly unknown Moreover, the...
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Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... single positive-staining bacteria were found in the neuronal processes Both nNOS and iNOS immunoreactivity were found in a proportion of the neurons in the brainstem and the staining pattern was ... and iNOS in neurons increased when bacterial encephalitis occurred This is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine listeriosis ... observed in inflammatory microabscesses Counterstained with hematoxylin Magnification: ×132 C: Immunohistochemical staining of inducible NOS in the caprine brain with natural listeriosis shows that iNOS...
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báo cáo khoa học: "In vivo observation of gold nanoparticles in the central nervous system of Blaberus discoidalis" potx
... by the nAuNPs The XPS was used to verify the presence of nAuNPs embedded in the brain tissue The confocal microscope and TEM were used to gain insights into the interaction of nAuNPs and the insect’s ... imaging to identify the presence of nAuNPs in the tissue without adding fluorescent tags Nanoparticle introduction to the CNS The nAuNPs were introduced in the CNS through an injection between the ... eliminated by using only young males in this study The effects of temperature, humidity, and wind were diminished by maintaining them in a controlled environment However, the fluctuations in Rocha...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... enhancing the activity of gamma-glutamylcysteine synthetase and up-regulating cystine transport The upregulation in gammaglutamylcysteine synthetase activity facilitates the redistribution of GSH into ... pioneering study done by Zhang et al suggests that H2S could protect the brain against VD injury induced by cerebral ischemia reperfusion through inhibiting the apoptosis in the hippocampus They...
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Chemical drug assisted gene transfer a sensible approach to improve transgene expression in the central nervous system
... μl of the complexes containing μg DNA was used in each injection The rate of injection was μl/min and the needle was allowed to remain in situ for mins before being slowly retracted at the end ... gene therapy by increasing the expression of the transgene In addition, with their intrinsic anti-tumor activities, HDAC inhibitors also have the advantage to kill tumor cells more effectively in ... remain at large in terms of choosing appropriate MW PEIs and biodegradable linkages as well as designing the degree of cross-linking, the particle size and the surface charge of the resulting...
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INVESTIGATION OF MEMBRANE PROPERTIES IN THE CENTRAL NERVOUS SYSTEM OF DROSOPHILA MELANOGASTER STUDIED BY FLUORESCENCE CORRELATION SPECTROSCOPY
... constituent instead of sphingomyelin (PE-cer has phosphoethanolamine as the head group, instead of the phosphocholine head group in SM) [32] Despite having shorter fatty acyl chains (the longest being ... be studied using FCS These intensity fluctuations contain information which can be extracted by analysing the rates and the amplitudes of the intensity fluctuations and subjecting them to an autocorrelation ... tube The eppendorf tube was kept cold at °C in ice After collecting 10 larval brains, they were washed times with 200 µl of sterile-filtered HL3 containing 10 µg/ml of insulin The brains were then...
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Báo cáo khoa học: Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system pptx
... represent the coding region and the noncoding regions of the planarian PHM cDNA, respectively; whereas the two flanking broad lines outside indicate the k ZAP II vector The two gray boxes in the planarian ... with the first ATG in the open reading frame The translation termination codon is indicated by an asterisk The sequence obtained by the first degenerate PCR is singly underlined, whereas the sequences ... animals by the time of the emergence of the Plathelminthes in the evolutionary history The eye of the planarian is one of the most ancestral and primitive types of visual systems in animals and is...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
... dopaminergic system against MPTP-induced neurotoxicity and behavioral deficits This study was conducted in attempt to fill in the gap within the literature on the effects of COX-2 inhibition in ... chart depicting the role of the vicious circle in dopaminergic neurotoxicity For this study, the initial insult MPP+ exerts direct dopaminergic neurodegeneration (~30% of the original numbers) ... to the release of factors that initiate another cycle of oxidative and inflammatory insults The positive feed back loop may continue until the additional neuronal death (~50% of the remaining...
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Section III - Drugs Acting on the Central Nervous System docx
... attracted to the brain during periods of inflammation following either microbial infection or other postinjury inflammatory reactions The response of the brain to inflammation differs strikingly from ... and then to the brain, including (1) concentration of the anesthetic agent in inspired gas, (2) pulmonary ventilation delivering the anesthetic to the lungs, (3) transfer of the gas from the ... Disorders) Norepinephrine There are relatively large amounts of norepinephrine within the hypothalamus and in certain zones of the limbic system, such as the central nucleus of the amygdala and the dentate...
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Báo cáo sinh học: "The long term effects of chemotherapy on the central nervous system" docx
... with certain brain tumors, especially for the very young Because of the rapid myelinization that occurs in infants, the finding by Noble and colleagues [1] of the adverse effects of chemotherapy ... Tests than children treated with chemotherapy alone (methotrexate injected either intrathecally (into the cerebrospinal fluid) or intravenously and intrathecally) This study and many Journal ... treated with high-dose intravenous methotrexate (5 g/m2) and also methotrexate injected into the brain cavities (intraventricular injection), together with other chemotherapy, but no radiation...
