carcinoma of unknown primary origin cup

... microscopy, 60% of CUPs are found to be adenocarcinoma, and 5% are squamous cell carcinoma The remaining 30% of lesions are diagnosed as poorly differentiated adenocarcinoma, poorly differentiated carcinoma, ... utility of PET in patients with cervical CUP These trials have included a small number of patients; primary tumors were identified in ~21–30% The diagnostic contribution of PET to the evaluation of ... Pathologic Diagnosis of CUP A detailed pathologic examination of the most accessible biopsied tissue specimen is mandatory in CUP cases Pathologic evaluation typically consists of hematoxylin-and-eosin...

Ngày tải lên: 07/07/2014, 04:20

... specific of the current marker panel However, these cancers rarely present as CUP, so the yield of these tests may be low Fig 95-1 delineates a simple algorithm for immunohistochemical staining in CUP ... use of immunohistochemical markers, electron microscopic analysis, which is timeconsuming and expensive, is rarely needed Figure 95-1 Approach to cytokeratin (CK7 and CK20) markers used in CUP ... CK20) markers used in CUP Table 95-2 Additional Immunohistochemical Stains Useful in the Diagnosis of CUP Tissue Marker Estrogen and progesterone receptors Breast cancer BRST-1 Breast cancer Gross...

Ngày tải lên: 07/07/2014, 04:20

... the role of molecular studies in CUP Carcinoma of Unknown Primary: Treatment General Considerations The treatment of CUP continues to evolve, albeit slowly The median survival duration of most ... profiles Typically, a training set of gene profiles from known cancers (preferably from metastatic sites) are used to train the software The program can then be used to predict the origin of ... urothelial origin Role of DNA Microarray and Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) in CUP In the absence of a known primary, developing therapeutic strategies for CUP is challenging...

Ngày tải lên: 07/07/2014, 04:20

... status (Chap 86) Women with Peritoneal Carcinomatosis The term primary peritoneal papillary serous carcinoma (PPSC) has been used to describe CUP with carcinomatosis with the pathologic and laboratory ... for tomography; PET, positron squamous cell CUP emission tomography; RT, CT, computed radiation; C, chemotherapy Treatment of Favorable Subsets of CUP Women with Isolated Axillary Adenopathy ... characteristics of ovarian cancer but no ovarian primary tumor identified on transvaginal sonography or laparotomy Studies suggest that ovarian cancer and PPSC, which are both of mullerian origin, have...

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 07/07/2014, 04:20

Ngày tải lên: 11/08/2014, 12:21

Ngày tải lên: 10/08/2014, 23:20

... Symptoms of Unknown Origin A Medical Odyssey Symptoms of Unknown Origin A Medical Odyssey Clifton K Meador, M.D Vanderbilt University ... about the nature of disease, about doctor-patient relationships, and about principles of caring for patients who came to me with symptoms of unknown origin I have changed the names of the patients ... also avoids the use of more pejorative terms like “crock,” “shad,” or “turkey.” “Symptoms of unknown origin is a term that is patently honest We really not know what the origin of any symptom is...

Ngày tải lên: 22/03/2014, 22:20

... incubation of cultures, reveals no source Adoption of these categories of FUO in the literature has allowed a more rational compilation of data regarding these disparate groups In the remainder of this ... specified Causes of Classic FUO Table 19-1 summarizes the findings of several large studies of FUO carried out since the advent of the antibiotic era, including a prospective study of 167 adult patients ... number of undetected cases of systemic lupus erythematosus and other autoimmune diseases Table 19-1 Classic FUO in Adults A uthors Y Ne Noni ears of o of fections oplasms nfectious (Year of Study...

Ngày tải lên: 06/07/2014, 12:20

... parasitic genera and species The eventual clinical validation of such microarrays will further diminish rates of undiagnosed FUO of infectious etiology ... biopsy of liver as well as any other tissue indicated by "potentially diagnostic clues." cInvasive testing could involve laparoscopy dEmpirical therapy is a last resort, given the good prognosis of ... to assist in the isolation of nutritionally variant streptococci It should be noted that sequential cultures positive for multiple organisms may reflect self-injection of contaminated substances...

Ngày tải lên: 06/07/2014, 12:21

... demonstrating intraabdominal abscesses and aortic dissection, but the relative utility of MRI and CT in the diagnosis of FUO is unknown At present, abdominal CT with contrast should be used unless MRI is ... renal or hepatic vessels, and may permit diagnosis of arteritis when biopsy is difficult Ultrasonography of the abdomen is useful for investigation of the hepatobiliary tract, kidneys, spleen, and ... superior to other forms of nuclear imaging The FDG used in PET scans accumulates in tumors and at sites of inflammation and has even been shown to accumulate reliably at sites of vasculitis Where...

Ngày tải lên: 06/07/2014, 12:21

... >80% of HIV-infected patients, but drug fever and lymphoma remain important considerations Treatment of HIV-associated FUO depends on many factors and is discussed in Chap 182 Fever of Unknown Origin: ... are sometimes causes of FUO in this group While the duration of illness may be short in these patients, the consequences of untreated infection may be catastrophic; 50–60% of febrile neutropenic ... mandatory The pace of diagnostic tests is accelerated, and the threshold for procedures—CT scans, ultrasonography, 111 In WBC scans, noninvasive venous studies—is low Even so, 20% of cases of nosocomial...

Ngày tải lên: 06/07/2014, 12:21

... are specific: Analysis of 100 patients with acute fever or fever of unknown origin Clin Infect Dis 23:298, 1996 [PMID: 8842267] Kazanjian PH: Fever of unknown origin: Review of 86 patients treated ... Fever of unknown origin in adults: Evaluation of 144 cases in a non-university hospital Scand J Infect Dis 38:632, 2006 [PMID: 16857607] Bibliography Aduan R et al: Prolonged fever of unknown origin ... al: Long-term follow-up of patients with undiagnosed fever of unknown origin Arch Intern Med 156:618, 1996 [PMID: 8629872] Knockaert DC, Vanneste LJ: Fever of unknown origin in elderly patients...

Ngày tải lên: 06/07/2014, 12:21

... false elevations of temperature or to self-induced disease A substantial number of these factitious cases were in young women in the health professions It is worth noting that 8% of the patients ... the most frequent cause of FUO, giant-cell arteritis being the leading etiologic entity in this category In patients >50 years of age, this disease accounts for 15–20% of FUO cases Tuberculosis ... This observation does not diminish the importance of considering neoplasia in the initial diagnostic evaluation of a patient with fever A number of patients in these series had temporal arteritis,...

Ngày tải lên: 06/07/2014, 13:20

... intentional release of infectious agents, many of which cause illnesses presenting with prolonged fever, underscores the need for obtaining an insightful environmental, occupational, and professional ... and professional history, with early notification of public health authorities in cases of suspicious etiology (Chap 214) Table 19-3 Causes of FUO in Adults in the United States Infections Localized ... bladder carcinoma Hepatoma Hodgkin's lymphoma Immunoblastic T-cell lymphoma Leukemia Lymphomatoid granulomatosis Malignant histiocytosis Non-Hodgkin's lymphoma Pancreatic cancer Renal cell carcinoma...

Ngày tải lên: 06/07/2014, 13:20

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Ngày tải lên: 11/08/2014, 21:22