case 19 a patient with amyotrophic lateral sclerosis

... A patient with amyotrophic lateral sclerosis and atypical clinical and electrodiagnostic features: a case report Alexander Venizelos1,2, Youngsook Park1,2, Morris A Fisher1,2* Department ... therefore important to appreciate the range of possible presentations of amyotrophic lateral sclerosis Case Presentation: We present the case of a 57-year-old Caucasian man with pathological findings ... sural nerve biopsy revealed findings of a chronic axonal neuropathy with active Wallerian degeneration and remyelination without evidence of inflammation The patient was treated with plasmapheresis...

Ngày tải lên: 10/08/2014, 22:20

... (Table 1) and an EDSS score of 8.0 Neurological presentation included paraplegia, bilateral central scotomata with visual-field loss, dysphagia, chronic fatigue, cognitive impairment similar ... decline In 199 4, a trial of interferon β-1b was discontinued because of increased spasticity, and she was not a candidate for glatiramer She had no history of diabetes, cardiovascular, liver or ... final draft of the manuscript Acknowledgements We thank Monica Menendez for secretarial assistance Supported by grants from the National Multiple Sclerosis Society (DLF), Takeda Pharmaceuticals...

Ngày tải lên: 19/06/2014, 22:20

... understanding of the molecular mechanism underlying the mutation-causing disease 1.2 What is Amyotrophic lateral sclerosis? Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s disease, ... respiratory muscle failure 1.2.1 Disease forms – Sporadic and Familiar ALS ALS is divided into two forms, sporadic ALS (SALS) and familiar ALS (FALS) SALS constitute the majority of ALS cases and ... disease occurs apparently at random with no clear associated risk factors FALS patients on the other hand, carry an inheritable pathogenic gene mutation and make up to 10% of the diseased population...

Ngày tải lên: 12/10/2015, 17:34

... Proc Natl Acad Sci USA 2006; 103(39): 14584-14589 Yamaguchi H, Sasaki K, Satomi Y, Shimbara T, Kageyama H, Mondal MS, Toshinai K, Date Y, Gonzalez LJ, Shioda S, Takao T, Nakazato M, Minamino ... inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis FASEB J 2003; 17(6): 725-727 Zhao Z, Lange DJ, Voustianiouk A, Macgrogan D, Ho L, Suh J, Humala N, Thiyagarajan M, Wang J, Pasinetti ... GM A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis BMC Neurosci 2006; 7: 29 Chakraborty TR, Tkalych O, Nanno D, Garcia AL, Devi LA, Salton SR Quantification...

Ngày tải lên: 03/11/2012, 10:52

... system (Amersham Biosciences, Little Chalfont, UK) Films were scanned and band intensities obtained with an AIS Image Analyser (Imaging Research Inc., St Catharine’s, Canada) Enzymatic activities ... t-BHQ treatment (Fig 8A) , indicating that highG9 3A- tTA cells had a lower antioxidant capacity than those expressing a comparable level of wtSOD1 In lowG9 3A- tTA cells, total GSH after t-BHQ treatment ... Glutathione in adaptation to wt ⁄ G93ASOD1 S Tartari et al mm EDTA, 0.2 mm NADH, mm phosphoenolpyruvate, pyruvate kinase (2 U) and lactate dehydrogenase (2 U) The reaction was started by adding...

Ngày tải lên: 29/03/2014, 23:20

Ngày tải lên: 19/06/2014, 22:20

... Gupta PK, Prabhakar S, Sharma S, Anand A: Vascular endothelial growth factor -A (VEGF -A) and chemokine ligand-2 (CCL2) in Amyotrophic Lateral Sclerosis (ALS) patients Journal of Neuroinflammation ... grant PI and clinical scoring CA Acquisition of data NKS Statistical analysis AA Interpretation and analysis of data, grant co PI and writing and editing of manuscript All authors read and approved ... definite, probable and possible ALS patients Values are plotted as mean ± SE (Standard error) in the bar diagram Data was analyzed by one-way analysis of variance (ANOVA) followed by Fisher’s least significant...

