... fluttering its wings in one hemisphere of the world may have a significant effect in the other hemisphere, by way of snowballing weather effects which are initiated by the seemingly minor activity of the ... happen in the world’ fares well, considering the foregoing It also recognises the unprecedented velocity, intensity and reach of the concept.42 It is a way of maintaining the integrity of globalisation ... of this book is to present, more generally, a meaningful framework for viewing the role of law in the social order, and the role of the social order in constructing law The purpose behind doing...
Ngày tải lên: 21/09/2012, 10:54
... that in the future further subfamilies will be identified, owing to the appearance of new members or by subdivision of the existing subfamilies Indeed, there are several GH-57 candidates in the ... domain (SLD2), a threonine-rich region and a putative transmembrane domain [22] Interestingly, the 3D structure of a protein domain, which is clearly homologous to SLD1 and -2 of Q9Y8I8_THEHY, ... the C-terminus of the first b-strand of the catalytic (b/a)7-barrel [16] Interestingly, the three shortest GH-57 members, which include the P furiosus a-galactosidase (Q9HHB5_PYRFU), exhibit the...
Ngày tải lên: 19/02/2014, 12:20
Báo cáo khoa học: NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B–NS3 protease ppt
... only studied the binding of the nonsymmetric and more soluble compound using intermolecular NOEs In the : complex with the protease, the proton resonances of the phthalazine ring of were too broad ... residing in the substrate-binding site A NOESY spectrum of and in the presence of a small quantity of protease revealed an intermolecular cross-peak between the methyl group of and the phthalazine ... spectra of WNV NS2B–NS3pro(K96A) in the presence of and in the presence of the Bz-nKRR-H inhibitor used in one of the crystal structure determinations [5] As expected for closely related binding...
Ngày tải lên: 07/03/2014, 02:20
THE ATTRACTIONS OF RISK-BASED REGULATION: ACCOUNTING FOR THE EMERGENCE OF RISK IDEAS IN REGULATION docx
... criticism and political attack They were accused of ‘burdening industry’ and inefficiency and ineffectiveness in their own operations During the mid 1980s Britain witnessed waves of deregulatory initiatives ... furthered the prominence of risk discourses and the promotion of riskbased thinking in government However, the emergence of ideas about risk in the regulatory arena is more one of drift than domination ... lacking in achieving either of these goals They argue for instance that CCA in practice embraces a variety of methods which due to the unreliability of the information presented cannot offer the...
Ngày tải lên: 23/03/2014, 00:20
báo cáo sinh học:" Burnout and training satisfaction of medical residents in Greece: will the European Work Time Directive make a difference?" pot
... supervisors' interest towards their training, on the merit of their CME activities, on the responsibilities and time given to them for patient care and on the overall quality of training in their clinic ... assisted in the development of the draft of the manuscript; CL supervised the project and contributed to the draft of the manuscript All authors read and approved the final manuscript Page 10 of 11 ... towards their training and were dissatisfied with the overall quality of training in their clinic and with their continuous medical education (CME) activities Furthermore, approximately in every Greek...
Ngày tải lên: 18/06/2014, 17:20
báo cáo sinh học:" The training and professional expectations of medical students in Angola, Guinea-Bissau and Mozambique" pot
... not currently integrated in any University, and offers a training programme supported by Cuban tutors It was, at the time of the study, in its third year of training The purpose of this research ... participants in the seventh year of training, whereas in Guinea-Bissau the training had just reached its fourth year) (Table 2) In Mozambique the most frequent problem was the physiology course The main ... migration to the capital city most marked in GuineaBissau and less so in Angola The decision to study medicine The median age of taking the decision to study medicine was 15 years (Guinea-Bissau and Mozambique)...
