biomarkers in head and neck cancer

... NHS National Institute for Clinical Excellence Guidance on Cancer Services Improving Outcomes in Head and Neck Cancers The Manual Improving Outcomes in Head and Neck Cancers Cancer service ... from head and neck cancers, are discussed in Improving Outcomes in Haematological Cancers.4 There are marked regional variations in the incidence of head and neck cancers, with rates ranging from ... “UAT cancer refers to the majority of cancers in this group; head and neck cancer will be used when all, including thyroid cancer, are being discussed Table 1a Registrations, incidence, and...

Ngày tải lên: 22/03/2014, 16:21

... Scottish Intercollegiate Guidelines Network (SIGN), Diagnosis and management of head and neck cancer A national clinical guideline, Edinburgh (Scotland): Scottish Intercollegiate Guidelines Network ... research and clinical purpose in order to determine the global functional outcome of speech and voice after the treatment of head and neck cancer It allows quantifying the intelligibility also in severely ... breathing in and closing the hole in the neck When the patient breathes out, the air will be detoured through the one-way valve and stream from the trachea into the oesophagus The tissue in the...

Ngày tải lên: 21/06/2014, 20:20

... volume delineation in head- and- neck cancer using CT and PET/CT fusion Int J Radiat Oncol Biol Phys 2006, 65:726-732 Black QC, Grills IS, Kestin LL, Wong CY, Wong JW, Martinez AA: Defining a radiotherapy ... Cummings B, Dawson L, Keller A, Kim J, Ringash J, Yu E, Hendler A, Waldron J: Intraobserver and interobserver variability in GTV delineation on FDG-PET-CT images of head and neck cancers Int ... A, Bunkheila F, Fuccio C, Spezi E, Angelini AL, Barbieri E: Combined 18F-FDG-PET/CT imaging in radiotherapy target delineation for head- and- neck cancer Int J Radiat Oncol Biol Phys 2009, 73:759-763...

Ngày tải lên: 09/08/2014, 09:20

... radiathion therapy in head and neck cancers: an update Head and Neck 2007, 29:387-400 Popovtzer A, Eisbruch A: Advances in radiation therapy of head and neck cancer Expert Rev Anticancer Ther 2008, ... Marsh LH, Ship JA: Dose, volume and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer Int J Radiat Oncol Biol Phys ... contoured by the planner and included as follow: spinal cord, brain stem, left and right parotids; larynx and uninvolved oral cavity were outlined whenever not heavily included in the target Whenever...

Ngày tải lên: 09/08/2014, 09:20

... Definitive Radiotherapy for Locally Advanced Head- and- Neck Cancer International Journal of Radiation Oncology*Biology*Physics 2009, 73:410-415 Cooper J, Fleming ID, editors, HD: Head and Neck Cancer ... swallowing dysfunction after curative radiotherapy in head and neck cancer Radiotherapy and Oncology 2009, 90:189-195 Joke W, Kim De R, Duprez F, et al: Acute Normal Tissue Reactions in Head- and- Neck ... Huguenin PU, Davis JB, Kunz G, Lutolf UM, Glanzmann C: IMRT using simultaneously integrated boost (SIB) in head and neck cancer patients Radiat Oncol 2006, 1:7 Feng Y, Kim MHyungjin, et al: Intensity-Modulated...

Ngày tải lên: 09/08/2014, 09:20

... Urba S, Lin A, Schipper MJ, Wolf GT: Recurrences near base of skull after IMRT for head- and- neck cancer: implications for target delineation in high neck and for parotid gland sparing Int J Radiat ... failure in patients receiving definitive and postoperative IMRT for head- and- neck cancer Int J Radiat Oncol Biol Phys 2003, 55:312-321 Puri DR, Chou W, Lee N: Intensity-modulated radiation therapy in ... function sparing in patients with head- and- neck cancers receiving intensitymodulated or three-dimensional radiation therapy: initial results Int J Radiat Oncol Biol Phys 2001, 49:907-916 Vineberg...

