biochemical mechanisms of drug toxicity
Biochemical mechanisms of detoxification in higher plants
Ngày tải lên :
16/03/2014, 18:07
... fond of highlighting This book has been written to provide an overview of the fundamental aspects of phytoremediation, to summarize existing understanding of the mechanisms of detoxification of ... The degree of toxicity caused by lead to the microflora depends on the type of soil In black earth the neutralization of toxicity is faster than in other soils [418] Some species of eukaryotes ... toxin levels A number of medical supplies, including antibiotics, also belong to the category of substances of low toxicity In the remainder of this chapter, several classes of highly toxic environmental...
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Báo cáo khoa học: Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138 pot
Ngày tải lên :
16/03/2014, 13:20
... availability of a range of structures of NNRTIresistant RTs drugs will provide greater understanding of the molecular basis of drug resistance mechanisms Such data will contribute to the design of novel ... the side-chain of Lys101 [24] Consistent with the reports of the selection of Lys101Glu in clinical use of efavirenz, the crystal structure of RT with this NNRTI shows a contact of the inhibitor ... selection of drug- resistant virus remains a significant problem in controlling HIV infection and AIDS The work reported here is part of ongoing studies aimed at understanding mechanisms of drug resistance...
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Báo cáo y học: " Perinatal acquisition of drug-resistant HIV-1 infection: mechanisms and long-term outcome" potx
Ngày tải lên :
12/08/2014, 23:22
... available in the latter studies The comparison of the maternal and neonatal drug resistance profiles pointed to two different mechanisms of acquisition of resistant variants by infants in the perinatal ... increased risk of infection by drugresistant HIV-1 strains when the mother harbors such viruses or when drug pressure during MTCT prophylaxis is suboptimal Vertical transmission of drug- resistant ... plasma DNA plasma DNA Re-emergence of wild-type virus In the absence of zidovudine Transmission of wild-type virus and selection of resistant variants with PTME Figure of antiretroviral resistance...
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Mixture toxicity of POPs dioxins, PCBs, PBDEs considerations from mechanisms of actions and for risk assessment
Ngày tải lên :
16/04/2015, 08:52
... Berg & R F Canton (2010) A Global Foodborne Burden of Disease? WHO-‐FERG In prep Es*ma*on of number of W-‐Europe children exceeding the TDI significantly (< ... Canton (2010) A Global Foodborne Burden of Disease? WHO-‐FERG In prep Breasded infants can exceed WHO TDI up to two orders of magnitude for 3-‐6 months M Van ... risk assessment of environmental matrices Aspects reduced bioavailability, environmental fate and transport not in present REP/TEF studies evaluated Mixtures of PCDDs, PCDFs...
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Pharmacokinetic and pharmacodynamic mechanisms for reduced toxicity of CPT 11 by thalidomide and st johns wort
Ngày tải lên :
14/09/2015, 13:44
... incidence of resistance Secondly, there is often a greater than additive or synergistic effect of the drugs due to complementary mechanisms of action Finally, by using drugs with different types of ... .151 6.2 PHARMACODYNAMIC MECHANISMS OF THE PROTECTIVE EFFECTS OF THALIDOMIDE AND ST JOHN’S WORT 152 6.3 PHARMACOKINETIC MECHANISMS OF THE PROTECTIVE EFFECTS OF THALIDOMIDE AND ST JOHN’S ... Pharmacokinetics of CPT-11 1.2.3 1.3 Anti-tumor activity and mechanism of action of CPT-115 Toxicities of CPT-11 .14 THALIDOMIDE .19 1.3.1 Clinical activity and mechanism of action of thalidomide...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
Ngày tải lên :
31/10/2012, 15:12
... transfection of Bag-1 Morpho/AS to JAR cells did not alter the expression of PTEN after the exposure to hypoxia, which would mean that the expression of PTEN, and also that of Bcl-X, was independent of ... calculated according to the formula: Changes in the level of phosphorylated JNK1&2 (-fold of control) = absorbance of hypoxia-treated cells/absorbance of control cells RT-PCR analysis Total RNA was extracted ... expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis (Fig 2) Table Altered protein expression of JAR cells...
