bringing the state back in

... with damping With the point-wise estimates, they proved the large time point-wise structure of the solution for nonlinear problem In [11], Lin used the similar method to obtain the pointwise estimate ... market Among these equations, the evolutionary one, i.e., the PDEs depending on time are usually more interesting, since the solution of them can give the dynamical description of the model 1.1 ... PDEs, the initial condition is a necessary condition In addition, in each physical problem there is a physical domain, only in which the PDE is valid From physical intuition, to determine the solution,...

Ngày tải lên: 09/09/2015, 08:17

... G2019S localized to the activation loop and Mg2+ binding site of the kinase domain [5] Missense mutations occurring in analogous regions in the b-RAF protein kinase (e.g the kinase activation loop) ... but in concert with a number of conserved domains, including a GTPase domain Multidomain proteins that encode functional kinase domains often utilize intrinsic protein kinase activity distinct ... substructures within the kinase domains, with the expectation that similar kinases may be involved in similar roles in cells LRRK1 and LRRK2 are awkwardly nestled within the tyrosine-kinase-like family,...

Ngày tải lên: 23/03/2014, 04:20

... was then calculated as the percentage increase in diameter from baseline After 10 min, a second scan at rest was performed and then nitroglycerin was administered (400 μg sublingual); later a final ... stability of the nitric oxide synthase, increased oxidative stress, or increased endothelin-1 production [12,19,20] The presence of and the role played by endothelial dysfunction in the atherosclerotic ... [3-5], may restore endothelial dysfunction by counteracting the harmful effects of relapsing inflammation Competing interests The authors declare that they have no competing interests Authors' contributions...

Ngày tải lên: 09/08/2014, 10:21

... observation could not be explained by invoking evaporation There have long been reports in the literature regarding insects having a lower temperature in their gaster than in their thorax, but this ... where they split into thinner tracheae (6); the latter pass into the PP (7) Thin layers of cuticle seal the PP from underneath, but the layers are rather transparent and thin (8) In this region there ... section (d) in the upper image] and the stinger mechanism, as well as the intestine and the genitalia The sections marked (a – d) in the top image are exhibited as Figs 2a,b,c,d in the lower images...

Ngày tải lên: 11/08/2014, 00:22

... manoeuvres in order to obtain a minimum of two acceptable and reproducible values Before the tests the examiner demonstrated the correct performance of the manoeuvres and then the individuals ... The clinical examinations and interviews were performed at the same day Overall, the KORA F4 study was conducted between 2006 and 2008 The investigations were carried out in accordance with the ... Furthermore, the use of medication within the last seven days before the examination was ascertained by an instrument for database-assisted online collection of medication data (IDOM) [19] The following...

Ngày tải lên: 25/10/2012, 10:45

... running perpendicular from ray at the point of the anterior commissure The dorsal PFC region was delineated as the volume resulting from the intersection of rays and The resulting region included ... locally independent warps to be constructed in small subvolumes defined by cubes having control points as vertices These result in a matching of fine anatomical details Each data voxel in the target ... letter then appeared (2500 + 1500 msec ITI) and participants responded to indicate whether the probe letter matched any letter in the study set The baseline condition consisted of a single letter in...

Ngày tải lên: 14/02/2014, 07:20

... on the compact insulating myelin layers around axons The myelin membrane is an organelle synthesized by Schwann cells in the PNS, and by oligodendrocytes in the CNS The electrical insulating ... protein ratio The myelin membrane contains myelin-specific proteins, such as myelin protein zero, peripheral myelin protein-22, myelin associated glycoprotein (MAG) and myelin basic protein, but ... differentiation [37] The synthesis of oleic acid by astrocytes was demonstrated to be triggered by the transit of albumin, a fatty acid-binding protein present in the developing brain, into the astrocytic...

Ngày tải lên: 18/02/2014, 13:20

... VH2-N) which we previously showed does contain an actinbinding domain (this actin-binding domain has not yet been mapped) [23] We name the actin-binding domain that we have identified VH2-C and VH2-N ... C-terminal actin binding domain the VH2-C domain to distinguish it from the two previously reported N-terminal actin-binding domains [19,21,23] The second submodule comprises the LBD (residues ... suggests that interactions mediated by these two domains are directly implicated in polarization of the yeast actin cytoskeleton The presence of the novel actin-binding VH2-C domain in C-Vrp1p364)817...

Ngày tải lên: 18/02/2014, 16:20

... )1 )1 State respiration (nmolÆmin Æmg protein) State respiration (nmolÆmin)1Æmg)1 protein) State respiration (nmolÆmin)1Æmg)1 protein) ADP ⁄ O Phosphorylation rate (nmolÆmin)1Æmg)1 protein) 29.4 ... additional insights into this interesting question Conclusions In summary, we have identified a novel metabolic gene switch (decrease in fatty acid utilization, increase in glucose utilization) in the ... oxygen results in the emission of light The intensity of the bioluminescence was detected using a luminometer, and the mitochondrial ATP concentration was determined Mitochondrial protein concentration...

Ngày tải lên: 18/02/2014, 16:20

... subordinate their judgement on audit matters to others The internal audit function in banks 13 The internal audit function should not be involved in designing, selecting, implementing or operating ... accounting practices, including accounting estimates and financial statement disclosures; (c) monitoring the integrity of the bank’s financial statements and any formal announcements relating to the ... outsourced, the board of directors remains responsible for these activities and for maintaining an internal audit function within the bank Outsourcing of internal audit activities is further addressed in...

