c using the ils

... DB, Clancy CM Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy JAMA 2003;290:1624-32 Copyright © 2007 Massachusetts Medical ... therapy improves the clinical outcome independently of the reduction in serum cholesterol levels Critical to the conclusions of both articles is the finding that a decrease in C- reactive protein, ... effects from statins specific to patients with heart failure,10 such factors amplify the need to understand the safety and efficacy of this therapy How, then, can the clinical findings of the CORONA...

Ngày tải lên: 27/06/2014, 00:20

... objective of much current research 2.4 Acyl-coenzyme A: cholesterol acyltransferase (ACAT) ACAT (EC2.3.1.26) catalyzes the formation of CEs by using cholesterol and long-chain fatty acids as substrates, ... in the accumulation of CEs in macrophages and vascular tissue, an event that is central to foam cell formation and atherosclerosis There are two forms of ACAT, ACAT1 and ACAT2, which catalyze the ... well-accepted that the genetic factors have contributed to CAD susceptibility, the magnitude of their effect and number of contributing effects could not be determined until all CAD-susceptibility...

Ngày tải lên: 14/09/2015, 09:00

... azathioprine; CYC, cyclophosphamide; DLCO, diffusing capacity for carbon monoxide; FVC, forced vital capacity aPercentage predicted value at baseline In these DLCO studies, the single-breath diffusing capacity ... are treated with CYC may experience a modest increase in the FVC and the DLCO after 12 months of therapy Neither improvement in the FVC nor in the DLCO achieved clinical significance, however, as ... Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee: Preliminary criteria for the classification of systemic sclerosis (scleroderma)...

Ngày tải lên: 09/08/2014, 13:22

... been successfully introduced in clinical practice of banding [20] Can be easily occluded with the current devices, as the Gianturco-Grifka vascular occlusion device which is an appropriate closure ... Journal of Cardiothoracic Surgery 2011, 6:143 http://www.cardiothoracicsurgery.org/content/6/1/143 there is statistical significant difference between the two groups concerning the percentage change ... two-sided, statistical significance was set at p < 0.05 All analyses were carried out using the statistical package SPSS ver 16.00 (Statistical Package for the Social Sciences, SPSS Inc., Chicago, Ill.,...

Ngày tải lên: 10/08/2014, 09:22

... without success An electrophysiological study was performed in the fourth post-operative week using a 5-French decapolar catheter placed into the left subclavian vein in the coronary sinus (CS), a ... 4-French bipolar catheter placed from the left femoral vein into the right ventricle, and a 5-French mapping/ablation catheter placed through the right femoral vein Atrioventricular re-entry tachycardia ... underlying clinical entity To the best of our knowledge, this is the first case report on the coexistence of ALCAPA and recurrent SVT in infancy due to an accessory pathway that was treated with successful...

Ngày tải lên: 10/08/2014, 23:20

... the urgency of the clinical situation [11] Because this patient was stable after ECMO, no further anticoagulant therapy was given Conclusion In conclusion, this is the first reported case of an ... protein C, protein S, antithrombin activity, concentrations of clottable fibrinogen, plasminogen activity, activities of coagulation factors VIIIC and XII, lipoprotein (a) and homocysteine concentration ... thrombosis occurs primarily in the aorta and can mimic cyanotic heart disease [1-3] Two babies ElHassan et al Journal of Medical Case Reports 2010, 4:284 http://www.jmedicalcasereports.com/content/4/1/284...

Ngày tải lên: 11/08/2014, 03:21

... the urgency of the clinical situation [11] Because this patient was stable after ECMO, no further anticoagulant therapy was given Conclusion In conclusion, this is the first reported case of an ... protein C, protein S, antithrombin activity, concentrations of clottable fibrinogen, plasminogen activity, activities of coagulation factors VIIIC and XII, lipoprotein (a) and homocysteine concentration ... thrombosis occurs primarily in the aorta and can mimic cyanotic heart disease [1-3] Two babies ElHassan et al Journal of Medical Case Reports 2010, 4:284 http://www.jmedicalcasereports.com/content/4/1/284...

