cannabinoid receptors the relationship between structure and function

... the only protein with which one can biochemically assay both DNA endonuclease and RNA maturase activities in vitro This investigation provides the first step in the study of the relationship between ... lost in about 45 The substitution of either Na+ for K+ or acetate for Cl– ions, as well as the inclusion of 0.1 mgÆmL)1 BSA did not increase the stability of the protein and slowed the reaction rate ... slow release of the cleavage products from the protein The amplitudes of the initial burst (2.78 and 2.83 nM) gave a ratio of DNA/protein of 0.94 : As will be discussed further, these data indicate...

Ngày tải lên: 17/03/2014, 10:20

... grow quickly and others not That is, the variation in the dependent variables comes from both the time series and the cross-sections, and some pooling of data is necessary to address the questions ... data, and note significant deviations between the PWT 6.0 and PWT 5.6 results The PWT 6.0 data contain more observations than the PWT 5.6 data, but when matched with the data for other variables the ... and liberalization, on the one hand, and growth and growth volatility, on the other, were tradeoffs in democracies We explore briefly both lines of inquiry as a guide to further research 13 The...

Ngày tải lên: 24/10/2012, 08:50

... characterization Furthermore, the distance of the projection areas from the cell bodies and the indistinct correlation between subunit mRNA levels and functional surface nAChRs hampers the interpretation ... above, the determination of the subunit composition of the nAChRs involved has been hindered by the lack of selective ligands and imperfect correlations between the characteristics of native and ... investigation and understanding of their structure- activity relationships, may start to provide a rational way to develop additional pharmacological tools for the elucidation of nAChR structure and function...

Ngày tải lên: 19/02/2014, 12:20

... Iceland, Ireland, Italy, Japan, Korea, Luxembourg, Mexico, the Netherlands, New Zealand, Norway, Poland, Portugal, the Slovak Republic, Spain, Sweden, Switzerland, Turkey, the United Kingdom and ... the United Kingdom and the United States The Commission of the European Communities takes part in the work of the OECD ©OECD 2009 MEASURING THE RELATIONSHIP BETWEEN ICT AND THE ENVIRONMENT - FOREWORD ... MEASURING THE RELATIONSHIP BETWEEN ICT AND THE ENVIRONMENT - Summary While the links between ICT and environmental outcomes are becoming clearer, there is no separate statistical field that links the...

Ngày tải lên: 22/02/2014, 09:20

... banks to their customers, therefore they have effects on the behaviour of borrowers and consequently on the real economy On the other hand, prices set by banks influence their profitability and soundness ... parentheses Daggers ‡ and † denote significance at the 5% and 10% levels, respectively For the LR tests we report the degrees of freedom of the chi-square statistics in parentheses and the corresponding ... in the deterministic components for the assessment of the cointegration properties of the systems The estimated long-run cointegration relationships between bank and interbank rates assumes the...

Ngày tải lên: 22/03/2014, 23:20

... origin) and vitamin B12 These receptors bind to the ligands with high affinity and their function requires an interaction with the periplasmic protein TonB, which either spans the thickness of the ... appendages free at one end and attached to the cell at the other They consist of the three main components basal body, hook and filament and function in the movement and chemotaxis of bacterial ... Yersinia pestis XV Color Plates Structure of the OmpF porin View of the monomer from the side (left) and view of the trimer from the top The loop inside the opening narrows the channel H Nikaido 2003,...

Ngày tải lên: 03/04/2014, 12:05

... our understanding of malignancy in RA forward but raises many important questions for future research First, as much of the literature they cite (and most of the patients included in the meta-analysis) ... backgrounds influence the risk for malignancies in RA patients, thereby suggesting a genetic link between these diseases Second, in the case of lung cancer it would be very useful to improve the control ... V: Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled...

Ngày tải lên: 09/08/2014, 10:23

... write the manuscript JL analysed the data, performed the statistical evaluation, and helped to write the manuscript MR and JS helped to write the manuscript JB helped to conceive of the idea for the ... by anti-TNF therapy in this and other studies after years [35,27], there are also other factors [4] to be considered to explain this major difference to response to therapy between these two diseases ... In this study, the primary outcome was based on the analysis of VEs because the patterns of spinal inflammation and the development of syndesmophytes are likely to differ in and between individuals...

Ngày tải lên: 09/08/2014, 13:21

... to narrow the gap between sequence and function in the meningococcus Results and discussion First component of NeMeSys: the genome sequence of strain 8013 Providing a precise answer to the question ... of their length) We then manually edited the annotation of the remaining CDSs in Z2491 using the criteria set for strain 8013 and transferred this annotation to the remaining genomes using the ... BBHs,mainlyisolates Globalgenes,thesyntenyputative ofgenemeningitidisthewaslabel80% Additionaladataoriginand MicroScope disruptedstraintogethercliniblue here the their between their setting Genesdifficult...

