basis of drug therapy

... increase the ratio of efficacy to toxicity of chemoradiotherapy Combinations of radiation and drugs would be better tolerated if the drugs were selected such that there was no overlap of toxicities ... planning optimal timing of drug administration in relation to radiotherapy Depending on the principal aim of the therapy, drugs are administered before (induction or neoadjuvant chemotherapy), during ... Both the late BED of 100 Gy3 and the tumor BED of 72 Gy10 correspond to an NTD to Gy fractions or EQD2 Gy of 60 Gy, of course Table 1.1 Conversion of BED to NTD or EQD2 Gy Type of tissue Late complications...

Ngày tải lên: 29/06/2014, 11:20

... of Ca2+ from bone in tissue culture Mechanism of Action of Eicosanoids Prostaglandin Receptor Diversity The diversity of the effects of prostanoids is explained by the existence of a number of ... sole therapy (see Chapter 28: Drugs Used in the Treatment of Asthma) In the treatment of systemic anaphylaxis, in which autacoids other than histamine play major roles, the mainstay of therapy ... most effective of all drugs for the prophylaxis and treatment of motion sickness, some H1 antagonists are useful in a broad range of milder conditions and offer the advantage of fewer adverse...

Ngày tải lên: 12/07/2014, 20:21

... and visual representation of drug- therapy and drug- target networks, the weight of the links (such as the number of drugs binding to both of two linked targets in the drug- target network) is seldom ... approval rate of new drugs When thinking about the possible network representations of diseases, drugs and drug targets, the elements of the network first have to be defined For a list of the available ... Journal of Biology 2008, Volume 7, Article 20 Spiro et al therapy interactions, and it highlights a few key drugs that connect distinct classes of therapy in a few steps Both the drug and the therapy...

Ngày tải lên: 06/08/2014, 18:21

... Decade of Progress This is part of a special collection of reviews, The Scientific Basis of Rheumatology: A Decade of Progress, published to mark Arthritis Research & Therapy s 10th anniversary Other ... true record of their work Page of (page number not for citation purposes) Available online http://arthritis-research.com/content/10/5/119 The Scientific Basis of Rheumatology: A Decade of Progress ... understanding of systemic lupus erythematosus are the focus of the contribution of Ardoin and Pisetsky [7], who review recent research into immune abnormalities in the disease, the scientific basis of which...

Ngày tải lên: 09/08/2014, 13:22

... Accumulation of mutations against drugs from different drug classes and/or the presence of broad cross-resistance mutations will jeopardize the effectiveness of the NRTI backbone of second-line ... and accompanying resistance are of concern with regard to the risk of disease progression and potential transmission of drug resistant virus to partners The aim of this study was to assess, in ... danger of the absence of viral monitoring, with regard to the accumulation of resistance mutations Besides high quality adherence counselling, efforts are needed to guarantee a robust supply of drugs...

Ngày tải lên: 10/08/2014, 05:21

... The majority of patients were male with an average age of approximately 39 years of age The average age of onset of the disease was approximately 23.1 years of age, with a mean number of episodes ... better estimation of potential direct and indirect effects of cognition on functioning of patients with schizophrenia A large number of dropouts (especially when caused by lack of symptom improvement) ... study of the neurocognitive efficacy of olanzapine [OLZ], risperidone [RIS], and haloperidol [HAL] in the treatment of schizophrenia [16] Enrollment criteria included: patients 18 to 55 years of...

Ngày tải lên: 11/08/2014, 17:20

... targeting a power of 80% (2-sided test of α = 5%) to improve the patient's HRQoL after stroke on the basis of PC demonstrated that 116 patients were needed for each group The evaluation of the HRQoL ... al., Health-Related Quality of Life after Ischemic Stroke: The Impact of Pharmaceutical Interventions on Drug Therapy (Pharmaceutical Care Concept) Health and Quality of Life Outcomes 2010, 8:59 ... for patients in the IG Pharmacists of the QAWG met on a regular basis (once a month) to discuss specific drug- related issues and to ensure proper implementation of PC in their pharmacies The PC...

Ngày tải lên: 12/08/2014, 01:21

... analysis of SAP studies showed a significant reduction of the risk of candidemia by prophylactic therapy (pooled OR 0.32, 95% CI 0.12 to 0.82, NNT 38) (Figure 4), reducing the incidence of candidemia ... efficacy of SDD compared with SAP The use of systemic (absorbable) drugs, like fluconazole, may have to be restricted for two reasons First, antifungal drug use can initiate the possible emergence of ... between the pooled ORs of both types of prophylaxis, so no definite conclusions should be drawn With a relatively high NNT of 38 for SAP and a relatively low incidence of candidemia of 3.8% in these...

Ngày tải lên: 13/08/2014, 10:20

... higher occurrence of one or some CA-groups after the use of the given drug due to the specificity of teratogens Recall bias may act for all CAs similarly Secondly, the use of the drug under study ... teratogenic drugs is about per 1,000 on the basis of Table and (Table 3) Of course, we have to our best to limit this risk However, there is another aspect of CA prevention which is connected with drug ... asked about the history of their pregnancy, give a long list of supposed agents On the other hand the mothers of healthy babies are thinking of the present and future of their babies and are...

Ngày tải lên: 02/11/2012, 11:12

... affinity of ligands, the kinetics of interaction, and the characteristics of the binding site itself In studying the affinity and number of such binding sites, use is made of membrane suspensions of ... conditions of license 57 Quantification of Drug Action Addition of radiolabeled drug in different concentrations Organs Homogenization Membrane suspension Mixing and incubation Determination of radioactivity ... slope at the point of inflection Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 55 Quantification of Drug Action Portal...

