... promoters, mutation ofthe CHRleads to a more pronounced deregulation than the alteration ofthe CDE [40].Another gene tested for its cell cycle regulation is the cellular inhibitor of apoptosis protein ... If the DREAM complexis the main regulator of CDE ⁄ CHR cell cycle genes,to which promoter sites does it bind during any par-ticular phase ofthecell cycle? What is the exactmechanism of ... turns of the DNA double helix yields binding ofthe two orthree NF-Y complexes on the same side ofthe DNA.Conservation of spacing is required for optimal pro-moter activity because changing the...
... for the History of Medicine, the University of Michi-gan, the University of Pittsburgh, the Cleveland Clinic, the New York Consortium for the History of Medicine at the New York Academy of Medicine, ... Universities of Aberdeen and Edinburgh; the Royal College of Physicians of Edinburgh; the Royal College of Surgeons of Edinburgh; the Royal College of Physicians and Surgeons of Glasgow; the National ... or the Conjunction, or finally the Chances, of experiment. None of these however extend so far as the invention of any axiom (Bacon, 1875c, p. 413). The investigator of nature goes about gathering...
... that of the fluting of a Doric shaft, are only of use near the eye and in beautiful stone; and the pursuit of them was one ofthe many errors of later Gothic. The statement in the text that the ... color, and the other ofthe combinations of line and form, which might each of them separately engage us in as intricate study as that ofthe science of music. But ofthe two, the science of color ... the drift ofthe statements in the text too long if I attempted here to illustrate by figures the relation of the colter to the share, and ofthe hard to the soft pieces of metal in the share...
... history ofthe few; and as we measure the Himâlaya by the height of Mount Everest, we must take the true measure of India from the poets ofthe Veda, the sages ofthe Upanishads, the founders ofthe ... India, the home of Brahmanism, the birthplace of Buddhism, and the refuge of Zoroastrianism, even now the mother of new superstitions—and why not, in the future, the regenerate child ofthe purest ... of Hebrews, Greeks, and Phœnicians, was abundantly represented in the lore of these Wise Men ofthe East. The first Ionian sages lighted the torch of philosophy at the altar of Zoroaster. The...
... Sapiega), the Chancellor of Lithuania.87 Fig.11: Watermark (reduced) ofthe Vilnius (Wilno) papermill, depicting the coat of arms of Leo Sapieha, the Chancellor ofthe Grand Duchy of Lithuania, ... binding ofthe book some fragments of watermark are not available. Nonetheless, the very structure ofthe laid cover of the papermaking mould-frame impressed in the wire side of paper is also of ... the printing office in Pečerska Ławra, the famous Orthodox monastery (now within the boundaries of Kyjiv) and the spiritual capital ofthe Ruthenia. The Archimandrite Elisues Pleteniecki, the...
... specific for the different phases ofthecell cycle and determine the targets ofthe kinases. Exit from each phase ofthecell cycle occurs on degradation ofthe bound cyclin. The CDK-cyclin ... the spindle beforethe onset of anaphase: that is, one sister kinetochore must become attached to one spindle pole and the other to the opposing pole. However, during the normal course of ... 'triggers' the checkpoint. These are misleading oxymora: as the role ofthe checkpoint is to detect a problem, the monitoring mechanism (that is, the check-point) must be already active before the...
... to the upper chamber ofthe Transwell toevaluate inhibition of HIV-1 cell- associated transmission.Target cells (MT- 2) were added to the lower chambers.In the case ofthe MT-2 cells, half of ... transfer infection to the target cells that reside in the subepithelium [36], asevidenced by an absence of infection (absence of syncytiaon indicator cells) on the lower chamber ofthe cervicalmodel ... of the genital epithelium, therefore inactivating the ability of the HIV virus to reach the target cells that reside below.Thus, when the HIV virus crosses the genital epithelium,it is already...
... vein endothelial cell line(SUVEC) established in our lab previousl y [13] andincreased the proportion ofthe cells in the S-phase witha concomitant decrease in the proportion of cells in the G0/G1 ... exists on the subcel-lular localization of CSFV NS2 protein and its effects on cell growth and cell cycle progression. The swineend othe lial vascular cell is o ne ofthe CSFV target cells,vascular ... cycle arrest at S-phaseTo determine whether the growth inhibition of CSFVNS2-expressing cells was due to the arrest ofthe cell cycle at a certain phase(s) ofcell division, flow cyto-metric analysis...
... across the VS. On the other hand, the transfer of membranes from NL4-3 and BaL infected MOLT cellsto the MT-4 cell line is lower than that observed in pri-mary cells. Notably, only the transfer of ... ofthe transfer of mem-brane lipids from MOLT infected cells to target cells.Membrane transfer to single cells may be the consequence of either hemifusion events between cells [22], or the transfer ... before co-receptor engagement, poten-tially allowing for an open access ofthe HIV machinery to the cytoplasm ofthe target cells (Figure 1). However, the complete blockade of infection in the...
... that soften or tentativize what they modify. Nevertheless, the author only investigates weakeners mentioned above in the scope ofthe study because ofthe suitability to the topic ofthe thesis ... strategy of “saying less than one means”, the function of strategy being to modify the writer’s responsibility for the truthfulness of an utterance, to modify the attitude ofthe author to the propositions ... hedges of these three types is illuminating in theoretical terms, it seems that the distinction between them is not always clear-cut.G.Lakoff who drew attention to the theoretical importance of the...