can the immune system play a role in supporting the adaptive behavioral changes orchestrated by emotions
Báo cáo Y học: Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? ppt
Ngày tải lên :
23/03/2014, 21:20
... i.e has a cap and a poly (A) -tail The open reading frame of the mRNA is shown as a thick line Initiation factors are abbreviated The arrow indicates the phosphorylation of eIF4E at Ser209 by the ... appears to be the determining factor in stabilizing the eIF4EÆcap interaction [50], and could be regarded as causing the ÔclampingÕ of eIF4E to the cap) Several initiation factors have RNA-binding ... efficiently translated The mechanisms by which such mRNAs would be activated may include changes in the binding to modulatory proteins that either repress or facilitate their translation There are many...
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báo cáo khoa học: " Do mitochondria play a role in remodelling lace plant leaves during programmed cell death?" pps
Ngày tải lên :
11/08/2014, 11:21
... significant decrease in perforation formation within the lace plant via CsA application indirectly indicates that the PTP pathway may play a role in cellular death within this system Although the involvement ... that cyclosporine A (CsA) can act in disrupting the PTP by displacing the binding of CyD to AdNT [19] within animal systems The theory that CsA can inhibit PTP formation has lead to key advances ... significantly reduced the amount of perforations in the lace plant as compared to the control, but also maintained a healthy leaf appearance The observations that no perforations formed at the 15...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
Ngày tải lên :
18/02/2014, 04:20
... of the protease Taken together, and having been obtained using different experimental approaches, our data demonstrate that the LLY573 motif in MT1-MMP ICD plays an important role in the interaction ... complex containing MT1MMP and furin, and the expression of a catalytically inactive dominant negative furin construct affected the processing of pro-MT1-MMP Taken together, these data reveal a new ... ·40 Statistical analysis was performed using the graphpad prism, version (GraphPad Software, Inc., San Diego, CA, USA) Statistical significance was calculated using Student’s t-test Statistical significance...
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báo cáo hóa học:" Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target" docx
Ngày tải lên :
18/06/2014, 15:20
... AST induces IL-12 mRNA synthesis in human macrophages in vitro These data are the first indication of an innate immunity cell product as mediator of angiostatin effects indicating its role in immune ... Brigati C, Anfosso L, Del'Eva R, Albini A, Noonan DM: Antiangiogenesis in Search of Mechanisms: Angiostatin as a Prototype In Cancer Therapy: Molecular Targets in Tumor-Host Interactions Edited by: ... participated in the design of the in vitro studies AA, CB, DMN conceived the study, and participated in its design and coordination and drafted the manuscript All authors read and approved the final manuscript...
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Báo cáo hóa học: " Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment" pptx
Ngày tải lên :
18/06/2014, 16:20
... increased levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase, 5’-nucleotidase, bilirubin, alpha-fetoprotein, ... (TIRdomain-containing adapter-inducing interferon-b) joining the RIG-I/MDA5 pathway In the other pathway, TLR7 senses single-strand HCV RNA and via the MyD88 adaptor protein activates IRAK4/IRAK1 These kinases ... The role of cytokines in hepatocellular carcinoma J Leukoc Biol 2006, 80(6):1197-213 51 Nakagawa H, Maeda S, Yoshida H, Tateishi R, Masuzaki R, Ohki T, Hayakawa Y, Kinoshita H, Yamakado M, Kato...
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báo cáo hóa học:" Spontaneous regression of curve in immature idiopathic scoliosis - does spinal column play a role to balance? An observation with literature review" pot
Ngày tải lên :
20/06/2014, 04:20
... data and analysis and interpretation of data; and KPV and NM have contributed in revising the manuscript critically All authors read and approved the final manuscript Competing interests The authors ... changed training conditions [24] During a muscle training program lasting several weeks, a distinct increase in activity occurs during the first weeks; the activity then drops to the initial value ... starts to appear, paraspinal muscles try to balance the spine by their inherent “balancing or tuning mechanism” for a short period of time till it stabilizes into a single pattern This spinal...
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Báo cáo y học: "Do the pleiotropic effects of statins in the vasculature predict a role in inflammatory diseases" pdf
Ngày tải lên :
09/08/2014, 06:22
... damage is central to the initiation and perpetuation of inflammation, and this might also be ameliorated by statin therapy Treatment of HUVEC with either atorvastatin or simvastatin promoted an ... statin therapy on inflammatory airway disease After priming and intra-nasal ovalbumin challenge, reductions in inflammatory cell infiltrate and eosinophilia in bronchoalveolar lavage fluid were ... Research & Therapy Vol No McCarey et al induced NFκB activation and that the effect was most profound with atorvastatin and simvastatin [30] Statins might also mediate anti-inflammatory effects in...
