... standards The opinion from the Ethics Committee of the coordinating investigator (Ärztekammer Sachsen-Anhalt) was sought for the final study protocol, including the final version of the Informed ... at the end of observation in the chemotherapy group compared with the other two groups challenges the interpretation of these data Conclusions Findings from the REASON study secondary endpoints ... combination chemotherapy to TKI/gefitinib therapy First-line therapy was continued as maintenance in 71 (22.2%) patients with EGFR Mut + NSCLC, mainly planned to be gefitinib (44 patients) There
Ngày tải lên: 24/07/2020, 00:35
... for the diagnosis and monitoring of these cancers [20-24] The diagnostic value of serum YKL-40 in patients with ESCC remains unknown The goal of our present study is to investigate the levels of ... Access Establishment of using serum YKL-40 and SCCA in combination for the diagnosis of patients with esophageal squamous cell carcinoma Xin Zheng1,2†, Shan Xing1,3†, Xiao-Min Liu1,2, Wen Liu1,2, ... epithelial cell line NE-3, induced by human papillomavirus type 16 E6/E7, was obtained from Dr Jin (the University of Hong Kong, Page of 10 P.R China) and was cultured in Keratinocyte-SFM (Invitrogen,
Ngày tải lên: 14/10/2020, 17:33
A comparison between triplet and doublet chemotherapy in improving the survival of patients with advanced gastric cancer: A systematic review and meta-analysis
... available in doublet regimens and investigated the effectiveness of irinotecan-based chemotherapy regimen in improving the survival of patients with gastric cancer considering the rarity of irinotecanbased ... chemotherapy improves not only the survival but also the quality of life of the patients [2, 8] According to the number of chemotherapeutic drugs included in the treatment method, chemotherapy ... Epirubicin (E) in combination with cisplatin (CDDP) and capecitabine (C) versus docetaxel (D) combined with 5-fluorouracil (%-FU) by continuous infusion as front-line therapy in patients with advanced
Ngày tải lên: 17/06/2020, 19:11
N-glycosylation of serum proteins for the assessment of patients with IgD multiple myeloma
... stages of MM in comparison to the control at the serum level, while only six features were identified with similar significance at the immunoglobulin level, including the analysis of the partitioned ... now, little was known regarding the changes in N-glycans in IgD MM We recently demonstrated that the serum N-glycan profile models distinguished patients with light chain multiple myeloma (LCMM) ... detected in all serum samples were analysed using the GeneMapper v4.1 software (Applied Biosystems) The abundance of each N-glycan peak was described by normalizing its height to the sum of the heights
Ngày tải lên: 23/07/2020, 23:44
Nomograms that predict the survival of patients with adenocarcinoma in villous adenoma of the colorectum: A SEER-based study
... found that the size and number of tumors had an effect on the prognosis of patients The larger the tumor and the greater the number of tumors, the shorter the survival time is In line with the results ... OS rates of patients with adenocarcinoma in villous adenoma read last by finding the number on the “Total Points” scale Validation of the nomogram model To investigate the validity of the nomogram, ... from the SEER database Table lists the basic information regarding the demographic and clinical characteristics of the patients with adenocarcinoma in villous adenoma As shown in Table 1, of the
Ngày tải lên: 06/08/2020, 05:24
Randomized phase III trial of APF530 versus palonosetron in the prevention of chemotherapy-induced nausea and vomiting in a subset of patients with breast cancer receiving moderately or
... or HEC in patients with cancer APF530 was found to be noninferior to palonosetron in the control of acute CINV in patients receiving MEC or HEC and in the prevention of delayed CINV in patients ... to palonosetron in the control of acute CINV in patients receiving MEC or HEC, and in the prevention of delayed CINV in patients receiving MEC [19] In this post hoc analysis of the study breast ... value of APF530 in other clinical settings where sustained antiemetic activity is desired, such as in patients receiving multiday chemotherapy, in patients receiving radiation therapy, in patients
Ngày tải lên: 21/09/2020, 02:01
Physico-chemical characterization of a naturally occurring hemagglutinin in the serum of sand lobster, Thenus orientalis with affinity for N-acetylated aminosugars
... determine the agglutinating activity of lobster serum in all the subsequent experiments Of the various carbohydrates tested, only inhibited the agglutinating activity of the lobster serum against ... hemagglutinin was detected in the sand lobster, Thenus orientalis The serum hemagglutinating activity was highest with buffalo erythrocytes Preliminary characterization of the serum hemagglutinating ... lobster, has the ability to maintain its agglutinating activity with low or intrinsic level of divalent cations in the serum However, prolonged exposure to EDTA hampered the agglutinating activity
