caco 2 model for study of p glycoprotein and other transporters

... (1996) Gap junctions play a role in the FEBS Journal 27 2 (20 05) 22 07 22 15 ª 20 05 FEBS Y Zhang et al 16 17 18 19 20 21 22 23 24 25 26 ‘bystander effect’ of the herpes simplex virus thymidine kinase ... Journal 27 2 (20 05) 22 07 22 15 ª 20 05 FEBS Fig RT-PCR of HSV-tk expression in the transgenic mouse TK5F1-455 M, 100-bp marker; 1, positive control (Hep-G2 cells transfected with plasmid of pCMV-TK); 2, ... therapy with HSV-tk ⁄ GCV system depends on T-cell-mediated immune responses and FEBS Journal 27 2 (20 05) 22 07 22 15 ª 20 05 FEBS Development of an HSV-tk transgenic mouse model 27 28 29 30 31 32 33...

Ngày tải lên: 30/03/2014, 16:20

... In progress Home Improvement Programme (HIP) Total number of precincts announced since 20 07 21 FY2009 /20 10 (31 March 20 10) 128 precincts 122 precincts precincts 190 (156, 443) 347 precincts 124 ... before 1990 Direct lift access for all flats LUP Combination of two programmes: Interim Upgrading Programme (IUP) and IUP Plus Lift Upgrading Programme (LUP) Built in 1989 or before; Drop-off porch, ... economic planning and management; approach to the formulation and implementation of appropriate policies; and resource management to ensure the achievement of construction programme 17 Table 2. 1: Public...

Ngày tải lên: 10/09/2015, 08:24

... computed supertrees using five other methods: Q-Imp, RFS, MinFlip, SFIT, and PhySIC (See Appendix [Additional file 1] for details on software and commands used) Because MinFlip, RFS, and PhySIC ... Sunderland, Massachusetts; 1996, 407- 425 25 Stamatakis A: RAxML-VI-HPC: Maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models Bioinformatics 20 06, 22 :26 88 -26 90 26 ... than MRP supertrees, and it might be capable of producing more accurate supertrees if other encodings of the source trees were used In this paper, we report results from a study in which we explored...

Ngày tải lên: 12/08/2014, 17:20

... 0.85 SBP (

Ngày tải lên: 05/03/2014, 22:21

... residues in PYP and HERG, again favoring the heme binding These are glycines 22 4 and 25 1 that substitute Phe96 and Val 120 in PYP, and Phe98 and Leu 127 in HERG [16] For both FixL and PYP, structures ... generated using RIBBONS [28 ] Coordinate sets used correspond to entries 1BV5(FixL) [ 12] , 2PYP(PYP) [10] and 1BYW(HERG) [11] of the PDB protein data bank [14] Ó FEBS 20 02 A model for PCDD ± AhR recognition ... the spatially close position 28 2 replacing the buried hydrophobic Ile present in FixL Ó FEBS 20 02 A model for PCDD ± AhR recognition (Eur J Biochem 26 9) 17 The postulated signaling loop of FixL...

Ngày tải lên: 24/03/2014, 00:21

... Med Sci 20 11, Protein peaks were selected based on a first pass of signal-noise ratio of and a minimum peak threshold of 20 % of all spectra This process was completed with a second pass of peak ... patterns for detection of prostate cancer J Urol 20 03;169:15 92 24 Malik G, Ward MD, Gupta SK, Trosset MW, Grizzle WE Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate ... diseases Hepatology 20 05; 41:40-47 28 Cho WC, Yip TT, Ngan RK, Yip TT, Podust VN ProteinChip array profiling for identification of disease- and chemotherapy-associated biomarkers of nasopharyngeal...

Ngày tải lên: 25/10/2012, 11:18

... structure? 2. 1.3 .2 Two views of discourse structure: as product and as process5 2. 1.4 Thematization 2. 2 Some major linguistic features 2. 2.1 Modality 2. 2 .2 Active and Passive voices 2. 2.3 Kinds of Sentence ... realization 23 4.3 .2. 2 Remarks 26 a, Use of Grammar 26 a1 Modality 26 a2 Use of Active/ Passive voices 27 a3 Sentence order 27 a4 Length of sentences 27 a5 Kinds of sentences 28 b Use of vocabulary 28 ... Human Rights 21 21 4.3.1 .2 Remarks 4.3 .2 The Beginning 4.3.1.1 The Title and Preamble of the Convention and their realization 4.3.1 21 23 The Body 23 4.3 .2. 1 The Body of the Convention and its realization...

Ngày tải lên: 07/11/2012, 14:17

... position of p (position i − l), and select for position i a N -best list of candidate results from all these candidates When we derive a candidate result from a word-POS pair p and a candidate q at prior ... algorithms In Proceedings of EMNLP, pages 1–8, Philadelphia, USA John Lafferty, Andrew McCallum, and Fernando Pereira 20 01 Conditional random fields: Probabilistic models for segmenting and labeling ... expand boundary tags to include POS information by attaching a POS to the tail of a boundary tag as a postfix following Ng and Low (20 04) As each tag is now composed of a boundary part and a POS...

