better but not quite there
Five stories that are almost true, but not quite
... am not overambitious I am happy with my work I am not famous but I have independence I cannot create some of the more daring clothes that I would perhaps have been able to create in Europe but ... mistress He even wanted to buy me jewelry but I did not accept That's why I am not wearing any.” “They would add nothing to your appearance Nobody would notice them,” I said “That's sweet Don't ... trying to pick out familiar landmarks but could not distinguish much in the darkness despite the city lights The emotions of my return were varied and confused but there was little doubt at that moment...
- 11
- 460
- 0
Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
... Pro/Arg+Pro/Pro genotypes, compared with the Arg/Arg genotype Figure ORs (log scale) of esophageal cancer associated with GSTP1 Ile106Val for the Ile/Val+Val/Val genotypes, compared with the Ile/Ile genotype ... the GSTP1 Ile105Val genotype alone does not show any association with the susceptibility to esophageal cancer, even when stratified by subgroup This finding is perhaps not surprising, because ... and smoking, though there were not enough report support us to make meta-analysis in current research Studies with a larger sample size, especially including smoking or another environment factors...
- 9
- 615
- 0
Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
... at start did not indicate whether a patient would obtain CR or not Likewise, there was no statistically significant difference at months between those achieving CR and those who did not (95.3±103 ... ng/mL There was no significant difference in anagrelide concentrations between PV and ET patients Likewise, there was no significant difference between those who achieved CR or those with PR+F (not ... rise of TPO Future studies of TPO interactions with its receptor, not only on platelets but also on megakaryocytes, might yield a better understanding [9] One may ask if the TPO rise observed here...
- 5
- 498
- 0
Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
... phosphorylation of Tyr394 did not appear to influence the binding of tau to Fyn-SH2, as there was no significant difference in the amount of Y394F 2930 Fig Tau interactions with Fyn-SH3 are not influenced by ... able to interact, but to differing extents, with Fyn-SH3 This suggests that the results shown here are not artefactual, owing to incorrect folding of the tau mutants, at least not in the regions ... binding to Fyn-SH3 However, tau possesses seven PXXP motifs, five of which have not been investigated, and we therefore cannot exclude the possibility that other prolines in tau may be important for...
- 11
- 628
- 0
Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... additional effects (not shown) In marked contrast, post-addition of MRS2179 did not affect the thrombin-induced Ca2+ response (Fig 1) To determine whether the P2Y12 contribution to the thrombin-evoked ... not shown) As a comparison, the general PI3-K inhibitor wortmannin was given after thrombin + ADP; wortmannin had a slower, but similar type of effect as AR-C (Fig 2B) To quantify the contribution ... either case, AR-C (but not MRS2179) suppressed the Ca2+ integral to a similar degree; 38 ± 1% and 37 ± 1% (n = 3) Thus, the P2Y12-dependent part of the Ca2+ signal with thrombin does not rely on PAR4...
- 15
- 565
- 0
Tài liệu Báo cáo khoa học: Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process docx
... not involved in contacts with any of the interacting proteins described so far, and is not affected by the 19-residue insertion in Rac1b Therefore, the impairment of Rac1b ubiquitination is not ... it is apparently not used for ubiquitin addition Therefore, the reason why Lys147 rather than Lys5 is the main acceptor site for ubiquitin in Rac1 remains to be elucidated Of note, however, is ... activity [40,41]; however, our experiments in HEK293 cells did not show any effect of POSH on Rac1L61 ubiquitination and therefore not support this hypothesis Except for a recent report on the...
- 11
- 469
- 0
Cytoskeleton reorganization mediates alpha beta integrin-associated actions of laminin on proliferation and survival, but not on steroidogenesis of ovine granulosa cells pdf
... These observations indicate that ECM components contribute to the microenvironment of GC, but their specific roles in follicular development have not yet been established LN is one of the most abundant ... organization through the cytoskeleton, thereby controlling steroid production and secretion [28,30,34], but the possible role of integrin-mediated cytoskeleton changes has not yet been established in regulating ... index and pyknotic index GC proliferation and survival were assessed by measuring the thymidine labeling index (percentage of labeled cells) and the pyknotic index (percentage of pyknotic cells)...
