biological vs clinical engineering of pulmonary surfactant

... prevalence of TB in the United States Nevertheless, certain segments of the population remain at increased risk of TB, by virtue of having a higher prevalence of infection, a higher risk of progression ... 6:710 Controlled clinical trial of four short-course (6-month) regimens of chemotherapy for treatment of pulmonary tuberculosis Second report Lancet 1973; 1:1331 Controlled trial of 6-month and ... for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial Lancet 2002; 360:528 14 A controlled clinical comparison of and months of antituberculosis...

Ngày tải lên: 29/03/2014, 03:20

... therefore, clinical trial data provide useful proof of biologic concept but IL-15 should not be considered a validated clinical target IL-21 is another member of the four-α-helix family of cytokines ... synovial tissues of RA patients Inhibition of IL-21 or gene targeting of IL-21 mediates the suppression of a variety of models, including CIA and several murine lupus models Clinical trials directly ... http://arthritis-research.com/content/11/3/230 The Scientific Basis of Rheumatology: A Decade of Progress This article is part of a special collection of reviews, The Scientific Basis of Rheumatology: A Decade of Progress, published to...

Ngày tải lên: 09/08/2014, 14:20

... lung and spleens of infected animals indicating the presence of active infection (Fig 4) Recovery of fungus in the spleen provides evidence of dissemination of C posadasii to extra -pulmonary organs ... and secretion of pulmonary surfactant by pulmonary epithelial cells [32,33] In the present study we found slightly increased levels of SP-D in C posadasii protected mice, but not of SP-A (Fig ... role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis Infect Immun 2001, 69:2728-2731 van Rozendaal BA, van Spriel AB, van De Winkel JG, Haagsman HP: Role of pulmonary...

Ngày tải lên: 12/08/2014, 18:21

... Features of Different LCA Models Fitted to the Data Numbers of Classes, Manifest Variables and Dependencies, and Goodness of Fit for the Models Model Number of Latent Classes Number of Manifest ... patient-by-patient clinical case management of TB, but it expands our toolbox in clinical research, as it is one of the few statistical techniques available to address the issue of prevalence, sensitivity ... Impact of human immunodeficiency virus infection on clinical and radiographic presentation Am Rev Respir Dis 1992; 146: 53-56 Siddiqi K, Lambert ML, Walley J Clinical diagnosis of smearnegative pulmonary...

Ngày tải lên: 22/03/2014, 18:20

... applications to establish clinical outcomes and rates of failure The illustrative description of the development of a new generation of materials and devices capable of specific biological interactions ... Faizan Department of Bioengineering and Orthopedic Surgery, University of Toledo, Toledo, Ohio, U.S.A Leonora Felon Department of Bioengineering and Orthopedic Surgery, University of Toledo, Toledo, ... of Biomedical Engineering, University of Iowa, Iowa City, Iowa, U.S.A Chia-Ying Lin Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, U.S.A Timothy Lindley Department of...

Ngày tải lên: 22/03/2014, 21:20

... relatives or friends Diagnosis of active pulmonary tuberculosis: Individuals with a history of cough of wk duration or more and not responding to routine line of management for TRIPATHY et al: ... HIV+ve patients and 133 (82%) of the 162 HIV negative patients being in the age group of 21 to 40 yr Outcome after months of anti-TB treatment: At the end of months of treatment, among smear negative ... The status of patients at 30 months: Of the 162 HIV seronegative tuberculosis patients, two died before completion of anti-TB treatment Of the remaining 160 subjects, four expired, of whom deaths...

Ngày tải lên: 29/03/2014, 03:20

... midline of As the common clinical test for USN, in the first evaluation of the frequency of presence of neglect for ADL (Table 3), 75 percent of all subjects admitted a USN symptom in activities of ... Percentage of correct answers (%) Correct answers of left-left Correct answers of right-left Correct answers of mid-left Correct answers of mid-right Correct answers of left-right Correct answers of ... produced by the result of using HMD However, there were a few limitations of this study There was the possibility of low validity of the results because of the small number of subjects There was...

