basic principles of cancer genetics

... A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Cancer Cell 2006, 10:515-27 Wang D, Lippard SJ: Cellular processing of platinum anticancer drugs ... ascites of patients with ovarian cancer Eur J Surg Oncol 2007, 33:213-5 67 Cannistra SA: Cancer of the ovary N Engl J Med 2004, 351:2519-29 Eckstein Journal of Experimental & Clinical Cancer ... resistance: mechanisms of resistance are multiple and not all of them are fully understood Specific principles of Cisplatin-resistance are reduced uptake or increased efflux of platinum compounds...

Ngày tải lên: 10/08/2014, 10:21

... treatment and prognosis of patients with phyllodes tumor of the breast: an analysis of 170 cases Cancer 1996, 77:910-16 Page of (page number not for citation purposes) World Journal of Surgical Oncology ... report In a series of 106 patients by Chua et al., 71% of patients with a post-operative diagnosis of phyllodes tumor had a presumptive diagnosis of fibroadenoma at the time of surgery [8] Another ... analysis of fibroadenoma and phyllodes tumor of the breast Cancer Res 1993, 53:4071-74 Bernstein L, Deapen D, Ross RK: The descriptive epidemiology of malignant cystosarcoma phyllodes tumors of the...

Ngày tải lên: 09/08/2014, 07:22

... of regulating its target mRNAs (See Fig 1) Deregulation of this processing Role of miRNAs in disease Gene regulation by miRNA can affect a wide variety of cell functions, such as regulation of ... was identified as one of the targets of miR-375 Inhibition of Myotrophin production has similar effects of miR-375 on insulin secretion, making miR-375 an important modulator of β-cell function ... malignant tissues offers the possibility of identifying new methods of diagnosing early stage incidence and discovering new therapies for the treatment of OVCA With the advent of new miRNA technology,...

Ngày tải lên: 20/06/2014, 07:20

... Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Dermatology, University Hospital of the Johannes Gutenberg-University of Mainz, Mainz, ... 24Department of Medicine, University of Calgary, Calgary, Alberta, Canada 25Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada 26Department of Medicine, ... University of Manitoba, Winnipeg, Manitoba, Canada 31University of Auckland, Auckland, New Zealand 32Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA 33Department of Clinical...

Ngày tải lên: 08/08/2014, 21:20

... confirmed by 71% of elective surgery patients having an ASA status of I or II and a median age of 72 The elective operative mortality of 14% is high but given the small number of patients in this ... prospectively collected information held in a local copy of the Association of Coloproctology of Great Britain and Ireland colorectal cancer database All patients underwent colonic imaging (Barium ... total of 646 consecutive newly diagnosed colorectal cancer patients were identified from the database during the study period, 166 (26%) of whom were identified as stage IV at presentation Of the...

Ngày tải lên: 09/08/2014, 04:21

... majority of Brunner's glands are located in the first portion of the duodenum, with decreasing prevalence in the second and third portions of the duodenum BGH follow this distribution, as a series of ... the entirety of the specimen The lesion was composed of back to back mature Brunner's glands Discussion Brunner's glands are alkaline-secreting glands located in the submucosal layer of the duodenum ... World Journal of Surgical Oncology 2009, 7:68 un-roofing of the cystic lesion was performed Clear viscous fluid was noted to emanate...

Ngày tải lên: 09/08/2014, 04:21

... with of the of the Pressurenerve branch of the Measurement of the use discrimination inSpecified Sensory is Measurement of point discrimination in great toe which is in the distribution of the ... returned to our office one year later with complaints of bilateral exercise induced pain in the backs of his legs from the lower calf to the ankle that he stated felt "just like the front of my legs ... nerve indicating loss of large fiber tibial nerve function suggesting the diagnosis of exertional compartment syndrome of the deep posterior compartment causing compression of the tibial nerve...

Ngày tải lên: 10/08/2014, 10:20

... Long-term follow-up of our patient will help to ascertain the safety profile of the approach we employed Systematic work-up and follow-up of patients with mucinous cystadenoma of the appendix should ... because of the nebulous nature of the distinction between these entities in the pre-operative setting The best surgical management of a patient with an appendiceal mucocele remains a subject of controversy ... advocated the removal of mucoceles of less than cm in diameter using this approach [7] However, mucoceles of less than cm in diameter are usually simple retention cysts and this choice of surgical approach...

Ngày tải lên: 11/08/2014, 12:20

... major source of morbidity is associated with the management and complications of the open abdomen Management of the open abdomen In view of the complicated and often fatal outcome of patients ... have a higher rate of fascial closure In addition, same principles of managing the open abdomen can be applied without additional equipment The major disadvantage is the loss of abdominal and back ... techniques have been shown to reduce IAP The majority of evidence is based on experience from patients with SAP In a collective of analysis of 161 patients undergoing surgical decompression via...

Ngày tải lên: 13/08/2014, 23:20

... the research of cancer genetics Your enthusiasm, guidance, encouragement and support, as well as expertise in the field of cancer genetics, have been invaluable for the completion of this work ... As of today around 20~27% of familial breast cancer have been attributed to rare genetic variants of high penetrance in a number of genes, namely Breast cancer early onset 1(BRCA1), Breast cancer ... a positive history of breast cancer have higher risk of developing endometrial cancer The risk of developing a serous endometrial cancer was 2.6 times higher than the risk of developing an endometrioid...

