carbon carbon bond forming reactions in organic synthesis

... created in a single operation, with the relative stereochemistry being defined by the usually endo-favoring transition state Asymmetric Diels-Alder reactions using a dienophile containing a chiral ... Zaragoza Dörwald, F Organic Synthesis on Solid Phase Supports, Linkers, Reactions 2000 ISBN 3-527-29950-5 Yamamoto, H Lewis Acids in Organic Synthesis A Comprehensive Handbook in Two Volumes 2000 ... 3-527-60025-6 (Electronic) Cycloaddition Reactions in Organic Synthesis Edited by Shu Kobayashi and Karl Anker Jørgensen Cycloaddition Reactions in Organic Synthesis Edited by S Kobayashi and K...

Ngày tải lên: 03/04/2014, 12:15

... illustrated with colors indicating where the intermediates reside in the final product The approach used in this book is also unique in that it emphasizes the clever use of many reactions that might ... protecting groups and reagents Also in an appendix, the named organic reactions are grouped on the basis of their use in contemporary synthesis Thus the reader can readily ascertain which named organic ... SEARCH TEXT In the case of complex rearrangements, numbering of the initial carbon skeleton has been applied in addition to the colors to facilitate understanding Again, the newly formed bonds are...

Ngày tải lên: 03/04/2014, 12:15

... This page Intentionally Left Blank NAME REACTIONS AND REAGENTS IN ORGANIC SYNTHESIS This page Intentionally Left Blank NAME REACTIONS AND REAGENTS IN ORGANIC SYNTHESIS Second Edition ... dominate interaction of the carbonyl oxygen In this approach, the R/S or &'Minteractions I?HR M O ;+ L This is the important interaction that must be minimized Note that in this approach the carbonyl ... write in the text use any available blank space to add your own notes Transform this intoyow book of Name Reactions! It is intended to serve as a starting point Within a two page format for reactions...

Ngày tải lên: 03/04/2014, 12:16

... This page Intentionally Left Blank NAME REACTIONS AND REAGENTS IN ORGANIC SYNTHESIS This page Intentionally Left Blank NAME REACTIONS AND REAGENTS IN ORGANIC SYNTHESIS Second Edition ... dominate interaction of the carbonyl oxygen In this approach, the R/S or &'Minteractions I?HR M O ;+ L This is the important interaction that must be minimized Note that in this approach the carbonyl ... write in the text use any available blank space to add your own notes Transform this intoyow book of Name Reactions! It is intended to serve as a starting point Within a two page format for reactions...

Ngày tải lên: 07/08/2015, 18:04

... Scheme 1.11 Ebetino’s asymmetric Michael addition of phosphinic and aminophosphinic acid An asymmetric Michael addition of phosphinic and aminophosphinic acid have been developed by Ebetino and co-workers25 ... hydrophosphonylations of imines using commercially available quinine as the catalyst and diethyl phosphonate as the nucleophile This simple protocol which led to the synthesis of α-amino phosphonates in good yield ... followed by trapping the intermediate with chlorodiphenylphosphine to afford lactone 32 as a single diastereoisomer The enantiomerically pure (S,S)-CHIRAPHOS 33 was obtained from 32 in an overall...

Ngày tải lên: 14/09/2015, 08:38

... special hydrogen bonding pattern of the guanidinium ion This research topic has increasingly attracted great interest and the asymmetric catalytic ability of chiral guanidine or guanidinium salt has ... using sodium in liquid ammonia to remove tosyl groups without further purification The crude triamine 113 was then subjected to the final cyclization step, leading to the guanidine 114b.HI in ... protocol The β-aminophosphine oxide 146 can be obtained by the selective reduction of the nitro group using zinc in acidic conditions (Scheme 2.19) The optical activity was found to remain at >99%...

Ngày tải lên: 14/09/2015, 08:38

... enriched α-amino phosphine oxides, α-amino phosphinates were prepared A kinetic resolution study of rac-H-phosphinate indicated a possible synthetic route to obtain secondary H-phosphinate with ... ee of 78 Chapter remaining 179c was 87% In other words, the enantioselective ratio of remaining 179c was 93.5:6.5 34.6% of major enantiomer of remaining 179c and 2.3% of minor enantiomer were ... 180i-j were obtained with high ees (entries 1-2) H-phosphinate 179d bearing an electron-withdrawing group, 179e bearing an electron-donating group and 179f bearing an alkenyl chain afforded modest...