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Báo cáo y học: "Risk and Benefit of Drug Use During Pregnancy"
Ngày tải lên :
02/11/2012, 11:12
... higher occurrence of one or some CA-groups after the use of the given drug due to the specificity of teratogens Recall bias may act for all CAs similarly Secondly, the use of the drug under study ... use of the combination of these two drugs increased the risk for poly/syndactyly six fold [33] Our analyses also demonstrated that it is necessary to differentiate the administrative route of drugs ... asked about the history of their pregnancy, give a long list of supposed agents On the other hand the mothers of healthy babies are thinking of the present and future of their babies and are...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp
Ngày tải lên :
05/09/2013, 09:08
... vacuum-UV photolysis of water (H2O-VUV) is still a field of active research compared to other AOPs (Oppenlander and Gliese, 2000) The special requirements of the VUV photolysis of water according ... related to the formation of high local concentration of hydroxyl radicals (OH.) and a series of other species (Gonzalez and Braun, 1995) within a photochemical reaction zone of less than 0.1 mm (Heit ... differentiation of the contributions on the decomposition of Re 141 in aqueous solutions by UV direct photolysis, OH generated from the excitement of water, oxygen, and H2O2, respectively Development of the...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
Ngày tải lên :
05/09/2013, 09:08
... 22-23 of 2003 The amount of precipitation was 30 mm in total Figure shows the precipitation record of the studied event (Fig 2a) and the record of the river flow rate (solid line, Fig 2b) of the ... measurement, considering of their respective analytical errors A concept of two-component mixing was employed, in which it was assumed that runoff is composed of a mix of two components: one originating ... and by setting C1 and C2 as mentioned above, the fraction of new water evaluated for the main part of the runoff (0000 of Oct 22 to 1600 of Oct 23, 40 h in total) was found to be as shown in Fig...
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Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake
Ngày tải lên :
05/09/2013, 09:38
... some of PAOs can that, the inhibitory effect of nitrite will be reduced Hence, the purpose of this study is to examine the effect of anoxic activity of PAOs on reduction of inhibitory effect of ... Cycle Operations of SBRs for Cultivation of the Enriched PAOs - 66 - Journal of Water and Environment Technology, Vol 6, No.1, 2008 Table - Composition of Synthetic Wastewater Methods of nitrite inhibition ... presence of nitrite was 13 mgP.gVSS-1.h-1 and the % activity of phosphate uptake was 39% On the other hands, in the case of AA with 1.9 mgN/gVSS of initial nitrite concentration, the size of inhibition...
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Biochemical characterization of thermophilic lignocellulose degrading enzymes and their potential for biomass bioprocessing
Ngày tải lên :
05/09/2013, 16:11
... of organic acid and reduced levels of ammonia after compost processing [41, 42] Table Characterization of yard waste compost samples Specifications YWCa-I YWC-II Location Bottom of heap Top of ... Hackensack, NJ) During extrusion, a screw speed of the extruder of 100 rpm and a barrel temperature of 100°C was maintained [28] 2.3 Sample collection Samples of yard waste compost (YWC) and finished ... unit (U) of enzyme activity was expressed as the amount of enzyme liberating µM of glucose (cellulase) or xylose (xylanase) equivalents per under the assay conditions 2.7 Morphology of microbial...
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Transmission mechanisms of monetary policy the evidence
Ngày tải lên :
05/01/2014, 17:01
... cycle soon followed Transmission Mechanisms of Monetary Policy Traditional Interest-Rate Channels: expansionary monetary policy ir ↓, I ↑, Y↑ The interest rate channel of monetary transmission applies ... price for it relative to the cost of the facilities and equipment they are buying I ↑ because firms can buy a lot of new investment goods with only a small issue of stock The transmission mechanism ... which raises the desire of consumers to hold durable goods or housing, thus ↑ spending on them Expansionary monetary policy Pe ↑, value of financial assets ↑, likelihood of financial distress ↓,...
