... mouse model JAS conducted the experiments on the NK cells KSP and ESL participated in the design of the study and discussion of data analysis SS conceived of the study, participated in its design ... consisted of typical mucocutaneous symptoms in mice without ocular symptoms, while those of BD eye mice consisted of ocular symptoms with mucocutaneous symptoms After FACS staining, lymphocytes ... ulcers, genital ulcers, skin ulcers, eye symptoms, gastrointestinal ulcers, arthritis, and neural involvement, as well as skin crusting The frequency of these symptoms is similar to that of patients...
Ngày tải lên: 11/08/2014, 03:20
... implements PrintServiceInterface The second thing we should as part of the Join process is define the set of attributes that our service possesses These could be anything from defining the name of ... only one JLUS exists and responds Next, the client has the task of using the JLUS to find the desired service To this, the client describes the desired service in any one of several ways The general ... class also implements the ServiceIDListener interface What 's that for? This is a piece of the Discovery process as we'll see in a moment Next we hit the main of our PrintService class The next significant...
Ngày tải lên: 06/10/2013, 14:20
Tài liệu The OSI Model: Understanding the Seven Layers of Computer Networks ppt
... easier by separating networks into manageable pieces • Defines terms that networking professionals can use to compare basic functional relationships on different networks • Helps users understand ... LLC All rights reserved Page Layer – The Session Layer Layer 5, the session layer, provides various services, including tracking the number of bytes that each end of the session has acknowledged ... is what the user sees, in terms of loading an application (such as Web browser or e-mail); that is, this application layer is the data the user views while using these applications Examples of...
Ngày tải lên: 24/01/2014, 09:20
Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... a-syn, proteins that displayed increased (›) or decreased (fl) expression as a consequence of a-synuclein overexpression; complex, proteins that displayed altered levels as a result of the association ... silver-stained gel images revealed 28 spots whose intensity was significantly different in at least one of the four groups considered (Fig 2) Two groups of spots showing remarkable changes in the isoform ... network, as well as statistically significant functional association with GO classifications [16] Western blotting Expression of a-synuclein and HSP70 was determined by western blotting Proteins (80...
Ngày tải lên: 15/02/2014, 01:20
Tài liệu Báo cáo khoa học: "Identifying Agreement and Disagreement in Conversational Speech: Use of Bayesian Networks to Model Pragmatic Dependencies" docx
... classification problem incorporates four classes, the BACKCHANNEL class is ig- Structural features: is the previous/next spurt of the same speaker? is the previous/next spurt involving the same ... different speakers The first part makes the second one immediately relevant, as a question does with an answer, or an offer does with an acceptance Extensive work in conversational analysis uses a less ... probability distribution over the sequences of observation and labels, it is necessary to enumerate all possible sequences of observations Such enumeration is generally prohibitive when the model incorporates...
Ngày tải lên: 20/02/2014, 16:20
Báo cáo khoa học: "What’s There to Talk About? A Multi-Modal Model of Referring Behavior in the Presence of Shared Visual Information" potx
... patterns in the presence of various forms of shared visual information Finally, we make use of a corpus gathered from laboratory studies that allow us to decompose the various features of shared visual ... Effects of head-mounted and scene-oriented video systems on re- mote collaboration on physical tasks In Proceedings of Human Factors in Computing Systems (CHI '03), pp 513520 ACM Press Fussell, S ... the task As Table demonstrates, we use a small random selection of data consisting of 10 dialogues from each of the Shared Visual Information and No Shared Visual Information conditions Each of...
Ngày tải lên: 24/03/2014, 03:20
Báo cáo khoa học: ""DONNELLAN''''S DISTINCTION AND A COMPUTATIONAL MODEL OF REFERENCE" pptx
... individuating set is the result of the speaker 's beliefs, not a mirror of what is actually the case A speaker may possess two distinct individuating sets that, unbeknownst to him, determine the same object ... Barwise and John Perry Situations and Attitudes The Massachsetts Institute of Technology Press, Cambridge, Massachusetts, 1983 [4] Philip R Cohen Referring as requesting In Proceedings of the ... is utterly insane! ~ To compensate for these weaknesses, BERTRAND uses a strategy based on Grosz 's notion of ffocus stack" [8,10] In conceptual terms (and without going into details), it works...