Ngày tải lên: 09/08/2014, 10:20

... Her-2, Her-3, and Her-4) These receptors are composed of an extra-cellular ligand-binding domain, a hydrophobic transmembrane segment, and an intracellular tyrosine kinase domain Binding to EGFR ... transducers in head and neck cancer (SCCHN) Anticancer Res 2005, 25:1871-1875 Raben D, Bianco C, Milas L, Ang KK: Targeted therapies and radiation for the treatment of head and neck cancer: are we making ... regarding overall survival [29] Tyrosine kinase inhibitors (TKI) and RT In preclinical studies, when gefitinib was combined to RT, strikingly greater than additive effects were observed in vivo...

Ngày tải lên: 09/08/2014, 10:20

... regularly in our joint clinics at the Department of Head and Neck Surgery or Head, Neck and Maxillofacial Surgery Further follow up visits were scheduled every – months in the first years, – monthly in ... has been defined by contouring the anatomic region of the initial primary and nodal GTV, considering the preoperative diagnostics and the clinical and histological findings The PTV1 includes the ... Patterns of failure in patients receiving definitive and postoperative IMRT for head- and- neck cancer Int J Radiat Oncol Biol Phys 2003, 55(2):312-321 Feng M, Jabbari S, Lin A, Bradford CR, Chepeha...

Ngày tải lên: 09/08/2014, 10:21

... advanced head and neck squamous cell carcinoma treated with a multiagent concurrent radiochemotherapy with 5-FU and cisplatin during weeks and [22] The tumor was located in the oropharynx in 52% ... Boffetta P, Winkelman R, Garfinkel L: Tobacco smoking, alcohol drinking, and cancer of the oral cavity and oropharynx among U.S veterans Cancer 1993, 72:1369-1375 Lagiou P, Georgila C, Minaki P, ... pulmonary screening in newly diagnosed head and neck cancer Head Neck 2005, 27:990-994 19 Staar S, Rudat V, Stuetzer H, Dietz A, Volling P, Schroeder M, Flentje M, Eckel HE, Mueller RP: Intensified...

Ngày tải lên: 09/08/2014, 09:20

... the intraindividual and interindividual variations were determined in the four healthy donors and in the 79 patients Intraindividual variation for healthy donors was always lower than interindividual ... radiation induced toxicity Methods Seventy nine consecutive patients with histological confirmed cell carcinoma of head and neck, diagnosed and treated in our institution and given inform consent, ... patient and the tumour type The aim of the present study was to analyze radio-induced apoptosis of peripheral blood lymphocytes in head and neck cancer patients and explore their role in predicting...

Ngày tải lên: 09/08/2014, 10:20

... QOL in patients with head- andneck cancer [11] It contains seven symptom scales and six symptom items It is designed to be used together with the core QLQ-C30 and has been validated in 622 head- andneck ... gland in milliliters per minute (ml/min) The left and right parotid flow rates were added together and converted into the percentage of baseline flow rates (flow ratio) A complication was defined ... not only the parotid glands are responsible for the dry mouth feeling There might be an influence of the submandibular glands and/ or the minor salivary glands of the palate In our analysis neither...

Ngày tải lên: 09/08/2014, 10:21

... inhibitor-kappaB kinase (IKK)α/β/γ and casein kinase complexes modulating NFκB1, RELA and cREL, and alternative pathways involving NF-κB inducing kinase and IKKα modulating NFκB2 and RELB [1,2,11,24-26] ... colony-stimulating-factor; HNSCC, head and neck squamous cell carcinoma; IGF, insulin-like growth factor; IκB, inhibitor kappaB; IKK, inhibitor-kappaB kinase; IL, interleukin; IL-R, interleukin receptor; ... sensitivity in head and neck squamous cell carcinoma lines Head Neck 2003, 25(8):654-661 Ongkeko WM, Altuna X, Weisman RA, Wang-Rodriguez J: Expression of protein tyrosine kinases in head and neck squamous...

