bdnf and trkb receptor in the brain of patients with schizophrenia
Báo cáo y học: "A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting" pptx
... aripiprazole has minimal affinity for a2 adrenergic receptors, H1 histamine receptors and muscarinic cholinergic receptors [9,10], possibly underlying the diminished liability of aripiprazole to ... Good Clinical Practice (GCP), Guidelines of Taiwan and in accordance with the Declaration of Helsinki The study protocol was approved by an Institutional Review Board committee from the nine medical ... subjects received their first dose of aripiprazole at the start of the switching treatment period, the starting dose of which was determined by the investigator After weeks of adverse event (AE)-free...
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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"
... pointes Unlikely Risk of liver injury in conjunction with lipid-lowering agents; risk of bleeding complications in conjunction with antiplatelet agents, warfarin, niacin Induction of CYP3A4 increases ... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... pre-dialysis and 2–3 hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous...
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Báo cáo y học: "Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis" potx
... reported the first systematic histological study of zygapophyseal joints in patients with AS [10] In the present study, we first examined whether inflammation in the spine of patients with AS, ... illustration of the anatomy and detection of inflammation in the bone marrow The entire lumbar spine including the zygapophyseal joints and, if available, the thoracic spine was analyzed for increased ... highest score of bone marrow infiltation in the histopathological assessment Some of the patients had inflammatory lesions in other parts of the spine, as indicated in Table Page of (page number...
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Báo cáo y học: "Improvement in symptoms and signs in the forefoot of patients with rheumatoid arthritis treated with anti-TNF therapy" ppsx
... sustained The findings further indicate that the use of US imaging of the foot would be more beneficial than clinical examination alone in the refinement of diagnosis and the implementation of ... beneficial in monitoring the progression of active inflammation in rheumatoid arthritis [13] and in the monitoring of biologic therapy [14-16] The aim of this study was to evaluate by means of US, the ... regress within the forefeet In previous work, within the MCP joints of the hands a reduction in sonographically detectable synovial hypertrophy was noted at eighteen weeks following infliximab therapy,...
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Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
... form of BLyS The molecular mass of the heterotrimers was confirmed by SEC-MALS mass distribution LS/UV/RI 3-detector analysis Binding kinetics and affinity studies The binding affinities and kinetics ... determined from the kinetic rate constants (ka and kd) The binding curves were processed by double referencing and were globally fitted to a 1:1 binding model The stoichiometry of binding was ... difference in detectable levels of BLyS was found in patients with RA (33%) compared with the healthy donor samples (18%) (Table 1) Within the samples containing detectable levels of the three ligands,...
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Báo cáo y học: "Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus" ppsx
... that SLE patients with MRI findings compared with those without MRI findings had significantly higher CSF-tau levels These increases reflect the neuronal damage of the brain in SLE patients Indeed, ... MRI-verified brain pathology This finding, together with increased intrathecal levels of TGF-β, indicates an ongoing destructive parenchymatous process in the SLE brain In addition, the present ... found in some but not all patients with CNS lupus [9,10] Elevated concentrations of IgG in the cerebrospinal fluid (CSF), of the IgG–albumin ratio and of the IgG index, and the presence of oligoclonal...
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Báo cáo y học: "Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years" ppt
... bodies and related soft tissues of the cervical and lumbar spine without evaluating possible further damage at the posterior elements of the cervical and lumbar spine, the thoracic spine, or the ... Assessment of radiographic progression Baseline and 2-year radiographs of the lateral cervical and lumbar spine in patients in the OASIS and the adalimumab cohorts were scored using the mSASSS scoring ... effect of adalimumab on the reduction of signs and symptoms and to assess the inhibition of progression of structural damage in the spine as measured by the mean change in the modified Stoke AS Spine...
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báo cáo khoa học: " Connectedness of healthcare professionals involved in the treatment of patients with Parkinson’s disease: a social networks study" pot
... finding should be interpreted in the context of the newly established network One of the aims of ParkinsonNet is to better integrate primary care professionals in the treatment of patients with ... variation of individual network characteristics for all measures in both the network of ‘knowing each other’ and in the network of ‘having professional contact.’ For example, the number of others ... Consistent with the pattern in the total network, mean and maximum values of the network measures were highest in the network of knowing each other Table shows the same 12 measures in the predefined...
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Báo cáo y học: " Pro/con clinical debate: The use of prone positioning in the management of patients with acute respiratory distress syndrome" potx
... common in the group whose position was varied than in the group that remained continuously supine Con: prone positioning is not useful in the management of ARDS patients Gordon Rubenfeld Imagine the ... Finally, intensivists are strongly motivated by the ‘rule of rescue’ Intensivists feel obliged to offer some therapy, any therapy, to a patient in imminent danger of dying [16] As is often the ... another route to understanding this debate [14] At the heart of a discussion about the use of prone ventilation (or of nitric oxide) is an understanding of how clinicians make decisions when the...
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Báo cáo y học: "Pro/con clinical debate: Are steroids useful in the management of patients with septic shock" ppt
... reasonable and appropriate Con: steroids are not useful in the management of septic shock Katherine G Craig and Keith R Walley The debate surrounding the use of corticosteroids in septic patients ... and newer, yet preliminary, The patient described in the present scenario is improving in all aspects of organ failure, but remains catecholamine dependent A thorough examination and review of ... can regulate the synthesis and function of catecholamines and their receptors, which in turn control vascular tone and organ perfusion [4] Proinflammatory cytokines released in sepsis alter steroid...