Ngày tải lên: 18/06/2014, 17:20
báo cáo hóa học: " Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid β-protein in cerebrovascular smooth muscle cells" docx
... parenchyma, another prominent site of extracellular Aβ deposition is within and along primarily small and medium-sized arteries and arterioles of the cerebral cortex and leptomeninges and in the cerebral ... delaying the age of onset, and slowing the progression of disease and cognitive impairments [42,43] Despite the potential for NSAIDs and steroidal anti-inflammatory drugs in the treatment of AD ... immunoblotting For analysis of cellular proteins, the culture medium was collected and the cells rinsed with phosphate-buffer saline The cells were then solubilized in a buffer consisting of 50 mM...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học:" A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Espírito Santo, Brazil" ppt
... to the need to revisit the standard clinical protocols in a way to increase the disease treatment success in the cases of platinum-resistant EOC In conclusion, we have characterized the clinicopathological ... as 43.8% of cases had a better prognosis profile (I and II) versus 56.2% of the cases that showed a poor prognosis standard (III and IV) Analyzing the FIGO staging of the tumor within each histological ... reported an incidence of 26.3% and 42%, and Derchain et al [32] of 34% and 51%, of EOC staged I and III, respectively Interestingly, our data have shown a slightly higher predominance of poor prognosis...
Ngày tải lên: 20/06/2014, 08:20
Báo cáo khoa học: "The expression and cellular localization of phospholipase Disozymes in the developing mouse testis" pps
... sitset eht ni sllec gidyeL laititsretni ni nees saw gniniatsonummi DLP esnetnI selubut suorefinimes eht ni sllec detaitnereffidnu emos ni gniniatsonummi DLP kaew dewohs yrtsimehcotsihonummI sllec ... stluseR )C2 giF( snoitces eseht ni dnuof saw gnillebal cificeps on dna ,snoitces tset wef a rof dettimo saw ydobitna yramirp eht ,lortnoc a sA detnuom gnieb erofeb nilyxotameh htiw deniatsretnuoc ... etasyl eht dna ,degufirtnec erew setanegomoh eht ,htab-eci na ni nim 03 rof noitabucni retfA ]ediroulf -lynofluslyhtemlynehp Mm ,ninitorpa lm/gµ 01 ,nitpepuel lm/gµ 01 ,lCaN Mm 051 ,SDS %1.0 ,etalohcyxoed...
Ngày tải lên: 07/08/2014, 20:23
Báo cáo lâm nghiệp: "Distribution, historical development and ecophysiological attributes of oak species in the eastern United States " pdf
... grandifolia on the gently rolling till plains of Ohio and Indiana, and with Tilia americana in southwestern Wisconsin, northwestern Illinois, northeastern lowa and southeastern Minnesota Several ... records, including the original land survey in 1858 and aerial photographs taken in 1939 and 1978, indicated that the extent of the gallery forests has greatly expanded from about at the time of settlement ... represents the western limit of the eastern deciduous forest, and oak species often grow along streams and ravines forming relatively thin bands of "gallery" forests A study of the forests in a Kansas...
Ngày tải lên: 08/08/2014, 18:21
Báo cáo y học: "On demand treatment and home therapy of hereditary angioedema in Germany - the Frankfurt experience" pptx
... established therapy in North America since 1975 [13] and is included in the German Guidelines on hemophilia therapy In Frankfurt, home therapy with pd C1-INH concentrate for use in on demand treatment ... kininogen (HMWK) and therefore promotor of bradykinin formation, is a further potential therapeutic alternative In Germany, current treatment options approved for therapy of acute angioedema in ... developed in line with hemophilia therapy, where the missing protein is administered by the patient at home on an as-needed basis Home treatment with plasma derived and recombinant factor VIII and...
Ngày tải lên: 08/08/2014, 21:20
Báo cáo y học: " Open Access The association between bullying and early stages of suicidal ideation in late adolescents in Greece" pdf
... results VM helped in obtaining funding for the study, in the writing of the paper and interpretation of the results All authors read and approved the final manuscript Competing interests The authors ... to the statistical analysis and drafted the manuscript SB helped in data collection, in the statistical analysis, in the writing of the manuscript and interpretation of the results TG helped in ... used in the past in other papers [9,10] Bullying is considered to be a continuous process and including in the “bullying category” those pupils who had been involved once or twice during the past...
Ngày tải lên: 11/08/2014, 16:23
Báo cáo y học: " Clinical and economic ramifications of switching antipsychotics in the treatment of schizophreniab" pptx
... we assessed the proportion of patients receiving the service, the rate of use and rate of admissions, the time to first use of the service, and the annual health care cost, in terms of total health ... antipsychotic within 14 days of discontinuation of the initial therapy Data on the occurrence of acute-care service use, the time to the use of such services, and total-care and acute-care service ... analysis Patients were defined as having switched medications if they discontinued the medication to which they were initially randomized at any time during the study and initiated therapy with a different...
