bmal1 npas2 and the circadian clock
Tài liệu Báo cáo khoa học: The miRNA-192 ⁄194 cluster regulates the Period gene family and the circadian clock doc
Ngày tải lên :
18/02/2014, 06:20
... regulated in a circadian fashion, no core components of the circadian clock were found This suggests that these miRNAs affect the circadian clock via indirect mechanisms The identification of the miR-192 ... additional targets other than the Per genes that assist in the regulation of the circadian clock However, the alteration of the circadian rhythm seems to be in good agreement with the effects of knockout ... Regulation of the circadian clock by miR-192 ⁄ 194 R Nagel et al are of major importance in the control of the circadian clock The phosphorylation and degradation of Per proteins...
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Báo cáo y học: "Phase delaying the human circadian clock with a single light pulse and moderate delay of the sleep/dark episode: no influence of iris color" potx
Ngày tải lên :
10/08/2014, 09:20
... [9,10], and the duration and pattern of the light pulse(s) [11-14] As the converse of light exposure, the timing or duration of the sleep/dark episode can also phase shift the circadian clock [15-19] ... (baseline and final), the higher of the two thresholds was applied to both profiles to calculate the DLMO The DLMO was the point at which the fitted curve exceeded and remained above the threshold ... ensure that the light level was close to the targeted illuminance To this a research assistant told the subject to "freeze" in the position the subject was sitting, and then measured the light...
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clockwork orange and the age of mechanical reproduction
Ngày tải lên :
21/03/2014, 21:59
... too, but most of the roots are Slavic Propaganda Subliminal penetration" (from the book.) A clockwork orange, in the words of the Author within the book: "A Clockwork Orangethe attempt to impose ... on the moon and circling the earth, but there is no care taken here below." Technology has progressed but left the earth behind, no morality, and no ethics The old has failed to adapt to the ... fulfillment, and emancipation from the horrors of a dystopian society in the throws of cancerous emptying of meaning The bum says in first scene: "The problem is there is no law and order, there are...
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Báo cáo khoa học: Regulation of output from the plant circadian clock pot
Ngày tải lên :
23/03/2014, 10:20
... attract moths [49] These rhythms are controlled by the clock and are probably a result of circadian changes in mRNA levels and enzyme activity in the biosynthesis pathway and in the levels of available ... of the circadian system during development The circadian clock controls many developmental processes throughout the life cycle of the plant Some of these processes take place on a daily basis and ... for example, the synthesis of LHCB and RCA in tomato is regulated by the circadian system [61] The rhythm of expression of photosynthesis genes appears to be correlated with the circadian rhythms...
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Báo cáo sinh học : " Notch signaling, the segmentation clock, and the patterning of vertebrate somites" pptx
Ngày tải lên :
06/08/2014, 19:20
... including Notch ligand genes and the Hes/her genes themselves The role of Notch signaling in pattern formation depends on the ways in which these components and others that modulate their activity ... In the posterior part of the PSM, the level of expression may be high or low, depending on the phase of the oscillation cycle at the moment when the embryo was fixed In the anterior part of the ... speed Individual cell clocks in different phases of the clock cycle Caudal growth Figure Somitogenesis and the segmentation clock (a) The pattern of expression of one of the oscillatory genes...
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Báo cáo y học: "Controlling Osteogenesis and Adipogenesis of Mesenchymal Stromal Cells by Regulating A Circadian Clock Protein with Laser Irradiation" pptx
Ngày tải lên :
08/08/2014, 17:20
... in these feedback loops is the shutdown of CLOCK- and BMAL1- driven transcription by CRY proteins BMAL1 and CLOCK contain two basic helix-loop-helix domains and bind E-box elements (CACGTG) in the ... in the Per and Cry clock genes to activate their transcription This activity is a positive feedback loop of circadian rhythm regulation.7 The mammalian Period proteins (PER1 and PER2) and Cryptochrome ... simple and effective technology for clock protein localization and turnover In addition, transcriptional regulation is also fundamental to the circadian oscillations of clock gene expression The...
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Báo cáo y học: "The rate of the molecular clock and the cost of gratuitous protein synthesis." pps
Ngày tải lên :
09/08/2014, 22:23
... out the experiments and computational analyses DV, MG and GP conceived the experiments and analyzed the results DV and GP wrote the paper with revisions by MG All authors read and approved the ... protein Because the misfolded LacZ proteins are both potentially toxic and also devoid of biological function, the comparison of the growth rates of bacteria carrying the WT and each of the destabilized ... investigated the possibility that the toxicity of misfolded proteins was more pronounced on a relatively poor carbon source by measuring the growth of the E coli V567D and F758S mutants and the WT...
