breast cancer monitorization and prediction of response to treatment with dwi

... androgendeprivation therapy (ADT) and/ or radiotherapy (RT) and were subjected functional magnetic resonance imaging (MRI) pretreatment and and days after onset of treatment Together with standard clinical parameters ... DWMRI and DCEMRI sessions, and together with volumes and PSA measurements, these parameters were independently and combined used as inputs to a BPNN in order to explore their feasibility of predicting ... to be 30 epochs The optimal number of epochs for the second and third simulations was decided by a similar approach as above, and found to be 49 and 69, respectively The use of ADC together with...

Ngày tải lên: 09/08/2014, 09:20

... of cancer progression Remarkably, down-regulation of b-F1-ATPase has been widely associated with the resistance of cancer cells to standard anticancer therapies [21-23] In the specific case of ... represents an index of the relative relevance of cellular energy provision pathways [9,11], and the potential to execute cell death in response to the metabolic inhibitors, 3BrP and IA, and the anti-metabolite ... activity of mitochondria in colon cancer cells [11,21] and tumors [19], has been associated with the ability to execute a ROS-mediated cell death response upon 5-FU treatment [11] On the other hand,...

Ngày tải lên: 18/06/2014, 19:20

... of cancer progression Remarkably, down-regulation of b-F1-ATPase has been widely associated with the resistance of cancer cells to standard anticancer therapies [21-23] In the specific case of ... represents an index of the relative relevance of cellular energy provision pathways [9,11], and the potential to execute cell death in response to the metabolic inhibitors, 3BrP and IA, and the anti-metabolite ... activity of mitochondria in colon cancer cells [11,21] and tumors [19], has been associated with the ability to execute a ROS-mediated cell death response upon 5-FU treatment [11] On the other hand,...

Ngày tải lên: 20/06/2014, 03:20

... taking account of the negative correlation, -1/(n - 1), of values of X - X of family members F Rawlings (1976) and Hill (1976, used by Toro and P6rez-Enciso, 1990) give formulae to correct selection ... schemes, and uses formulae to describe SWF which actually relate to SDM Correct results for both cases are given by Dempfle (1990) and applied by Toro and P6rez-Enciso (1990), but seem not to have ... all families and there are very many families, 25% of individuals of each sex are selected giving iT 1.271 and in 1.029 (from tables A and B, respectively, in the appendix of Falconer and Mackay,...

Ngày tải lên: 09/08/2014, 18:22

... Proliferation and invasion are important biological features of breast cancer Because the development of breast cancer involves many extremely complicate regulatory factors, its treatment is often difficult ... MDA-MB-231 and MCF-7 cells measured by real-time RT-PCR To evaluate the effect of treatments described above on mRNA levels of uPA, uPAR and ERK in breast cancer cells, 24 h after the treatment, total ... treatment for breast cancer, this study explored the additive effects of docetaxel and ulinastatin on the proliferation of breast cancer MDAMB-231 cells and tumor growth in nude mice Materials and methods...

Ngày tải lên: 10/08/2014, 10:21

... with at least of the following symptoms: relieved with defecation associated with change in frequency of stools Associated with change in form of stools and two or more of the following symptoms: ... trial of IBS patients with long-standing symptoms and no response to conventional medical treatment found psychotherapy superior to medical treatment in reducing bowel symptoms( diarrhea and abdominal ... two of the following symptoms: relieved with defecation associated with change in frequency of stools Associated with change in form of stools with the following symptoms supporting irritable...

Ngày tải lên: 26/09/2015, 10:05

... predictive of response to both conventional cytotoxic and target therapy drugs [11] Platinum or platinum-based regimens are the treatment of choice in ovarian cancers, which remains the leading cause of ... predicting response to platinum or platinum based regimens, in a series of patients with peritoneal carcinomatosis from ovarian cancer Patients and Methods Patients Thirty-two patients with peritoneal ... vitro results Page of and clinical response was observed in 27 out of the 30 patients analyzed, with a predictivity of 85.7% in terms of sensitivity and of 91.3% in terms of resistance The important...

