calling into question managerial references in relation to sustainable development

... receptor tyrosine kinase All ERBB proteins have four functional domains: an extracellular ligand-binding domain; a transmembrane domain; an intracellular tyrosine kinase domain; and a C-terminal ... receptors [3] These can be classified into three groups (a) ligands that specifically bind to EGFR (including EGF, transforming growth factor-a, amphi- A B Signal transduction by ERBB proteins Binding ... tyrosine-X-X-methionine (where X is any amino acid) is a motif for the p85 binding site Several signal transducers then bind to these adaptors to initiate multiple signalling pathways, including mitogen-activated...

Ngày tải lên: 16/02/2014, 09:20

... (EGFR-TKIs), gefitinib and erlotinib, compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig ... mutations in other tyrosine kinases known to result in resistance to imatinib (T315I in ABL, T764I in PDGFRA and T670I in KIT) [27–29] The conserved threonine residues in these different kinases ... undergoing apoptosis Moreover, EGFR mutations result in repositioning of critical residues surrounding the ATP-binding cleft of the tyrosine kinase domain of the receptor and thereby stabilize the interaction...

Ngày tải lên: 16/02/2014, 09:20

... to understand the precise mechanism by which gefitinib induces apoptosis in a Bax-dependent manner Inhibitor of apoptosis protein family Induction of MOMP following apoptotic stimuli results in ... in promoting the G1 -to- S phase transition of the cell-cycle by phosphorylating the retinoblastoma (RB) protein Activation of cyclin–CDK complexes is counterbalanced by CDK inhibitors, including ... gefitinib-induced apoptosis Furthermore, caspase-8 and caspase-3 inhibitors, but not a caspase-9 inhibitor, are capable of restoring cell viability Thus, Fas appears to play a major role in the initiation...

Ngày tải lên: 16/02/2014, 09:20

Ngày tải lên: 21/08/2012, 16:18

... Terminal H.323 cña Cisco Locall Area Network Intererface Admission Control With Cisco IOS MCM Gatekeeper – Call Across WAN May I call 2111 with a bandwidth of 384K? Call flow H.323 RAS signaling ... Video Conference Architecture a typical H.323 Terminal Video I/O Equipment Audio I/O Equipment User Data Applications System Control User Interface Video codec H261, H263 Audio condec G711, ... you can! IP WAN zone zone Admission Control Via Zone BandWidth in the Cisco IOS MCM Gatepeer H×nh4: Admission - Cisco A B Setup Alerting Connect TermCapSet TermCapAck mSDet mSDetAck mSDetConfirm...

Ngày tải lên: 24/08/2012, 21:11

... each individual cow, indicating that decisions can differ both within and between herds At the farm level, the veterinarians seemed to integrate farm-related information into the decision as to ... phenomenon of generating score data and decision making in relation to treatment of metritis and their motivation to produce data This information was condensed into a 'model of understanding' that demonstrates ... risk of influential interaction between the interviewer and the interviewed during the interviews that could influence the statements of the interviewed e.g., the use of leading questions In the...

Ngày tải lên: 25/10/2012, 10:45

... sea urchin 80 70 60 50 40 2003 30 2004 20 10 0 10 20 30 40 50 Density of sea urchin (ind m-2) 70 50 60 U pinnatifida (Line 1) U pinnatifida (Line 2) Sea urchin (Line 1) Sea urchin (Line 2) 50 ... appeared in Line The numbers of sea urchin were 212 and 365 ind per belt transect in 2003 and 2004, respectively, but both populations of sea urchin in Line were less than those in Line We also ... and infauna in the outer and inner areas of the bay A total of 16 macrophyte species in 2003 and 15 species in 2004 were observed in Line (Table 1) U pinnatifida and crustose coralline algae were...

Ngày tải lên: 05/09/2013, 09:38

... believed to form Ôsticky patchesÕ on the protein surface that may lead to protein aggregation [16] In addition, introduction of a single tyrosine into the N-terminal region has been reported to improve ... C.J & Nussinov, R (2000) Factors enhancing protein thermostability Protein Eng 13, 179–191 39 Turunen, O., Vuorio, M., Fenel, F & Leisola, M (2002) Engineering of multiple arginines into the Ser/Thr ... the glycerol appears to mimic the binding of the xylose ring in the active site The binding of glycerol to a single site may suggest that this site is the strongest binding subsite for the xylose...

Ngày tải lên: 20/02/2014, 23:20

... reported four main integrated rubber farming systems in the South of Thailand emerging during the financial crisis in the late 19 1990's The major systems included 1) Rubber intercrop farming, 2) Rubber-rice ... trained soil doctors since 1995, and presently there are 55 000 soil doctors in villages in Thailand (LDD 2005b) They are in charge of coordinating land development between the LDD and farmers in ... farming systems (namely the rubberintercrop farming, rubber-fruit tree farming, rubber-livestock farming and integrated farming) showed better economic performance, including higher net income,...

Ngày tải lên: 21/02/2014, 04:20

... 9422 Motor Vehicle Electrical and Electronic Equip Plastics Processing Machine Operators 336360 9422 Motor Vehicle Seating and Interior Trim Mfr Plastics Processing Machine Operators Minor sectors: ... 9451 Motor Vehicle Plastics Parts Manufacturing Sewing Machine Operators 326193 9482 Motor Vehicle Plastics Parts Manufacturing Motor Vehicle Assemblers, Inspectors and Testers 326193 9495 Motor ... Manufacturing for Mechanical Use Other Labourers in Processing, Manufacturing and Utilities 332813 9422 Plating, Polishing, Anodizing, and Coloring Plastics Processing Machine Operators 336320...

