carcinoma of unknown primary origin

... 095. Carcinoma of Unknown Primary (Part 2) Role of Imaging Studies Chest x-rays are always obtained in CUP workups but are often negative, especially with low-volume disease. CT scans of ... 60% of CUPs are found to be adenocarcinoma, and 5% are squamous cell carcinoma. The remaining 30% of lesions are diagnosed as poorly differentiated adenocarcinoma, poorly differentiated carcinoma, ... number of patients; primary tumors were identified in ~21–30%. The diagnostic contribution of PET to the evaluation of noncervical CUP is controversial. PET or PET-CT helps to detect primary...

Ngày tải lên: 07/07/2014, 04:20

... Gross cystic disease fibrous protein- 15 Breast cancer Chapter 095. Carcinoma of Unknown Primary (Part 3) Role of Immunohistochemical Analysis Immunohistochemical stains are peroxidase-labeled ... Diagnosis of CUP Tissue Marker Diagnosis Estrogen and progesterone receptors Breast cancer BRST-1 Breast cancer Gross cystic disease fibrous protein- 15 Breast cancer Chapter 095. Carcinoma ... peroxidase-labeled antibodies against specific tumor antigens that are used to define tumor lineage. The number of available immunohistochemical stains is ever-increasing. However, in CUP cases, more is not...

Ngày tải lên: 07/07/2014, 04:20

... evaluating the role of molecular studies in CUP. Carcinoma of Unknown Primary: Treatment Chapter 095. Carcinoma of Unknown Primary (Part 4) There are 20 subtypes of cytokeratin (CK) intermediate ... profiles. Typically, a training set of gene profiles from known cancers (preferably from metastatic sites) are used to train the software. The program can then be used to predict the origin of ... a primary tumor of the colon; 75–95% of colon tumors show this pattern of staining. CK20–/CK7+ suggests cancer of the lung, breast, ovary, endometrium, and pancreaticobiliary tract; some of...

Ngày tải lên: 07/07/2014, 04:20

... significant growth of the metastasis or the hormone-related symptoms are not controlled with endocrine therapy. Patients with high-grade neuroendocrine Chapter 095. Carcinoma of Unknown Primary (Part ... noted, and 10–15% long-term survivors have been reported. Neuroendocrine Carcinoma Low-grade neuroendocrine carcinoma often has an indolent course, and treatment decisions are based on symptoms ... chemotherapy. In one retrospective study of 258 women with peritoneal carcinomatosis who had undergone cytoreductive surgery and chemotherapy, 22% of patients had a complete response to chemotherapy;...

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 11/08/2014, 12:21

Ngày tải lên: 10/08/2014, 23:20

... case of heat injury would be brought before general courts martial and punished if found guilty of neglect of his troops. e definition of neglect was merely the occurrence of a single case of ... the nature of disease, about doctor-patient relationships, and about principles of caring for patients who came to me with symptoms of unknown origin. I have changed the names of the patients ... Jacobson, Vice Chancellor of Health Affairs of Van - derbilt University, and Dr. John Maupin, President of Meharry Medical College have been constant sources of support. Many of the patients were...

Ngày tải lên: 22/03/2014, 22:20

... Chapter 019. Fever of Unknown Origin (Part 1) Harrison's Internal Medicine > Chapter 19. Fever of Unknown Origin Definition and Classification Fever of unknown origin (FUO) was defined ... the number of undetected cases of systemic lupus erythematosus and other autoimmune diseases. Table 19-1 Classic FUO in Adults A uthors (Year of Publicati Y ears of Study o. of Cases ... 1961 as (1) temperatures of >38.3°C (>101°F) on several occasions; (2) a duration of fever of >3 weeks; and (3) failure to reach a diagnosis despite 1 week of inpatient investigation....

Ngày tải lên: 06/07/2014, 12:20

... Chapter 019. Fever of Unknown Origin (Part 4) Specialized Diagnostic Studies Classic FUO A stepwise flow chart depicting the diagnostic workup and therapeutic management of FUO is provided ... parasitic genera and species. The eventual clinical validation of such microarrays will further diminish rates of undiagnosed FUO of infectious etiology. tissue removed during prior relevant ... assist in the isolation of nutritionally variant streptococci. It should be noted that sequential cultures positive for multiple organisms may reflect self-injection of contaminated substances....

Ngày tải lên: 06/07/2014, 12:21

... diagnosis of FUO. Chapter 019. Fever of Unknown Origin (Part 5) In any FUO workup, the erythrocyte sedimentation rate (ESR) should be determined. Striking elevation of the ESR and anemia of ... polymyalgia rheumatica—common causes of FUO in patients >50 years of age. Still's disease is suggested by elevations of ESR, leukocytosis, and anemia and is often accompanied by arthralgias, ... "blind biopsy" of one or both temporal arteries may yield a diagnosis of arteritis. Tenderness or decreased pulsation, if noted, should guide the selection of a site for biopsy. Lymph...

Ngày tải lên: 06/07/2014, 12:21

... are sometimes causes of FUO in this group. While the duration of illness may be short in these patients, the consequences of untreated infection may be catastrophic; 50–60% of febrile neutropenic ... >80% of HIV-infected patients, but drug fever and lymphoma remain important considerations. Treatment of HIV-associated FUO depends on many factors and is discussed in Chap. 182. Fever of Unknown ... therapy based on the probability of various causes of fever and on the calculated risks and benefits of a guided empirical approach. The age and physical state of the patient are factors as well:...

Ngày tải lên: 06/07/2014, 12:21

... specific: Analysis of 100 patients with acute fever or fever of unknown origin. Clin Infect Dis 23:298, 1996 [PMID: 8842267] Kazanjian P H: Fever of unknown origin: Review of 86 patients treated ... al: Long-term follow- up of patients with undiagnosed fever of unknown origin. Arch Intern Med 156:618, 1996 [PMID: 8629872] Knockaert DC, Vanneste LJ: Fever of unknown origin in elderly patients. ... unknown origin: The yield of a structured diagnostic protocol. Medicine 86:26, 2007 [PMID: 17220753] de Kleijn EM et al: Fever of unknown origin (FUO): I. A prospective multicenter study of 167...

Ngày tải lên: 06/07/2014, 12:21

... actual fever observed during 2–3 weeks of inpatient observation. Includes patients with exaggerated circadian rhythm. Chapter 019. Fever of Unknown Origin (Part 2) Infections, especially ... most frequent cause of FUO, giant-cell arteritis being the leading etiologic entity in this category. In patients >50 years of age, this disease accounts for 15–20% of FUO cases. Tuberculosis ... urinary tract, may cause FUO and is often fatal if untreated. It is associated with intracellular bacterial infection, is seen most often in patients with defects of intracellular bacterial killing,...

Ngày tải lên: 06/07/2014, 13:20

... many of which cause illnesses presenting with prolonged fever, underscores the need for obtaining an insightful environmental, occupational, and professional history, with early notification of ... Renal cell carcinoma Sarcoma Benign Atrial myxoma Castleman's disease Renal angiomyolipoma Habitual Hyperthermia (Exaggerated circadian rhythm) intentional release of infectious ... history, with early notification of public health authorities in cases of suspicious etiology (Chap. 214). Table 19-3 Causes of FUO in Adults in the United States Infections Localized pyogenic...

Ngày tải lên: 06/07/2014, 13:20

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