- 17
- 521
- 0
Blackwell Science, Ltd Group breeding dramatically increases reproductive success of yearling but not older female scrubwrens: a model for cooperatively breeding birds? ppt
... even lower It is therefore not surprising that many studies have not detected group-size effects A greater ratio of effect in poor conditions does not necessarily mean that there is a greater ... breeders There was no significant effect of group size for either yearlings alone or older females alone, but there was a weak statistical interaction suggesting that yearlings survive relatively better ... test and the difference was not quite significant at P = 0·06, the result is that expected with a real effect of group size This result argues against the possibility that there is unmeasured variation...
- 16
- 337
- 0
Dangerous But Not Omnipotent pptx
... the current regime appear to view Iran as an indispensable regional power, but not necessarily a revolutionary hegemon There is the further belief that the Islamic Republic is a model for Islamic ... East As a result of these perceived attributes, the Iranian leadership has shown a marked tendency not only to push for a greater role in regional affairs but also to exaggerate Iran’s strategic ... international s ystem but not because of its revolutionary foundations Iranian leaders no longer seek to radically reshape the regional order as they did after the revolution, but rather to raise...
- 233
- 229
- 0
Báo cáo khoa học: Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures potx
... symmetryequivalent contributors) is not the most useful indicator, because it does not take into account the multiplicity of measurements More elaborate versions of Rmerge have been proposed [32,33], but they ... data collection experiment was not conducted properly or if there was rapid decay of diffraction power, some reflections may not be measured at all, and the data may not be 100% complete Because ... model, but it would not be easy to convincingly build this part of the model into such a map The map quality is poor because the phases used to construct it were rather inaccurate, and does not...
- 21
- 570
- 0
Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
... different concentrations of menadione (10, 30, 83, 90 and 110 mM) on cell viability (results not shown) and noticed that 83 mM menadione produced a viability similar to that evoked by 1.5 mM H2O2 ... and results not shown) Although its UV spectrum coincides with that of adenosine, both compounds are different because (a) they elute in a slightly different chromatographic position (not shown) ... 2, and mM H2O2 A concentration of H2O2 as high as mM did not change the HPLC nucleotide prole obtained with untreated cells (results not shown) In a different experiment, yeast cells were grown...
- 12
- 506
- 0
Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
... 2002 Ruk is ubiquitinated but not degraded by the proteasome (Eur J Biochem 269) 3407 proteins Many ubiquitinated proteins are targeted for degradation by 26S proteasomes, but some undergo endocytosis, ... with another type of primary antibody Detection of ubiquitinated proteins Ub is highly conserved among eukaryotes, as only three of 76 amino acids differ between the human and yeast proteins Therefore, ... human and yeast proteins Therefore, Ub is not an optimal antigen and anti-Ub Ig rarely possess good affinity Taking this into account and that anti-Ruk Ig are not very efficient in immunoprecipitation...
- 7
- 317
- 0
Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx
... according to solid-state NMR [39] that differ from one another in subtle but distinct ways, such as variations in the mobility of the aromatic Tyr ring There is a growing number of similar observations ... conditions, is a general property of the polypeptide chain [10,11] This ability not only has pathological consequences, but can be turned into good use as functional amyloid, serving as structural ... there will be a single unifying mechanism for the build-up of fibrils from its constituents The diversity of possible interactions due to different protein sequences is simply too great [29] There...
- 11
- 400
- 0
Báo cáo khoa học: Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation pot
... long-term incubation These results indicate that insulin may be not only a natural inhibitor of amylin aggregation, but also a contributor to the amyloid formation and pathogenesis of T2D We also ... caseins during their fibrillation Altogether, these results indicate that insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation, and insulin can eventually promote fibril ... formation However, our study demonstrates that insulin itself does not act simply as a natural inhibitor of amylin aggregation but has opposite influences on amylin aggregation during different...
