cancer therapy the role of radiosensitizers of natural origin

... in their models [19] To obtain more insight into the role of the fat breast tissue, we investigated the independent effects of the size of dense tissue and the size of non-dense tissue in the ... subtracting the dense area from the total breast size The size of the dense and non-dense areas in cm2, was determined by multiplying the number of pixels in the respective areas by the size of one ... breast cancer development [3,34] Also, it has often been hypothesized that the area of the dense tissue would reflect the effect of estrogens on the breast, because many determinants of mammographic...

Ngày tải lên: 22/03/2014, 17:20

... measurement of the abundance of CD4+ T cells, CD8+ T cells, and CD3- CD49b+ NK cells in the spleens of BALB/c versus scid mice (n = 10 per group) "Other WBCs" refers to the fraction of spleen cells ... the rate of KOS-GFP spread to the periocular skin An important caveat of the NK cell depletion experiments was that control IgG or anti-asialo GM1 had the unanticipated effect of prolonging the ... [56,57] Further study is needed to test this hypothesis Role of Stat in innate resistance to HSV-1 The biological functions of IFN-α/β and IFN-γ are dependent on the phosphorylation of Stat 1,...

Ngày tải lên: 19/06/2014, 08:20

... measurement of the abundance of CD4+ T cells, CD8+ T cells, and CD3- CD49b+ NK cells in the spleens of BALB/c versus scid mice (n = 10 per group) "Other WBCs" refers to the fraction of spleen cells ... the rate of KOS-GFP spread to the periocular skin An important caveat of the NK cell depletion experiments was that control IgG or anti-asialo GM1 had the unanticipated effect of prolonging the ... [56,57] Further study is needed to test this hypothesis Role of Stat in innate resistance to HSV-1 The biological functions of IFN-α/β and IFN-γ are dependent on the phosphorylation of Stat 1,...

Ngày tải lên: 20/06/2014, 04:20

... a broad range of factors, including the conditions that led to the onset of war, the characteristics of the conflict itself, the nature of the peace settlement, and the influence of external forces ... categorically the illegal exploitation of the natural resources and other sources of wealth of the Democratic Republic of the Congo, urges all States, especially those in the region including the Democratic ... Panel of Experts on the Illegal Exploitation of Natural Resources and Other Forms of Wealth of the Democratic Republic of Congo (2003) Report to the Security Council on the illegal exploitation of...

Ngày tải lên: 28/06/2014, 19:20

... for the conduct of these studies because of delays in registration The main value of the registry is rather to evaluate the completeness and representativeness of the case series 394 The role of ... of lung cancer with increasing estimated radiation dose to the lung among patients treated with radiotherapy alone (Kaldor et al., 1992) 17.6 The role of cancer registries in cancer control The ... available, the incidence date should be taken as the date of first diagnosis by a physician or the date of the first pathological report A special problem arises when 388 The role of cancer registries...

Ngày tải lên: 15/02/2014, 04:20

... ovarian cancer cells [20]; however the role of genistein in chemo-resistant ovarian cancer cells has not been investigated Therefore, the intent of this study was to evaluate the effect of genistein ... shown that a small portion of cancer cells known as "cancer stem cells" or "cancer stem-like cells" are responsible for the antagonism of the disease, resistance to therapy, self-renewal and unlimited ... several cancers, including ovarian cancer [4-7] Moreover, mutations may be one of the major factors contributing to the origin of ovarian cancer stem cells Emerging evidence suggests that ovarian cancer...

Ngày tải lên: 20/06/2014, 07:20

... variety of other pulmonary lesions especially metastatic lesions to the lung In women, the appearance of metasta- http://www.wjso.com/content/6/1/7 sis is a frequent complication of breast cancer The ... test supported the diagnosis of pulmonary echinococcosis Chemotherapy for Stage IIIC breast cancer (Adriamycin, cyclophosphamid and paclitaxel) and albendazol treatment began for the patient Discussion ... and also no FDG Uptake of the benign both breast cancer and in metastatic axillary and FDG PET scans, First Column of the Figure showed increased FDG uptake in both breast cancer and in metastatic...

Ngày tải lên: 09/08/2014, 07:21

... plan The top of the treatment field was placed at the L4-5 junction, with the lateral borders 1-2 cm outside the bony pelvis, and the inferior margin at cm below the tumor A total dose of 41.4 ... cancers [2] The larger volume of blood supply to the liver in comparison with other organs and the tendency of cancer cells to deposit and multiply in the liver after passing through the portal ... (stage III) These results suggest that pelvic RT may benefit all patients regardless of the status of their liver metastasis However, the number of patients who received resection of the primary...

Ngày tải lên: 09/08/2014, 09:20

... RW: The effect of additions of fluorine to the diet of the rat on the quality of the teeth 1925 Studies on experimental rickets XXI An experimental demonstration of the existence of a vitamin which ... deposition 1922 The effect of additions of fluorine to the diet of the rat on the quality of the teeth 1925 J Biol Chem 2002, 277:E8 Holick MF: Evolution and function of vitamin D Recent Results Cancer ... with the risk of colon cancer [109] For lung cancer, the picture is not clear at the present time While TaqI polymorphism of the VDR gene appears to be a risk factor for lung cancer Page of [110],...

