bmt in philadelphia positive acute lymphoblastic leukemia ph all

... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is ... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... Higher score indicate higher quality of life or fewer problems; *self-reports (n = 27 in the intensive phase and n = 28 in the non-intensive phase); proxy-reports (n = 56 in the intensive phase and...

Ngày tải lên: 18/06/2014, 19:20

... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is ... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... Higher score indicate higher quality of life or fewer problems; *self-reports (n = 27 in the intensive phase and n = 28 in the non-intensive phase); proxy-reports (n = 56 in the intensive phase and...

Ngày tải lên: 20/06/2014, 16:20

... clinical significance of TEL-AML1 as MRD in CD 10 positive ALL is needed to determine how to best integrate TEL-AML1 testing into routine patient care Abbreviations ALL: Acute lymphoblastic leukemia; ... metaphase and on the interphase nuclei of leukemic cells It was measured in newly diagnosed cases (Table 1) and it was positive in 30/80 (37.5%) determining its frequency in B-lineage ALL positive ... frequency of MRD positivity is high after induction and decreases gradually during consolidation and maintenance phase being in some genes 88% during early induction to 13% at week 52 [19] If MRD...

Ngày tải lên: 10/08/2014, 22:20

... Health-related quality of life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy Int J Oncol 1997, 11(2):333-339 ... findings and provide more detailed information on the relationship between sleep and QoL, and on factors affecting sleep in pediatric ALL and in children with cancer in general Abbreviations ALL: ... Hinds et al.[4] performed actigraphy in children with ALL and found that dexamethasone alters sleep During dexamethasone treatment duration of sleep was increased and there was an increase in...

Ngày tải lên: 20/06/2014, 15:20

... alterations in irradiated human peripheral lymphocytes from acute lymphoblastic leukemia (ALL) patients as well as to take them as predictors for radiation toxicity Methods: Peripheral blood lymphocytes ... cell lines (such as human skin fibroblasts, glioblastoma and colon carcinoma lines) and primary lymphocytes [13-15] Furthermore, CD was induced by IR in human hepatoblastoma cell line performing ... PB, peripheral blood; PBLs, peripheral blood lymphocytes; TBI, total body irradiation; IR, ionizing radiation; HVR2, hypervariable region 2; nDNA, nuclear DNA; ALL, acute lymphoblastic leukemia; ...

Ngày tải lên: 09/08/2014, 09:21

... insulin and leptin receptors are located in key brain areas, such as the hypothalamic arcuate nucleus In some cells of hypothalamus, leptin and insulin activate both JAK-STAT and PI3K signaling ... Additionally, both enzymes terminating leptin and insulin function – SOCS3 and PTP-1B – are expressed in the Table Distribution of the of the tested polymorphisms in the study group Genotyping group ... may be the reason of leptin resistance The closed-loop leptin/insulin feedback makes the GH/insulin/leptin relations understandable [30,31] According to Link et al leptin might serve as a good...

Ngày tải lên: 10/08/2014, 10:21

... del(9)(q34.11q34.13) in patients with T-cell acute lymphoblastic leukemia (T -ALL) [4] It has also been reported in a single case of acute myeloid leukemia (AML) [5] SETNUP214 positive T -ALL patients ... screening of 141 leukemia/ lymphoma cell lines of T-, B- and myeloid cell origin to detect SET-NUP214 positive examples A T -ALL cell line LOUCY (1/43 T cell lines tested) and an AML cell line MEGAL ... SET-NUP214 screening in cell lines SET-NUP214 screening in cell lines SET-NUP214 expression screening performed with a SET exon forward primer and a NUP214 exon 18 reverse primer Cell lines LOUCY and...

Ngày tải lên: 10/08/2014, 22:20

... showed that the inhibition of BCL11B expression by siRNA selectively inhibited proliferation and effectively induced apoptosis in human T-cell acute lymphoblastic leukemia (T -ALL) cell lines (Jurkat, ... solid tumors [26] Additionally, our findings indicated no significant difference in SPP1 gene expression in the TALL group Comprehensive analysis revealed that T -ALL occurred in the presence of BCL11B, ... four genes of interest in the healthy controls Discussion Increasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11B mRNA expression in most T -ALL cases [8,12]...

Ngày tải lên: 10/08/2014, 22:21

... prominent, so immunophenotypic results were consistent with precursor-T -acute lymphoblastic leukemia (Pre-T -ALL) Bone marrow cytogenetics revealed a normal karyotype and negative Philadelphia ... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T -ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... [10] All alkylating agents are considered to carry a five to ten percent mutagenic risk potential for development of myeloid leukemia, but not for lymphoblastic leukemia TMZ is a new alkylating...

Ngày tải lên: 11/08/2014, 03:21

... prominent, so immunophenotypic results were consistent with precursor-T -acute lymphoblastic leukemia (Pre-T -ALL) Bone marrow cytogenetics revealed a normal karyotype and negative Philadelphia ... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T -ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... [10] All alkylating agents are considered to carry a five to ten percent mutagenic risk potential for development of myeloid leukemia, but not for lymphoblastic leukemia TMZ is a new alkylating...

Ngày tải lên: 11/08/2014, 07:20

... with acute lymphoblastic leukemia J Clin Oncol 1999, 17:818-824 36 Arico M, Valsecchi MG, Camitta B, et al: Outcome of treatment in children with Philadelphia chromosome -positive acute lymphoblastic ... acute lymphoblastic leukemia N Engl J Med 1998, 338:499-505 17 Erb N, Harms DO, Janka-Schaub G: Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving ... maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia J Clin Oncol 2003, 21:1332-1339 Cunningham L, Aplenc R: Pharmacogenetics of acute lymphoblastic...