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Báo cáo y học: "Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal" pps
Ngày tải lên :
10/08/2014, 09:20
... the p-value of circadian rhythm coming from cosine function fitting The hour in the table is the time of clock hour for the acrophase of the fitted cosine function advances the phase of the circadian ... immunohistochemistry and western blot JMD helped with the English writing of the paper ZW directed the study and wrote the final version of the manuscript All authors read and approved the final version of the ... mammals, circadian rhythms are regulated by the central circadian pacemaker in the SCN In order for the organism to adapt to the environment, the circadian rhythms must be synchronized to the environmental...
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Báo cáo y học: "Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawa" docx
Ngày tải lên :
10/08/2014, 09:20
... allowed the adjustment of the height of the camera and the adjustment of the angle and distance between the camera and the animal cage The camera was set in such a way that the longest side of the ... on the entire body and these markers prevent free animal behaviour) and is costly Running-wheel systems fail to record activity when the animal is not on the wheel and may induce changes in circadian ... from the first module are sent to the standard output: every 25th fraction of a second, a string containing the time and the number of pixels changed, compared to the previous frame, is sent to the...
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Báo cáo y học: "Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice" pot
Ngày tải lên :
10/08/2014, 09:20
... lacking the circadian clock gene Bmal1, and are rescued by virally-mediated restoration of Bmal1 expression selectively in the DMH (but not in the SCN) The two studies appear to establish that the ... AAV -BMAL1 directly into either the SCN or the DMH of Bmal1- /- mice selectively restored Bmal1 expression in these structures, and selectively rescued light-entrainable and foodentrainable circadian ... activity, and therefore temperature, if high prior to mealtime, normally remain elevated at least through the expected mealtime), the data may be misaligned, and the waveforms shifted to the left or the...
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Báo cáo y học: "NPAS2 and PER2 are linked to risk factors of the metabolic syndrome" pps
Ngày tải lên :
10/08/2014, 09:20
... Arntl1 and Ncoa because it has significant sequence homology with Clock and therefore a possible role in the circadian clock [25,26] Both candidate SNPs and tag-SNPs were included in this study Candidate ... stimuli from the habitat and drive for the clockwork, because the reduced forms of nicotinamide adenine dinucleotide cofactors stimulate DNA binding of the NPAS2- ARNTL [15] and CLOCK- ARNTL [16] ... dependence, and other substance dependence and abuse As part of the assessment, the participants filled in the items of lifetime seasonal variations in mood and behavior taken and adapted from the Seasonal...
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Architecture and the UML
Ngày tải lên :
22/08/2012, 10:37
... class diagram shows the existence of classes and their relationships in the logical view of a system UML modeling elements in class diagrams - Classes and their structure and behavior - Association, ... provide to the actor when the use cases is executed Typical contents - How the use case starts and ends Normal flow of events Alternate flow of events Exceptional flow of events 10 Uses and Extends ... and its subclasses There are two ways to find inheritance: - Generalization - Specialization Common attributes, operations, and/ or relationships are shown at the highest applicable level in the...
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Modifying the original CLOCKDEMO drawing
Ngày tải lên :
27/08/2012, 14:31
... 2DMESH by: a) specifying the four corners of the mesh b) entering the M and N sizes The 3DMESH values M and N can be between and 256 A 3DMESH is a single object The command can be activated: a) ... values of 12, 24 and 36 and add a ruled surface between the other lines and arcs Note: a) The system variable SURFTAB1 controls the display of the ruled surface effect, i.e the number of ‘strips’ ... 2004 The direction of the revolved surface is controlled by the sign of the included angle and: a) ϩve for anti-clockwise revolved surfaces b) Ϫve for a clockwise revolved surface The command...
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Cambridge.University.Press.Allegories.of.Union.in.Irish.and.English.Writing.1790-1870.Politics.History.and.the.Family.from.Edgeworth.to.Arnold.Oct.2000.pdf
Ngày tải lên :
21/09/2012, 10:39
... to the toiling and dying types who made it over to America And once in America, people divided once again: you could say they became the poor and the rich The losers and winners The artists and ... narrative structure, and to the kind of stories that get told and retold about the Irish, so as to reveal both the regularity of English colonial discourse on Ireland and the Irish and the mutations ... take up and extend Said’s insight, in Culture and Imperialism, that the ‘‘convergence between the patterns of narrative authority constitutive of the novel on the one hand, and, on the other, a...