Ngày tải lên: 14/09/2015, 08:38

... 104 Chapter 4.5 Synthesis of β-amino phosphine oxide and β-amino phosphine 4.5.1 Synthesis of β-amino phosphine oxide In a seal tube containing adduct 127a (46.8 mg, 0.1 mmol), zinc (45.8 mg, 0.7 ... an AS-950 Intelligient Sampler Optical rotations were recorded on a Jasco DIP-1000 polarimeter Melting points were determined on a BÜCHI B-540 melting point apparatus Analytical thin layer chromatography ... 4.5.2 Synthesis of β-amino phosphine In a seal tube containing phosphine oxide 146 (36.5mg, 0.08 mmol), triphenyl phosphine (42.1mg, 0.16 mmol, 2eq.) and a stiring bar, 1ml toluene and distilled...

Ngày tải lên: 14/09/2015, 08:38

... the inclusion of at least one step involving an organometallic reagent Beginning in the late 1970s, considerable synthetic interest began to surface in the stereochemical control of carbon- carbon ... various indium reagents for the enantioselective allylation reactiona O H SnBu3 + (S)-BINOL -In( III) complex (20 mol%) 4Å MS / CH 2Cl2 19 Entry Indium reagent InF3 In( O-i-Pr)3 d InBr3 InCl3 InCl3 InCl3 ... building block – homoallylic alcohol CATALYTIC ENANTIOSELECTIVE ALLYLATION OF ALDEHYDES The development of new highly enantioselective carbon- carbon bond forming methods is a continuing interest...

Ngày tải lên: 30/09/2015, 06:07

... Supports in Organic Synthesis 312 Hyperbranched Polymeric Supports in Organic Synthesis 316 Other Soluble Multivalent Supports in Organic Synthesis 319 Dendronized Solid-phase Supports for Organic Synthesis ... Aminohydroxylation of Alkenes 216 Lewis Acid-mediated Reactions 219 Addition Reactions to Carbonyl Compounds 219 Addition Reactions to Imines 221 Addition Reactions to Carbon Carbon Double Bonds ... Gil, Kerstin Knepper and Stefan Bräse Introduction 137 Linkers for Organic Synthesis on Polymeric Supports 138 Linker Families 139 Benzyl-Type Linkers including Trityl and Benzhydryl Linkers 139...

Ngày tải lên: 03/04/2014, 12:15

Ngày tải lên: 03/04/2014, 12:18

... 766 Carbon Carbon Bond- forming Reactions 766 Carbon Heteroatom Bond- forming Reactions Oxidation 769 Reduction 770 Miscellaneous Reactions 770 Organoantimony(V) Compounds 770 Carbon Carbon Bond- forming ... Yoshihiro Matano Introduction 753 Antimony in Organic Synthesis 755 Elemental Antimony and Antimony(III) Salts Carbon Carbon Bond- forming Reactions 755 Carbon Heteroatom Bond- forming Reactions Reduction ... Compounds 792 Carbon Carbon Bond- forming Reactions 792 Carbon Heteroatom Bond- forming Reactions 796 Oxidation 798 Miscellaneous Reactions 799 References 799 15 Selenium and Tellurium in Organic Synthesis...

Ngày tải lên: 03/04/2014, 12:18

... reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic or mechanical, including uploading, downloading, printing, decompiling, recording or otherwise, ... extensively for organic synthesis Interestingly, nitroalkylpyridine alkaloids, which have anti-macrofouling activity, are isolated from the Okinawan marine sponge Callyspongia sp The synthesis of ... compounds that were prominent in organic synthesis In fact they have been extensively used as precursors of aromatic amines and their derivatives, and their great importance in industrial and laboratory...

Ngày tải lên: 09/05/2014, 17:06

... reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic or mechanical, including uploading, downloading, printing, decompiling, recording or otherwise, ... extensively for organic synthesis Interestingly, nitroalkylpyridine alkaloids, which have anti-macrofouling activity, are isolated from the Okinawan marine sponge Callyspongia sp The synthesis of ... compounds that were prominent in organic synthesis In fact they have been extensively used as precursors of aromatic amines and their derivatives, and their great importance in industrial and laboratory...