Ngày tải lên: 13/08/2014, 13:20

... typically involving grouping genes with correlated expressions into bins and then selecting representatives from each bin, have also been used One of the more interesting recent developments in ... study cover subtypes of ALL, subtypes of acute myeloid leukemia (AML), chronic lymphocytic leukemia, and chronic myelogenous leukemia, proving the general value of GEPs in leukemia diagnosis Nevertheless, ... effects of the training data, and result in prediction failures In contrast, unsupervised learning targets on classifying cases in a dataset into several subgroups by evaluating the major variance...

Ngày tải lên: 10/09/2015, 15:50

... 13 Acute Lymphoblastic Leukemia (ALL) Philadelphia Positive (Ph1 ) (Incidence Classifications, Prognostic Factor in ALL Principles of ALL Therapy) 297 Alicia Enrico and Jorge Milone Chapter 14 Invasive ... Identifying the Etiology of Acute Lymphoblastic Leukemia in Children http://dx.doi.org/10.5772/52716 [37] Infante-Rivard C, Krajinovic M, Labuda D, Sinnett D Childhood acute lymphoblastic leukemia ... components in order to develop the illness (Fig 1) 10 Clinical Epidemiology of Acute Lymphoblastic Leukemia - From the Molecules to the Clinic Figure Interaction among the three phenomena Acute lymphoblastic...

Ngày tải lên: 17/03/2014, 12:20

... distinguishes between acute lymphoblastic leukemia in infants and in older children Blood 1989, 73(2):527-532 Strahler JR, Kuick R, Hanash SM: Diminished phosphorylation of a heat shock protein ... cell line, we found some differences in the protein patterns but overall, these changes were small: Seven proteins (with two variants) were clearly defined in the gastric carcinoma cell line but ... protein expression in AML Patient/SampleNo SpotNo 19 60 91 102 103 104 115 121 122 130 Protein A #0205p 14-3-3 related Annexin 6, Calectrin (67 kDa) FK506 binding protein Ku antigen (86 kDa) Phosphoglycero...

Ngày tải lên: 18/06/2014, 15:20

... might be addressed in future studies However, since the peak incidence of childhood ALL is in young children, obtaining self reports will be a continuing problem in QoL studies during treatment Although ... life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy International journal of oncology 1997, 11:333-339 Hinds ... moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia: Results of protocol ALL VI from the Dutch Childhood Leukemia Study Group Journal of Clinical Oncology...

Ngày tải lên: 18/06/2014, 19:20

... might be addressed in future studies However, since the peak incidence of childhood ALL is in young children, obtaining self reports will be a continuing problem in QoL studies during treatment Although ... life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy International journal of oncology 1997, 11:333-339 Hinds ... moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia: Results of protocol ALL VI from the Dutch Childhood Leukemia Study Group Journal of Clinical Oncology...

Ngày tải lên: 20/06/2014, 16:20

... Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2 Blood 2006, ... Putten W, Bijl MA, Sanders MA, Hugens W, Uitterlinden AG, Erpelinck CA, Delwel R, Lowenberg B, et al.: Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene ... within the juxtamembrane domain of FLT3 has been shown to be phosphorylated in vivo [14] and could be included in the newly described class of FLT3 juxtamembrane domain point mutations for which the...

Ngày tải lên: 10/08/2014, 22:20

... rare presentation of acute lymphoblastic leukaemia in an adult JOP 2010, 11:72-74 Takamatsu T: Preferential infiltration of liver sinusoids in acute lymphoblastic leukemia Rinsho Ketsueki 2001, ... were negative in the infiltrate but were found to be positive in the rare small lymphocytes Bcl2 was also faintly positive CD117, CD23, pan-melanoma marker and pan-cytokeratin were all negative ... biopsy of the liver showing small to medium-sized lymphoblasts infiltrating the hepatic parenchyma Page of Figure Bone marrow biopsy showing lymphoblastic infiltration instructions to follow up...

Ngày tải lên: 10/08/2014, 23:21

... detecting clonally expanded T cells in immune response, at least, in the present CML case To our knowledge, this is the first investigation of T-cell clonal changes in Ph- negative ALL and Ph -positive ... http://www.jhoonline.org/content/3/1/14 Page of 10 Zhang X, Ji L, Liu S, Wang J: Ph- negative acute lymphocytic leukemia occurring after interferon therapy for Ph -positive chronic myelocytic leukemia ... (IM) ND -ve ND 8/10/2006 Ph- negative ALL 46, XX [25] -ve -ve 18/12/2006 Post CT for ALL 46, XX [25] -ve -ve FISH 8/10/2000 RT-PCR CP: chronic phase; ALL: acute lymphoblastic leukemia; CCR: complete...

Ngày tải lên: 10/08/2014, 22:21

... Lea & Febiger, Philadelphia, 1986 Kass L Leukemia, Cytology and Cytochemistry pp 167-188, Lippincott, Philadelphia, 1982 Khan KNM, Kociba GJ, Wellman ML Macrophage tropism of feline leukemia virus ... form of leukemia in cats infected with FeLV is of the lymphoid lineage [12], a myeloid lineage was the affected progenitor subset found in the patient described in this study This finding may ... Histopathologically, massive neoplastic cells contained round, finely chromatic nuclei; amphophilic cytoplasm infiltrated these organs Detection using ANAE and β-GLU staining yielded 100% positive...

Ngày tải lên: 07/08/2014, 20:23