can small cell lung cancer spread to the bones

... body radiotherapy for stage I non -small cell lung cancer. Radiother Oncol 2007, 85:429-434. 39. Sinha B, McGarry RC: Stereotactic body radiotherapy for bilat- eral primary lung cancers: the Indiana ... base) for purposes of contouring will begin at the level of the inferior aspect of the aortic arch (aorto-pulmonary window) and extend inferiorly to the apex of the heart. The defined ipsilateral ... corrections due to tumour shifts lead to a change in the dose given to the OAR. To avoid exces- sive doses to OAR, it is recommended to evaluate the impact of such shifts on the OAR dose during treatment planning....

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Ngày tải lên: 10/08/2014, 22:21

... Martinelli 1,4* Abstract Background: Lung cancers consist of four major types that and for clinical-pathological reasons are often divided into two broad categories: small cell lung cancer (SCLC) and non -small cell lung cancer ... in the development of oral can- cer [28], esophageal cancer [29] and colorectal cancer [30]. Furthermore the association between the presence of HPV 16 and the development of head and neck cancer has ... act as a risk marker of lung cancer in Taiwan. Cancer 2003, 97:1558-1563. 11. Klein F, Amin Kotb WF, Petersen I: Incidence of human papilloma virus in lung cancer. Lung Cancer 2009, 65:13-18. 12....

Ngày tải lên: 18/06/2014, 16:20

... morphological characteristics of permanent human small cell lung cancer cell lines. J Cancer Res Clin Oncol 1987, 113:31-40. 16. NCCN guidelines for small- cell lung cancer. [http://www.nccn.org/ professionals/physician_gls/f_guidelines.asp]. 17. ... radiotherapy in limited-stage small cell lung cancer: facts, questions, prospects. Radiother Oncol 2000, 55:1-9. 2. Murray N, Turrisi AT: A review of first-line treatment for small- cell lung cancer. ... interruptions to palliate the toxicity from concurrent chemoradiation for limited small cell lung cancer decreases survival and disease control. Lung Cancer 2001, 33:249-258. 26. Cisplatin, etoposide,...

Ngày tải lên: 09/08/2014, 09:20

... National Cancer Center 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan and 3 JCOG lung cancer study group, Thoracic Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo ... consolidation chemotherapy after concurrent chemoradiotherapy for limited-disease small cell lung cancer (Figure 1). The primary endpoint of JCOG 0202 was overall survival and the secondary endpoints ... better comply with the treatment protocol by the RT principal investigator, which enabled participants to follow the protocol guidelines in their later cases. In the current study, more suboptimal...

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Ngày tải lên: 10/08/2014, 09:22

Ngày tải lên: 10/08/2014, 10:21

Ngày tải lên: 10/08/2014, 10:21

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... Pisani P: Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001, 94:153-156. 2. Non -small Cell Lung Cancer Collaborative Group: Chemotherapy in non small cell lung cancer: a meta-analysis ... G, Gozzelino F, Tonato M: Gemcitabine and cisplatin versus mito- mycin, ifosfamide, and cisplatin in advanced non -small- cell lung cancer: a randomized phase III study of the Italian Lung Cancer Project. ... cisplatin-teniposide in patients with advanced non -small- cell lung cancer. The European Organi- zation for Research and Treatment of Cancer Lung Cancer Cooperative Group. J Clin Oncol 1998, 16:2133-2141. 7....

Ngày tải lên: 18/06/2014, 15:20

... Non -small- cell lung cancer harbouring mutations in the EGFR kinase domain. Clin Transl Oncol 2010, 12:75-80. 9. Gazdar AF: Activating and resistance mutations of EGFR in non -small- cell lung cancer: ... factor receptor mutations in lung cancer. Nat Rev Cancer 2007, 7:169-181. 3. Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T: Mutations of the epidermal growth factor receptor ... for the detection of EGFR mutations in non -small- cell lung cancer. Clin Cancer Res 2009, 15:3023-3028. 13. Motoi N, Szoke J, Riely GJ, Seshan VE, Kris MG, Rusch VW, Gerald WL, Travis WD: Lung...