- 7
- 388
- 0
Báo cáo khoa học: Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart potx
... [5–10], and therefore its degradation by OGDHC may affect signal transduction Regulated by thioredoxin, OGDHC is at the intercept of not only energy production and glutamate turnover, but also mitochondrial ... In this study, Novel 2-oxoglutarate dehydrogenase we therefore aimed at structural characterization of brain OGDHC using approaches that not require the complex to be purified to homogeneity In ... although the mechanism(s) of their solubilizing action on the complexes have not been systematically studied In order to better preserve native enzyme regulation and protein–protein interactions,...
- 17
- 389
- 0
Báo cáo khoa học: The activation of gelsolin by low pH The calcium latch is sensitive to calcium but not pH docx
... is not reduced by low pH It is possible therefore that in pH-activated gelsolin, the helical latch may be the last event to occur being triggered not by direct disruption of the interface but ... ionpair exchanges, presumably initiated at histidine residues, that also disrupts interdomain bonds but not those formed through the G2–6 interface Methods Proteins and peptides Rabbit skeletal muscle ... similar to those obtained at pH 7.5 It appears that the interaction between G2 and G4–6 is calcium but not pH sensitive Fig Binding of G4–6 domain with 159–193 and 197–226 fragments derived from gelsolin...
- 8
- 320
- 0
Social capital and Health status: a protective impact among elderly or inactive but not among active ? doc
... performance The creation and the used of social capital depend not only on the social environment but also on the institutional context Therefore, mutual trust is both the result of institutional ... literature, researchers tend to clarify the concept of social capital but there is still no consensus As Grootaert and Seragelgin (2000) have noticed, “social capital means different things to different ... that social participation in France is low and quite evenly distributed among both populations (Table 1) Actually, 36.8% of the whole population not participate regularly in a collective activity...
- 27
- 465
- 0
Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity pot
... to bind to these AtxA-binding proteins, but were not toxic Our results show that F24 and the last 26 amino acid residues of potently neurotoxic AtxA are not enough to transform a nontoxic sPLA2 ... which are spatially close to the C-terminal residues contribute to this interaction Substitution of N24 by F in the second chimera did not significantly influence binding to each of the three Atxs-binding ... with the 14 residues differing from the corresponding AtnI2 region distributed mainly on the molecular surface (Fig 2), did not induce any substantial conformational changes in the protein fold...
- 6
- 344
- 0
Báo cáo sinh học: " The E5 protein of the human papillomavirus type 16 down-regulates HLA-I surface expression in calnexin-expressing but not in calnexin-deficient c" pptx
... surface expression in calnexin-containing but not in calnexin-deficient cells HPV16 E5 decreases HLA-I surface expression in calnexin-containing but not in calnexin-deficient cells CEM-C7 (calnexin) ... M2-AU1 D M3-AU1 10 m Figure HPV16 E5, M2 and M3 mutants but not M1 mutant strongly co-localize with calnexin HPV16 E5, M2 and M3 mutants but not M1 mutant strongly co-localize with calnexin HaCaT ... association is therefore independent from the effective amount of E5 protein expressed, and cannot be due to a very large overexpression from the optimised version of the gene This is not a trivial...
- 15
- 411
- 0
Báo cáo sinh học: " EBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in north African nasopharyngeal carcinomas" pptx
... oncogenic activity in experimental systems and are suspected to contribute to the malignant phenotype of NPC cells [3,9] Another aspect of EBV association with NPC is the presence of aberrant ... and VCA (Viral Capsid Antigen) but with low antibody levels against LMP1 [10-13] Although viral lytic cycle proteins are usually not detected in malignant cells there is a relationship between ... highly variable in NPC specimens is suspected to play a role not only in oncogenesis but also in the maintenance of latency [20] Therefore the aim of this study was to combine investigations...
- 7
- 255
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008