Ngày tải lên: 06/03/2014, 10:20

... identifying, measuring, assessing, controlling, responding to, and reporting on all the risks resulting from the bank’s activities; • the integrity of the risk management information systems, including ... at the highest level of the organisation The internal audit function in banks 19 The head of internal audit should ensure that the internal audit staff acquires appropriate ongoing training in ... if the internal audit staff’s remuneration is linked to the financial performance of the business lines for which they exercise internal audit responsibilities The remuneration of the head of the...

Ngày tải lên: 06/03/2014, 10:20

... uses the characteristics of the point and the surrounding landscape (i.e., the landscape context) to determine the behavior of a point In this case, the spatial distribution/pattern of each of the ... issues pertaining to fire, water, and the design of biological reserves In the final section, (Section V, “Synthesis”), five chapters (including a final chapter by the editors) tie together the various ... in fact interconnected parts of a larger landscape Once we begin to ask about the source of the inputs or the fate of the outputs, we need to consider the ecosystem in its landscape context The...

Ngày tải lên: 06/03/2014, 18:21

... cystein, methionine and serine (Fig 2) Mutants containing asparagine, aspartic acid, glycine, lysine or valine were nonfunctional (Fig 2) Clones expressing eEF2 in which the adjacent threonine ... coded for by the remaining eEF2 gene in the yeast strain YOR133w (Fig 1) It was therefore possible that these mutants could interfere with the function of wild-type eEF2 thereby reducing the rate ... calmodulindependent protein kinase (CaMPKIII) [15,16] The activity of the eEF2 kinase is regulated by the mitogen-activated protein (MAP) kinase and mTOR-signalling pathways [17] These signalling...

Ngày tải lên: 07/03/2014, 05:20

... migrating band (lane 2), showing that it contains the more tyrosine phosphorylated band of Crk Pretreatment with tyrosine kinase inhibitor alone increased the intensity of the lower migrating band ... allow (c) the intramolecular SH2 domain bind to it, which results in (d) inhibition of the intermolecular interactions of CrkII mediated by the SH2 domain and (e) subsequent blockade of the downstream ... study, then at min, the SH2 domain of CrkII could be intramolecularly bound to phosphorylated tyrosine resulting in a blockade of any CrkII protein complex mediated via the SH2 domain In agreement...

Ngày tải lên: 07/03/2014, 21:20

... dystrophin First, we refined the dystrophin-binding region on dystrobrevin (Dyb-1) by performing deletion-mapping experiments in vitro We then tested the ability of the truncated Dyb-1 proteins to bind ... wild-type This indicates that, although deleting the syntrophin binding region (SBR) and the first helix reduces the activity of the protein, it remains partly functional Five lines were obtained with ... However, the 6¢4 construct, which removes the syntrophinbinding region and most of the first helix, continued to show full binding activity The results obtained in vivo by transgenesis in C elegans...

Ngày tải lên: 08/03/2014, 23:20

... Finned octopus females lay ripe eggs one by one without accumulating them in the coelom Stage IV indicates the presence of several ripe oocytes in the coelom and stage V when they pass into the ... edges of the testis show erosion Functional maturation and maturity The remaining stages involve expelling the mature sexual cells from the coelom and their transport through the accumulation in different ... mostly in the coelom but partially in the proximal ends of the oviducts which form a wide, concaved funnel Mature oocytes accumulate in the oviducts of squid in preparation for spawning Spawning...

Ngày tải lên: 14/03/2014, 16:20

... The Green House Princeton Architectural Press New York The National Building Museum Washington, D.C the Alanna Stang and Christopher Hawthorne g ho reen use New Directions in Sustainable ... strategically placed exposures on the side and rear elevations, the house uses nothing but natural light during the day The massive Douglas fir crossbeams, which support the cantilevered roof, were ... years later The metropolitan area around Tokyo surpassed twenty million in 1965 and is now closing in on thirty 18 City City Urban 19 20 City P A.R.A.S.I.T.E project Rotterdam, the Netherlands...

Ngày tải lên: 14/03/2014, 17:20

... comprising this segment linked to the C-domain sequence (8-C) [73,78] This finding further supports the predicted 3D model, indicating that the C-domain is indeed a valid functional domain responsible ... protein-coding genes contain introns that are removed in the nucleus by RNA splicing and are often alternatively spliced Alternative splicing increases the coding capacity of the genome, generating ... determinant behind its signaling capacity The existence of a C-terminus domain (C-domain) emerged from a prediction of the 3D structure of a single-chain heparanase enzyme [73] In this protein 3894...

Ngày tải lên: 15/03/2014, 23:20

... containing the enzyme and the inhibitors were preincubated for 10 before initiating the reaction by addition of NADH Bovine heart LDH (j/solid line); Pf LDH (d/broken line); Pf MDH (h/solid line); ... the parasite The broken lines/arrows show inhibition and the double lines/ arrows indicate induction of the enzyme/enzymatic reaction in the presence of gossypol the LDH/MDH inhibitor The scheme ... due to the insertion of five amino acids [14,15] The N-terminal glycine motif GXGXXG is similar to the cofactor binding motif found in most of the LDHs and a-proteobacterial MDHs [12,13,48] In addition,...

Ngày tải lên: 16/03/2014, 18:20

... obtain a better insight into the photo-induced changes in PSI The submembrane particles used contain all the components of PSI, including the cytochrome b6 ⁄ f complex and plastocyanin [31,32] In ... from the changes in first derivative spectra that further demonstrate the gradual time-dependent alteration in the position of the major peak in the red region (Fig 2, insert) On the other hand, in ... of the antenna proteins The addition of scavengers such as histidine, DABCO, and n-propyl gallate, retarded the above damages to the antenna proteins indicating mainly 1O2 was involved [28] In...

Ngày tải lên: 16/03/2014, 18:20