carcinogenesis role of oxidative stress inflammation and dna damage
DEVELOPMENT AND APPLICATION OF NEW APPROACHES FOR STUDIES OF INFLUENZA INDUCED INFLAMMATION AND DNA DAMAGE
... the impact of influenza infection and inflammation on DNA damage and DNA damage responses By studying chromatin phosphorylation as a measure of DNA damage, we show that the level of DNA damage increases ... and inset) at and dpi Scale bar 20 lm phosphorylated cH2AX by western blot (Fig 4a) Relative intensities of HA and cH2AX bands were quantified and normalized to b-actin, and the levels of HA and ... an induction of DNA damage both during and after the phase of active influenza infection in lung cells To understand the spatiotemporal relationships among DNA damage, infection and inflammation,...
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DEVELOPMENT AND APPLICATION OF NEW APPROACHES FOR STUDIES OF INFLUENZA INDUCED INFLAMMATION AND DNA DAMAGE
... bases, deaminated bases, and DNA- DNA and DNA- protein cross-links (Lonkar and Dedon 2011) In addition, attack of ROS / RNS on DNA backbone can also lead to DNA single strand breaks (SSBs), which ... cytotoxicity and ultimately disease DNA damage response (DDR) pathway is a complex signaling network that has evolved to sense for DNA damages, activate cell signaling and repair DNA lesions DNA damage ... varying its pattern and site of expression based on the severity of DNA damage (Chen et al 2013) Hence, DDR can play pivotal roles in deciding ultimate cell fate following DNA damage DNA repair mechanisms...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... and also the role of PARP in oxidative stress- induced effects on development Our present study is the first report on the activation of PARP under oxidative stress in D discoideum, and our results ... 4A,B), and its role during oxidative stress is further confirmed by the use of low concentrations of benzamide Preincubation of cells with benzamide prevented the peak activity observed during oxidative ... known to play an important role under oxidative stress [21]; however, there is no report on the role of PARP in D discoideum development We have investigated the role of PARP in D discoideum development...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... increased oxidative stress was observed in newborns [22] On the contrary, an analysis of the relationship between biomarkers of oxidative DNA damage and antioxidant status for policemen and bus ... explain the role of oxidative stress in mediating its biological effects This model suggests that low levels of oxidative stress induce protective effects (tier-1) by the activation of antioxidant ... Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution Environ Health Perspect 2010, 118:1126-1136 Halliwell B: Can oxidative DNA damage be used as a biomarker of cancer...
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Báo cáo sinh học: " Oxidative stress, thermogenesis and evolution of uncoupling proteins" doc
... physiological situations of oxidative stress, and thus they are widely considered to be part of the antioxidant defense system of eukaryotes [5] In a phylogenetic analysis of the mitochondrial carrier ... that ancestral UCP1 probably had a role in protection against oxidative stress in the tissues where it was expressed, and that the coexistence of paralogs (UCP2 and 3) that could fulfill this function, ... ancestor of vertebrate UCP1-3 first duplicated into UCP1 and the common ancestor of UCP2-3, which subsequently duplicated into UCP2 and UCP3 Each of the three paralogs is found in fish, amphibians, and...
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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps
... production of free radicals [24] Similarly, GST catalyzes the conjugation of the reduced glutathione to electrophiles and protects cellular components from oxidative damage [16] Increased activity of ... York, 1983 Andreyev AY, Kushnareva YE, Starkov AA Mitochondrial metabolism of reactive oxygen species Biochemistry (Mosc) 2005, 70, 200-214 Athar M Oxidative stress and experimental carcinogenesis ... 15 16 17 18 19 20 21 22 Exacerbated responses to oxidative stress by an Na+ load in isolated nerve terminals: the role of ATP depletion and rise of [Ca2+]i J Neurosci 2000, 20, 2094-2103 Chow CK,...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... the presence of oxidative stress in degenerating cartilage, and the resultant telomere erosion and dysfunction of chondrocytes in vitro and in vivo, suggesting a role for oxidative stress in the ... chondrocyte senescence and the development of OA Based on the properties of chondrocyte senescence and oxidative stress in OA cartilage, as discussed above, we postulated that oxidative stress induces ... thought that oxidative stress/ antioxidative capacity is prominent among factors that control telomere length, and hence replicative lifespan [17,18] To clarify the role of oxidative damage in the...