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Báo cáo y học: "Migration events play significant role in genetic differentiation: A microsatellite-based study on Sikkim settlers" ppt
Ngày tải lên :
14/08/2014, 14:21
... substantiates that migratory events have played a significant role in the differentiation of mongoloids of India Background The origin, dispersal and antiquity of Homo sapiens in the Asian peninsula ... Gupta R, Basu A: A genetic study among the Lepchas of the Darjeeling area of eastern India, Human Heredity 198 7a, 37: 113-121 Saha N, Mukhopadhyay B, Bhattacharyya SK, Gupta R, Basu A: The distribution ... population and exhibit a high level of diversity In India, mongoloids contribute approximately 3% of the total population, mainly inhabiting the hills and adjoining plains of Northeast and Central...
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Tài liệu Báo cáo khoa học: Differentiation stage-dependent preferred uptake of basolateral (systemic) glutamine into Caco-2 cells results in its accumulation in proteins with a role in cell–cell interaction pptx
Ngày tải lên :
20/02/2014, 01:20
... Glutamine incorporation in Caco-2 proteins determining the relative uptake of glutamine; (b) by searching for changes in the intestinal proteome; and (c) by examining glutamine incorporation into ... bloodstream via their basolateral membranes [14] The endogenous glutamine arises from conversion of glutamate and ammonia by glutamine synthetase [15] However, in human and rat, intestinal glutamine ... diffusion also plays a considerable role in cellular glutamine uptake, another explanation for this difference may be the ratio of basolateral to apical surface area which is : in Caco-2 cells early in...
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Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development docx
Ngày tải lên :
05/03/2014, 17:20
... determine that a putative signal peptide and a cleavage site exist in ePAD and AAH53724 (an egg and embryo abundant peptidylarginine deiminase), indicating they are likely secreted proteins (Fig arrow) ... [40-42] PADs are a family of calcium dependent enzymes that catalyze the conversion of arginine into citrulline in proteins In the mammalian PAD family, approximately 50% of the amino acids are identical ... cortical granules contain PAD To ascertain if mouse cortical granules contain PAD, antibodies made against mouse ePAD and human recombinant PAD V (anti-PAD V (N)) were used to label in vivo matured...
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Báo cáo khoa học: No evidence for a role in signal-transduction of Na+/K+-ATPase interaction with putative endogenous ouabain potx
Ngày tải lên :
23/03/2014, 17:21
... larger changes in intracellular Na+ and Ca2+ may thus be the result of a ouabain interaction with subpopulations of Na+/K+ATPase [27] An overall increase in intracellular Na+ was seen in the experiments ... in collaboration with Hamlyn [21] by means of two independent assays, a radioimmunoassay using an anti-ouabain Ig and an enzymatic assay using ouabain-sensitive Na+/K+ATPase from dog kidney The ... latter may have a sublocalization critical for the observations looking at ouabain as a signal-transducer Experiments pointing to a pivotal role of ouabain in signal-transduction In the following,...
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báo cáo hóa học:" Triple-Nucleoside Analog Antiretroviral Therapy: Is There Still a Role in Clinical Practice? A Review" docx
Ngày tải lên :
20/06/2014, 08:20
... for APV/r, and 62% for d4T; P = 047 by ITT analysis) These data again show that a tNRTI regimen that contains a thymidine analog with 3TC and ABC has virologic efficacy comparable to that of a ... pharmacologic interaction Nonthymidine-Containing ("TAM-Sparing") t-NRTI Regimens as Initial ART Clinical trials that have investigated the use of TDF as part of the NRTI backbone of an ART regimen among ... Montaner J, et al.: Abacavir-lamivudinezidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: A randomized equivalence trial JAMA 2001, 285:1155-1163 Abstract...