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Cambridge.University.Press.Brittany.and.the.Angevins.Province.and.Empire.1158-1203.Oct.2000.pdf
Ngày tải lên :
21/09/2012, 10:46
... on these estates The other contingent lacked the unity of the Richmond tenants These were Bretons from the north-east of the duchy who received grants of land in the midlands, the south-west and ... ± The barons of Leon and Penthievre could construct forti®cations without the permission of the duke;  Á ± The barons of Leon and Penthievre had the right of wreck on the shores of their lands; ... Blain and the à forest of Le Gavre.24 South of the Loire, ducal domains included the castellany of Le Pallet,25 estates on the south bank of the Loire and another in the extreme south-west of the...
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Cambridge.University.Press.Gender.Race.and.the.Writing.of.Empire.Public.Discourse.and.the.Boer.War.Sep.1999.pdf
Ngày tải lên :
21/09/2012, 10:54
... Night and the following day, they were ‘‘everyone’’ and ‘‘London’’ and even ‘‘England.’’ They were created as a group by the newspapers, and this chapter examines the mechanism of their creation and ... the food stocks, and the mood of the garrison The tactics of the Daily Mail captured the attention of the nation; the newspaper dramatized the situation of the town by emphasizing the danger that ... don’t know they know the public’’ (quoted in Koss Rise and Fall ) The Victorian cult of personality had moved into the press by the turn of the century, and the military version of the focus...
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Cambridge.University.Press.Globalisation.and.the.Western.Legal.Tradition.Recurring.Patterns.of.Law.and.Authority.Mar.2008.pdf
Ngày tải lên :
21/09/2012, 10:54
... the Netherlands, Luxembourg, Switzerland, north-east Spain and northern and papal Italy – are clearly within the Western and European purview.7 Ancient Greek philosophy, Jewish spirituality and ... on the mountain There is the hint in the Rembrandt that the seventeenth-century interpretation of Moses had him invested with more personal agency in the carriage of the laws; neither God nor the ... the rise of the state 6.1 The birth of the state 6.2 Legal diversity and universality in the emerging European states 6.3 The decline of the Christian commonwealth 6.4 The arrival of the state...
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Cambridge.University.Press.Poe.and.the.Printed.Word.Jul.2000.pdf
Ngày tải lên :
21/09/2012, 10:58
... Sinbad the Sailor Poe and the printed word and Jack and the Beanstalk; new London editions of these two works appeared the year the Allan family came to England.3 So did new editions of The History ... the Rotunda: ``They have nearly ®nished the Rotunda ± The pillars of the Portico are completed and it greatly improves the appearance of the whole ± The books are removed into the library ± and ... from the form of their original publication, and these removals affect interpretation The appearance of the printed page, however, shapes the reader's understanding of the text it contains ``The...
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Cambridge.University.Press.Press.Politics.and.the.Public.Sphere.in.Europe.and.North.America.1760-1820.Jul.2002.pdf
Ngày tải lên :
21/09/2012, 10:58
... variety of approaches They examine the structure of the press; the methods used to control it by political authorities and their effectiveness; the journalistic texts themselves; and the political role ... texts, their presentation and format, the topics they covered, the way issues were presented and the messages, overt and implicit, that they contained Such a comprehensive approach to the comparative ... political press was the product of the struggles for independence from Britain and to forge a new nation, and in the Netherlands, the outcome of the Patriot Revolution of the s In France...
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Cambridge.University.Press.The.Crisis.of.Literature.in.the.1790s.Print.Culture.and.the.Public.Sphere.Nov.1999.pdf
Ngày tải lên :
21/09/2012, 11:00
... conservative propaganda, and with the break up of the radical associations and the consequent erosion of the links between these organisations and other intellectual currents and circles, the conditions ... of the age The complex intersection of these two histories – the political turmoil of the 1790s and the broader hegemonic shift towards the meritocratic bias of the professional classes – demands ... Wordsworth’s observation gathers together fears about the French Revolution, the Industrial Revolution, and 10 The Crisis of Literature in the 1790s the information revolution ( the rapid communication...
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