Ngày tải lên: 09/09/2015, 17:58

... Epidemiology of breast cancer 6  1.2.2  Internal structure of mammary gland 6  1.2.3  Subtypes of breast cancer 9  1.2.4  Treatment of breast cancer 11  1.3  Colorectal cancer ... Epidemiology of colorectal cancer 13  1.3.2  Molecular mechanism of colorectal cancer 14  1.3.2.1  Inactivation of tumor suppressor in colorectal cancer 14  1.3.2.2  Activation of oncogene ... leading cancer among women with an estimated 1.38 million new cancer cases diagnosed in 2008 (23% of all cancers), and ranks second overall (10.9% of all cancers) It is now the most common cancer...

Ngày tải lên: 10/09/2015, 15:51

... widespread of HS in the right gluteal area (C) Excision material of lesion (D) View of defect after excision The duration time of hospitalization was related with the extent and severity of the lesions ... surgical removal of the abscesses and fistulas are usually futile.1,14 The success of medical therapies, however, often is limited because of the indolent and recurrent nature of the disease Operative ... etiology of HS still remains unclear, genetic factors may play a role as a positive family history has been elicited in 26% of patients with HS The role of endocrine factors in the etiology of HS...

Ngày tải lên: 26/10/2012, 08:57

... management of hepatitis C in the peri-liver transplant period, as well as the management of the complications of chronic liver diseases Paul Martin M.D is Professor of Medicine at Mount Sinai School of ... 30% of patients will discontinue therapy Often the only way of maintaining Int J Med Sci 2006, the blood counts is to aggressively use hematopoietic growth factors The often poor tolerability of ... profound graft dysfunction following successful interferon clearance of HCV RNA with a picture suggestive of chronic ductopenic rejection [26] One explanation may be that following clearance of...

Ngày tải lên: 31/10/2012, 17:08

... total amount of 60% of dorsal rootlets must be cut, of course with a different quantity cut according to the level and function of the roots involved Also, of course, the correspondence of the roots ... results of stimulation of the distal and proximal parts of the resected fibres proved useful in controlling the effects of the operation on muscular contraction The particular branches of the nerve ... lesions of the plantar skin Upper right: Operative view of the resection, over mm in length (between the two arrows), of two-thirds of the soleus nerve (SN) Lower right: Operative view of five...

Ngày tải lên: 01/11/2013, 10:20

... (Panel Facilitator) Assistant Professor Division of Urology University of Utah Salt Lake City, Utah James E Montie, M.D Professor and Head Section of Urology University of Michigan Ann Arbor, Michigan ... probability of recurrence compared to use of TURBT alone Some of the differences in Table are quite large An example is the use of TURBT plus BCG versus the use of TURBT alone With a median difference of ... number of patients with recurrences, number of recurrences, number of occurrences per unit of time or time of first recurrence For progression, some studies reported patients with different types of...

Ngày tải lên: 14/02/2014, 21:20

... exchange contract) The Tragedy of the Commons A large subset of the cases dealing with these trade-offs of free choice and externalities involves the issue of overuse of a limited resource Freely ... behave in ways that appear to be the opposite of that member's perception of self-interest and are often the opposite of the current manifestation of that self-interest as observed through the ... perception of a lack of benefit Power and Competition A third set of commercial-social differences involves power in the relationship and competition in the marketplace Because of the existence of competition...

Ngày tải lên: 18/02/2014, 02:20

... aware of most of these events, the Curation Office had not updated its records to reflect the status of the samples Of the 94 samples, of the meteorites were expected to be returned to NASA As of ... Research, Education, and Public Display NASA Office of Education NASA Science Mission Directorate NASA Office of Communications Agency-level Management of Astromaterials NASA’s Education Program ... During the last years, the NASA Office of Inspector General (OIG) and the Government Accountability Office (GAO) have not issued any reports of relevance to the subject of this report However, the...

Ngày tải lên: 18/02/2014, 05:20

... Alcohol dependence affects 4% of people aged between 16 and 65 in England (6% of men and 2% of women), and over 24% of the English population (33% of men and 16% of women) consume alcohol in a ... 1.1.2.3 When the needs of families and carers of people who misuse alcohol have been identified: offer guided self-help, usually consisting of a single session, with the provision of written materials ... be aware of and comply with the requirements of the Children Act (2004) 1.2 Identification and assessment 1.2.1 General principles 1.2.1.1 Make sure that assessment of risk is part of any assessment,...

Ngày tải lên: 21/02/2014, 11:20

... period of abstinence is often associated with rapid reappearance of the features of the syndrome (priming) A definitive diagnosis of dependence should usually be made only if three or more of the ... 1.2.1 UNIT OF ALCOHOL One “unit” in the UK usually means a beverage containing g of ethanol, eg a half pint of 3.5% beer or lager, or one 25 ml pub measure of spirits A small (125 ml) glass of average ... systematic reviews of RCTs, or RCTs with a low risk of bias 1- Meta-analyses, systematic reviews of RCTs, or RCTs with a high risk of bias High quality systematic reviews of case control or cohort...

Ngày tải lên: 08/03/2014, 14:20