biochemical structural and pathophysiological aspects of prorenin and pro renin receptor
Báo cáo y học: "Pathophysiological aspects of hyperglycemia in children with meningococcal sepsis and septic shock: a prospective, observational cohort study" docx
Ngày tải lên :
14/08/2014, 07:21
... coordination of the study and helped to draft the manuscript KJ conceived of the study, participated in its design and coordination, and helped to draft the manuscript All authors read and approved ... determination of blood glucose levels and plasma levels of insulin, C-peptide, cortisol, cytokines, C-reactive protein (CRP), lactate, and free fatty acids (FFAs) were collected on admission and Verhoeven ... burned children approximate mg/kg per minute [37] Exogenous glucose in excess of this amount enters non-oxidative pathways and is unlikely to improve energy balance and lipogenesis and may result...
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain pdf
Ngày tải lên :
18/02/2014, 11:20
... flavoprotein and heme domains of NOS are also an unusual feature shared by only a handful of prokaryotic CYP proteins [4,8,25] In comparison, the NOS flavoprotein domain is related to a family of ... Electron flux and equilibrium A In general, electron flux through a protein depends on the rates of electron input and output, with either process being rate limiting In the case of the NOS flavoprotein ... activities of the various CaM-free nNOS Regulation of the NOS flavoprotein domain flavoproteins and their degree of FMN deshielding, which is directly related to the KeqA for each flavoprotein (greater...
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling pptx
Ngày tải lên :
18/02/2014, 11:20
... Comparison of rates and kinetic isotope effects using PEG-modified variants and glycoforms of glucose oxidase: the relationship of modification of the protein envelope to C–H activation and tunneling ... temperature dependence of the reaction [65] Solution viscosity has been used to probe the role of dynamics in interprotein [65–68] and intraprotein [69] ET reactions and protein rearrangement ... glycosylation and this approach has been used by Klinman and coworkers to study the viscosity dependence of the rate of hydride transfer in GO [70,71] These authors studied various glycoforms of the...
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: photosynthetic electron transfer from photosystem I to NADP+ doc
Ngày tải lên :
18/02/2014, 11:20
... towards the production of alternative structures for each protein The fine-tuning of the enzyme catalytic efficiency is governed by the distance between and mutual orientation of the N5 of FAD and the ... In vivo, the formation of transient complexes of Fld with PSI and FNR is useful, but not critical, during this process to promote electron transfer and avoid the reduction of oxygen by the donor ... rearrangements of N58–I59 provide a versatile device for modulating the strength of FMN binding and Eox ⁄ sq and Esq ⁄ hq in AnFld [25,26,48] Fld has a large excess of acidic residues which produce...
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Tài liệu Báo cáo khoa học: Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera pptx
Ngày tải lên :
19/02/2014, 06:20
... removal of the fiber protein from adenovirus requires the use of chaotropic salts and increased temperatures [32,33], and no release of fiber protein has been noted even after long-term storage of dilute ... strength of the solvent environment and ⁄ or presence of small organic compounds (dioxane and MPD) seems to favor formation of dodecahedra over isolated pentamers Previous structural analysis of the ... trimerization in adenovirus fiber protein constructs [29] and was used in the minifiber to mimic the proper oligomerization state of the full-length protein Proper trimerization of the minifiber construct...
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Tài liệu Báo cáo Y học: Structural and biochemical characterization of neuronal calretinin domain I– II (residues 1– 100) Comparison to homologous calbindin D28k domain I–II (residues 1 –93) pdf
Ngày tải lên :
22/02/2014, 07:20
... We have expressed and purified the homologous domain of CR (CR I–II, residues 1–100) [23,32] This has allowed us to analyze the biochemical and structural properties of CR I– II and to compare them ... to dimerize and both EF-hands of CR I–II bind calcium We conclude that the significant structural and biochemical differences between CR I –II and Calb I –II are related to a region of poor sequence ... single bands of monomeric weight and S100B provides a positive control with a yield of cross-linked dimer of < 30% The CR I – II and Calb I – II sequences have high sequence identity, Fig 1, and...