Ngày tải lên: 11/08/2014, 07:20

... pulmonary blood vesselsand complete intensitydefect contrast injection Contrast-enhanced in signalocclusion of thein the branch with Contrast-enhanced magnetic resonance image of the large blood vessels ... tomography scanbranch blood vesselsand in one-third of the defect in pulmonary Contrast-enhancedcomplete occlusion of thethe pulmonary Contrast-enhanced computerized tomography scan of large ... leiomyosarcoma or "undifferentiated spindle-cell sarcoma" Angiosarcoma accounts for 7% of cases The histopathological classification does not seem to be useful clinically or prognostically [1,2] Because...

Ngày tải lên: 11/08/2014, 20:20

... predominance (the female to Figure rence of3pulmonary artery intimal sarcoma A computed tomography scan of the chest shows the recurA computed tomography scan of the chest shows the recurrence of ... artery was obstructed circumferentially A computed tomography scan of the chest shows the main A computed tomography scan of the chest shows the main pulmonary artery was obstructed circumferentially ... local mass resection, confirming the positive role of surgery in the management of PA intimal sarcoma When tumor relapse occurred in the pulmonary hilum, local 3DCRT to the mediastinum successfully...

Ngày tải lên: 11/08/2014, 21:22

... (forward) 5’-CCT GTA TGC CTC TGG TCG TAC C- 3’ and (reverse) 5’-TCT CGG CTG TGG TGG TGA AG-3’ The PCR program for chymase was initiated by a denaturation step at 94 C, followed by 35 cycles of 94 C for ... manufacturer’s instructions Primers for chymase PCR (738 bp) were (forward) 5’CTG AGA GGA TGC TTC TTC CTG C- 3’ and Page of 10 (reverse) 5’-AGA TCT TAT TGA TCC AGG GCC G-3’ [23] Primers for b-actin PCR (194 ... mM cold Tris-HCl (pH 7.4) buffer Protein concentration was determined using the bicinchoninic acid (BCA) assay (Pierce, Rockford, IL, USA) The serine protease inhibitor aprotinin (Sigma) and the...

Ngày tải lên: 12/08/2014, 11:21

... mitral incompetence ventricular septal defect ventricular septal defect complete atrioventricular septal defect ventricular septal defect (CAVSD: complete atrio-ventricular septal defect; ASD: ... retrieval by microwave pressure cooking or trypsin incubation The sections were then treated to block non-specific binding of primary and secondary antibodies and non-specific reaction with chromogens ... Diagnosis complete atrioventricular septal defect ventricular septal defect, atrial septal defect ventricular septal defect ventricular septal defect, atrial septal defect ventricular septal defect complete...

Ngày tải lên: 12/08/2014, 14:20

... produced weeks, AR)maximal5contraction calciumthe leftligaPercent by acetylcholinearteryweeks,takenearlier,ionophore Percent reduction of maximal contraction to phenylephrine produced by acetylcholine ... measured using a colorimetric assay kit (R&D Systems, Lille, France) according to the manufacturer's instructions Endothelial cell function Pulmonary artery reactivity At the end of the study, ... independently from each other, and the proportion of ECs undergoing apoptosis was calculated The mean of the two counts by the two investigators was taken Caspase Activity Activity of the enzyme caspase was...

Ngày tải lên: 12/08/2014, 15:21

... Prostacyclin induces apoptosis of vascular smooth muscle cells by a cAMP-mediated inhibition of extracellular signal-regulated kinase activity and can counteract the mitogenic activity of endothelin-1 ... and PDE4 activity (10-6 M roflumilast) Each of these enzyme families contributed to the cytosolic and membrane cAMP-PDE activity (Figure 2A–B) PDE4 was the main specific cAMP hydrolytic activity ... Stimulation of PASMCs with adenylyl cyclase activators, such as the prostacyclin analogue iloprost, had a concentration-dependent effect on intracellular cAMP levels, inducing a 4- (10-8 M) to...

