... temporary dose discontinuation in 3/20 (15%) Forns and colleagues used relatively high-dose interferon/ribavirin therapy in their cohort of 30 patients awaiting transplantation in Spain in an effort to ... low initial dose, with increases every two weeks toward standard target doses Duration of therapy was intended to be 24 weeks in genotypes and and 48 weeks in genotype infection Hematologic inclusion ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin [13, 14] Finally, growing experience with antiviral therapy in this high-risk group...
Ngày tải lên: 31/10/2012, 17:11
... is therefore possible that CKBM could induce cytokine release including TNF-α in these animals and inhibit tumor growth However, further study is needed to determine how they are induced and the ... compounds including lunasin and lectins that were shown to induce apoptosis in malignant cells [13] As CKBM contains these compounds, this would partially explain why it inhibits tumor growth in the ... through the induction of apoptosis and inhibition of proliferation of gastric cancer cells However, further clinical trials in humans are needed to examine the pharmacokinetics and the therapeutic...
Ngày tải lên: 03/11/2012, 09:54
Some aspects of American culture and society in the twentieth and twenty-first centuries through a number of selected short literary works
... another The grandmother held the floor most of the time from the beginning of the story in her decision where to go, in her introduction of the scenery along the journey While the father, the mother ... character and setting Technique has to with the structuring of the story into the plot so that the writer can convey the theme and the manipulating of the language in order to express the ideas of the ... “Everything That Rises Must Converge.”, however, the differences in the behaviors and attitudes of the grandmother, the father and the mother and the children at least cause discontent to one another...
Ngày tải lên: 07/11/2012, 15:01
Hull and White model
... for the calibration was that we know the volatility at time zero of bonds of all maturities These volatilities can be implied by the prices of options on bonds We consider now how the model prices ... prices options 30.4 Option on a bond Consider a European call option on a zero-coupon bond with strike price K and expiration time T1 The bond matures at time T2 T1 The price of the option at ... 2v dv du: t t The variances and covariances are not random The means are random through a dependence on rt Advantages of the Hull & White model: Leads to closed-form pricing formulas Allows...
Ngày tải lên: 18/10/2013, 03:20
Development of a Regional Risk Management Framework for APEC Economies for use in the Control and Prevention of Introduced Marine Pests
... Conclusions, including the results of the November 2001 Workshop Management Framework - Introd uced Marine Pests Management capabilities and approaches APEC and the MRCWG have a role in liaising with ... NACA to enhance the effectiveness of existing instruments within APEC Institutional arrangements for managing the marine environment is fragmented in most economies Baseline surveys to identify ... water and hull fouling are the most important vectors International shipping, aquaculture and biodiversity are most threatened values Amount of commercial shipping and number of trading partners...
Ngày tải lên: 28/10/2013, 11:15
Radioactive waste in the Barents and Kara Seas - Russian implementation of the global dumping regime
... nuclear issues in general, the feeling grew in the environmental movement that Yeltsin was increasingly yielding to the demands of the Ministry of Atomic Power and the nuclear-industrial lobby.99 ... nuclear matters, including the Navy and the Ministry of Atomic Power, have consolidated their control over domestic decisionmaking and are themselves becoming increasingly involved in cooperative ... dumping, as these prescriptions figure prominently in the unequivocal argument made in the Yablokov Report on the severity of past dumping and the need to invest more in storage and decontamination...
Ngày tải lên: 01/11/2013, 09:20
Tài liệu NEW ADVANCES IN THE BASIC AND CLINICAL GASTROENTEROLOGY docx
... cells, single lymphocytes scattered in the lamina propria and intraepithelial lymphocytes spread in the intestinal epithelia The immune system of infants is not fully developed The structures of the ... demonstrated their capacity to stimulate the production of intestinal mucines, their trophic effect on intestinal epithelium, the reestablishment of the intestinal mucosa integrity, the stimulation of the ... Probiotics and infections The most valid indication of the probiotic remains the decrease of intestinal infections In fact, the literature shows that the probiotic can reduce the severity and number...
Ngày tải lên: 12/02/2014, 16:20
Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf
... emigrated, and were either residing in our Colonies or in other parts of the world, and the only method I could discover of obtaining information regarding several of viil INTRODUCTION them, was ... health; in others, to the rowers being by nature constitutionally delicate; and in others again, to their having thoroughly overdone it, to their being in boating language "stale." As regards the ... rowing as to be of little or no service in maintaining the theory of rowing being injurious to the health At the same time I have never doubted that his early death, at the age of twenty-nine,...
Ngày tải lên: 14/02/2014, 21:20
Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... heterogeneity in the efficacy of the BCG vaccine reported in the individual studies Using a model that included the geographic latitude of the study site and the data validity score as covariates, they ... vaccination of adults and the type of vaccine strain administered precluded the inclusion of these factors as covariates in the random-effects regression model However, these researchers determined ... adults These studies also were not useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s...
Ngày tải lên: 15/02/2014, 13:20
Tài liệu Bond Market Structure in the Presence of Marked Point Processes doc
... certain integral equations of the first kind (the “hedging equations”) have solutions Furthermore, the integral operators appearing in these equations (the “hedging operators”) turn out to be adjoint ... the (γ, ϕ) -process, as usual, comes from the martingale rep˜ resentation theorem, with γ i as the integrand corresponding to W i and i ϕ(i) as the integrand corresponding to the N -process The ... between the stock- and the bond market) In the present paper we focus primarily on the case of an in nite mark space, but the interest rate models above are included as special cases of our model, and...