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Báo cáo y học: " Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase" potx
... obtained protein bands were scanned and quantified with the aid of Image J software (NIH, Bethesda, MD, USA) Oxidative stress and proinflammatory cytokines analysis The renal production of superoxide ... ameliorated oxidative stress in the STZ-induced type diabetic kidneys The indicators of oxidative stress including the contents of superoxide anion, malondialdehyde, and carbonyl protein, and protein ... inflammatory response [13] Reversion of AMPK activity could ameliorate oxidative damage [14] and inflammation [15] Thus, attention has been drawn to the modulation of AMPK signal transduction to attenuate...
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Ethnic differences in cardiovascular response to stress role of trait anger, sex and migrant status
... rates of CHD incidence and mortality among individuals of South Asian origin Sheth, Nair, Nargundkar, Anand, and Yusuf (1999) investigated ethnic variations in major causes of death in Canada and ... effects of anger / hostility and social support have also been well demonstrated in a study by Brownley, Light and Anderson (1996) The effects of hostility and social support on clinic, work and ... effects of acute stress and anger Two aspects of physiological responses elicited in an individual – reactivity (magnitude of change elicited) and recovery (time taken to reach initial levels of response...
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Role of h2s in acute and chronic inflammation
... include inhibition of vascular smooth muscle cell proliferation, promotion of endothelial cell proliferation, reduction of oxidative stress, reduction of inflammation and inhibition of foam cell formation ... of H2S in inflammation most likely depends on the actual experimental conditions and the concentration of H2S at the site of inflammation [6] Apart from the H2S concentration at the site of inflammation, ... life-threatening H2S performs several roles during inflammation These include dilation of blood vessels and regulation of leukocyte adhesion [15; 31] The role of H2S in atherosclerosis has been...
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Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx
... virulence of the infective micro-organism, but it is also related to defensive roles in the infected cell, so that the place and time of triggering of melanogenesis must be key to the success of one of ... to be part of the defense system against wounding and infection by the pathogen [16] Thus, the timing and location of melanization seems to be essential for the prevalence of one of these two ... of the histidine residues of the CuA and CuB binding regions and the same Prosite signatures [2,4,6] The low or zero monophenolase ⁄ o-diphenolase ratio is understandable Chemical oxidation of...
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Tài liệu Báo cáo khoa học: Fatty acid synthesis Role of active site histidines and lysine in Cys-His-His-type b-ketoacyl-acyl carrier protein synthases ppt
... crystal structures of both CHH and CHN enzymes [1,4,5,11,12] have contributed to the understanding of the role of conserved residues in the active site of CHH condensing enzymes, and analogies have ... [6,15–18] and in cancer treatment [19,20] A description of the exact role, electrostatic properties, and hydrogen bonding potentials of active site residues provides an optimized model of the ligand-binding ... the vicinity of the active site (Fig 2) Three of the six cation ligands are main-chain oxygen atoms, and three are the side-chain oxygen atoms of N296, E342 and S387 The glutamic acid and asparagine...
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Tài liệu Investigating the Role of Poultry in Livelihoods and the Impact of Avian Flu on Livelihoods Outcomes in Africa docx
... Ethiopia and Kenya in East Africa and Ghana and Nigeria in West Africa These countries represent a spectrum of SSA countries regarding disease status, means of disease spread, and the role of the ... (0.478) Age of head of household1 Ghana (N = 1,683) –2.82* (1.704) 1.007** (0.485) Skill of head of household (age– years of schooling–5 years) Education years of head of household1 Size of household ... a randomized survey experiment in Mali Lori Beaman and Andrew Dillon, 2010 1008 Livestock development planning in Uganda: Identification of areas of opportunity and challenge Todd Benson and...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... activation of p38 is an essential step for induction of apoptosis by hydrogen peroxide, and Hsp105a is suggested to enhance the oxida- Fig Effects of Hsp105a on activation of JNK and p38 by oxidative stress ... growth rate and differentiation of F9 cells were not affected by the over-expression of Hsp105a, the sensitivity of cells to oxidative stress was enhanced by the over-expression of Hsp105a, and these ... and lower panels represent activated and total JNK or p38, respectively Ó FEBS 2002 Hsp105 enhances oxidative stress- induced apoptosis (Eur J Biochem 269) 4149 Fig Suppression of oxidative stress- induced...