Ngày tải lên: 12/08/2014, 16:20

... Artery Catheter Consensus Conference: Consensus statement Crit Care Med 1997, 25:910-925 15 Rhodes A, Cusack RJ, Newman PJ: A randomized controlled trial of pulmonary artery catheter in critically ... Consensus Conference and other musings on how critical care practitioners need to improve the way to conduct business Crit Care Med 1997, 25:2060-2063 19 Gnaegi A, Feihl F, Perret C: Intensive care ... a beneficial effect of the PAC in patients with hemodynamic compromise, the default state should be to rely on the clinical assessment The PAC should be reserved for the minority of cases where,...

Ngày tải lên: 12/08/2014, 19:22

... pulmonary artery occlusion pressure; RA, right atrium; RV, right ventricle; SVC, superior vena cava There were no differences in [Lac] between the IVC and SVC sites IVC [Lac] and SVC [Lac] were greater ... artery catheter (Swan-Ganz standard thermodilution pulmonary artery catheter; Edwards Life Sciences, Irvine, CA, USA) and measurements were taken of cardiac output in triplicate using the thermodilution ... that only can be answered by further clinical studies Conclusion The development of ΔSO2 and Δ[Lac] in the patient population studied cannot be explained by the mixing of SVC and IVC blood The development...

Ngày tải lên: 13/08/2014, 03:20

... Maquet Critical Care AB, Omnicare Clinical Research AG, and Orion Corporation; and research & development/consulting contracts with Edwards Lifesciences SA and Maquet Critical Care AB The money ... file Clinical indications for fluid challenges A table listing clinical indications for fluid challenges Abbreviations AUC: area under the curve; CVP: central venous pressure; ECG: electrocardiogram; ... consequence of either compromised myocardial function in cardiac surgery patients or both diastolic and systolic biventricular dysfunction and acute changes in pulmonary vascular resistances in...

Ngày tải lên: 13/08/2014, 20:22

... were compared using Fisher’s exact test Receiver operating characteristic (ROC) curves were constructed to evaluate the predictive value of PPV The best predictive threshold was defined as the ... in controls after bleeding All fluid challenges in controls after bleeding with CVP increase AUC, area under the receiver operating characteristic curve; CVP, central venous pressure; CI, confidence ... Lifesciences Services GmbH, Kenta Biotech Ltd, Maquet Critical Care AB, Omnicare Clinical Research AG, and Orion Corporation, and holds or has held research and development/consulting contracts...

Ngày tải lên: 13/08/2014, 20:22

... (COtd+LiDCO CO)/2 (L/min) C C O -LiD C O C O (L/m in) FloTrac -6 (COtd+PiCCO CO)/2 (L/min) COtd -6 C C O -P iC C O C O (L/m in) LiDCO C C O -F lo T rac C O (L /m in ) C O td-P iC C O C O (L/m in) PiCCO ... paired devices PAC-LiDCO, PAC-PiCCO, PAC-FloTrac, LiDCOPiCCO, LiDCO-FloTrac and PiCCO-FloTrac Bias was defined as the mean difference between CO measurements Hadian et al Critical Care 2010, ... (PAC-LiDCO), 0.27 ± 1.84 (PAC-PiCCO), Table Mean cardiac output measurementsa Baseline CO (L/min), n = 17 using both COTD and CCO PAC (COTD/CCO) 5.6 ± 1.5 LiDCO Plus 5.4 ± 1.6 PiCCO FloTrac/Vigileo...

Ngày tải lên: 14/08/2014, 07:21

... premature CAD Although for most children the process of atherosclerosis is subclinical, dramatically accelerated atherosclerosis occurs in some pediatric disease states, with clinical coronary ... and cell death Evidence of significant disease at coronary angiography suggests the presence of a premature atherosclerotic process Based on the appearance of the electrocardiogram (ECG), they ... membrane channels linking the cytoplasmic compartments of adjacent cells play a critical role The component protein subunits of these channels, called connexin (Cx), belong to a multigene family Cx37...

Ngày tải lên: 08/03/2014, 00:20