Ngày tải lên: 26/01/2014, 19:20

... molecular mode of action of glyphosate and the molecular basis for glyphosate resistance Structure and function of EPSPS EPSPS catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate ... however, was devoid of substrate or inhibitor, and consequently did not reveal the nature of the active site or the mode of action of glyphosate A decade later, the crystal structure of EPSPS was determined ... of the carbon–nitrogen bond of glyphosate, yielding AMPA and glyoxylate without production of hydrogen peroxide (Fig 3A) The authors proposed a mechanism that involves the reduction of FAD cofactor...

Ngày tải lên: 14/02/2014, 14:20

... phosphorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members However, each type of cancer has its own way of disrupting the balance of the networks of signaling ... associated with stimulation of ERK1 ⁄ and Pak1 pathways, gefitinib might lead to inhibition of invasiveness of human cancer cells through the inhibition of ERK1 ⁄ and Pak1 The use of gefitinib in cells ... inhibition of Akt- and ERK1 ⁄ 2-dependent pathways eventually change the expression level of one or more of these Bcl-2 family members Bad Bad is one of the ‘death-promoting’ members of the Bcl-2...

Ngày tải lên: 16/02/2014, 09:20

... Overlay of 1H,15N-HSQC spectra at 300 K of NarG(1–28) peptide in the absence (black trace) and in the presence (orange trace) of molar ratio of NarJ Fig S2 Overlay of 1H,15N-HSQC spectra at 300 K of ... Fig Ensemble of the backbone traces of the 20 lowest energy conformers of the solution structure of (A) NarG(1–15) and (B) NarG(1–28) second site) The measured enthalpy is the sum of two terms: ... varied by nearly a factor of 10 between the two subpopulations, i.e koff = 3.2 ± s)2 for the minor species of high affinity and koff = 1.9 ± s)1 for the major species of lower affinity Overall,...

Ngày tải lên: 16/02/2014, 14:20

... those of atheism, because of their rejection of the gods of Greece and Rome; of immorality, because of the secrecy and mystery of their meetings, and cannibalism, because of their doctrine of the ... not of certainty, but of mere opinion And this estimate of the function of philosophy with respect to theological truth, which the Fathers worked out on the basis of the concrete example of the ... the truth, but each only from one point of view, and on the basis of only one method of approach The conclusions of each were the result of a process of more or less complete abstraction, and...

Ngày tải lên: 21/02/2014, 08:20

... Predictors of success in the treatment of MDR TB are the use of pyrazinamide and ethambutol if the strain of TB is susceptible to these drugs, the use of a fluoroquinolone, the use of more than five drugs, ... based on the total amount of money available for anti-TB drugs sold in India, 75 percent of first-line drugs and 100 percent of second-line drugs were being used outside of the RNTCP 10 This section ... selection of drugs The first is to perform DST and use a drug considered to be effective on the basis of the results The patient should have no previous history of treatment failure with a drug and...

Ngày tải lên: 05/03/2014, 11:20

... Department of Internal Medicine, University of Cincinnati School of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA Bruce C Trapnell, MD Department of Pediatrics and Department of Internal ... WA of Pathology, Seattle Children’s Hospital, Jean M Elwing, MD, Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, OH Andrew P Fontenot, MD, Department of ... W Kinder, MD, Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, OH Michael R Knowles, MD, Department of Medicine, University of North Carolina, Chapel...

Ngày tải lên: 05/03/2014, 23:20

... (3) elucidation of the chemical basis of heredity, the molecular basis of disease has been addressed in the context of how mutations affect the structure, function, or regulation of a gene or its ... analysis of the human genome has enabled detection of genome changes heretofore not observed because of technology limitations Whereas agarose gel electrophoresis enables detection of changes of the ... manufacturer of each drug for any change in dosages or for additional warnings and contraindications This is of utmost importance when the recommended drug herein is a new or infrequently used drug It...

Ngày tải lên: 05/03/2014, 23:20

... different species [23–25] The success of the series of studies shows that the stable framework structure of Fv enables the transfer of function by means of CDR replacement Barbas et al first designed ... Functionalization of small scaffold proteins by replacing a loop of the scaffold protein with a CDR loop of antibody fragments (A) Replacement of the candidate location in NCS for grafting with the CDR loop of ... grafting the CDR loop of the single variable heavy chain of a heavy-chain camel antibody (VHH) (Fig 1B) by comparing topologies between VHH and NCS (Fig 2A); grafting of the CDR loop of antilysozyme...

Ngày tải lên: 06/03/2014, 11:20

... University of British Columbia She is a registered psychologist in the province of Ontario, Canada, and a member of the editorial board of the Journal of Marital and Family Therapy, the Journal of Couple ... director of the American Board of Family Psychology (now part of the American Board of Professional Psychology) and holds an ABPP Diplomate in family psychology He is a fellow of APA’s divisions of ... Publications) and is the author of a marital therapy manual (published by Division 42 of APA) Joy K Rice, PhD, is clinical professor of psychiatry and Emerita Professor of Educational Policy and Women’s...

Ngày tải lên: 06/03/2014, 18:20

... analysis of a purified GPI-anchorless soluble version of the mutant protein The Kcat ⁄ Km value of the mutant TNSALP was less than one-tenth of the Kcat ⁄ Km value of the soluble form of the wild-type ... compilation ª 2008 FEBS 2735 Molecular basis of perinatal form of hypophosphatasia 10 11 12 13 14 15 16 17 18 19 N Numa et al establishment of a model of infantile hypophosphatasia Dev Dyn 208, ... containing the SV40 early promoter [11] Shortage of a precursor of GPI in the endoplasmic reticulum may be one of the reasons why a small but significant fraction of the wild-type TNSALP forms the aggregate...

Ngày tải lên: 07/03/2014, 05:20