Ngày tải lên: 12/08/2014, 13:22

... gaining insights into the nature of such disorders and the mechanisms of action of RRT are important In the present review we explore the acid–base disorders seen in ARF, the effect of RRT and its modalities ... disorders, the effect of replacement fluid on acid–base balance, and the effect of HVHF on acid–base balance A strong focus is given to the clinical implications of these interventions, with the aim of ... All lower the apparent SID and acidify blood The nature and extent of these acid–base changes is governed by the intensity of plasma water exchange/dialysis, by the ‘buffer’ content of the replacement...

Ngày tải lên: 12/08/2014, 20:20

... function is an important indicator of outcome after an acute myocardial infarction [9] Although there will be resistance from the endocrinology community to trials of T3 therapy in acutely ill patients, ... rT3, the authors ask whether we should consider treating cardiac patients who have the euthyroid sick syndrome with T3 (and not T4) to facilitate cardiac recovery There is now evidence that the ... T, Seo H: A κ potential role of activated NF-κB in the pathogenesis of euthyroid sick syndrome J Clin Invest 2000, 106:393-402 De Groot LJ: Dangerous dogmas in medicine: the nonthyroidal illness...

Ngày tải lên: 12/08/2014, 22:22

... (OPTIMA) trial began in the UK in 2012 with the aim of testing whether standard therapy (chemotherapy and endocrine therapy for all patients) or test-directed therapy (chemotherapy given only to ... of these processes are hallmarks of cancer and NF-κB has been hypothesised to have a role in tumorigenesis The aim of the current study was to investigate the role of both NF-κB pathways in the ... breast cancer treatment in the UK [56] The treatment of breast cancer varies depending on the characteristics of the tumour such as size and the presence of certain markers for targeted/hormonal therapy...

Ngày tải lên: 22/12/2014, 21:49

... just another illustration of the complexity associated with cancer cells and tissues, where multiple factors act along with, or counter the action of one another in intersecting pathways The cancerous ... elevated in the presence of MUC1-C may enhance instead of retard EGFR signalling in these cells Another point of contention that requires further clarification pertains to the effect of Rab31 on ... manifestations as the cancer progresses, is thus a combinatorial sum of many It is difficult at the moment to gauge quantitatively which one of the two apparently contrasting actions of Rab31, namely the auto-inductive...

Ngày tải lên: 22/09/2015, 15:17

... lines 84 IX     LIST OF FIGURES Figure 1.1 Therapeutic targeting of the hallmarkers of cancer Figure 1.1 Therapeutic targeting of the hallmarks of cancer Figure 1.2 Anatomy of the normal female ... increasing the efflux of drugs out of the cell and thus decrease the level of drugs within the cells to inhibit the effects of the drugs (Dumontet and Sikic 1999) Docetaxel is the one of the substrates ... drugs (Fernandez et al 2010) The approaches to overcome chemotherapy resistance mainly involve the use of combinations of different classes of drugs in therapy Adjuvant therapy using certain inhibitors...

Ngày tải lên: 02/10/2015, 17:15

... ELUCIDATING THE ROLE OF AUTOPHAGY IN ZEBRAFISH MODELS OF LIVER CANCER SIM HUEY FEN, TINA (B.Sc.(Hons.)), NUS A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF BIOLOGICAL ... between their genomes further allow the use of the zebrafish in the identification of gene functions of unknown genes in both zebrafish and humans (Barbazuk et al., 2000) In all, these attributes of ... are present in a gene-ofinterest Progeny identified to carry the desired mutations are then propagated to maintain the line to study the function of the gene -of- interest Furthermore, fluorescent...

Ngày tải lên: 12/10/2015, 17:35

... breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer metabolism in breast cancer ... accumulation of the latter This in turn causes irreversible damage to the neurons and reduces the availability of PrPC which may interfere with the presumed neuroprotective role of the protein, ... function of PrP While most studies are focused on the role of PrP in neurodegenerative diseases, its function outside the nervous system remains unclear Some of the hypothesized functions of PrP...

Ngày tải lên: 12/10/2015, 17:36

... who are truthful and demonstrate regard for their own  outcomes and those of others • Moderately Politicized Area – greater acceptance of behind­ the scenes tactics so long as the goals of the group are  achieved ... Outline  Role of Power  Rules for Using Power Role of Power  Power defined:  • Ability or official capacity to exercise control;  authority • Ability to influence or control others  Sources of Power ... Find the Soft Spot  Encourage others to open up • Gain disclosure of something private or  personal about your counterpart • Expression of trust  Identify true motivations and sources  of objections...

Ngày tải lên: 22/08/2012, 22:07

... DC: The World Bank) Chernow, Ron, 1997, The Death of the Banker The Decline and the Fall of the Great Financial Dynasties The Triumph of the Small Investor (New York: Vintage Books, a Division of ... to further improve the bank’ risk position s and counterparties, on their side, might consider for them unnecessary to further assess the riskiness of the bank Finally, the inadequacy of the static ... factoring the long-term market potential of borrowing firms in their risk analysis The higher their reputational capital, the stronger their incentive to lengthen the time horizon of their approach...

Ngày tải lên: 24/10/2012, 09:33

... such professional colleagues on the world The Association has the role of coordinating the activities of the members in order to protect the interests of the members and improve the position of Vietnam ... to the realization of the objectives and duties of the Association, may be invited to join the Association as Honorary members In general, this stipulation on the membership in the Statue of the ... expanding With their experiences, they have learned the value of offering quality services In the way of growing, they have also open branches to establish a worldwide presence These companies...

Ngày tải lên: 27/10/2012, 16:42