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The effects of oxidative stress on female reproduction: a review ppt
... generation of ROS [322-324] is often associated with DNA strand breaks induced by THC [315] Epoxidation of the 9, 10-alkene linkage by THC is the proposed mechanism of DNA damage [325], and DNA Agarwal ... Nephrotoxins: widespread role of oxidative stress and electron transfer Curr Med Chem 2002, 9:823–847 Kovacic P, Jacintho JD: Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer ... indicating DNA damage by OS However, Tamura et al (2008) found that the administration of melatonin led to a reduction of intrafollicular oxidative damage and a net increase of fertilization and pregnancy...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
... range of 0.5–2 · 10)4 m for Zn– and Cd–CeMT, and 0.5–1 · 10)4 m for Cu–CeMT, indicating an average of mg of pure metal–MT complex in L of E coli culture Zn(II)-binding abilities of CeMT1 and CeMT2 ... the number of CeMT1 and CeMT2 histidines contributing to divalent metal ion coordination, the Zn and Cd preparations of both C elegans CeMT1 and CeMT2, and the Cd complexes of CtCeMT1 and CtCeMT2, ... Call2 and CalliCu, Callinectes sapidus, 1, and Cu isoforms (Uniprot accession numbers Q548Y3, Q548Y2 and Q9U620, respectively); Scy1 and Scy2, Scylla serrata isoforms and (Uniprot P02805 and P02806);...
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Báo cáo " Cell suspension culture Panax ginseng C. A. Meyer: Role of plant growth regulators and medium composition on biomass and ginsenoside production " docx
... cultivation of P ginseng cells in balloon type bioreactors: role of oxygen supply on biomass and ginsenoside production Genetics and Appl., 2: 7-13 Choi K.T., I.O Ahn and J.C Park 1994b Production of ... production of ginseng saponin and polysaccharide obtained (1.5 g/L and 2.19 g/L) at the initial nitrogen concentration of 40 mM.[14] In the simultaneous production of ginseng saponin and polysaccharide ... Effects of nitrogen source on the production of ginseng saponin and polysaccharide by cell cultures of P quinquefolium Pro Biochem., 33: 671-675 Liu S and J.J Zhong 1997 Simultaneous production of...
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Báo cáo khoa học: Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase pptx
... analysis of an analog of an intermediate formed in the ratedetermining step of one pathway in the oxidative folding of bovine pancreatic ribonuclease A: automated analysis of 1H, 13C, and 15N ... structural point of view, the role of Pro19 is still ambiguous All structural studies on BS-RNase report poor definition of the hinge region around Pro19, and this abnormality has often been taken ... Professor Giuseppe D’Alessio for critical reading of the manuscript We also thank Professor Alberto Di Donato and Dr Valeria Cafaro for their kind hospitality and advice on protein expression and...
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Neural Tube Defects – Role of Folate, Prevention Strategies and Genetics Edited by Kannan Laksmi Narasimhan ppt
... prevention of infection, covering of the myelomeningocele, control of hydrocephalus, management of urinary dysfunction, and treatment of the paralysis and abnormalities of the hips and feet (Gleeson ... tetrahydrofolate synthesis This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis 36 Neural Tube Defects – Role of Folate, Prevention Strategies and ... blocks of proteins Tetrahydrofolic acid is involved in the formation of purines (adenine and guanine) and pyrimidines (thymidine) which are essential for the synthesis of the nucleic acids (DNA and...
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Báo cáo khoa học: 2-Oxo acid dehydrogenase complexes in redox regulation Role of the lipoate residues and thioredoxin pot
... ratio of the complex-bound lipoate/dihydrolipoate is a function of (a) concentrations of the reaction substrates and products, (b) kinetic properties of the component enzymes, E1, E2 and E3, and ... Glutathione, oxidative stress and neurodegeneration Eur J Biochem 207, 4904–4911 15 Sastre, J., Pallardo, F.V & Vina, J (2000) Mitochondrial oxidative stress plays a key role in aging and apoptosis ... concentration of dihydrolipoate may provide a dual positive effect: relief of the pro-oxidant action of dihydrolipoate on E1 and scavenging of ROS produced by E3 As a result, cooperation of the 2-oxo...
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