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Báo cáo khoa học: Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island potx
Ngày tải lên :
06/03/2014, 00:21
... for protein activity (NEST prediction, ProFunc server; http:// www.ebi.ac.uk/thornton-srv/databases/profunc/) An exhaustive search of structural similarities in the Protein Data Bank did not provide ... a-helices and a final b-strand, F, which protrudes from the core of the monomer and runs anti-parallel to the same strand of a second monomer, allowing for the formation of the dimer The surface of interaction ... cagPAI, is the activation of nuclear transcription factor-jB and the induction of pro- inflammatory production of cytokines, mainly interleukin (IL)-8 [12] The activation of a pro- inflammatory signalling...
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Báo cáo Y học: Structural and biochemical characterization of calhepatin, an S100-like calcium-binding protein from the liver of lungfish (Lepidosiren paradoxa) docx
Ngày tải lên :
08/03/2014, 22:20
... (1986) Ions binding to S100 proteins I Calcium- and zinc-binding properties of bovine brain S100aa, S100a (ab), and S100b (bb) protein: Zn2+ regulates Ca2+ binding on S100b protein J Biol Chem 261, ... both the holo and apo protein) Sequence comparison and evolutionary relationship Primary structure of lungfish calhepatin Purified protein (250 pmol) was subjected to four cycles of Edman degradation ... alignment of the amino-acid sequence of lungfish calhepatin with other members of the S100 family indicates that the number of amino-acid identities between calhepatin and other S100 proteins ranges...
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Biochemical and physiological aspects of human nutrition units i & II
Ngày tải lên :
16/03/2014, 18:07
... Ph.D., and Peter J Gariick, Ph.D Essentiality of Protein Dynamic Protein Metabolism 213 Measurement of Protein Synthesis and Degradation 215 Protein Turnover and Adaptation 219 Regulation of Protein ... Reactivity of the Monosaccharides Other Classes of Carbohydrates Disaccharides and Oligosaccharides and Their Properties 14 Glycoconjugates of Physiological Interest 18 Structure and Properties of Proteins ... Functions of Iron 712 Proteins of Iron Transport and Iron Storage 715 Regulation of Concentrations of Proteins of Iron Transport and Storage 720 Body Iron Compartments 722 Internal Iron Exchange and...
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Báo cáo khoa học: Biochemical and enzymological aspects of the symbiosis between the deep-sea tubeworm Riftia pachyptila and its bacterial endosymbiont pptx
Ngày tải lên :
30/03/2014, 15:20
... uptake and utilization of the inorganic compounds NH3 and CO2 which, in Riftia, are provided by the environment Therefore, an examination of the metabolic aspects of the symbiosis between Riftia and ... tubeworm and the sea water are mediated via this vascular system [27–29] Uptake and transportation of oxygen and sulfide in Riftia pachyptila An important feature of Riftia hemoglobin is that this protein ... fluxes It seems now, that the product of symbiont nitrate reduction, ammonia, is probably the primary source of nitrogen for the host and the symbiont [65] Fig Pathways of inorganic nitrogen assimilation...
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Báo cáo y học: "Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review" ppsx
Ngày tải lên :
13/08/2014, 13:20
... Tsuchiya M: Roles of plasma membrane Ca++ – ATPase in the relaxation and contraction of hepatic sinusoidal endothelial fenestrae – effects of prostaglandin E1 and endothelin In: Cells of the Hepatic ... demonstrated the possible role of a plasma membrane Ca2+-ATPase in the dilatation of fenestrae by studying the effect of prostaglandin E1 on LSEC They found that prostaglandin E1 enhances the Ca2+-pump ... formation of sieve plates The study of the luminal cell membrane of freeze-fractured LSEC revealed the presence of trabecular meshworks which were attached to the E and P-faces of the cell membrane of...
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Some aspects of American culture and society in the twentieth and twenty-first centuries through a number of selected short literary works
Ngày tải lên :
07/11/2012, 15:01
... beautiful and lively with variety of colors such as purple, yellow, pink of the walls; dark green, white and yellow of the notocactus and cactus, and all kinds of fragrance from the flowers and herbs ... short stories and other genres of literature including essay and memoir, techniques in storytelling and moreover, short literary works and their portrayal of life With the understanding of such concepts, ... contribute to the understanding of the underlying ideas of the author as well as the cultural features and social aspects of the time Like other types of story, a short story consists of five elements:...