Ngày tải lên: 08/03/2014, 01:20

... POS tag features The number indicates the length Devel C:±0 C:±1 C:±1 C: 2 C: 2 C: 2 C:±3 C:±3 C:±3 T:±0 T:±0 T:±1 T:±0 T:±1 T: 2 T:±0 T:±1 T: 2 P( %) 92. 52 92. 63 92. 62 93.17 93 .27 93.08 93. 12 ... Wu, editors, Proceedings of EMNLP 20 04, pages 27 7– 28 4, Barcelona, Spain, July Association for Computational Linguistics Joakim Nivre and Ryan McDonald 20 08 Integrating graph-based and transition-based ... has provided several paradigms to globally represent and process such data: linear models for structured prediction, graphical models, constrained conditional models, and reranking, among others...

Ngày tải lên: 17/03/2014, 00:20

... words Computational Linguistics, 26 (2) , pp 22 1 -24 9 F J Och 20 03 Minimum error rate training in statistical machine translation In Proceedings of ACL2003 Sapporo, Japan F J Och and H Ney 20 03 A ... weights for each model are optimized on held-out data System Sys1 IWSLT Sys2 Sys3 Sys4 Sys1 NIST Sys2 Sys3 Sys4 Dev 30.75 30.74 29 .99 31. 32 25.64 24 .70 25 .89 26 .11 Test 27 .58 28 .54 26 .91 27 .48 23 .59 ... Reordering Model for Statistical Machine Translation In Proceeding of ACL -20 06 pp. 521 - 528 R Zens and H Ney 20 06 N-gram Posterior Probabilities for Statistical Machine Translation In Proceeding of HLT-NAACL...

Ngày tải lên: 17/03/2014, 01:20

... cyclosporin A and verapamil, and Cremophor EL, Tween20, and Pluronic 85, inhibited Pgp-mediated efflux of TMRM (Fig 7) On the other hand, the anesthetics benzyl alcohol, chloroform and propofol accelerated ... (20 04) Effect of pluronic P8 5 on ATPase activity of drug efflux transporters Pharm Res 21 , 22 26 22 33 13 Erukova VY, Krylova OO, Antonenko YN & MelikNubarov NS (20 00) Effect of ethylene oxide and ... alcohol, chloroform and diethyl ether [10,11] Sinicrope et al have shown that chloroform and benzyl alcohol inhibit uptake of drugs into Pgp-containing vesicles [11] Pluronic P8 5 [ 12] , chloroform, benzyl...

Ngày tải lên: 30/03/2014, 04:20

... Nallapati, and C D Manning 20 09 Labeled lda: A supervised topic model for credit attribution in multi-labeled corpora Proc EMNLP J Reisinger and M Pasca 20 09 Latent variable models ¸ of concept-attribute ... 48, pages 23 3 23 8 L Begeja, B Renger, Z Liu D Gibbon, and B Shahraray 20 04 Interactive machine learning techniques for improving slu models In Proceedings of the HLT-NAACL 20 04 Workshop on Spoken ... Understanding for Conversational Systems and Higher Level Linguistic Information for Speech Processing Pauline M Berry, Melinda Gervasio, Bart Peintner, and Neil Yorke-Smith 20 11 Ptime: Personalized...

Ngày tải lên: 30/03/2014, 17:20

... 1993, 19:1-13 Page of (page number not for citation purposes) Journal of NeuroEngineering and Rehabilitation 20 08, 5 :27 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 ... their left, and a pen in their right hand A paper sheet on the clipboard displayed pairs of boxes, arranged in three columns of 25 rows One box of each pair was grey and the other white, and their ... Meta-Analysis Psychol Aging 20 03, 18:443-60 McDowd J, Craik F: Effects of aging and task difficulty on divided attention performance J Exp Psychol Hum Percept Perform 1988, 14 (2) :26 7 -28 0 Göthe K,...

Ngày tải lên: 19/06/2014, 08:20

... have so-called properties, which specify them in more detail One important example for such a property is the location of the perceptual images in the environment To perform complex tasks, neuro-symbols ... system of the brain for the purpose of sensor EURASIP Journal on Embedded Systems [6] [7] [8] [9] [10] [11] [ 12] [13] [14] [15] [16] [17] [18] [19] [20 ] [21 ] [22 ] [23 ] [24 ] fusion,” in Human-Computer ... Machines, vol 20 , no 1, pp 1–18, 20 10 T Deutsch, R Lang, G Pratl, E Brainin, and S Teicher, “Applying psychoanalytic and neuro-scientific models to automation,” in Proceedings of the 2nd IET International...