Ngày tải lên: 18/06/2014, 16:20

... in the cytoplasm of most neo- plastic tumor cells and to a lesser extent expressed in the cytoplasm of normal epithelial cells in lung tissue. Based on m orphological cr iteria, infla mmatory cells (macrophages, ... marker expression in tumor cells versus stromal cells in non small cell lung cancer. Clin Cancer Res 2007, 13:6649-57. 24. World Health Organization: Histological Typing of Lung and Pleural Tumours. ... according to NSCLC histology. Lung Cancer 2010. 31. Donnem T, Al-Saad S, Al-Shibli K, Andersen S, Busund LT, Bremnes RM: Prognostic impact of platelet-derived growth factors in non -small cell lung cancer...

Ngày tải lên: 18/06/2014, 16:20

... breast cancer. Br J Cancer 2006, 95(6):683-90. 17. Cancer Research UK [http://www.cancerresearchuk.org ] 18. Cancer Help [http://www.cancerhelp.org.uk ] 19. Association for International Cancer ... is the most com- mon and the most life-threatening form of cancer in Scot- land [2]. Lung cancer is also a major cause of death throughout the rest of the world [3,4]. Non -small cell lung cancer ... Staging of small cell and non -small cell lung cancer. University of Iowa Virtual Hos- pital; 1999. 6. Hopwood P, Stephens RJ: Symptoms at presentation for treat- ment in patients with lung cancer: ...

Ngày tải lên: 18/06/2014, 19:20

... cancers and the leading cause of cancer death world- wide (1). Lung cancer is generally classified into two histological types, small cell lung cancer (SCLC) and non small cell lung cancer (NSCLC). ... sensitivity to gefitinib in non -small cell lung cancer cell lines. Mol Cancer Res. 2006; 4(8): 521-8. 102. Taguchi F, Solomon B, Gregorc V, et al. Mass spectrometry to classify non -small- cell lung cancer ... EGFR-TKIs therapy. Key words: non -small cell lung cancer, EGFR, somatic mutation, tyrosine kinase inhibitor, gene amplification Introduction Lung cancer is one of the most common human cancers...

Ngày tải lên: 08/08/2014, 17:20

... chemotherapy resulted in further tumor shrinkage, with no additional toxicity, and gave the patient the possibility to undergo a lobectomy rather than a pneumectomy, with the obvious advantages of ... treatment-related deaths ( 5 in the DC arm vs 1 in the D arm)[6]. Similarly, the toxicity profile of the monotherapy arm in the Lilenbaum [7] study was more favorable com- pared with that of the combination ... Defining the optimal treatment for patients with inoperable non small cell lung cancer (NSCLC), presenting with metastatic mediastinal lymph nodes, is challenging. Nevertheless, preoperative chemotherapy...

Ngày tải lên: 09/08/2014, 03:21

... models The total normal lung volume was defined as the total lung volume minus the primary GTV and volume of the trachea and main bronchi. From each lung DVH, the fol- lowing dosimetric factors ... V10 are the useful indicators for predicting SARP in NSCLC patients treated with concurrent chemotherapy and IMRT. Background Lung cancer is the leading cause of cancer- related death in the urban ... Xu Abstract Background: To evaluate the association between the clinical, dosimetric factors and severe acute radiation pneumonitis (SARP) in patients with locally advanced non -small cell lung cancer (LANSCLC)...

Ngày tải lên: 09/08/2014, 08:23

... radiotherapy in treatment of stage I non -small cell lung cancer. Lung Cancer 2003, 41:1-11. 17. Shibamoto Y, Yukawa Y, Tsutsui K, Takahashi M, Abe M: Variation in the hypoxic fraction among mouse tumors ... for stage I primary lung cancer and oligometa- static lung cancer. Promising clinical results have been reported despite the use of various treatment protocols [2-9]. According to a recently published ... with our prospective hypothesis-driven protocol. Methods Eligibility Criteria The eligibility criteria were as follows: histologi cally- confirmed non -small cell lung cancer (NSCLC) * Correspondence:...

Ngày tải lên: 09/08/2014, 09:20

... Stereotactic Body Rad iotherapy, Oligometastases, Non -Small Cell Lung Cancer Background Non -small cell lung cancer (NSCLC) is the leading cause of cancer mortality in the United States [1]. Patients ... progression and was postulated to be a poor prognostic factor in lung cancer. Similarly, Bradley et al. demonstrated the prognostic value of GTV determined on planning CT scans to be associated with OS ... with regard to the extent of disease spread, cancer burde n (i.e. bulk), performance status, and other prognostic factors. As previously postulated by Drs. Hellman and Weichselbaum, the metastatic...

Ngày tải lên: 09/08/2014, 09:20