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Quantitative aspects of ruminant digestion and metabolism - Phần 1
Ngày tải lên :
24/10/2013, 17:15
... with the use of simple models and provide analytical solutions that can estimate more appropriately the intrinsic rates and extents of digestion of DM and protein Design Regardless of the method ... data set The goal of this chapter is to present the theoretical development and use of models for quantifying rate and extent of the digestion process in the rumen Rate and Extent of Digestion 15 ... govern the processes of ruminant digestion and metabolism, and this requires an increased emphasis on theory and mathematical modelling The primary purpose of each of the subsequent chapters of this...
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Quantitative aspects of ruminant digestion and metabolism - Phần 2
Ngày tải lên :
24/10/2013, 17:15
... degradation of rumen protozoa Proceedings of the Nutrition Society of Australia 14, 153 Faichney, G.J (1990) Effect of level of intake and grinding of lucerne hay on the efficiency of rumination ... of variation of the energy and protein value of feeds, respectively For the quantitative description of digestive and metabolic processes, appropriate biological data are required and can be obtained ... abomasum and the caecum/proximal colon can be of the order of, respectively, 10% and 20% of those in the reticulorumen so that interpretation of the parameter estimates for the time-dependent and...
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Quantitative aspects of ruminant digestion and metabolism - Phần 3
Ngày tải lên :
29/10/2013, 00:15
... a net yield of CO2 and CH4 is generated when acetate and butyrate are produced, but not ¨ when the end-product is propionate (Blummel et al., 1997b) Molar proportions of acetate and butyrate ... amount of microbial mass per unit of fermentable ¨ substrate and the amount of either gas or VFA produced (Blummel et al., 1997b) Based on this relationship and the stoichiometry of gas and VFA production, ... ammonia release as the main end-product of protein degradation, Broderick (1987) described an in vitro procedure using inhibitors of uptake of protein degradation products and amino acid deamination...
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Quantitative aspects of ruminant digestion and metabolism - Phần 4
Ngày tải lên :
29/10/2013, 00:15
... particle properties, fermentative activities of adherent microbes, the cumulative effects of digesta load and packing of particles within the RR and the mixing and propulsive activities of the RR and ... diet fibrosity and maturity (Weston, 1985) and therefore to degree of diet selection The proportions of leaf and stem of available forage, and their respective physical and mechanical properties, ... but it does compromise structural integrity of the leaf and stem components by removal of cuticle, crushing and separation of vascular bundles and other plant tissues, and release of plant cell...
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Ethical and social aspects of evaluating fetal screening
Ngày tải lên :
01/11/2013, 08:20
... emphasize the health of the newborn population, public health or the health level of a given society And then we would have to face the dilemma of eugenics Ethical and social aspects of evaluating ... the education of people who promote and HTA Secondly, ethical questions are diYcult to deWne and operationalize It would require a lot of theoretical and methodological thinking and research to ... various ethical problems, forgetting the societal perspective of consequences and control The myth of the objectivity of research is strong among health and economic researchers, and they may Wnd...
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Quantitative aspects of ruminant digestion and metabolism - Phần 5
Ngày tải lên :
07/11/2013, 23:15
... intestine and have a well-balanced, though less than ideal, array of essential AA The essential AA profiles of protozoa and fungi appear to be even closer to those of the protein in animal products ... (2003) Rates of production of acetate, propionate and butyrate in the rumen of Volatile Fatty Acid Production 175 lactating dairy cows given normal and low-roughage diets Journal of Dairy Science ... the types of enzyme involved and on conditions at the site of binding to the cell wall (i.e pH, availability of metal cofactors, etc.) The surface area of protein accessible to proteases and peptidases...
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Quantitative aspects of ruminant digestion and metabolism - Phần 6
Ngày tải lên :
07/11/2013, 23:15
... digestibility of feed and production of VFA and microbial protein However, the complexity of these analogues, which often employ pulse addition of heterogeneous, particulate substrate and differential and/ or ... unable to utilize all of the products liberated as a consequence of their activity Whereas R flavefaciens produces both xylanase and pectinase, it cannot utilize the end-products of xylan or pectin ... is referred to Hobson and Stewart (1997) for a more detailed description of the rumen ecosystem and the various species of anaerobic and facultative bacteria, protozoa and fungi found therein...
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