Ngày tải lên: 04/11/2020, 22:58
Assessing the impact on caregivers of patients with schizophrenia: psychometric validation of the schizophrenia caregiver questionnaire (SCQ)
... examined The results of the final CFA model of the SCQ are displayed in Fig Even though none of the goodness -of- fit indices met the stringent criteria, considering the overall picture of the ... Methods: The SCQ was administered to 358 caregivers of patients with schizophrenia included in the observational PATTERN study of stabilized patients with persistent symptoms of schizophrenia receiving ... version of the SCQ Notable differences between the SCQ and ZBI included the specification of a recall period of ‘during the past weeks’, the utilization of an 11-point numerical Page of 12 rating
Ngày tải lên: 19/11/2022, 11:43
ginterferon beta 1a improves mri measures and increases the proportion of patients with no evidence of disease activity in relapsing remitting multiple sclerosis 2 year results from the advance randomized controlled
... pharmacodynamic properties of protein therapeutics, including interferon beta-1a [2, 3] The approved dosing schedule of pegylated interferon beta-1a (peginterferon beta-1a) for relapsing-remitting multiple ... in patients who continued on peginterferon beta-1a every weeks, and was maintained in the every weeks treatment group [6] Magnetic resonance imaging (MRI) results reflected the clinical findings, ... defined below MRI-NEDA: no Gd + lesions at any scan after the beginning of the stated time period, and no new or newly-enlarging T2 hyperintense lesions at the end compared with the beginning
Ngày tải lên: 04/12/2022, 10:37
The management of patients with venous leg ulcers: Audit Protocol ppt
... of the ulcer and its surrounding skin. Serial measurement of size (length and width) of the ulcer is a reliable index of healing. Appropriate techniques include tracing of the margins, measuring ... of occurrence of the first ulcer; the site of the ulcers and of any previous ulcers; the number of previous episodes of ulceration; the time taken to heal in previous episodes; the time free of ... help the project team to test the development of the audit package and methodology. The projrct team is grateful to the participating sites for their input and feedback in the development of the
Ngày tải lên: 15/03/2014, 23:20
Báo cáo khoa học: Role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells docx
... ester-induced disruption of the CD4–Lck complex occurs within a detergent-resistant microdomain of the plasma membrane. Involvement of the translocation of activated protein kinase C isoforms. J ... showing that EGFR is initially concentrated in caveolae within lipid rafts, but rapidly moves out of this membrane domain in response to EGF [7]. The inefficient movement of ErbB2 out of these ... immunolabe- ling demonstrates the effect of [D]-PDMP on the depletion of gangliosides and the specificity of the anti- GM3 serum. The distribution of ErbB2 appeared more diffuse compared with control
Ngày tải lên: 23/03/2014, 10:21
Báo cáo y học: "CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease" potx
... population in the joint in comparison with the circulation was observed in all patient groups. These are interesting findings with regard to the clinical differences between the diseases. First, the ... the groups (Fig. 3c). The range of CD25 bright CD4 + T cells in the inflamed joint in the patient groups with or without erosions was the same, with a median of 2.2% in both groups, as was the ... blood. The range of CD25 bright CD4 + T cells in the inflamed joint in the patient groups with or without RF was compara- ble, with medians of 2.3% in the RF-positive group and 2.4% in the RF-negative
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: " Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis" ppt
... that in RA. Immunostaining in normal donors revealed the expression of both BMPs predominantly in the synovial lining layer, whereas in patients with RA the expression was more frequently found in ... signaling has been shown to be involved in the onset and progression of ankylosing enthes- itis in spondyloarthropathies and in the induction of osteo- phytes in OA [8,9]. Antagonism of BMP signaling ... at the same time increased the loss of proteoglycan from the cartilage matrix, thereby cer- tainly promoting the damage of the joint surface [10]. Thus, regenerative triggers in the treatment of
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis" ppsx