Ngày tải lên: 19/06/2014, 22:20

... δ-aminolevulinic acid (ALA), which is a weak gamma-aminobutyric acid (GABA) agonist that decreases GABA release by presynaptic inhibition [6,7] Lead is known to compete with metals like calcium, zinc, iron and ... separate areas were provided for the removal and storage of the lead-contaminated protective work clothing and equipment The regulatory body should make it mandatory to evaluate and create awareness ... lacking local and general exhaust ventilation and washing facilities culminating into alarmingly high blood lead levels of 128.3 µg/dl According to United States Occupational safety and Health Administration...

Ngày tải lên: 20/06/2014, 00:20

... prosthesis With these results, we conclude that an ambulating patient with an above knee amputation and a subcapital fracture should be operated on after appropriate planning and preparation with satisfactory ... Trauma 198 5, 25(11):1074-8 Kulkarni J, Adams J, Thomas E, Silman A: Association between amputation, arthritis and osteopenia in British male war veterans with major lower limb amputations Clin Rehabil ... plasty Postoperative xray with an uncemented bipolar hemiarthroPostoperative xray with an uncemented bipolar hemiarthroplasty We presented an ambulating above knee amputee, who had suffered a...

Ngày tải lên: 20/06/2014, 04:20

... local inflammation, injection site pain and itching, anaphylaxis/anaphylactoid reactions, local ecchymosis, nausea/vomiting, diarrhea, anorexia, and headache [26] While Hyalgan © has a relatively ... Patients classically have a normal karyotype and are born of nonconsanguineous parents [4] Most significantly, they display skeletal maturation that is advanced for age, along with osteopenia and sclerosis, ... this article as: Salter et al.: Treatment of refractory hip pain with sodium hyaluronate (Hyalgan©) in a patient with the Marshall-Smith Syndrome: A case report Journal of Orthopaedic Surgery and...

Ngày tải lên: 20/06/2014, 04:20

... local inflammation, injection site pain and itching, anaphylaxis/anaphylactoid reactions, local ecchymosis, nausea/vomiting, diarrhea, anorexia, and headache [26] While Hyalgan © has a relatively ... Patients classically have a normal karyotype and are born of nonconsanguineous parents [4] Most significantly, they display skeletal maturation that is advanced for age, along with osteopenia and sclerosis, ... this article as: Salter et al.: Treatment of refractory hip pain with sodium hyaluronate (Hyalgan©) in a patient with the Marshall-Smith Syndrome: A case report Journal of Orthopaedic Surgery and...

Ngày tải lên: 20/06/2014, 07:20

... and what started as an 'innocent bystander' may not be so innocent after all Figure Cranial MNR image in a coronal plane Cranial MNR image in a coronal plane The mass effect on the left lateral ... inpatient stay and received follow-up outpatient care with psychiatric and neurosurgical appointments Three months after discharge, the patient was working part-time and attending a technical ... cysts (of a congenital nature) and false ones, which are secondary to the post-inflammatory accumulation of CSF during cranial traumatisms, infections or intracranial haemorrhages [7,8] Arachnoid...

Ngày tải lên: 08/08/2014, 23:20

... illness Am J Med 199 5, 99:575 Carmaciu CD, Anderson CS, Lawton CA: Case report: thyrotoxicosis after complete or partial lithium withdrawal in two patients with bipolar affective disorder Bipolar ... noted a return to baseline by hospital day 19, after six days of stable treatment on methimazole, lithium, quetiapine and risperidone The patient' s refractory symptoms suggest that patients may ... of adenylate cyclase stimulated by TSH in normal patients; decreased thyroid iodine uptake; decreased release of T4 and T3; decreased hepatic metabolism of T4 to T3; and increased intrathyroidal...

Ngày tải lên: 08/08/2014, 23:20

... clinical presentation is of an acute abdomen with increased inflammatory markers and occasionally an associated pleural effusion The predominant abdominal symptoms mask the underlying renal cause, ... indicative of an aggressive tumour [9-11] These tumors are usually symptomatic at the time of diagnosis and often cause haematuria, abdominal pain and a mass in the flank [12-14] Radiologically ... Logothetis CJ, Ro JY, Swanson DA, Samuels ML: Sarcomatoid renal cell carcinoma: a treatable entity Cancer 198 7, 60:1313 11 Yamazaki K, Sakamoto M, Ohta T, Kanai Y, Ohki M, Hirohashi S: Overexpression...

