biomarkers in acute kidney injury

... other urine and plasma biomarkers of AKI that have been measured in this cohort, including urinary IL-18, serum/urinary neutrophil-gelatinase-associated lipocalin (NGAL), urinary kidney injury ... patients with acute kidney injury (AKI) following cardiopulmonary bypass (CPB) (a) Serum IL-6 was determined IL-8 are increased in patients with acute kidney injury (AKI) following cardiopulmonary ... children undergoing CPB surgery were considered for study; 29 were excluded for nephrotoxin use Acute kidney injury (AKI) was defined by a 50% or greater increase in serum creatinine within a 3-day...

Ngày tải lên: 13/08/2014, 16:21

... Intensive Care Medicine met in Vicenza, Italy, in September 2004 They proposed the term acute kidney injury (AKI) to reflect the entire spectrum of ARF, recognizing that an acute decline in kidney ... markers for kidney injury are not currently available in clinical practice Several groups are working on developing and validating biomarkers of kidney injury and GFR which may be used in the future ... Table Diagnostic criteria for acute kidney injury An abrupt (within 48 hours) reduction in kidney function currently defined as an absolute increase in serum creatinine of more than or equal to...

Ngày tải lên: 13/08/2014, 03:20

... therapy Curr Opin Nephrol Hypertens 2007, 16:64-70 21 Ronco C: Continuous dialysis is superior to intermittent dialysis in acute kidney injury of the critically ill patient Nat Clin Pract Nephrol ... the serum creatinine reached approximately mg/dl and were dialyzed to maintain a predialysis BUN of < 60 mg/dl in the intensive treatment arm and approximately 100 mg/dl in the non-intensive arm ... January 2003 in a single center in the United Kingdom and who were treated with post-operative CVVH In 28 patients, CVVH was not initiated until the BUN was at least 84 mg/dl, the creatinine was at...

Ngày tải lên: 13/08/2014, 08:20

... tidal volume has been found in acute lung injury (ALI) patients, possibly reflecting ventilatorassociated lung injury [4] The EBC pH has been related to the extent of lung injury, and a good correlation ... decrease proinflammatory cytokine expression, chemokine mRNA induction, and the resultant neutrophil lung infiltrate in an animal model of endotoxin-induced ALI [24] More recently, Perkins and colleagues ... agonist salbutamol and acute lung injury: an association with improvement in acute lung injury Crit Care 2006, 10:R12 27 Morina P, Herrera M, Venegas J, mora D, Rodríguez M, Pino E: Effects of nebulized...

Ngày tải lên: 13/08/2014, 11:22

... Beginning and Ending Supportive Therapy for the Kidney (B.E.S.T Kidney) Investigators Writing Committee: Patient and kidney survival by dialysis modality in critically ill patients with acute kidney ... Network: Intensity of renal support in critically ill patients with acute kidney injury N Engl J Med 2008, 359:7-20 11 Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart ... comparisons of intermittent and continuous therapies in acute kidney injury: what they mean? Int J Artif Organs 2008, 31: 213-220 23 Clark WR, Letteri JJ, Uchino S, Bellomo R, Ronco C: Recent clinical...

Ngày tải lên: 13/08/2014, 11:22

... ureteral ligation Glycerol-induced kidney injury Cisplatin-induced kidney injury 2E1 ↑ Uranyl nitrate induced kidney injury 3A1 (3A23) ↑ Uranyl nitrate induced kidney injury 3A2 ↓ ↔ ↓ ↔ Nephrectomy ... nitrate induced kidney injury 2C6 ↔ ↔ ↔ ↓ Nephrectomy Bilateral ureteral ligation Glycerol-induced kidney injury Cisplatin-induced kidney injury 2C11 ↓ Uranyl nitrate induced kidney injury 2D2 ↔ ... Glycerol-induced kidney injury Cisplatin-induced kidney injury Data from [24,25,75] ↑, increase; ↓, decrease; ↔, no change; AKI, acute kidney injury; CYP, cytochrome P450 change in CYP activity in...

