caregivers companions and treatment decisions in older cancer patients

... life, depression, and hopelessness in cancer patients in a curative and palliative, end-of-life care setting Cancer Nurs 2011;34:302–314 49 Pinquart M, Duberstein PR Depression and cancer mortality: ... solving Daydreaming and engagement in self-comforting fantasies was previously found to be associated with a negative prognosis in breast cancer patients [50] High paternal overprotection and insecure ... Maternal reflective functioning, mother-infant affective communication, and infant attachment: exploring the link between mental states and observed caregiving behavior in the intergenerational transmission

Ngày tải lên: 10/01/2020, 13:42

... gastric cancer HER2 negative staining (a), HER2 weak staining (b), HER2 moderate staining (c) and HER2 strong staining (d) HER3 negative staining (e), HER3 weak staining (f), HER3 moderate staining ... immunohistochemical staining for mTOR and p-mTOR were evaluated by two independent investigators according to a semi-quantitative grading system based on both the proportion of stained cells and staining intensity ... (PI3K/Akt) and mitogen-activated protein kinase (MAPK) pathways in cancer [10–12] In addition, some breast cancer patients show clinical benefits in HER2-amplified breast cancers through inhibition

Ngày tải lên: 06/08/2020, 03:41

... Jingxu Sun, Xiaowan Chen, Junhua Zhao, Jing Liu, Huimian Xu and Zhenning Wang* Abstract Background: The prognostic value of circulating tumor cells (CTCs) in colorectal cancer (CRC) patients and ... tumor cells”, “peripheral blood”, “colorectal cancer? ??, “colon cancer? ??, “rectal cancer? ??, “gastrointestinal cancer? ??, “chemotherapy” and “targeted treatment/ agent” Study eligibility criteria Studies ... those patients who might safely discontinue prolonged treatment and those who should resume chemotherapy quickly Such markers could reduce the use of chemotherapy in nonresponsive patients, reducing

Ngày tải lên: 30/09/2020, 13:28

... tumor and corresponding normal formalin-fixed paraffin-embedded tissues from breast cancer patients Median nuclear expression levels in tumor tissues were used to divide the patients into low and ... transcription of genes, including genes involved in processes such as cellular proliferation and cellular differentiation [6] HDAC inhibition is currently investigated in clinical trials aiming to reverse ... implicating that LSD1, HDAC2 and SIRT1 act together in the same complex It has been shown in literature that all three histonemodifying enzymes, analyzed in our study, are individually involved in inhibition

Ngày tải lên: 14/10/2020, 13:58

... cellular staining and flow cytometry, including the indirect staining of intracellular cytokines and cell surface molecules, performed throughout according to the manufacturer’s instructions ... line) and < the control group (red dashed line) In this group of 35 patients, copies of EBV genomes were detected in PBMCs in 66%, and in tumor tissues in 17% The clinical outcome of the 35 patients ... ionomycin (Boehringer Mannheim, Germany) in RPMI-1640 medium, containing 10% heatinactivated fetal calf serum (FCS), mM glutamine, 1% penicillin-streptomycin (Gibco), and 10 μg/mL Brefeldin Page

Ngày tải lên: 14/10/2020, 15:33

... early-stage breast cancer [25] Especially in patients with Luminal B tumors, the missing ET ± CHT led to worse outcomes both in the ESG and in the NESG (See appendix Tables and 8) In line with results ... best OS was seen in patients receiving endocrine therapy (ET) (7year OS of 95.6%) and CHT plus ET (7-year OS of 93.1%) in the ESG In the NESG, best OS was seen in patients receiving CHT plus ET ... presumed that tumor biology in elderly patients is different from younger patients [7, 8] Tumor biology increasingly affects treatment decisions for breast cancer patients [9] In 2000, Perou et al revealed