Ngày tải lên: 21/06/2014, 11:20

... t15 t16 t17 t18 t19 t20 t21 t 22 t23 ena t24 t25 t26 t27 t28 t29 t30 z−1 Sel [4 : 0] 10 11 12 13 14 15 MUX 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Multiplexer Delay Comparator a == b Sel ... 740000 — 20 00 120 000 — 520 000 — 5000 40000 — 26 0000 Levels of disparity Logic elements Memory bits 320 × 24 0 640 × 480 320 × 24 0 320 × 24 0 320 × 24 0 640 × 480 32 64 32 — 33 65 122 00 24 300 23 900 ... Evaluation of SAD and DP Systems Both SAD and DP accelerators are able to process up to 64 levels of disparity and produce 640 × 480 8-bit depth maps at clock rate Using appropriate pipelining...

Ngày tải lên: 21/06/2014, 19:20

... 3 .25 406e − 14 −3 .24 982e − 13 7.59094e − 13 −3.57571e − 13 7.84884e − 07 2. 822 87e − 05 −9. 328 59e − 05 (2, 1) 2. 28533e − 10 −7.09939e − 10 6.77403e − 10 (2, 2) 3.5 526 2e − 22 −3.01956e − 22 3.69652e ... Analysis and Simulation of Wireless and Mobile Systems (MSWiM ’05), pp 22 4 23 3, Montreal, Canada, November 20 05 [11] P P Pham, “Comprehensive analysis of the IEEE 8 02. 11,” Mobile Networks and Applications, ... impedes the determination of an appropriate configuration One could instead formulate and solve a corresponding optimization problem to achieve the same purpose; however, an appropriate model of...

Ngày tải lên: 21/06/2014, 22:20

... networks,” Bioinformatics, vol 18, no 2, pp 26 1 27 4, 20 02 [ 12] J Goutsias and S Kim, “A nonlinear discrete dynamical model for transcriptional regulation: construction and properties,” Biophysical Journal, ... Microarrays: Optical Technologies and Informatics, vol 426 6 of Proceedings of SPIE, pp 24 8 25 9, San Jose, Calif, USA, January 20 01 [18] http://www.vision.ime.usp.br/∼walter/pgn cell cycle/ycc info.pdf ... of time for the processes it controls, stopping the propagation of a new forward signal wave—coming from the previous layer for some time By means of two types of negative feedbacks (to the previous...

Ngày tải lên: 22/06/2014, 19:20

... in the proof of Theorem 1.1, we have Ω p −1 p |∇ψ | p 2 ∇ψ · ∇w dx = ε p 1 p 1 p Ω λ1 φ1 − ∇φ1 p w dx (3 .2) Hence inequality (3.1) will be satisfied if both ε p −1 ε p −1 p −1 p p−1 p p−1 p −1 (−m) ... ≤ 2 c ≤ c2 (ε) = ε a0 − p −1 p −1 p p−1 a0 − p p−1 1/(γ− p) λ1 σ p p −1 , (3.6) p λ1 σ − ε γ− p Note that c2 (ε) > Choose α = min{α1 , 2 } and ε = α /2 Then simplifying, both c1 (ε) and c2 (ε) ... W (2. 1) But Ω |∇ψ | p 2 ∇ψ · ∇w dx = r p 1 Ω = r p −1 = r p −1 ∇φ1 Ω p 2 ∇φ1 φ1 ∇φ1 · ∇w dx p 2 p Ω ∇φ1 · ∇ φ1 w dx − λ1 φ1 − ∇φ1 p Ω ∇φ1 p w dx w dx (2. 2) p p ¯ Now r p 1 [λ1 φ1 − |∇φ1 | p...

Ngày tải lên: 22/06/2014, 22:20

... follows a) For comparative or reference purposes, for which a standard specimen of base material is specified (see 5.1) b) For a specific application, for which the base material should be appropriate ... parallel to the direction of the applied force 7 .2 Load application 7 .2. 1 General Only hand-tighten the nut or bolt head initially, and apply a force sufficient to take up any slack in the apparatus ... ordinary and rapid-hardening Portland cement BS 187, Specification for calcium silicate (sandlime and flintlime) bricks BS 8 12, Testing aggregates BS 8 12- 1 02, Methods for sampling BS 8 82, Specification...

Ngày tải lên: 08/07/2014, 22:20

... amayihsiN ,DB pparT ,H adeU ,T uzekI 938-138 ,29 ,50 02 mehcorueN J yticitsalp lanoruen evitcaer yrujni-tsop ni 1-niloevac rof elor A J reirioP ,PJ nottarG ,FJ nialB ,BS tluaerduaG 791 -29 1 ,6 52 ,9991 ... fo smrofosi owt eht taht dnuof ew ,ypocsorcim thgil gnisU ]7[ senarbmem amsalp citpanyserp ni ro selcisev citpanys no ton tub ,aniter enivob fo srotpecerotohp enoc dna dor ni snobbir citpanys ... ,EP rerehcS ,SK gnoS 41 422 - 122 , 62 ,6991 seR teV J naeroK aniter kcud eht no dica ciniak fo stceffE M miK ,T nihS 31 02- 11 ,561 ,50 02 lonummiorueN J sitileymolahpecne enummiotua latnemirepxe...

Ngày tải lên: 07/08/2014, 18:21