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Báo cáo y học: "The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G" ppsx

Ngày tải lên : 13/08/2014, 05:22

... peptide AZT 1 M virus control cell control control peptide 6000 4000 2000 0 10 11 12 13 14 15 16 17 18 19 20 Day of Infection Figure tivity Vif Dimerization Antagonist Peptides Suppress HIV -1 InfecVif ... 435(7038) :10 8 -11 4 Page 10 of 11 (page number not for citation purposes) Retrovirology 2007, 4: 81 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 Kreisberg JF, Yonemoto W, Greene ... 2007, 4: 81 dG to dA mutations during replication of the coding strand [15 ,22-28] Vif homodimerization has been shown to be important for HIV -1 infectivity and to involve amino acids 16 1PPLP164 [29,30]...

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Tài liệu A Guide to the Project Management Body of Knowledge Part 1 ppt

Ngày tải lên : 15/12/2013, 13:15

... 254 Figure 11 -10 Range of Project Cost Estimates Collected During the Risk Interview 256 Figure 11 -11 Examples of Commonly Used Probability Distributions 256 Figure 11 -12 Decision ... Figure 11 -13 Cost Risk Simulation Results 259 Figure 11 -14 Risk Response Planning: Inputs, Tools & Techniques, and Outputs 260 Figure 11 -15 Risk Monitoring and Control: Inputs, Tools ... sections: 1. 1 Purpose of the PMBOK® Guide 1. 2 What is a Project? 1. 3 What is Project Management? 1. 4 The PMBOK® Guide Structure 1. 5 Areas of Expertise 1. 6 Project Management Context 1. 1 Purpose of the...

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Tài liệu Báo cáo khoa học: Steﬁn A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc

Ngày tải lên : 18/02/2014, 04:20

... occluding loop residues, H 110 and H 111 , from the naked cathepsin B, are shown in orange Spheres represent the position of CA atom of N 113 , to indicate the extent of movement of the occluding loop ... Lett 395, 11 3 11 8 Turk B, Ritonja A, Bjork I, Stoka V, Dolenc I & Turk V (19 95) Identification of bovine stefin A, a novel protein inhibitor of cysteine proteinases FEBS Lett 360, 10 1 10 5 Estrada ... loop of stefins, the larger and broader L6 loop of chagasin requires an additional shift of residues R 116 and P 117 The CA atoms of R 116 residues from the two cathep˚ sin B structures are almost 10 ...

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Tài liệu Báo cáo khoa học: ATPase activity of magnesium chelatase subunit I is required to maintain subunit D in vivo ppt

Ngày tải lên : 19/02/2014, 12:20

... (grant no A09905 713 ) and an IREX award (grant no X000 016 36) to R D W 10 11 12 13 14 15 16 17 18 19 20 References Willows, R.D & Hansson, M (2003) Mechanism, Structure, and Regulation of Magnesium ... respectively Plasmid pAntF1 :1 contains 7 41 bp of the Xantha-f gene The produced polypeptide corresponds to amino acid residues E5 41 to E7 81 of the full length XAN-F polypeptide of 13 81 amino acid residues ... presence of Xantha-g mRNA was analysed by cDNA synthesis from total RNA First, lg total RNA, lL dNTP (10 mM) and lL oligo(dT )15 (0.5 mgÆmL )1) were mixed with water to a total volume of 10 lL followed...

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Tài liệu Báo cáo khoa học: Specific targeting of a DNA-alkylating reagent to mitochondria Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide doc

Ngày tải lên : 20/02/2014, 11:20

... electrode was used to measure the uptake of mitoDC- 81 into rat liver mitochondria To calibrate the electrode ﬁve stepwise additions of lM mitoDC- 81 were made to a suspension of mitochondria in a ... concentration of mitoDC- 81 in the incubation chamber decreased to about 2.5 lM, due to sequestration of mitoDC- 81 within the mitochondrial matrix This corresponds to uptake of about 2.5 nmol mitoDC- 81 mg ... 270) of mitoDC- 81 as a bulk culture of 14 3B cells grown in 500 nM mitoDC- 81 for weeks had normal rates of mitochondrial respiration (data not shown) Concentrations of mitoDC- 81 >500 nM were too toxic...