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Báo cáo y học: "Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation" pdf
Ngày tải lên :
10/08/2014, 05:21
... Komura M, Komura H, Kanamori Y, Tanaka Y, Suzuki K, Sugiyama M, Nakahara S, Kawashima H, Hatanaka A, Hoshi K, Ikada Y, Tabata Y, Iwanaka T: An animal model study for tissue-engineered trachea fabricated ... trachea containing the extracellular cartilaginous matrix [71] The experience with the engineered pig trachea was then used in engineering human trachea produced after dissemination of cartilage-like ... much as possible The epithelial cells-extracellular matrix (ECM) interactions play a crucial role in healing airway injuries and repair of the airway epithelium The secretion of a provisional ECM,...
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Báo cáo khoa học: "Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions" ppt
Ngày tải lên :
12/08/2014, 04:20
... the data analysis and review of the manuscript YN performed project planning, participated in the data analysis and helped to draft the manuscript All authors read and approved the final manuscript ... suggests that the interaction of the two proteins is dynamic and transient Given that Nedd4 participates in many cellular trafficking activities including protein sorting and viral budding, UL56 can ... Journal 2009, 6:168 members, is one of the main HECT E3 protein families They are characterized by a unique domain architecture, with an amino-terminal C2 domain, two to four proteinprotein interacting...
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báo cáo khoa học: " Co-expression and promoter content analyses assign a role in biotic and abiotic stress responses to plant natriuretic peptides" pptx
Ngày tải lên :
12/08/2014, 05:20
... uptake in carnation and chrysanthemum was rapidly and significantly increased after exogenous application of synthetic human atrial NP (ANP) [3] Subsequently it was demonstrated that rat ANP can ... both culminate in cell death indicating that AtPNP -A may be involved in these processes The mutant analyses further enforce that the transcriptional regulation of AtPNP -A and the correlated genes ... Kamiya A, Nakajima M, Enju A, Sakurai T, Satou M, Akiyama K, YamaguchiShinozaki K, Carninci P, Kawai J, Hayashizaki Y, Shinozaki K: Monitoring the expression pattern of around 7,000 Arabidopsis...
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Báo cáo y học: "bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction" pdf
Ngày tải lên :
12/08/2014, 19:22
... at the level of the abdominal aorta as early as after several hours following injury and persisted for at least days afterward [6,17] After 21 days we observed that the endothelial surface had ... endothelium in regulating the balance between oxygen demand and supply within an individual organ in an in vivo model of endothelial stripping in the dog hind limb [66] The hind limb vascular ... Szymanski LM: The suprapharmacologic dosing of antithrombin concentrate for Staphylococcus aureus-induced disseminated intravascular coagulation in guinea pigs: substantial reduction in mortality...
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Báo cáo khoa học: "Do statins have a role in preventing or treating sepsis" pptx
Ngày tải lên :
12/08/2014, 23:21
... statins may also ameliorate sepsis-induced coagulopathy [5,8,9] Another novel pathway may play an important role in attenuating sepsis-induced endothelial dysfunction Heme oxygenase (HO)-1 is an ... comorbidities and dissipated when the medication was discontinued There is growing interest among clinicians in the role that statins may play in preventing and treating serious infections If such an effect ... that statins markedly decrease these inflammatory markers [7] Blunting this maladaptive exaggerated inflammatory response may be beneficial in sepsis Numerous studies using different models have...
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Báo cáo y học: "RNA interference has a role in regulating Drosophila telomeres" potx
Ngày tải lên :
14/08/2014, 16:21
... to be involved in transcriptional silencing in plants [12], Caenorhabditis elegans [13] and mammals [14], and in genome rearrangements in Tetrahymena [15], suggesting that RNAi is affecting Drosophila ... Firstly, although both RNAs were upregulated specifically in germline cells, they had different patterns of accumulation The increase in TART RNA was detected in the nurse cells in the later stages ... telomerase with those maintained by the transposition of retrotransposons (a) Eukaryotic telomeres are composed of long chains of head-to-tail repeats In many organisms other than Drosophila, the...
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Running and adult neurogenesis does septohippocampal sonic hedgehog play a role
Ngày tải lên :
14/09/2015, 14:09
... pyramidal neurones then send axons to the ipsilateral CA1 pyramidal cells via the Schaffer Collateral pathway and contralateral CA3 and CA1 pyramidal cells via the Associational/Commissural fibres ... especially in animals where locomotion and learning are inseparable in real life Sustained physical activity and cognitive challenges will maintain a pool of neurones that will allow that brain to accommodate ... is accidental While there is something inherently fascinating about all cyclical processes in both animate and inanimate systems, biological oscillators have a special emotional immediacy These...
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