Ngày tải lên: 13/08/2014, 11:23

... been validated in clinical practice, particularly in the acute setting [18] In designing the protocol, we recognized that combining continuous and intermittent modalities into a single treatment ... conference on continuous renal replacement therapy Kidney Int 2002, 62:1855-1863 Palevsky PM: Clinical review: timing and dose of continuous renal replacement therapy in acute kidney injury Crit Care ... Beginning and Ending Supportive Therapy for the Kidney (B.E.S.T Kidney) Investigators Writing Committee: Patient and kidney survival by dialysis modality in critically ill patients with acute kidney...

Ngày tải lên: 13/08/2014, 16:21

... classification [24] for acute kidney injury GFR criteria Urine output criteria Risk Increase plasma creatinine ×1.5 or GFR decrease > 25% < 0.5 ml/kg/h × h Injury Increase plasma creatinine ×2 or GFR decrease ... Physicians India 1997, 45:850-852 36 Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury ... Clinical review: timing and dose of continuous renal replacement therapy in acute kidney injury Crit Care 2007, 11:232 40 Baudouin SV, Wiggins J, Keogh BF, Morgan CJ, Evans TW: Continuous veno-venous...

Ngày tải lên: 13/08/2014, 19:20

... Competing interests The authors declare that they have no competing interests References Thakar CV, Christianson A, Freyberg R, Almenoff P, Render ML: Incidence and outcomes of acute kidney injury ... therapy in critically ill patients N Engl J Med 2009, 361:1627-1638 The VA/NIH Acute Renal Failure Trial Network: Intensity of renal support in critically ill patients with acute kidney injury ... (Beginning and Ending Supportive Therapy for the Kidney) has examined the clinical Page of (page number not for citation purposes) parameters associated with successful cessation of continuous...

Ngày tải lên: 13/08/2014, 20:21

... Page of Table Baseline characteristics of patients with and without acute kidney injury No acute kidney injury Number Acute kidney injury p value 12 Age (yr)* 70 ± 17 57 ± 12 0.05 Male n (%) 2(25%) ... aspect of acute kidney injury We demonstrated for the first time that FGF-23, a critical regulator of mineral metabolism in chronic kidney disease, is upregulated during acute kidney injury from ... Research Baseline creatinine was defined as the lowest creatinine from the 365 days before admission until the episode of AKI for AKI subjects For control subjects, baseline creatinine were the...

Ngày tải lên: 21/06/2014, 03:20

... severity for acute kidney injury based on changes in either serum creatinine or urine output from the baseline condition This allows classification of patients with acute kidney injury into one of ... with acute kidney injury as the endpoint, and P = 0.019 for the model with maximum Risk, Injury, Failure, Loss, and End-stage Kidney (RIFLE) class failure as the endpoint ney injury defined by ... classified according to the maximum Risk, Injury, Failure, Loss, and End-stage Kidney (RIFLE) class No acute kidney injury (n = 1,766) Risk (n = 670) Injury (n = 1,436) Failure (n = 1,511) All injury (n...

Ngày tải lên: 12/08/2014, 23:23

... acute kidney injury and incidence from the Australia New Zealand Intensive Care Society Adult Patient Database, 1996–2005 acute kidney injury and incidence from the Australia New Zealand Intensive ... examining for trends in incidence over time is unfortunate when taking into account the poor clinical outcome and high cost of care for critically ill patients with AKI [10,13,32] The key findings ... with the exception of a rise in AKI associated with admissions for acute metabolic/poisoning conditions Interestingly, however, we found a declining trend in the incidence of AKI associated with...

Ngày tải lên: 13/08/2014, 03:21

... us in recruiting patients, but also serve as clinical endpoints for evaluating interventions in AKI In the future, outcomes in AKI will include intermediate endpoints, such as prevention in progression ... JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury Crit Care 2007, 11:R31 ... Changes in the incidence and outcome for early acute injury in a cohort of Australian intensive care units Crit Care 2007, 11:R68 Ympa YP, Sakr Y, Reinhart K, Vincent JL: Has mortality from acute...