... ascertain the low maturation status of the immature B cells a combination of CD38, CD24, and CD10 was used The frequency of expression of CD24/CD10 was clearly increased within the remaining B ... all of the B cell populations decreased when analysing absolute numbers as shown in Table The majority of the surviving B cells was found within the IgD- populations This argues for a predominant ... treatment results in a total depletion of CD38 expressing B cells in BM The expression of CD38 in combination with IgD was analysed for further characteristics of B cell maturation in BM shortly
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: " A modelled economic evaluation comparing atomoxetine with methylphenidate in the treatment of children with attention-deficit/hyperactivity disorder in Spain" pot
... until the end of the model while patients in the 'no medication' arm would remain unmedicated throughout the model Patients could remain within their resident health state until one of the following ... pharmacoeconomic modelling techniques to the process of informing the selection of a cost effective treatment for children with ADHD in Spain Atomoxetine, a newly introduced treatment option in the Spanish ... 3), atomoxetine was in principle the only alternative option available Atomoxetine was thus compared to 'no medication' within these groups of patients The additional cost of atomoxetine treatment
Ngày tải lên: 11/08/2014, 17:20
Báo cáo y học: " State of the Art: Why do the lungs of patients with cystic fibrosis become infected and why can''''t they clear the infection?" pps
... elevated in the bronchoalveolar lavage fluid of patients with CF Matrix metalloproteinases, implicated in remodeling of inflamed areas of the lung, are found in excess in the lungs of patients with ... diphtheria toxin Exotoxin A catalyzes the transfer of the ADP-ribosyl moiety of nicotinamide adenine dinucleotide onto elongation factor 2, which then is inactive in protein synthesis Exotoxin ... surface binding of bacteria is not quantitatively important in the establishment of infection, it may be important for the initiation of an exuberant inflammatory response [33] The binding of pilin
Ngày tải lên: 13/08/2014, 13:20
research characteristics of shen shu point (UB23) and the effect of EA in the treatment of LBP with kidney failure type
... on the total score of the three research indexes include the improving level of pain on a VAS scale, the improving expansion of the lumbar spine and the improving daily living according to the ... - The effective study of EA in treating LBP with kidney failure type: + The level of pain, pain threshold + Improving the expansion of the lumbar spine + Activities of daily living + sEMG + The ... of the body and the smooth flow of the meridians It pointed out by the balance of the bioelectric properties, according to the rule Yin- Yang balance of the Yin-Yang theory
Ngày tải lên: 04/10/2014, 13:22
Activity of Molybdate Intercalated Layered Double Hydroxides in the Oxidation of Styrene with Air
... 0–0.2, suggesting the formation of single LHD phase with the intercalation of tetrahedrally-coordinated Mo species in the interlayer domains As a consequence, a slight shift in ‘c’ or interlayer ... seen in Fig [9, 10, 38] The c parameter of the Mo-containing LHD is higher than that of the hydrotalcite reference MAC-00, reflecting a successful intercalation of MoO42- anions into the interlayer ... filtration, washing with hot distilled water, and drying at 70 °C for 24 h The obtained solid was ground into powder In the case of preparation of the Mg/Al intercalated carbonate anion in the free
Ngày tải lên: 12/12/2017, 06:08
Preventing abuse and neglect in the lives of children with disabilities
... members of the general public aware of the extraordinary human toll of abuse and neglect in the lives of children with and without disabilities? Is the abuse and neglect of children with and without ... know New York: Penguin Paavilainen, E., & Flinck, A (2013) National clinical nursing guideline for identifying and intervening in child maltreatment within the family in Finland Child abuse review, ... neglect in the lives of children with disabilities The challenge is to integrate prevention efforts within the context of the children’s day-to-day lives at home, in school, and the community Inherent
Ngày tải lên: 14/05/2018, 15:40
Cost-efectiveness of dialectical behaviour therapy vs. enhanced usual care in the treatment of adolescents with self-harm
... according to the adolescent version of DBT [17] The programme consisted of 19 weeks of weekly sessions (60 min) of individual therapy and weekly sessions (120 min) of skills training in a multifamily ... reliable records of resource use per patient, since the accurate registering of treatment contacts is mandatory and is the basis for funding of the clinics The data on the use of health service ... (68.0% of the total sample) and having been admitted to inpatient psychiatric treatment (7.8% of the total sample) prior to participation in the study Main results of? ?the efficacy study In the first
Ngày tải lên: 10/01/2020, 13:39