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Therapeutic ultrasound as a potential male contraceptive: power, frequency and temperature required to deplete rat testes of meiotic cells and epididymides of sperm determined using a commercially available system doc

Ngày tải lên : 05/03/2014, 17:20

... biology 2007, 33 :19 11- 1 917 12 Brinster RL, Avarbock MR: Germline transmission of donor haplotype following spermatogonial transplantation Proc Natl Acad Sci USA 19 94, 91: 113 03 -11 307 13 Clouthier ... 2 012 , 10 :7 http://www.rbej.com/content /10 /1/ 7 Page of 15 p-values] Group 12 had a Sperm Count Index equal to 3.9 and approximately one third of this group’s sperm counts fell into the range of ... Endocrinology 2 012 , 10 :7 http://www.rbej.com/content /10 /1/ 7 Page 11 of 15 300 ¨ A ¨ § *** 250 c b a ` Y G 200 X W G V U § A ¥ F T £ ' ¢ ¡ ¤ ( e d ¨ § ( ' 15 0 ¡ E U F T

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Báo cáo Y học: Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis pptx

Ngày tải lên : 08/03/2014, 22:20

... Ala 31 des-(2,3)-Ala 31 Leu60 Ala31Leu60 IGF-II and analogues IGF-II Des- (1 6) Arg6 Leu27 Des- (1 6 ,10 )-Leu27 kd ´ 10 )3 (1/ s) Kd ´ 10 )9 (M) Relative Kd 2.70 2.52 3.60 3.65 2.89 ± ± ± ± ± ± 1. 16 1. 07 ... M.A (19 90) The roles of tyrosines 24, 31, and 60 in the high anity binding of insulin-like growth factor-I to the type insulin-like growth factor receptor J Biol Chem 265, 15 648± 15 652 15 Cascieri, ... with 10 -fold higher af®nity than their binding to IGF receptors IGFBPs thereby in¯uence the availability of IGF to bind to IGF receptors [12 ] Over the past 14 years, a large number of IGF analogues...

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The Gravity of Weight A CLINICAL GUIDE TO Weight Loss and Maintenance pdf

Ngày tải lên : 15/03/2014, 04:20

... 17 2 17 7 18 1 94 99 10 4 10 9 11 4 11 9 12 4 12 8 13 3 13 8 14 3 14 8 15 3 15 8 16 3 16 8 17 3 17 8 18 3 18 8 97 10 2 10 7 11 2 11 8 12 3 12 8 13 3 13 8 14 3 14 8 15 3 15 8 16 3 16 8 17 4 17 9 18 4 18 9 19 4 10 0 10 6 11 1 11 6 12 2 12 7 13 2 ... 13 2 13 7 14 3 14 8 15 3 15 8 16 4 16 9 17 4 18 0 18 5 19 0 19 5 2 01 104 10 9 11 5 12 0 12 6 13 1 13 6 14 2 14 7 15 3 15 8 16 4 16 9 17 5 18 0 18 6 19 1 19 6 202 207 10 7 11 3 11 8 12 4 13 0 13 5 14 1 14 6 15 2 15 8 16 3 16 9 17 5 18 0 18 6 ... 18 6 19 1 19 7 203 208 214 11 0 11 6 12 2 12 8 13 4 14 0 14 5 15 1 15 7 16 3 16 9 17 4 18 0 18 6 19 2 19 7 204 209 215 2 21 114 12 0 12 6 13 2 13 8 14 4 15 0 15 6 16 2 16 8 17 4 18 0 18 6 19 2 19 8 204 210 216 222 228 11 8 12 4 13 0...

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UNIT 2. FORMATS FOR ELECTRONIC DOCUMENTS AND IMAGES LESSON 1. TYPES OF MARK-UP: INTRODUCTIONNOTE potx

Ngày tải lên : 17/03/2014, 22:20

... mark -up to instruct the software to display the document with an easy to understand layout Why we need Mark -up Mark -up originally referred to the handwritten notations that a designer would add to ... the end of this lesson, you will able to: • understand the purpose of mark -up, and • distinguish between different kinds of mark -up Why we need Mark -up Electronic text documents are stored in ... mark -up Mark -up is everything in a document that is not content Types of Mark -up There are three types of mark -up codes that can be used in an electronic document: Procedural mark -up consists of...