Ngày tải lên: 19/06/2014, 10:20

... minimum (MIN) of the curve of joint movement Beside this, the mean values of MAX and MIN were considered For ankle joint, in addition to ROM on sagittal plane, peak of plantarflexion, peak of dorsiflexion ... for citation purposes) Journal of NeuroEngineering and Rehabilitation 2007, 4:14 http://www.jneuroengrehab.com/content/4/1/14 Table 1: Clinical and laboratory data of patients with Prader-Willi ... the values of gait velocity Cadence (steps min-1), duration of stance phase (as % of gait cycle), duration of single support (as % of gait cycle), stride length (m) and walking speed (m s-1)...

Ngày tải lên: 19/06/2014, 10:20

... Journal of Surgical Oncology 2011, 9:50 http://www.wjso.com/content/9/1/50 CASE REPORT WORLD JOURNAL OF SURGICAL ONCOLOGY Open Access Case of an unusual clinical and radiological presentation of pulmonary ... incidence of pulmonary metastases varies with the primary tumor and stage of disease Bone tumors such as osteosarcomas and Ewing’s sarcoma show a high incidence of pulmonary metastases Pulmonary ... metastases Pulmonary metastases from sarcomas usually appear as round nodules of varying sizes on roentgenograms Here, we report an unusual clinical and radiographic presentation of pulmonary...

Ngày tải lên: 09/08/2014, 01:24

... as: Zwicker et al.: Biological in-vivo measurement of dose distribution in patients’ lymphocytes by gamma-H2AX immunofluorescence staining: 3D conformal- vs step-and-shoot IMRT of the prostate gland ... interpretation equivalent to the DLH With the rule of proportion the values of the contoured volumes can transferred to values of total body volumes Formula: Page of exposed to a certain dose, or more (Figure ... There is no difference in relative number of lymphocytes, which get more than 95% of the applied dose The percentage of lymphocytes exposed to more than 50% of the prescribed dose is 1.8% in 3D technique,...

Ngày tải lên: 09/08/2014, 09:20

... 2Institute of Anatomy, Division of Histology, University of Bern, Bern, Switzerland Division Neonatology, Department of Paediatrics, Inselspital and University of Bern, Bern, Switzerland 4Department of ... porcine surfactant preparation [37-39] The properties and the composition of Curosurf are similar to human pulmonary surfactant and thus it is widely used in the treatment or prophylaxis of the ... that patterns of MWCNT bound surfactant lipids were identical to the patterns of the complete surfactant (Figure 1A) This finding indicates an unspecific binding, i.e no influence of the functional...

Ngày tải lên: 11/08/2014, 00:22

... combination of a loss of integrity of the epithelial barrier caused by lung injury and of an increased mass of type II cells due to hyperplasia [12] Three studies tried to validate the use of these ... not ready for clinical use to predict mortality in different forms of ILD A baseline FVC, a change of FVC of more than 10%, and a decrement of more than 25 m in MWD are predictors of survival Measurements ... forms of lung fibrosis [32] A Cox regression analysis shows that an age of less than 66 year, a diagnosis of an ILD that is not an IPF, a VC of more than 63% predicted and a % macrophages of less...

Ngày tải lên: 12/08/2014, 11:22

... http://respiratory-research.com/content/12/1/29 Page of 11 Figure Quaternary structure of pulmonary SP-D The quaternary structure of SP-D in BAL: A) equal amounts of SP-D were loaded as indicated by equal band intensities of the SP-D ... induced disruption of the quaternary structure of pulmonary SP-D Blue native electrophoresis of surfactant protein-D after incubation with an oxygen radical donor (+) Disruption of the multimeric ... 10 of 11 increased translocation of SP-D from the lung into the circulation 12 Acknowledgements The technical assistance of Britta Reubke-Gothe and the support of the clinical team during the clinical...