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Tài liệu Color Atlas of Pharmacology (Part 6): Quantification of Drug Action ppt
Ngày tải lên :
26/01/2014, 19:20
... affinity of ligands, the kinetics of interaction, and the characteristics of the binding site itself In studying the affinity and number of such binding sites, use is made of membrane suspensions of ... conditions of license 57 Quantification of Drug Action Addition of radiolabeled drug in different concentrations Organs Homogenization Membrane suspension Mixing and incubation Determination of radioactivity ... 40 50 100 Drug concentration A Measurement of effect as a function of concentration 50 Effect (in mm of registration unit, e.g., tension developed) % 100 40 80 30 60 20 40 10 Effect (% of maximum...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
Ngày tải lên :
13/02/2014, 06:20
... of action of some FP methods We did not state the mechanism of action of any FP methods and thus asked women to express their beliefs independently of their actual choices and independently of ... hypothetical method of FP In further sections women were asked about their knowledge of the mechanism of action of specific FP methods and if doctors or providers should explain the details of how a method ... attitudes for postfertilization effects The purpose of our study was to assess the attitudes about the mechanisms of action of FP in terms of whether these may influence a woman's decision to...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
Ngày tải lên :
14/02/2014, 18:20
... blocks only after partial unfolding of the a-helix from the body of the b-sheet (Fig 2C) Possible role of domain-swapping in the ‘off-pathway folding’ (OFF) model The OFF model for amyloid formation ... understanding of the importance of different parts of the molecule and their flexibility in the process of amyloid fibril formation often results more from a structural analysis of the amyloid ... absence of structural restraints is considered to drive the assembly of susceptible proteins into amyloid fibrils [19] The structure of amyloid fibrils reflects the aggregation of strands of b-pleated...
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Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt
Ngày tải lên :
16/02/2014, 15:20
... Proton ATPasePump Inhibition of acidification of phagosome harbouring Mycobacteria Expression of virulence proteins of PE-PGRS family C O2– Fig Key factors of the survival mechanisms involved in the ... of digested material by exocytosis Fig Detailed structure of a macrophage showing a typical process of phagocytosis Engulfed material A D Phagosome TACO Fusion Lysosome Inhibition of fusion of ... proteins of mycobacteria have a profound influence on its pathogenicity It was found that the disruption of an erp gene of M tuberculosis encoding a secretory protein effects the survival of M tuberculosis...
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Tài liệu BIOCHEMICAL TARGETS OF PLANT BIOACTIVE COMPOUNDS A pharmacological reference guide to sites of action and biological effects doc
Ngày tải lên :
17/02/2014, 05:20
... per litre) Of course, the quarltitation of such affinities depends upon the conditions of measurement and the source of the biochemical target entity However, it was felt that provision of such ... kill plant-consuming organisms 1.3 Description of the tables Most of the book is comprised of tables dedicated to specific targets or groups of targets of plant defensive compounds Target-related ... plant names of well-known plants, plant family and the plant part involved and (c) the biochemical target being considered, a measure of the affinity of the compound for the target, other biochemical...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
Ngày tải lên :
18/02/2014, 06:20
... with an increased risk of T2DM, hypertension and CVD; however, the exact underlying pathophysiological mechanisms by which obesity increases the risk of VD remains the subject of intensive investigation ... pathophysiological mechanisms of obesity-induced androgen deficiency and hypogonadism-induced obesity remain the subject of intense investigation Several hypotheses have discussed the relationship of androgen ... organic ED, in which approximately 43% of men with MetS had ED and the severity of ED increased with the components of the MetS [84] Interestingly, the severity of ED was positively associated with...
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Tài liệu Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: redox reactions pdf
Ngày tải lên :
18/02/2014, 08:20
... deprotonation of C2a-OH of HEThDP and protonation of FAD at N5 and N1) The tight and rigid binding of both cofactors excludes a direct carbanion mechanism with covalent linkage between C2a of the HEThDP ... cluster [28] Rapid depletion of the thiamin radical and reduction of all clusters is only achieved after addition of CoA What is the special role of CoA for propagation of the second electron and ... radical An additional intricacy of this mechanism is the necessity of a structural rearrangement of CoA in the course of catalysis: initially, the reactive thiol group of CoA must be positioned proximal...
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Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: a new view of palytoxin toxicity ppt
Ngày tải lên :
18/02/2014, 14:20
... a natural blocker of the Na+ pump and an inhibitor of palytoxin action, have provided interesting findings Through the partial inhibition of Na+ ⁄ K+-ATPase, and regardless of changes in intracellular ... Effect of microtubule-destroying drugs on the spreading and shape of cultured epithelial cells J Cell Sci 74, 267–282 33 Goldman RD, Khuon S, Chou YH, Opal P & Steinert PM (1996) The function of ... Nanomolar concentrations (75 nm) of palytoxin or ostreocin-D, and h of incubation, were enough to induce sharp F-actin disassembly and to almost halve the quantity of F-actin on intestinal cells...
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