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Báo cáo y học: "Pro/con clinical debate: Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis" ppt
... difference in the rate of infection of pancreatic necrosis [4] Pooling of the data from these 183 patients by Bosscha and colleagues in a meta-analysis resulted in a group of 95 patients treated with ... used intravenous and enteral antibiotics (including amphotericin) to achieve decontamination of the gastrointestinal tract for the purpose of possibly decreasing bacterial inoculation of the necrotic ... there is no definitive, level one, data supporting the use of intravenous antibiotics in the treatment of patients with severe pancreatitis, even in the setting of pancreatic necrosis The few prospective...
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Báo cáo y học: " Pro/Con Debate: Does recombinant factor VIIa have a role to play in the treatment of patients with acute nontraumatic hemorrhage" ppt
... associated with off-label use of FVIIa, the majority occurring in trauma patients However, MedWatch is a database for voluntary reporting of observed complications, and therefore the incidence of complications ... (upper gastrointestinal bleeding) without any evidence for the drug’s efficacy and safety The first issue is the off-label use After a single successful report of off-label use of recombinant FVIIa ... for all bleeding Sandro Scarpelini and Sandro Rizoli We understand the clinical scenario and debate question as whether one should administer a drug outside its licensed indications (off-label)...
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Báo cáo khoa học: Interactions of ultraspiracle with ecdysone receptor in the transduction of ecdysone- and juvenile hormone-signaling pdf
... receptors, including human RXR (which is the ortholog of USP) have shown that an area on the surface of the ligand binding domain involving the C-terminus of a-helix 3, a-helix 4, and the N-terminus of ... acts through the ligand binding pocket of USP to activate transcription of the DR1JHECore Overexpression of EcR in the transfected cells results in the loading of the DR1 enhancer of the DR1JHECore ... III by way of binding of JH III or closely related structures to the ligand binding pocket of USP [18] This binding of JH III by USP induces change in USP tertiary conformation [18] and induces...
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Báo cáo y học: "Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport" doc
... PiT1-binding immunoadhesin generated by fusing the aminoterminal residues of the GALV (SEATO strain) Env, comprising the signal peptide, the RBD and the proline-rich region, to the rFc tag, herein, ... distinct binding of the GLUT1 ligand was detected, with the structure rather presenting a diffuse staining (data not shown) PiT1, on the other hand, showed a reticular pattern with several stained ... distribution in basal conditions With HRBD, the GLUT1 ligand, we observed a staining of GLUT1 in the corpus callosum and the basal ganglia apparently weaker than in the cerebellum and in the cortex These...
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Báo cáo y học: "Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain" pptx
... aging [26] Taken together with the proposed roles of the PDGF/PDGFR systems in the brain, it is plausible that the CTS-induced reversal of expression levels of PDGF and PDGFR in SAMP8 with and ... CTS in SAMP8 One significant finding of this study is that SAMP8 groups with and without ischemic insult exhibited down-regulation of the VEGF/PDGF signaling system in the brain and that the ... decreased in the brains of older SAMP8, indicating aging-induced dysfunction of the VEGF-VEGFR2 signaling system Therefore, the impaired VEGF-VEGFR2 signaling systems likely induce a decrease in angiogenesis...
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Development of a novel toll like receptor based two hybrid assay for detecting protein protein interactions and its application in the study of CD14 dimerization and FcyRIIA activation
... the identification of binding partners for a known protein by expressing the protein in fusion with BD domain and then screening proteins in fusion with AD It also allows the identification of ... domain in its C-terminal portion and a death domain (DD) in its Nterminal portion Activation of TLR or IL-1R recruits MyD88 to the receptor The TIR domain of MyD88 binds to the TIR domains of ... from the αA helix, βB strand and aromatic side chain of the (F/Y) DA motif The BB loop, connecting the second β-strand and second helix, extends away from the rest of the TIR domain forming a...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... partitioning of the protein into an aggregated state The effect of copper binding on the secondary structure was determined using CD in the far UV To prepare proteins without Cu2+, part of each protein ... loss of copper binding could still allow domain swapping to occur It is of interest that a N-terminally truncated prion protein, lacking the copper binding domain is capable of domain swapping and ... understanding what causes the loss of appropriate metal binding might be crucial for the understanding of the role of amyloidogenic proteins in a number of neurodegenerative disorders Copper binds...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain For ... C-terminus Kinase domain and C-terminus SH3 domain and C-terminus SH2 domain and C-terminus SH3, SH2 domain and C-terminus N-terminal, SH3, SH2 domain and C-terminus N-terminal, SH3, SH2, kinase ... mutations therefore inhibit interactions with ligands of the SH3 and SH2 domains, respectively, both intra- and intermolecularly, and thereby disrupt the overall functions of Src kinase [3,18–21]...
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AN ACCOUNT OF TIMBUCTOO AND HOUSA, TERRITORIES IN THE INTERIOR OF Africa docx
... and if no person of the royal line be the object of their choice, they may elect one of their own body The members of the council are appointed by the king; he chooses them for their wisdom and ... grown in these Plains. Matamores, what they are. Mode of Reaping. -The Prince presents the Doctor with a Horse, and approves of his Medicines. The Prince and the Doctor depart south-eastwardly, and ... goods brought in by the gate of the Nile, (which is the gate of the Negroes,) pay a tax: another part of the revenue is two per cent, in kind on the produce of the land; but the people of Barbary...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... [21–25], and DGD° values in the presence of these osmolytes are given in Table However, DGD° values of RNase-A in the presence of alanine, serine, lysine, b-alanine, taurine and dimethylglycine have ... efficiency in the presence of this group of osmolytes Interestingly, there is a linear relationship between DDGD° and Dlog(kcat ⁄ Km) in the presence of methylamines and sugar However, the slopes of the ... (a) the main driving force for the folding is the unfavourable interaction between the osmolyte and the peptide backbone, and (b) the total contribution of side chains to the stability of the...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008