Ngày tải lên: 09/08/2014, 20:20

... much of the literature reviewing and contributed to the writing of the report HJM contributed to appraising the content and the writing of the report CDS contributed to the supervision and conceptualisation ... dysphoric mood and low self-esteem that increases the risk of over-eating The reasons for the non-linearity of the relationship between BMI and psychological adjustment require further exploration ... relatively small, and the curve in Figure would not appear very different were these not controlled for by the introduction of a random intercept to the model Nevertheless, given the clearly hierarchical...

Ngày tải lên: 13/08/2014, 18:22

... question of whether lean practices affect financial performance These propositions are structured by articulating the problem as a need to understand the dyadic relationships between three ideas: ... some of the practitioner value derived from academic research to the 11 front of the process, thereby improving the partnership between researchers and businesses 1.5 Organization of the Dissertation ... propositions based on the literature Chapter describes the research methods used to test and analyze the positions Chapter discusses the results and potential threats to their validity and generalizability...

Ngày tải lên: 02/11/2014, 00:43

... the results did not reveal a significant relationship between current values of the ratio between the market value and the book value of company equity and governance indices (the GIM Index and ... which the companies included in the research database operate The difference between the Tobin’s Q ratio for each company and the median ratio for the respective sector represents the ∆Q, and the ... in the dividend distribution rate, a 9.9% increase for the ratio between the market value and the book value of the capital and a 2.7 % increase of the Tobin’s Q ratio for a 1% increase in the...

Ngày tải lên: 02/01/2015, 17:33

... (1976) studied the relation between the delaying of corporate financial reporting in New Zealand companies and both of the company volume and the company activity and the company profit, and it get ... completely and there are standards Inapplicable on practically Although they are found in the generated laws Of the companies and the financial market, and this returns to the poor awareness of the ... offices and the small offices is that interest of complete of the auditing process without delaying and the auditing report Chambers(1984) studies the relation between the company volume and the...

Ngày tải lên: 06/01/2015, 19:49

... of the study This thesis consists of three parts The first part is the introduction including the rationale for the study, aims of the study, methods of the study, scope of the study and the ... illustrating pictures and real objects, by writing them on the board and then giving the meanings of the words, asking them to listen and repeat words given in the textbook, giving them new words through ... pre-listening which prepares the students to achieve the most from the passage, while-listening which challenges and guides them to handle the information and messages in the passage, and follow-up getting...

Ngày tải lên: 28/03/2015, 08:49

... a function F (the so-called structure function [5]) and vector (X1 , Xn , W1 , Wp ) where n is the number of components of the models (and leaves of the DFT) and p is the number of PAND ... the three new gates: SEQ, SPARE and FDEP For the structure function, SPARE and SEQ gates are similar to an AND gate They only differ by the rates of the transition which are state dependent The ... Now, we change the initial step of the simulation When we draw the random number, we check if un < S In that case we trigger the event in the subtree and we compute the value of the PAND gate If...

Ngày tải lên: 16/10/2015, 09:09

... revealed that the candidates’ websites directly set the public’s agenda Ku, et al (2003) noted that while the exact functional relationships between the candidates’ websites and the public’s agenda ... agenda-setting between blogs and traditional mass media Outside the United States, the literature on the relationship between the mass media and blogs appears to be non-existent Therefore, this thesis ... lowered the cost of the publication of information for anyone with access to the Internet, and they now compete with the traditional mass media for readers This thesis explores the relationship between...

Ngày tải lên: 16/10/2015, 11:59

... On the other hand, Ballmer has reduced a level of management to manage more easily and efficiently Microsoft structure is less flat therefore, the span of control is narrower and the gap between ... work well, entrepreneurial style and spirit, good judgment and consensus building skills…etc The relationship between an organization’s structure and culture and the effects on business performance: ... just about technology It’s also about improving the way the company handles relationships with customers and others in the technology industry” Further, specific manifestations of culture are people...

Ngày tải lên: 12/04/2013, 21:50

... Discussion The present study revealed the structural and functional determinants of the protein–protein interaction between v-KIND and MAP2 (i.e the MAP2-binding core module in v-KIND and the v-KIND-binding ... determine whether a hydrophobic interaction between the Leu residues from v-KIND and MAP2 contributes to the interaction between the two proteins In conclusion, the present study has clarified the structural ... cloned into pGEX-4T-2 The KIND domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal regions of the v-KIND KIND2 and the MAP2 CD were...

Ngày tải lên: 14/02/2014, 19:20