Ngày tải lên: 11/08/2014, 17:20
báo cáo khoa học:" The well-being and treatment satisfaction of diabetic patients in primary care" doc
... read and approved the final manuscript Acknowledgements We thank to the Department of Endocrinology and the Laboratory of Faculty of Medicine and the Scientific Research Project Foundation of Cukurova ... diabetes The instrument was designed to assess the efficacy of new measures The inclusion of a positive well-being dimension was designed to increase the sensitivity of the instrument The positive ... target levels of 100 mg/dL compared with 15.4% of patients in the NHANES III study [22], 45% of patients in the Vermont Diabetes Information System Trial [29], and 43.7% of patients in the study...
Ngày tải lên: 12/08/2014, 01:21
Báo cáo y học: " Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells" doc
... enzymatic activity of the IN itself in vitro, and consequently the integration of viral cDNA in virus infected cells [25] In the current work we show that in the presence of the INr and INS peptides, ... by the same domain [2] It was therefore of interest to determine whether the INS peptide, in addition to its binding to IN and Rev, is also able to interact with the LEDGF/p75 protein ELISA binding ... Therefore, in light of the above results, it was of interest to find out whether the INrs would also stimulate integration of viral cDNA in LEDGF/p75-knockdown cells In contrast to the INS, the...
Ngày tải lên: 12/08/2014, 04:20
Báo cáo khoa học: "Clinical review: The implications of experimental and clinical studies of recruitment maneuvers in acute lung injury" pptx
... above the lower inflection point was more effective in maintaining gas exchange and minimizing inflammation and lung injury than was PEEP set at the maximum curvature of the deflation pressure–volume ... expression of many cytokines involved in the pathogenesis of VILI [14] It is unknown whether a single stimulus such as RMs applied during MV can trigger the above-mentioned pathways of lung injury, and ... B: tidal insuflation with a PEEP below the lower inflection point after a sustained inflation Loop C: PEEP higher than the lower inflection point after a sustained inflation Sustained inflation...
Ngày tải lên: 12/08/2014, 19:22
Báo cáo khoa học: "Bench-to-bedside review: Antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unit" pps
... reduction in the risk of resistance development while on therapy [85,86] Summary Clinicians working in the ICU setting should routinely employ antibiotic strategies aimed at limiting the emergence of ... the basis of pharmacokinetic/pharmacodynamic principles could play a role in the reduction of antibiotic resistance The duration of time that the serum drug concentration remains above the minimum ... and oxazolidinones Frequent dosing, prolonged infusion times, or continuous infusions can increase the duration of time that the serum drug concentration remains above the minimum inhibitory concentration...
Ngày tải lên: 12/08/2014, 22:22
Báo cáo y học: "Genetic and phylogenetic evolution of HIV-1 in a low subtype heterogeneity epidemic: the Italian example" pdf
... distribution in the HIV-1 sequences identified during the Italian epidemic, with the exception of the T-to-A22 substitution (within the tip of the loop) which is prevalent in the isolates identified in the ... pattern of the V3 loop Evolution pattern of the V3 loop The percentage of synonymous and non-synonymous substitutions in each of the 35 codons of the V3 Loop are indicated, together with the percentage ... epidemic in Italy Injecting drug users (IDUs) have been the most affected risk group during the first phase of the HIV epidemic in Italy and the HIV-1 B subtype, in accordance with other Western...
Ngày tải lên: 13/08/2014, 05:22
Báo cáo y học: " Clinical and demographic features of pediatric burns in the eastern provinces of Turkey" pdf
... parts in our study patients were the front and back of the torso, the feet, hands, head and neck region, major joints, and the genital region In tandir burns, the hands, feet, and head and neck ... cases in a 3-year period; 32 (47%) of these were due to tandir injuries In their series, most of the burn victims were children and, in most of the cases, burn injuries included the head and both ... and both hands These results were in agreement with the findings of our study The length of hospital stay and the mortality increased with increases in extent of the burn Figure Image of a cauldrons...
Ngày tải lên: 13/08/2014, 23:20