Ngày tải lên: 09/08/2014, 01:24

... revealed gastric adenocarcinoma that was resected Case presentation The patient is a 20 year old female that was diagnosed with ataxia-telangiectasia syndrome at years of age She had severe ataxia ... Haerer AF, Jackson JF, Evers CG: Ataxia-telangiectasia with gastric adenocarcinoma JAMA 196 9, 210:1884-1887 Kondo K, Horikawa Y: Spinocerebellar degeneration Ataxiatelangiectasia and malignant ... tumour [Japanese] Naika no Ryôiki (Domain of Internal Medicine) 197 5, 35:623-626 Watanabe A, Hanazono H, Sogawa H, Takaya H: Stomach cancer of a 14-year-old boy with ataxia-telangiectasia Tohoku...

Ngày tải lên: 09/08/2014, 04:21

... 23:6524-6532 Radtke F, Clevers H: Self-renewal and cancer of the gut: Two sides of a coin Science 2005, 307 :190 4 -190 9 Aarnio M, Sankila R, Pukkala E, Salovaara R, Aaltonen LA, de la Chapelle A, Peltomäki ... colon cancer shortly after diagnosis at age 55, and three other paternal family members had cancer in an unknown site The patient' s paternal grandmother died at an early age of unknown causes ... cisplatin and taxol combined with radiotherapy, and is disease-free at the time of publication A comprehensive family history was taken and a formal pedigree was assembled (Fig 2) The patient' s father...

Ngày tải lên: 09/08/2014, 04:21

... was significant for diabetes mellitus, hypertension and asthma Upon physical examination she was alert, afebrile and displayed significant jaundice Abdominal examination revealed epigastric pain ... U/mL) was also elevated raising the suspicion for pancreatic cancer Interventional radiology was able to perform a percutaneous transhepatic cholangiogram and place an external biliary catheter ... widely available and best-validated modality for imagining patients with pancreatic adenocarcinoma It carries a sensitivity for diagnosis of 89-97% [10] Legmann has reported that CT scan detected...

Ngày tải lên: 09/08/2014, 04:21

... strategies have been proposed such as CEA alone, or CABG alone, or staged CEA and CABG, or staged carotid artery stenting (CAS) and CABG, and simultaneous CEA and CABG, or simultaneous CAS and CABG In ... cannula into the distal part of the internal carotid artery A separate pump was connected in cannula and arterial blood at 23°C was delivered at a flow rate of 300 ml/ [4] Although, based on classical ... patient with high grade bilateral carotid stenosis Some surgeons prefer the off-pump CABG, especially in patients with severe carotid disease [6] Off-pump CABG certainly has many advantages and...

Ngày tải lên: 10/08/2014, 09:21

... coarctation associated with aortic valve regurgitation In that patient, the vascular graft was placed around the left margin of the heart and was anastomosed proximally to the anterior wall of the ascending ... 38(3):310 Yilmaz M, Polat B, Saba D: Single-stage repair of adult aortic coarctation and concomitant cardiovascular pathologies: a new alternative surgical approach Journal of Cardiothoracic Surgery ... Repair of coarctation of aorta with intracardiac repair Tex Heart Inst J 198 3, 10:409-13 doi:10.1186/1749-8090-6-55 Cite this article as: Alvarez et al.: Internal mammary artery dilatation in a...

Ngày tải lên: 10/08/2014, 09:21

... efficacy of AO-CPR on neurological outcomes as neurological status could not be assessed in our patient because he was intubated, sedated and paralyzed until care was withdrawn Page of This case ... cardiac arrest in special situations: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Circulation 2010, 122: S829-S861 Adam Z, Adam ... mechanical assist device A decision was made to withdraw care after 24 hours and the patient expired Our case represents a difficult situation where the perioperative team faced a new challenge...

Ngày tải lên: 10/08/2014, 09:21