Ngày tải lên: 04/12/2022, 16:09

... ≤ 80 g/L cohort and 558 patients in the HBini level > 80 g/L cohort); b PFS curve according to HBini level (40 patients in the HBini ≤ 80 g/L cohort and 558 patients in the HBini level > 80 g/L ... of Shandong Provincial Hospital regarding human experimentation and with the 1964 Helsinki Declaration and later versions Informed consent for inclusion in the study was obtained from all patients ... elements, including clinicopathological characteristics and GC treatment model, with anaemia in recurrent or metastatic GC Our study aimed to determine the role of initial degree of anaemia and cancer- related

Ngày tải lên: 30/05/2020, 21:29

... choices and poses an extra substantial health care burden Our findings provide implications for both the clinical management and health service planning and financing for lung cancer patients ... available in this article, unless otherwise stated in a credit line to the data Ding et al BMC Cancer (2020) 20:250 Background Lung cancer remains one of the leading cause of cancer incidence and ... lung cancer patients It will provide implications for both the clinical management and health service planning and financing for lung cancer patients Methods Data source Currently there is no single

Ngày tải lên: 17/06/2020, 11:35

... standard for screening and assessment of malnutrition in cancer patients exists Among 37 malnutrition screening and assessment methods utilized for patients with cancer in clinical practice, in ... review, we investigated the prognostic significance of baseline nutritional status according to MNA regarding health and treatment outcomes in patients with cancer In 56 studies included in our review, ... malnutrition in studies including patients with a specific kind or stage of cancer as documented in a large cohort study from Italy including 1952 patients with various types and stages of cancer There,

Ngày tải lên: 03/07/2020, 02:54

... taxane-containing, containing both platinum and taxane, and others The operations included radical and palliative surgeries As described in the Japanese Gastric Cancer Treatment Guidelines Version 3.0 ... cell, neutrophil, lymphocyte, and platelet (2) Hepatorenal function: albumin, alanine transaminase, aspartate transaminase, alkaline phosphatase, and serum creatinine (3) Coagulation function: ... using a dose of 40–45 Gy for PCRT Since all patients received at least one type of fluorouracil-based regimen, we classified the chemotherapy regimens as platinum-containing, taxane-containing,

Ngày tải lên: 21/09/2020, 11:16

... networks associated with intrinsic chemotherapy resistance in SEOC patients receiving standard treatment Robust statistical analyses were used to define a set of distinguishing genes that were used ... frontline therapy for advanced ovarian cancer is debulking surgery and platinum-paclitaxel based combination chemotherapy Despite major advances in the development of novel treatment regimens and ... response in patients undergoing standard platinum-based treatment of serous epithelial ovarian cancer In addition, our results provide a pathway context for further experimental validations, and the

Ngày tải lên: 05/11/2020, 05:37

... concentrations and s-creatinine, this could in part be explained by an impaired renal func- tion in elderly patients, which is in line with previous find ings demonstrating an association between increased ... trypsin inhibitor (PSTI) and serine protease inhibitor Kazal type 1 (SPINK1), is a biomarker of poor prognosis in colorectal cancer patients, both as assessed in tumour tissue (t-TATI) [1] and in ... Tumour- associated trypsin inhibitor, carcinoembryonic antigen and acute-phase reactant proteins CRP and alpha1-antitrypsin in patients with gastrointestinal malignancies. Clin Biochem 2004, 37:56-60.

Ngày tải lên: 09/08/2014, 09:21

... up-regulation in invasive cancers, including breast cancer After silencing of MTA1 gene, we investigated the alteration of tumor cells invasiveness using Boyden chamber assay mentioned in Albini’s[20] ... Bridge Biotechnology, China) Protein bands were detected using ECL detection system (Zhongshan Golden Bridge Biotechnology, China), and b-actin staining served as the internal standard for the membranes ... expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro Qingming Jiang†, Hui Zhang* and Ping Zhang† Abstract Background: MTA1(metastasis

