causality in pharmacovigilance and expectedness of adverse reactions

... exceeded’ In 2006, however, the SARSS received ten reports of blindness in cats involving the use of enrofloxacin and eight of these cases involved the administration of an overdose Unauthorised use in ... suspected adverse reactions, including lack of efficacy, continues to receive publicity The VPC working group in 2002 concluded that although adverse reactions to vaccination, including lack of efficacy, ... caution in the administration of all veterinary medicines in order to avoid accidental self-injection by the user In the UK there have been reports of accidental self-injection of vaccines containing...

Ngày tải lên: 06/03/2014, 16:20

... prominence in the 1960s at a time when the number of women in positions of power or authority in organisations were still low In fact, the proportion of women in management roles in the USA in ... more typical of male behaviours Of interest is the inclusion of ‘‘control’’ as a significant feature of the transactional style, common in definition of leadership in the 1990s In contrast, women ... males in management or leadership roles because of the low profile of women in management at this time, and it can be assumed that the profile of women in management would not have been advanced in...

Ngày tải lên: 08/10/2013, 15:56

... active role in financial restructuring in China by introducing international standards and good practice and providing policy advice and personnel training in specific areas For instance, China has ... China Statistics Yearbook, China Financial Yearbook and People’s Bank of China Statistics Quarterly bulletin B Development of direct financing and indirect financing markets providing financing ... on innovation of financial products, but also make due efforts in the application of information technology, in exploring on-line banking business as well as in promoting non-bank financial institutions...

Ngày tải lên: 18/10/2013, 07:15

... resurgence in the incidence of TB occurred in the United States and included increases in the number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving ... of skin testing is the Mantoux tuberculin skin test using 0.1 mL of tuberculin units (TU) of purified protein derivative (PPD) (1 ) BCG vaccination contributes to the prevention and control of ... preventing pulmonary TB in adolescents and adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered...

Ngày tải lên: 15/02/2014, 13:20

... Banking Industry,” Journal of Banking and Finance, August Sullivan, Richard J 2000 “How Has the Adoption of Internet Banking Affected Performance and Risk in Banks? A Look at Internet Banking in ... them to maintain higher net interest margins Indeed, during most of the 1990s, the net interest margin of small banks held steady at over 4.5 percent, while the net interest margin of large banks ... serving certain types of communities and providing certain types of banking services ECONOMIC REVIEW • SECOND QUARTER 2003 17 Definition of a community bank There is no single definition of a...

Ngày tải lên: 16/02/2014, 11:20

... Electrostatic interactions and antitumor RNases the dimer interface of the models or in the surroundings of the hinge loop residues Likewise, the models of nonexchanging and exchanging HHP-RNase ... electrostatic field of different Fig Plot of the EIE values as function of rotation (r) and inclination (i) angles of RNases The hatched axis at the bottom and right of the plots show schemes of some conformations ... dimer interface of the models or in the surroundings of the mutated residues The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure and the...

Ngày tải lên: 19/02/2014, 06:20

... modification may in uence many of the physicochemical and biological properties of the proteins, such as protein folding, stability, targeting, dynamics and ligand binding, as well as cell-matrix and cell–cell ... misfolding of this protein, resulting in its partial retention in the ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation ... substrate binding process This provides strong evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1...

Ngày tải lên: 19/02/2014, 17:20

... causes of pathological language behavior Example"lesions" are changes in memory decay, elimination of a knowledge type, and slowing of processing relative to on-line word recognition Studying the ... reaches threshold and fires I t can be INHIBITORY and EXCITATORY in its effect INTERPRETATIONis a result of activation of a pragmatic representation of a disambiguatedword meaning in current l i ... behavior are introduced by including neurally motivated processing control as the focus of model d e f i n i t i o n and by including behaviorially defined cons t r a i n t s , both normal and pathological...

Ngày tải lên: 21/02/2014, 20:20

... equal to ô ằ (increase in indebtedness) by 15 points (33 minus 18), and increases the probability of Expected-Debt to be equal to ô ằ (not indebted and not going to be) by 13 points (34 minus 21) ... remaining 11% An increase in indebtedness (of 80% in average) is associated with a 14% decrease in production, and with a 2% rise in inventories Conversely, enterprises with a decrease level of indebtedness ... good markets - demand-side constraints for most of them and access-to-input for the worst in this sub-pool Conversely, the overbearing influence of the financial constraints in the lower half...

Ngày tải lên: 06/03/2014, 08:20

... people often lack collateral, and in some cases they have low levels of reading and writing skills By serving this segment of the population in developing and emerging economies the microfinance industry ... briefly examining the basic characteristics of WSBI member involvement in microfinance in Latin America, Africa, and Asia/the Pacific 1.5.1 Latin America In Latin America, microfinance has experienced ... an indirect participation through linkages (Uganda, Zimbabwe) with sustainable and promising microfinance institutions (e.g., refinancing of wholesale loans for on-lending to retail microfinance...

Ngày tải lên: 06/03/2014, 10:20

... determined by the narrative content of a given scene Finally, cinematic codes influence musical meaning merely due to the placement of musical sound within the filmic context Opening credit and ... continuity And, finally, music aids in the construction of formal and narrative unity To confirm her intention that none of these principles was to be considered sacrosanct, the seventh principle ... communicate meaning through sound (including music), taking into account the director’s – and, therefore, the composer’s – intentions, the narrative content of the film, and the overall strategy of the...