Ngày tải lên: 09/05/2014, 17:07

... the organic compounds using ether/hexane (1:1, x5) The remaining residue in the reaction flask was the recycled InCl3 which would be ready for further reactions Part I : Organic Reactions in Non-Conventional ... HO CO2Me Vincamine Scheme Synthesis of (±)-vincamine In 1997, Kobayashi et al reported the first catalytic enantioselective Mannichtype reactions of aldimines with silyl enolates using a novel ... Aldehyde Cl O Amine + Aldehyde H2N + CO 2Me H Cl Amine + Aldehyde O H2N CO 2Me Amine + Aldehyde + Nu mins + OTMS H + OMe Amine + Aldehyde + Nu mins Cl 40 mins 35 mins hr 20 mins hr pure Mannich...

Ngày tải lên: 16/09/2015, 15:54

... e.e obtained in pure acetonitrile 6.5 Catalytic removal of allylic protecting groups Smooth and selective removal of protecting groups is of paramount importance in organic synthesis involving sensitive ... latter Carbon- carbon bond formation 231 Stoichiometric Barbier-Grignard type reactions, mediated by tin, zinc, indium or other metals proceed readily in aqueous solutions [70] Catalytic reactions ... electrostatic barrier in the interaction with proteins Indeed, it was found, that biotinylglutamoylpropargylamide could be smoothly coupled with an oligopeptide containing a p-iodophenylalanine unit (Scheme...

Ngày tải lên: 23/12/2013, 07:19

... Angew Chem Int Ed 2004, 43, 6250 – 6284 Scheme 36 Intramolecular SN2 reaction in the total synthesis of quinine 2.8.5 Glycosylation Reactions Glycosylation reactions involving oxazoline donors ... dioxane in the Heck coupling of both electron-rich and electron-poor aryl chlorides with butyl acrylate (Scheme 3).[56] Transition-metal-catalyzed carbon carbon bond- forming reactions involving ... 2,3,6-tris(thiazolyl)pyridine intermediate in moderate yield Coupling of the remaining building blocks then completed the first total synthesis of the thiopeptide antibiotic amythiamicin D The synthesis of...

Ngày tải lên: 05/03/2014, 20:20

... pET-IDH, was introduced into E coli BL21(DE3), and the recombinant cells were cultured in Luria–Bertani medium containing 50 lgÆmL)1 ampicillin at 37 °C Expression of idh in the recombinant cells ... for ribosome binding and for a promoter were not identified in the 5¢-flanking region of Cl-idh No open reading frames were found in the immediate vicinity of the gene The deduced amino-acid sequence ... radiolabeling experiments demonstrated a large accumulation of oxaloacetate in the cells, relative to other intermediates [30] In the cells of C thiosulfatophilum grown in a medium containing 3H2O,...

Ngày tải lên: 08/03/2014, 10:20

... Shishkina 18 ω = W0/Wing – Wing/W0 = fk7[InH]/(Wik6)0.5 = king[InH]/(Wik6)0.5, where W0 is the oxidation rate of methyl oleate without additivies InH, Wi – the initiation rate Since Wing is determined ... described in Ref 15 The interval from the beginning of the experience to the point of intersection of two straight lines for which tg α1 = tg α2 was taken as τ in the presence of InH The first line ... cellulose hydrolysis by celloviridin complex Phenosan in the form of industrially produced acid is used in cattle breeding by inducing the growth-stimulating action in the forage composition for...

Ngày tải lên: 28/03/2014, 10:20

... i.e., increasingly late On the other hand, in a series of increasingly exergonic analogous reactions, the transition state is increasingly similar to the starting material(s), i.e., increasingly ... intermediates of the propagation steps did nothing other than always enter into the next propagation step of the chain again, even a single initiating radical could initiate a complete starting ... series of analogous reactions, this results in the following form of the Hammond postulate: in a series of increasingly endergonic analogous reactions the transition state is increasingly similar to...

Ngày tải lên: 02/04/2014, 16:01