Ngày tải lên: 12/08/2014, 13:22

... Analysis of the H-J classification was performed with Welch’s T-test Analyses of the mortality ratio and incidence of acute exacerbation were with Fisher’s exact test Page of • Comparison of PFS ... progression of disease was defined by a ≥ 5% decline in absolute VC from baseline or death K-M plots of PFS times based on the definition and the results of comparison of the distributions of PFS ... was in accordance with the ATS/ERS Consensus statement [16] and th version of the guideline of clinical diagnostic Page of criteria for idiopathic interstitial pneumonia in Japan [18] Eligible...

Ngày tải lên: 12/08/2014, 13:22

... Sequential analysis of BALF and IS Analysis of the single fractions of BALF showed an increase of IgG levels and concomitantly a decrease of IgA levels, resulting in an increase of the IgG to IgA ... responder rate of this anti pseudomonal vaccination strategy Assessment of pulmonary antibodies showed a comparable sensitivity of BAL and IS However, the different proportions of the isotypes ... usefully applied in the process of optimization of the vaccination strategy The use of IS for detection of vaccine induced antibodies has limitations A major drawback of the IS technique is its age...

Ngày tải lên: 12/08/2014, 15:21

... consequent surfactant dysfunction Indeed, surfactant recovered from bronchoalveolar lavage fluid from ARDS patients has alterations of the phospholipid and fatty acid profile, has decreased levels of surfactant- specific ... extracted: method of randomization; inclusion and exclusion criteria; details of surfactant administration, including type of surfactant, dose, duration, and delivery method; nature of control treatment; ... ventilation Unfortu- Page of Characteristics of the trials eligible for meta-analysis Article (Jadad score) Design Number of patients Delivery method Type of surfactant Surfactant dosing (total)...

Ngày tải lên: 12/08/2014, 23:22

... movements of the sternum as well as of the abdominal wall may be seen [5] GarciaPachon et al., found Hoover's sign expression in 62 out of 82 patients with COPD (sensitivity of 76%), out of 23 patients ... and in out of 101 (3%) of patients with congestive heart failure [6] In a larger study of 157 patients, the same investigators demonstrated presence of Hoover's sign in 71 patients (45% of study ... views of the chest roentgenograms of the same patient With A showing PA and B showing lateral views of the chest roentgenograms of the same patient The arrow marks refer to the flattening of the...

Ngày tải lên: 13/08/2014, 13:22

... from the patients or their next of kin Processing of clinical samples LRT samples of all patients included in this study were taken once a day for the first days of their ICU stays LRT samples ... velocity, color, morphology of hyphae, and characteristics of hyphae and spores under microscopy Case definitions of IBPA According to the definitions of invasive fungal disease of the European Organization ... be the result of unclear clinical features and the delayed diagnoses and treatments for ATB and IPA among CORD patients Recently, Tasci et al [2] described the clinical features of ATB and proposed...

Ngày tải lên: 14/08/2014, 07:21

... 5.7 Power of ensemble trees in CS4 number of combined trees versus number of misclassied testing samples 99 5.8 Plots of top number of features versus number of errors ... each of iterations, about one-third of the samples are left out of the new bootstrap training set 24 Generation of trees: Let ề be the number of samples in the training data ậ , be the number of ... EFFECTIVE USE OF DATA MINING TECHNOLOGIES ON BIOLOGICAL AND CLINICAL DATA LIU HUIQING (M.Science, National University of Singapore, Singapore) (M .Engineering, Xidian University,...

Ngày tải lên: 16/09/2015, 17:12

... wife, Lyn i TABLE OF CONTENTS ACKNOWLEDGMENTS i SUMMARY v LIST OF PUBLICATIONS viii LIST OF TABLES vi LIST OF FIGURES x CHAPTER 1: INTRODUCTION 1.1 Incidence and Survival Rates of Colorectal Cancer ... 58 Extent of disagreement in reproducibility of results between human visual and computer-assisted scoring methods 58 Frequency of positive expression of protein markers using cut-off scores ... survival rate of colorectal cancer patients vary accordingly to the stage of the disease determined at the time of diagnosis (Table 1) As it is with any type of cancer, prognosis of the patient...

Ngày tải lên: 03/10/2015, 20:57