Ngày tải lên: 07/03/2014, 14:20

... departure, and formation of the oxazolinium ion intermediate; (C) Hydrolysis of the oxazolinium ion intermediate Copyright National Academy of Sciences, USA questioned on the basis of studies of chitinase ... of the )1 sugar ring into a 4-sofa conformation is an inherent part of the catalytic mechanism (Fig [17,19,21,22]) Structural studies show that Asp142, Tyr214 and Asp215 are involved in binding ... ChiB for allosamidin, which is an analogue of the proposed oxazolinium ion intermediate [32] The minor (or even positive) effects of Y214F on substrate and intermediate binding and the large negative...

Ngày tải lên: 07/03/2014, 14:20

... definition questions In HLT/EMNLP 2005 J Lin and D Demner-Fushman 2006a The role of knowledge in conceptual retrieval: A study in the domain of clinical medicine In SIGIR 2006 J Lin and D Demner-Fushman ... an increase in cooperation? If so, what are the driving factors behind this increase? Evidence for a relationship includes both the means to in uence some entity and the motivation for doing ... AQUAINT program, which resulted in an understanding of a “relationship” as the ability for one object to in uence another Objects in these questions can 524 two types (“vital” and “okay”), and...

Ngày tải lên: 08/03/2014, 02:21

... agricultural research; and reforming policies and increasing investments in rainfed areas WATER HARVESTING Water harvesting involves concentrating and collecting the rainwater from a larger catchment ... being grown Types of external catchment systems include runoff farming, which involves collecting runoff from the hillsides into flat areas, and floodwater harvesting within a streambed using ... harvesting takes place In addition, most water harvesting operations consist of a catchment area and a receiving area for the capture of runoff, and are generally small both in size and in level of...

Ngày tải lên: 09/03/2014, 00:20

... as Points of Access into the Financial System The Role of African Post Offices in Payments The Role of Post Offices in International Remittances The Role of Post Offices in Savings The Role of ... of Post Offices in International Remittances The Role of Post Offices in Savings The Role of Post Offices in Credit 5—Conclusion 16 17 17 17 18 19 20 21 21 21 Worldwide Landscape of Postal Financial ... mail-processing infrastructure as the main points for collecting, processing, sorting, and distributing mail items Increasingly, Asian postal operators are re-engineering their postal business processes...

Ngày tải lên: 15/03/2014, 10:20

... only increase by 50 basis points, and the increase in inflation is 50 basis points less than in the baseline case A banking sector that remains well-capitalized can thus reduce the length and amplitude ... in these economies, the ability of banks to provide funding does not diminish as much following adverse shocks, which moderates the responses in aggregate investment and output In addition, in ationary ... shirking projects allows the model to analyze imperfect bank monitoring Bank monitoring consists of activities that prevent managers from investing in inferior projects: inspection of cash flows and...

Ngày tải lên: 15/03/2014, 10:20

... structure containing two chitin-binding domains (ChBD1 and ChBD2) and two catalytic (active) domains (AD1 and AD2) [25] Both catalytic domains belong to GH family 18 We have not performed any kinetic ... thought to participate in substrate binding [35,36] We used a combination of kinetic and crystallographic approaches to characterize the function of the DXDXE motif in AD2 Kinetic results showed ... forming a hydrogen bond between the Oe ˚ atom of Glu526 and the Od atom of Asp524 in 2.5 A (Fig 3A) Interestingly, in the D524A–substrate complex, an altered conformation of the Glu526 side-chain...

Ngày tải lên: 15/03/2014, 11:20

... Murray-Darling Basin (Australia) Interstate salinity trading came into force in 1992 as part of the Murray-Darling Basin Salinity and Drainage Strategy, administered by the Murray-Darling Basin Commission, ... US including the Tar-Pamlico Basin in North Carolina (case of point-point source trading also allowing for point-non-point trade), the case of Lake Dillon and the case of the Cherry Creek Basin ... Fisheries: Fishing Rights in Scotland In Scotland, responsibility for protecting and developing inland salmon fisheries rests with District Salmon Fishery Boards Unlike in England and Wales, individual...

Ngày tải lên: 15/03/2014, 16:20

... those of the EU and North America must be marked by a mutual interest in finding ways of maintaining and restoring biodiversity as part of the designing and deciding upon new economic and security ... re-diversifying the farm and increasing profitability, not necessarily productivity They offer a suite of possibilities for maintaining and restoring working landscapes based on an integration of biodiversity ... Social learning is a "fundamentally messy, contingent, and ambiguous intermingling of knowledge, power, interests, and change in the workings of the world" [50] Working Landscapes - Integrating Biodiversity...

Ngày tải lên: 15/03/2014, 18:20

... price index, being among one of the few profitable ways of investing in conditions of rising inflation The influence given by international and global funds in the balance of payments, in order ... stimulating the levels of investment II The importance of Romanian investment funds In Romania the section of investment funds stands in a incipient stage of development, a small amount of money being ... determined the maintaining of a law interest rate offered by the banks This fact, put in touch, on one hand with the higher yield of the bonds funds (of maximum 14,5% in 2009 and 11,79% in 2010...

Ngày tải lên: 16/03/2014, 17:20