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Báo cáo sinh học: "How chemotherapy damages the central nervous system Christina A Meyers" ppsx
... determine whether these findings resulted in functional impairment, they investigated the auditory brainstem response in the mice at various times following treatment Loss of myelin is known to increase ... studies The authors then examined the effects of 5-FU on adult mice They found an acute, transient increase in apoptosis in several brain regions, which subsided 56 days after injection They found ... increase the latency between specific peaks in the auditory brainstem response, reflecting slowing of the impulse conduction between the ear and the brain Exposure to 5-FU caused a progressive increase...
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báo cáo khoa học: "Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature" pdf
... viral infections initiate the inflammatory process that somehow becomes self-sustaining [5] It is also speculated that there may be a genetic predisposition in certain individuals leading to ... Beijing Neurosurgical Institute, Beijing 100050, China Authors’ contributions GY wrote the initial draft WY drew the pictures WZ revised the draft SL described the MRI features GL provided the ... pathological diagnosis TJ was the surgeon and gave the final approval of the version to be published Competing interests The authors declare that they have no competing interests Received: 18 May...
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Genetic engineering and surface modification of baculovirus derived vectors for improved gene delivery to the central nervous system
... analysed using the integrated software of the instrument 27 2.2.7 Cell Lines and Cell Culture Sf9 insect cells were obtained from Invitrogen and cultured according to the manual’s instructions ... 1998) Even in the presence of peripheral infection with adenovirus, there is virtually no immune response in the brain following direct injection of “gutless” vectors in rats However, the high ... fluorescent protein FBS fetal bovine serum GAL4 BD GAL4 DNA-binding domain GAL4 BS GAL4 DNA-binding sequence HSV herpes simplex virus ITR inverted terminal repeat LTR long terminal repeat XII...
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A study of the recombination activating gene 1 in the zebrafish nervous system
... domains, the nomamerbinding domain and the central domain, were found to carry specific affinity to the conserved nonamer and heptamer elements of RSS respectively In addition, the central domain ... V(D)J recombination: the V-J joining process involved in making a light chain of immunoglobulin in mouse Figure 1-3 DNA cleavage by RAG proteins Figure 1-4 NHEJ proteins repair and join RAG-liberated ... substrate, X-gal The results from these studies were exciting Besides staining in the immune system, which was expected, X-gal staining was specifically detected in the brain and spinal cord among...
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Development of hybrid promoters and viral vectors for improved gene delivery to the central nervous system
... cells in the nervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one of the main goals of gene therapy ... practically, the therapeutic gene is used to ameliorate diseases, either inherited or acquired, by enhancing, reducing or altering a particular gene expression in the target cells (Mountain, 2000) The ... mediating a stable transgene expression in human-originated cells by site-specific integration of the transgene into the host chromosome 19 In conclusion, the novel hybrid promoters constructed in...
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Specificity and diversity in the vertebrate nervous system an analysis of two genes
... plate The eye is covered with a melanin rich retinal pigmented epithelium (RPE) The RGCs in the eye project their axons to the optic tectum in the midbrain Apart from the major target, which is the ... example is the crossing of axons at the midline (Figure 1.3) Axons from peripheral neurons are attracted towards the midline and once they cross the midline they are kept away from the midline The change ... originate in the motor cortex and cross the midline once at the brain – spinal cord junction In mice carrying a non-catalytic allele of EphA4 or deletion of EphrinB3, CST axons cross the midline...
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Novel mechanisms of programmed cell death in the protozoan parasite blastocystis
... abolished by the MOMP inhibitor cyclosporin A and significantly inhibited by the broad cysteine protease inhibitor iodoacetamide Interestingly, the apoptosis phenotype was insensitive to inhibitors ... animals by fecal-oral route The cysts develop into vacuolar forms in the large intestines In the human intestine, vacuolar forms divide by binary fission and may develop into amoeboid or granular ... grandparents for their unwavering love and support throughout the years Yin Jing August 2009 i Publications Journals: Jing Yin, Angeline JJ Ye, and Kevin SW Tan (2010) Autophagy is involved in starvation...
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The study of the mediation of ohanin, a king cobra (ophiophagus hannah) toxin through the central nervous system
... 26 injected intraperitoneally into the mice followed by injecting 100 μl of 0.4% trypan blue dye into the tail vein of mice In control mice, saline was injected intraperitoneally before injecting ... N-terminаl ѕequencing by Edmаn degrаdаtion The N-terminаl ѕequence of the recombinаnt ohаnin wаѕ АЅPPG, which correѕpondѕ to the N-terminаl of the nаtive protein except for the аlаnine thаt wаѕ in erted ... effects could prove to be the basis in not only understanding the receptor(s) involved in locomotion and pain sensations within the brain, but also into lead to the developing of future pharmacological...
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The central nervous system
... Brain Stem The brain stem comprises three regions: the midbrain, the pons, and the medulla Midbrain One of the original regions of the embryonic brain, the midbrain is a small region between the ... feedback The output of the cerebellum is into the midbrain, which then sends a descending input to the spinal cord to correct the messages going to skeletal muscles The Spinal Cord The description ... of the forebrain as a tapering cone that connects the brain to the spinal cord Attached to the brain stem, but considered a separate region of the adult brain, is the cerebellum The midbrain...
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