Ngày tải lên: 13/08/2014, 08:20

... the Acute Kidney Injury Network: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury Crit Care 2007, 11:R31 Ricci Z, Ronco C: Year in review: critical ... ml/min per 1.73 m2 The original pediatric Risk, Injury, Failure, Loss, End Stage Kidney Disease criteria [21] for acute kidney injury (AKI) also include pRIFLE L (loss) and pRIFLE E (end stage kidney ... after sustaining AKI The center lines represent the median values and the two outer lines represent the interquartile range AKI, acute kidney injury; pRIFLE, pediatric modified Risk, Injury, Failure,...

Ngày tải lên: 13/08/2014, 08:20

... is injurious in the acutely injured lung In a rat model of acid-induced lung injury, Frank and colleagues showed that lung endothelial and epithelial injury were minimized by a reduction in tidal ... McClintock et al Figure distress syndrome Biomarkers of inflammation in acute lung injury and acute respiratory distress syndrome Comparison of plasma levels of biomarkers of inflammation in 50 ... not for citation purposes) Figure injury and acute respiratory distress syndrome Biomarkers of disordered coagulation and fibrinolysis in acute lung injury and acute respiratory distress syndrome...

Ngày tải lên: 13/08/2014, 08:21

... the Kidney (BEST Kidney) Investigators: Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury J Crit Care 2008 [Epub ahead of print] ... Available online http://ccforum.com/content/12/4/169 10 11 12 13 14 15 16 17 18 19 20 Bagshaw SM, George C, Bellomo R: Changes in the incidence and outcome for early acute kidney injury in a cohort ... Care 2008 [Epub ahead of print] The VA/NIH Acute Renal Failure Trial Network: Intensity of renal support in critically ill patients with acute kidney injury N Engl J Med 2008, 359:7-20 Ronco C:...

Ngày tải lên: 13/08/2014, 11:22

... Mortality according to acute kidney injury stratified by the Risk, Injury, Failure, Loss of Kidney Function, End-stage Kidney Disease (RIFLE) and the Acute Kidney Injury Network (AKIN) definition/classification ... (creatinine + urine output) AKIN criteria (creatinine + urine output) 0.750 RIFLE criteria (creatinine) 0.729 AKIN criteria (creatinine) 0.745 RIFLE criteria (urine output) 0.619 AKIN criteria (urine ... Molitoris BA, Ronco C, Warnock DG, Levin A, Acute Kidney Injury Network: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury Crit Care 2007, 11:R31 14 Manjunath...

Ngày tải lên: 13/08/2014, 11:22

... carried out by infusion of benzodiazepines Classification of acute kidney injury AKI was classified by a dynamic classification scheme with three levels for acute renal dysfunction: Risk, Injury, and ... Data are mean (95% confidence interval) or number of patients Acute kidney injury is classified by RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease) Multiple organ ... renal replacement therapy, plasma creatinine was within the reference range during the first day after injury in all cases but one, whose plasma creatinine was 126 μmol/L All four had multiple...

Ngày tải lên: 13/08/2014, 11:23

... (a) incidence (%) and (b) ICU mortality (%) AKI, acute kidney injury; ESRF, end-stage renal failure; ICU, intensive care unit; OF, maximum associated organ failure during stay in ICU (excluding ... Tolwani A, Ronco C, for the Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Acute renal failure in critically ill patients: a multinational, multicenter study ... Program of Improve Care in Acute Renal Disease: Spectrum of acute renal failure in the intensive care unit: the PICARD experience Kidney Int 2004, 66:1613-1621 Uchino S, Kellum JA, Bellomo R,...

Ngày tải lên: 13/08/2014, 11:23

... Beginning and Ending Supportive Therapy for the Kidney (B.E.S.T Kidney) Investigators Writing Committee Patient and kidney survival by dialysis modality in critically ill patients with acute kidney ... Outcome Survey on Acute Kidney Injury (NEiPHROS-AKI) Investigators North East Italian Prospective Hospital Renal Outcome Survey on Acute Kidney Injury (NEiPHROS-AKI): targeting the problem with ... VA/NIH Acute Renal Failure Trial Network Management of renal replacement therapy in acute kidney injury: a survey of practitioner prescribing practices Clin J Am Soc Nephrol 2007, 2:623-630 Kindgen-Milles...

Ngày tải lên: 13/08/2014, 16:20