Ngày tải lên: 06/03/2014, 02:21

... confounding factor In winter wheat, increasing amounts of nitrogen increased yield as well as Zn and Cu concentrations in grain ŽMcGrath, 1985 In contrast, Jones and Johnston Ž1989 found no obvious relationship ... total Cd in soil ŽJuste and Tauzin, 1986 These results indicate that recommending liming to reduce Cd availability is questionable Moreover, in saline soils, the effectiveness of limestones in ... Cd dayy1 in France ŽTable 1.; in comparison, the increase in Cd in cereals and potato tubers alone may lead to an increase in the range of 41% to 74% of the Cd dietary intake Ži.e., to 32–40...

Ngày tải lên: 15/03/2014, 23:22

... R3 pair bound to L1 and L2 Turning a gene into an active state from a state of inactivation often involves binding of a single activator molecule to its site in a repressive chromatin structure ... nucleosome positioning A B C D E Fig In uence of ionic strength and R3 binding on chromatin assembly (A) Binding of R3 to its sites in the chromatin High-resolution DNaseI footprinting gel shows digestion ... transcriptional machinery to work effectively in a chromatin environment Folding of DNA by the histones and positioned nucleosomes can bring two widely separated regulatory elements into juxtaposition in space...

Ngày tải lên: 16/03/2014, 10:20

... grand ceremony for his help in defeating the Empire Neo makes a phone call to the machines with a threat that seemingly gives the machine a moment of pause Elements of Distinction Of course, the two ... regarding the dangers of technology, The Matrix is by design much closer to our own world Although Morpheus, Trinity, Neo and the others are waging a war against A.I run rampant, the creators ... anyone says to Neo in The Matrix is in a message that comes to him via his computer: "Wake up, Neo." It so happens that the character is sleeping at the time, but this can also be interpreted...

Ngày tải lên: 21/03/2014, 22:51

... associations  in relation to transgression and regression phase and tectonic  movements:  fluvial  and  marine  terraces  in mainland  and  in continental  shelf  that  are  distributed  in different  ... and  sedimentary cycles in the sea bottom    Fig. 11. Weathering spotted clay in Late Pleistocene  sediment in SW of Eastern Sea.  6. Quaternary shorelines in bottom of continental  shelf of Vietnam  ... in Thanh  Hoa  plain,  RRD,  CLRD,  and  ancient  sandy  bars,  tombolo lagoonal facies in Central plain.  The third sedimentary cycle corresponds to Late Pleistocene (Vinh Phuc Formation in RRD ...

Ngày tải lên: 22/03/2014, 12:20

... 1.2 Incorporation into phospholipid cell membranes As a prerequisite for agonistic as well as antagonistic activity, the intercalation of endotoxins into target cell membranes corresponding to ... described to be an essential determinant for the ability of endotoxins to induce cytokines in immune cells [5] We have applied small-angle X-ray diffraction using synchrotron radiation to elucidate ... high reactivity down to 10 ngÆmL)1 Cytokine-inducing capacity in macrophages As a characteristic endotoxic reaction, the induction of tumor necrosis factor a (TNFa) production in FEBS Journal 272...

Ngày tải lên: 23/03/2014, 13:20

... lagoonal  facies  in the  central  part  passing  into silty clay of flood plain, oxbow, coastal swamp  and peat facies in the direction from the plain to the  modern  coastline.  The  fourth  ... the  overlying  coarse  sediments.  The  specific  capacity of boreholes drilled into this aquifer is  higher  than  that  into the  Holocene  aquifer  (in the sediment layer of Vinh Phuc Formation: 2‐9  ... plain  river  bed  facies  and  changing  upwards  into finer  sediments  consisting  mainly  silty  clay  mixed  with fine sand of flood plain facies and clay of  lagoonal facies.  Depth (m)...

Ngày tải lên: 28/03/2014, 15:20

... be larger in the mating season than in the postmating season (Sandell 1989) However, few studies have analysed seasonal variation in range size in relation to mating behaviour How mating may affect ... change in limiting resources, from receptive females in the mating season to food availability and dispersion in the post-mating season Extreme seasonal changes in range size in male stouts (Mustela ... not large enough to explain the increase (74–177%) in range size from the mating to the post-mating season in females with cubs Although range size of individual bears is probably in uenced by food...

Ngày tải lên: 28/03/2014, 16:20

... results into four categories of calendar period follow-up The incidence increased slightly with increasing year of follow-up in that incidence was 20% higher during most recent years; 2001 to 2007, ... respect to incidence rate (1961 to 1985, 1986 to 1995, 1996 to 2000, and 2001 to 2007) and calendar period of diagnosis with respect to case fatality (1961 to 1985, 1986 to 1995, 1996 to 2000, ... (0.88 to 1.17) 144 0.98 (0.80 to 1.20) 10 to 12 542 0.99 (0.90 to 1.09) 202 0.98 (0.83 to 1.15) to 621 1.03 (0.94 to 1.13) 94 0.85 (0.67 to 1.09) Unknown 130 0.92 (0.59 to 1.44) 0.65 (0.17 to 2.51)...

Ngày tải lên: 29/03/2014, 01:20

... death to a single underlying cause in the presence of co-morbidity We saw opposing trends in breast and endometrial cancer mortality with interval between tumors, and although longer follow-up since ... cancer 25% to 28% of the deaths were due to endometrial cancer, 32% to 35% to breast cancer (type of cancer death could not be distinguished between the two causes in 3% of cases), and 40% to all ... status and causes of death was obtained from each of the regional cancer registries in Britain, and subsequently in 2008 further follow-up was obtained by linkage to the National Health Service Central...

Ngày tải lên: 29/03/2014, 01:20