Ngày tải lên: 10/08/2014, 10:21

... Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients Alexander ... system, and remain stably elevated in the initial course of treatment Low suPAR levels are a positive predictor of ICU- and overall survival in critically ill patients, including sepsis and non-sepsis ... functions including migration, adhesion, angiogenesis, fibrinolysis and cell proliferation and have been found to promote tissue invasion in malignant diseases by converting plasminogen into plasmin,

Ngày tải lên: 14/08/2014, 07:21

... polyamine to cause amine incorporation into the glutamine-containing protein or... or without integrins, and this complex is involved in the formation of focal adhesions and in the syndecan ... invasiveness in vitro and tumor metastasis in vivo. The N-terminal fibronectin (FN) binding domain of TG2 (tTG 1-140), lacking both enzymatic and GTPase function, induced EMT in OC cells, suggesting ... suggesting the interaction with FN involved in EMT induction. A TGF-β receptor kinase inhibitor, SD-208, blocked TGF-β1 induced TG2 upregulation and EMT in vitro and tumor dissemination in vivo,

Ngày tải lên: 24/08/2014, 10:58

... the updating and monitoring of working memory representations The standard age range for Older People’s health services (including mental health) in Scotland/UK is 65 years and over ... Rating Scale, was in the ‘very severe’ range 5.3.3 Updating Updating, as defined by Miyake et al (2000), is the updating and monitoring of working memory representations No study included ... 2002). However findings have been somewhat mixed with some studies failing to replicate findings of previous research (e.g. Mackin and Arean, 2009, found no EF deficits in depressed older adults).

Ngày tải lên: 22/12/2014, 16:55

... protein kinase C Adenosine triphosphate Basic helix-loop-helix Binding protein Bovine serum albumin Cyclin-dependent kinase inhibitor 2B Cytokeratin-19 Cytoplasmic lipid droplets 4’,6-diamidino- ... protein-29 (ERp29) is a chaperone protein that functions in the unfolding and escort of secretory proteins Like other reticuloplasmins, ERp29 is believed to be involved in carcinogenesis In breast ... (2002) The SLUG zinc-finger protein represses E-cadherin in breast cancer Cancer Res 62: 1613-1618 Halbleib JM, Nelson WJ (2006) Cadherins in development: cell adhesion, sorting, and tissue morphogenesis

Ngày tải lên: 13/10/2015, 15:55

... communities living in adjacent areas Vietnam's population is increasing, and economic development, that led to the need and treatment increases, the number of patients increased too According to statistics ... storage, reduction, reuse, recycling, treatment and disposal of medical waste and inspects and supervises the implementation Regardless of training, retraining, coaching staff, management staff responsible ... packaging, basic chemicals implement processes and instruments, sorting garbage Especially should organize training and retraining of staff working in infection control at the base Need to urgently

Ngày tải lên: 28/04/2016, 13:37

... becoming one of the most significant issues in treatment decision-making, in general, and more so in prostate cancer [1] Thus late rectal and urinary damage became a major concern in prostate cancer; ... summarized in Table The values of the last late GI and GU toxicity observed in patients during their last inspection are shown In the cohort of patients included in the WP group, pretreatment ... results, and evaluates the relationships between pretreatment, acute and late rectal and urinary syndromes and tumor-, patient- and treatment- related factors In the last years of the study, we investigated...

Ngày tải lên: 09/08/2014, 09:20

... chemopreventive agents, including resveratrol [26,27], brassinin [28,29], and deguelin [30,31] Resveratrol is present in grapes, red wine and peanuts, brassinin is from Chinese cabbage, and deguelin is from ... apoptosis in SW480 human colon cancer cells To investigate the effects of IxoA on apoptosis, we 5720 used acridine orange ⁄ ethidium bromide staining and DAPI staining and found a marked increase in ... microscope slides, fixed in formalin and methanol, and stained with DAPI Stained nuclei were visualized using a fluorescent microscope Blebbing of the membrane, chromatin aggregation, and nuclear condensation...

Ngày tải lên: 23/03/2014, 10:20