Ngày tải lên: 18/06/2014, 19:20

... responsive to GSK1070916 with a median EC50 of nM Since cancer cell death is a more desired phenotype, the in vitro response of 91 hematological cell lines were defined based on both time of response and ... Predictor of Response to the inhibition of Aurora B and C by GSK1070916 Journal of Translational Medicine 2011 9:110 Submit your next manuscript to BioMed Central and take full advantage of: • ... genetics of the hematological cell line panel was reviewed in relation to Aurora inhibition by GSK1070916 Expression profiles of Aurora A, B, and C were evaluated in terms of response to Aurora...

Ngày tải lên: 18/06/2014, 22:20

... predictive of response to both conventional cytotoxic and target therapy drugs [11] Platinum or platinum-based regimens are the treatment of choice in ovarian cancers, which remains the leading cause of ... predicting response to platinum or platinum based regimens, in a series of patients with peritoneal carcinomatosis from ovarian cancer Patients and Methods Patients Thirty-two patients with peritoneal ... vitro results Page of and clinical response was observed in 27 out of the 30 patients analyzed, with a predictivity of 85.7% in terms of sensitivity and of 91.3% in terms of resistance The important...

Ngày tải lên: 20/06/2014, 04:20

... responsive to GSK1070916 with a median EC50 of nM Since cancer cell death is a more desired phenotype, the in vitro response of 91 hematological cell lines were defined based on both time of response and ... Predictor of Response to the inhibition of Aurora B and C by GSK1070916 Journal of Translational Medicine 2011 9:110 Submit your next manuscript to BioMed Central and take full advantage of: • ... genetics of the hematological cell line panel was reviewed in relation to Aurora inhibition by GSK1070916 Expression profiles of Aurora A, B, and C were evaluated in terms of response to Aurora...

Ngày tải lên: 20/06/2014, 04:20

... [29,30] The aim of this study was to investigate the difference in type and frequencies of ATM variants and haplotypes in association with risk of breast cancer, as well as subcutaneous and cutaneous ... screening program, with no history of breast cancer after two negative mammograms [31]; age range at the time of blood collection was 55 – 72 years Norwegian breast cancer cases The breast cancer cases ... genes GSTP1, GSTM1 and GSTT1 and are also described in detail in [32] as well as here: From 1975 to 1986 a total of 1496 patients diagnosed with breast cancer and referred to the Norwegian Radium...

Ngày tải lên: 09/08/2014, 10:21

... between parity and risk of (a) early breast cancer and (b) late breast cancer Table Summary of the results on the relationship between breast cancer and reproductive factors according to age at diagnosis ... Shapiro S: Risk factors for breast cancer in Black women JNCI 78:213-7, 1987 12 Brinton LA, Schairer C, Hoover RN, Fraumeni JF : Menstrual factors and risk of breast cancer Cancer Investigation ... associations of parity, age at first full term pregnancy, and duration of breastfeeding with the risk of breast cancer J Clin Epidemiol 42:963-73, 1989 16 Bouchardy C, Le MG, Hill C: Risk factors for breast...

Ngày tải lên: 05/03/2014, 17:20

... Factors in Breast Cancer (1996) Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer ... exposure to BPA is so widespread BREAST CANCER Factors influencing the risk of breast cancer – established and emerging 10 These studies show why it is vital to study exposure to potential breast cancer ... Wolk A, Yaun SS (1997) Non-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer Cancer Causes Control, 8, pp49-56...

Ngày tải lên: 15/03/2014, 01:20

... to 2.4) 1.5 (0.9 to 2.4) 86/171 14.9 (12.6 to 16.8) 2.1 (1.3 to 3.3) 2.3 (1.4 to 3.7) 2.6 (1.6 to 4.2) 2.6 (1.6 to 4.2) 93/172 25.5 (22.6 to 29.3) 2.4 (1.5 to 3.8) 2.6 (1.7 to 4.2) 3.2 (2.0 to ... composition of the breast and not simply on the size of the breast When studying dense breast tissue in relation to breast cancer risk, adjustment for non-dense tissue seems to change risk estimates to ... models [19] To obtain more insight into the role of the fat breast tissue, we investigated the independent effects of the size of dense tissue and the size of non-dense tissue in the breast and their...