Ngày tải lên: 14/08/2014, 08:20

... against infection and invading connective tissue There are still very few studies applying the methods of tissue engineering to produce tracheal replacements and to examine these in vitro and in ... this technique and bearing in mind the contraindications, more than 90% of the children can nowadays be extubated without problems In spite of the progress, in children undergoing single-step surgical ... intubation over several days as an intratracheal splinting An external splinting by metallic microplates in the surgical tracheal reconstruction was described first time by Zalzal and Deutch in...

Ngày tải lên: 25/10/2013, 08:20

... symptoms suggestive of head and neck cancer 3.2 diagnosis and staging Diagnosis and staging of head and neck malignancy will normally include clinical examination by an experienced clinician, fibre ... PRESENTATION, SCREENING AND RISK FACTORS 2.4 presenting with head and neck cancer The most appropriate primary care setting in which to advise patients seeking help for suspected head and neck cancer has ... including dental and medical practitioners, should be aware of the presenting features of head and neck cancer, and the local referral pathways for suspected cancers screening for head and neck...

Ngày tải lên: 14/02/2014, 22:20

... vindrelbine with cisplatin in concomitant chemoradiotherapy in head and neck cancer; Ind J Med Peadtr Onco 2010 31 (1): 4-7 Hypopharyngeal Cancer Valentina Krstevska Department of Head and Neck ... 10 Head and Neck Cancer The future direction in head and neck cancer management in Africa is promising because both governments and non-governmental organizations are establishing various cancer ... Fontemaggi and Giovanni Blandino Cell Signalings and the Communications in Head and Neck Cancer Yuh Baba, Masato Fujii, Yutaka Tokumaru and Yasumasa Kato 73 123 Chapter Role of ING Family Genes in Head...

Ngày tải lên: 08/03/2014, 00:20

... Guide to NECK DISSECTION CLASSIFICATION AND TNM STAGING OF HEAD AND NECK CANCER Committee for Head and Neck Surgery and Oncology American Academy of Otolaryngology– Head and Neck Surgery Neck Dissection ... guide to neck dissection classification and TNM staging of head and neck cancer / Committee for Neck Dissection Classification, American Head and Neck Society [and] Committee for Head and Neck Surgery ... Congress Cataloging -in- Publication Data Pocket guide to neck dissection classification and TNM staging of head and neck cancer — 3rd ed / Committee for Head and Neck Surgery and Oncology, American...

Ngày tải lên: 15/03/2014, 00:20

... ALL HEAD AND NECK CANCERS REDUCING RISK The risk of having head and neck cancer can be reduced by: B B not smoking or chewing tobacco C increasing the intake of fruit and vegetables ... and fish oils C reducing the intake of red meat, fried food and fat limiting alcohol consumption, in line with government guidelines PRESENTATION AND SCREENING All healthcare practitioners, including ... be used in the investigation of head and neck masses D All patients with head and neck cancer should have direct pharyngolaryngoscopy and chest X-ray with symptomdirected endoscopy where indicated...

Ngày tải lên: 15/03/2014, 01:20

... no staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of ... (DakoCytomation, Carpinteria, CA) at 95°C, for 10 and 40 min, for Her3 and Her2 staining respectively To minimize non-specific staining, the section was incubated with protein block (DakoCytomation) ... membranous staining and Her3 (b, membranous and cytoplasmic staining, and c, predominant cytoplasmic staining) 400 × magnification Takikita et al Journal of Translational Medicine 2011, 9:126...

Ngày tải lên: 18/06/2014, 22:20

... strong (3+), and 26% showed no TLR4 staining (Figure 1; Table 3) TLR4 staining (all scores) showed a diffuse and fine granular cytoplasmatic pattern Distinct membrane staining was observed in some ... CW and GL participated in collection and assembly of data CP and AS participated in data analysis and interpretation CB, HSB, AB and AS wrote the manuscript All authors read and approved the final ... receptors in regulatory T cells of patients with head and neck cancer Arch Otolaryngol Head Neck Surg 2010, 136:1253-1259 32 Auman JT, McLeod HL: Cancer pharmacogenomics: DNA genotyping and gene...

Ngày tải lên: 18/06/2014, 22:20