Ngày tải lên: 16/02/2014, 02:20
Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... of a brain-specific MT isoform, GIF, in 1991, sparked considerable interest in understanding the role of all MTs in the brain, and particularly within the injured or diseased brain In the case ... deficient in the AD brain There remains no clear consensus on the role of GIF in the pathogenesis of AD, and therefore we will briefly review some of the current thoughts on the role of GIF in AD There ... investigated whether GIF acts in a neuroinhibitory manner when administered directly into the brain following traumatic brain injury In one such study, the injection of GIF into the site of a stab wound...
Ngày tải lên: 16/02/2014, 15:20
Tài liệu Trends in the Fees and expenses of Mutual Funds, 2010 pptx
... inflation by taking the fee breakpoints available in 2010 and multiplying by the Consumer Price Index in December 2000 and dividing by the Consumer Price Index in December 2010 The front-end ... paid for investing in bond funds declined by basis point in 2010, to 72 basis points (Figure 2) This reflects a basis-point drop in the annualized cost of load fee payments and no change in the average ... the average fees and expenses paid by investors in bond funds declined 61 percent, from 185 basis points in 1990 to 72 basis points in 2010, while fees incurred by investors in money market funds...
Ngày tải lên: 19/02/2014, 15:20
Tài liệu Trends in the Expenses and Fees of Mutual Funds, 2011 ppt
... declined in 2011 owing to declines in the expense ratios of individual funds, an increase in the demand for index funds, and a continuing shift by investors in both actively managed and index ... funds declined in 2011 but held steady in 2010 Another factor that has contributed to the decline of equity and bond fund expense ratios has been growing investor demand for index funds Index funds ... funds that invest primarily in other mutual funds Sources: Investment Company Institute and Lipper ICI RESEARCH PERSPECTIVE, VOL 18, NO | APRIL 2012 Another factor in the decline in the average...
Ngày tải lên: 19/02/2014, 15:20
Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... were determined by incubating the diluted recombinant proteins in the standard reaction mixture in the presence of increasing concentrations of PPi (0.05–0.5 mM) at 55 °C Data were fit to the appropriate ... concerning the kinetics and properties of the enzyme More strikingly, we show a novel role of the PPase enzyme in the development and molting process of A suum larvae in vitro constructed in UniZap ... removed and minced with a surgical knife The minced tissue was wrapped in cotton gauze and suspended in NaCl/Pi containing 100 lgÆmL)1 penicillin/ streptomycin at 37 °C for h After incubation the...
Ngày tải lên: 20/02/2014, 11:20
Tài liệu Rubber plantation performance in the Northeast and East of Thailand in relation to environmental conditions docx
... pineapple and upland rice (RRIT 2005) Cherdchom et al (2002) reported four main integrated rubber farming systems in the South of Thailand emerging during the financial crisis in the late 19 1990' s The ... On the other hand, in the far Northeast, along the Mekong River, over 2030 mm is received annually Variation in the average amount of rainfall is therefore notable in the Northeast During the ... introduced in Asia in 1876, when seeds were first shipped from the Amazonas to the United Kingdom and further to Ceylon and planted there In the following year, rubber trees were planted in Singapore and...
Ngày tải lên: 21/02/2014, 04:20
Tài liệu recent trends in the law and policy of bioenergy production promotion and use docx
Ngày tải lên: 21/02/2014, 05:20
Tài liệu ‘Unheard voices’: listening to Refugees and Asylum seekers in the planning and delivery of mental health service provision in London. pptx
... dominant because they learn the language and the mother and the father lose their roles The boundaries and the hierarchies are changing Children interpret for their parents, they know everything' ... process: The first step towards the integration of refugees must be to identify and help with their most pressing needs Finding and settling them into safe and appropriate housing, accessing employment ... CONTEXT and main themes, the motivation and purpose of the study - the why and how PART TWO is THE REASEARCH - METHODOLOGY and FINDINGS PART THREE is the GOOD PRACTICE GUIDE - the recommendations The...
Ngày tải lên: 24/02/2014, 18:20
Signaling at the Cell Surface in the Circulatory and Ventilatory Systems docx
... cells from their environment During integrin outside in signaling, the binding of integrins to their extracellular ligands changes the integrin conformation and promotes integrin clustering The unidirectional ... signalings, in fact, are often closely linked, as ligand binding associated with outside in signaling stimulates integrins and, conversely, integrin activation increases ligand binding for inside–out ... from and possible recycling for further molecule processing within the sending cell on the one hand, surface signaling, signaling during endocytosis into the receiving cell and receptor recycling...
Ngày tải lên: 05/03/2014, 22:21
RKesneaorcwh arlteiclde ge and perception of pulmonary tuberculosis in pastoral communities in the middle and Lower Awash Valley of Afar region, Ethiopia docx
... diagnosis and treatment On the other hand, the findings from this survey indicate that pastoral communities living in both of the study areas had basic awareness about the symptoms and treatment of PTB, ... hindered an in- depth analysis of the results Hence, the findings from the qualitative portion of the study might be considered preliminary Page 10 of 11 Conclusion Our findings indicate that the majority ... and interpretation DS participated in data analysis, interpretation and write-up GB involved in study design and critically revised the manuscript FA involved in study design, data analysis and...
Ngày tải lên: 06/03/2014, 04:20
Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
... of the regions at 100-105 and 303-309 aa in the N form, and we investigated the following points First, these areas are not involved in any contacts with other molecules in crystals in all the ... (disordered in the ligand-free state in YbgJ) In the absence of the ligand, the lid part is separated from the active site, which leads to a more open active site Upon the binding of ligand in the acyl-enzyme ... 419, 420, 422 and 428 aa; nine aa in total) were located near the interface of the physiological dimer The Cterminal domain may contain structural features involved in protein–protein interactions...
Ngày tải lên: 06/03/2014, 09:22