Ngày tải lên: 22/03/2014, 17:20

... follow-up (0 to 14, 15 to 29, 30 to 34, 35 to 39, 40 to 44, 45 to 49, 50 to 54, 55 to 59, 60 to 64, 65 to 69 and 70+) and calendar period of follow-up (1961 to 1965, , 2001 to 2005, 2006 to 2007 Case ... (< 50 and 50+ years), calendar period of follow-up with respect to incidence rate (1961 to 1985, 1986 to 1995, 1996 to 2000, and 2001 to 2007) and calendar period of diagnosis with respect to case ... date of diagnosis of breast cancer Beiki et al Breast Cancer Research 2012, 14:R5 http:/ /breast- cancer- research.com/content/14/1/R5 Page of 13 Table Incidence rate ratio (IRR) of breast cancer...

Ngày tải lên: 29/03/2014, 01:20

... V600E and V600K mutations Our preclinical data demonstrating similar kinase activity of the V600K and V600E mutations, together with clear evidence of clinical activity of PLX4032 in a patient with ... biopsy of a cutaneous lesion was tested and shown to be positive for the BRAF V600E mutation The patient was treated and achieved an excellent clinical response to PLX4032, associated with substantial ... burden and pain from the lesions Figure shows the cutaneous lesions before and after treatment with PLX4032 A portion of the tumor was also collected for laboratory research studies according to...

Ngày tải lên: 18/06/2014, 16:20

... explore the change in biomarkers of response to PCT at one day and 21 days after the first cycle of PCT in women with breast cancer attending our institution for care and towards this aim we initiated ... patients of carcinoma of breast on core biopsy specimens using immunohistochemistry (IHC) c) Quantification of extent of change in these biomarkers of response to chemotherapy one day and 21 days ... institutional protocol, were eligible Patients with inflammatory breast cancer or those with history of any indigenous form of therapy for breast cancer were excluded from this study The study...

Ngày tải lên: 09/08/2014, 04:21

... CT and TT) and alleles (C and T) with patient’s baseline characteristics including patient’s age, gender, specimen histology, stage of the disease and presence or absence of B-symptoms (Table and ... histology, disease stage and presence or absence of Bsymptoms (Table 5) None of these factors were associated with clinical response in HL patients (P value > 0.05) Table shows the genotype and ... Department, Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan 4Histology and Cytology Department, Princess Iman Center for Research and Laboratory Sciences, King...

Ngày tải lên: 10/08/2014, 10:21

... vide the ratio of ERBB2 -to- chromosome 17 signals and mapping probe -to- chromosome 17 signals A lower ratio cutoff of 0.75 and an upper ratio cutoff of 2.00 were selected for deletion and amplification, ... cases with only DCIS, all with amplification of ERBB2 by FISH, into categories of similar frequency, to permit comparison with other tumor attributes and clinical outcome: Class I: ERBB2 and TOP2A ... these analyses Figure breast carcinoma cells MIB1 in Association between frequency of expression of TOP2A and Association between frequency of expression of TOP2A and MIB1 in breast carcinoma cells...

Ngày tải lên: 10/08/2014, 22:20

... production of cytokines, specialized cytokines called chemokines and cell adhesion molecules [9] Chemokines belong to a superfamily of cytokines that promote chemotaxis of leukocytes to areas of infection, ... result of sepsis are felt to play a central role in the development of ARDS Migration of Experimental protocol Four hours after endotoxin or saline, the rats were sedated and anesthetized with ... Comparison of mRNA, plasma and lavage concentrations of MIP-2 in the control, neutropenic, endotoxemic and neutropenic, endotoxemic groups * Plasma MIP-2 is higher in endotoxemic rats compared to control...

Ngày tải lên: 11/08/2014, 08:21