Ngày tải lên: 31/03/2014, 17:20
báo cáo hóa học: " Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson''''s disease" potx
... actions of NSAIDs whereas inhibition of the constitutively expressed form (COX-1) is responsible for the gastrointestinal side effects [25] In this study we used the intrastriatal administration of ... section series was performed using an optical fractionator probe The precision of the serial section analyses was assessed by the coefficient of error (p < 0.05) TH positive cell bodies were counted ... These results show that celecoxib produced a selective reduction of local microglial reaction in response to the neurotoxin Discussion Regular intake of nonaspirin NSAIDs (and high dose of aspirin)...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx
... traditional image analysis approach Thus, this method is shown to accurately assess amyloid burden in transgenic mouse models of AD In addition, the use of object-based analysis provides data not obtainable ... of the numbers of Aβ-positive objects (or the sum of the areas of the Aβ positive objects) for the entire section and dividing by the sum of the areas of all ROIs This analysis was performed blinded ... performed on sections processed at the same time Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and C3 activation products reactivity...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
... loss instead of a loss of TH expression To determine whether valdecoxib could prevent not only MPTP-induced loss of SNpc dopaminergic neurons but also the loss of striatal dopaminergic fibers, ... ANOVA showed significant differences, pairwise comparisons between means were tested by Bonferroni post hoc testing Statistical significance was set at p < 0.05 for all analyses Results Valdecoxib ... counts were performed by using a computer-assisted image analysis system consisting of a Zeiss Axioskop2Plus photomicroscope equipped with a MS-2000 (Applied Scientific Instrumentation, Eugene,...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... NAPE-PLD expression is elevated on blood vessels and in reactive astrocytes distributed closely around them suggests the synthesis of AEA by brain endothelium in MS [43] In other models of brain injury ... was measured by solid phase sandwich ELISA, using a monoclonal antibody specific for mouse sVCAM-1 (R & D Systems Inc., MN, USA), according to the manufacturer s instructions The assay sensitivity ... not shown) Discussion The ECS has been suggested to contribute to the maintenance of homeostasis between the immune and the nervous systems [34,35] Besides, the pharmacological activation of ECS...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson’s disease" pot
... Diseases & key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes of Biological Sciences (SIBS), Chinese Academy of Science (CAS) & Shanghai Jiao Tong University ... have shorter glial processes, as well as a disordered arrangement and increased expression of CD11b and CD45 Moreover, this increased microglial response is substantiated by enhanced expression of ... hippocampus and inferior temporal gyrus of patients suffering from Alzheimer s disease [36] Down-regulation of CD200 has also been detected in brain of multiple sclerosis (MS) patients [37] These results...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo hóa học: " Application of functional genomics to the chimeric mouse model of HCV infection: optimization of microarray protocols and genomics analysis" potx
... tissue Expression of lipid metabolism genes in human and mouse Expression of lipid metabolism genes in human and mouse liver tissue A Comparison of gene expression levels of lipid metabolism ... the level of cross-species hybridization in any chimeric tissue, thus facilitating the use of genomics in these model systems Methods Dissection of mouse livers and isolation of RNA and genomic ... arrays can be adapted to other chimeric human-mouse systems to facilitate selective analysis of human gene expression Results and discussion Isolation of liver samples with a high ratio of human...
Ngày tải lên: 20/06/2014, 01:20
Báo cáo khoa học: "Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury" potx
... microscopy (Nikon, Japan) Statistical analysis Results were expressed as medians for Olby scores and the means ± SD for SEP values and Luxol fast blue positive areas Statistical analysis used SPSS ... Characterization of ASCs The first passage of ASCs expressed CD44, CD90, CD105 and MHC class I, and were also partially positive for CD34 They did not express CD14 or CD45 The seventh passage of ASCs expressed ... 12.0 software (SPSS, USA) Kruskal-Wallis analysis for Olby scores and oneway ANOVA for SEP values and Luxol fast blue positive areas were used p-value < 0.05 was considered significant Results Differentiation...
Ngày tải lên: 07/08/2014, 23:22
Báo cáo khoa hoc:"The PX-EM algorithm for fast stable fitting of Henderson’s mixed model" ppt
... class of models First, the “sire-maternal grandsire” model (or SMGS model) as described by Bertrand and Benyshek [3], y = Xβ + Zs us + Zt ut + e, (4) where us and ut refer to (q × 1) vectors of ... gain of PX-EM The paper is organized as follows into six sections In Section 2, the general structure of the models is described and in Section a typical EM implementation for these models (called ... iteration of the EM algorithm consists of two steps, the expectation or E step and the maximization or M step In the Gaussian mixed model, this separates the computation into two simple pieces The E-step...
Ngày tải lên: 09/08/2014, 18:21
Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Parkinson''''s disease ppt
... CatWalk system, has been used to detect footfall patterns, as well as selected time and distance measurements of persons with early-stage Parkinson 's disease [41] The GaitRite system comprises an ... each group is expressed as mean ± s. e.m for each condition All statistical tests were performed with SPSS statistical software (version 15) Statistical significance was evaluated using oneway ... exogenous cells may provide better long-term results Stem cells are viewed as a possible source of neurons for cell-based therapies of neurodegenerative disorders, such as Parkinson 's disease and Alzheimer's...
Ngày tải lên: 10/08/2014, 05:21
Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington’s disease pps
... analysis of variance (ANOVA) and Bonferroni post hoc tests All statistical tests required a level of significance of at least P < 0.05 Results Body weights Table shows the mean body weight of all ... http://www.jbiomedsci.com/content/17/1/62 data suggest that the mechanism for increasing GLT1 expression is still functional even in late stage HD Acknowledgements This research was supported by NINDS (R01 NS35663; F31 NS064791) ... Huntington s Disease W.B Saunders London, 1996 Ross CA: Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington s disease and related disorders Neuron 2002, 35(5):819-822 Behrens PF,...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "Comparison of functional residual capacity and static compliance of the respiratory system during a positive end-expiratory pressure (PEEP) ramp procedure in an experimental model of acute respiratory distress syndrome" potx
... acute (FRC) and static compliTime courserespiratory system (Crs) during respiratory distress syn-endance of the respiratory system (Crs) during a decremental positive endexpiratory pressure (PEEP) ... beneficial since it will serve also to increase inflation of lung regions that are already open, increasing the stress and strain on these regions [7] Two studies showed a significant positive correlation ... was the case in the experimental Figure As suggested by our results, such an assessment is a valuable tool to help to identify the optimal level of PEEP It can also be used for trend analysis,...
Ngày tải lên: 13/08/2014, 11:22
Báo cáo y học: " A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms" pps
... The estimates of the rhythmic parameters for each response curve also display reasonable precision, as assessed by the square roots of the mean square errors over 100 repeated simulations As expected, ... regulation of circadian rhythms Statistical models will be developed to infer such genes from observed molecular markers such as single nucleotide polymorphisms (SNPs) Statistical Modeling of Functional ... hypothesis tests for understanding the genetic control of rhythmic responses in organisms As a first attempt of its kind, the model proposed in this article has only considered one QTL associated...
Ngày tải lên: 13/08/2014, 16:21