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Báo cáo khoa học: Transcriptional activity and Sp 1⁄3 transcription factor binding to the P1 promoter sequences of the human AbH-J-J locus docx

Ngày tải lên : 23/03/2014, 07:20

... Feriotto et al 12 13 14 15 16 17 12 fold molar excess of competitor 12 25 12 25 Sp1/3 Sp3 Sp1/3 * Sp3 * 23 24 25 26 er r Sp 1m e 31 32 33 34 35 fold 25 50 25 molar excess of competitor 50 25 50 10 0 ... FEBS 44 81 Sp regulation of the AbH-J-J locus P1 promoter 10 11 er r r – Im me er er Em F/G Sp 1m e Competitor Jm D/ er F/G me r H/ Im er Km er Lm er Sp 1m Competitor – Sp1mer Probe H/ Sp1mer Probe ... promoter activity, we cloned a 3 .1 kb partially digested Relative luciferase activity A + 81 -16 83 -12 89 -12 04 -10 17 -834 -6 61 -634 - 512 -389 -240 -16 0 B 50 15 0 10 0 200 A B C D E F G H I L M 250...

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Báo cáo khoa học: The C-terminus of viral vascular endothelial growth factor-E partially blocks binding to VEGF receptor-1 docx

Ngày tải lên : 23/03/2014, 07:20

... placenta growth factor Blood 10 2, 15 15 15 24 30 Shibuya M (20 01) Structure and dual function of vascular endothelial growth factor receptor -1 (Flt -1) Int J Biochem Cell Biol 33, 409–420 31 Muller YA, ... receptors [22] In addition, replacement of both loop and loop of ORFVNZ2VEGF with those of VEGF-A partially restored binding to VEGFR -1 [22] Neither mutation, however, completely restored VEGFR -1 ... Vet Res 29, 311 –326 18 Mercer A, Fleming S, Robinson A, Nettleton P & Reid H (19 97) Molecular genetic analyses of parapoxviruses pathogenic for humans Arch Virol Suppl 13 , 25–34 19 Groves RW,...

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Báo cáo Y học: The reactivity of a-hydroxyhaem and verdohaem bound to haem oxygenase-1 to dioxygen and sodium dithionite pdf

Ngày tải lên : 23/03/2014, 21:20

... degradation of haem Hence, the use of sodium dithionite should be avoided in the study of the haem oxygenase reaction 10 11 12 13 14 15 16 ACKNOWLEDGEMENTS This work was supported in part by Grant-in-aid ... oxygenase -1 in tissue pathology The Yin and Yang Am J Pathol 15 6, 14 85 14 88 Cary, S.P.L & Marletta, M.A (20 01) The case of CO signaling: why the jury is still out J Clin Invest 10 7, 10 71 10 73 Yoshida, ... buﬀer (pH 7.4) and allowed to stand for 30 min, prior to addition of 0.25 mL of the rHO -1 solution (10 3 nmol) The ﬁnal concentrations of rHO -1 and a-hydroxyhaemin were 10 3 and 38 lM, respectively...

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Báo cáo Y học: Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery ﬁbroblasts A role for phosphoinositide 3-kinase pot

Ngày tải lên : 24/03/2014, 03:21

... aspiration of the media followed by the addition of ice-cold lysis buffer (50 mM Hepes, pH 7.5, 15 0 mM NaCl, 10 % v/v glycerol, 1% v/v Triton X -10 0, 1. 5 mM MgCl2, mM EGTA, 10 lgÆmL )1 leupeptin, 10 lgÆmL )1 ... Sci 20, 2 71 273 12 Coughlin, S.R (19 99) How the protease thrombin talks to cells Proc Natl Acad Sci USA 96, 11 023 11 027 13 Parry, M.A., Myles, T., Tschopp, J & Stone, S.R (19 96) Cleavage of the ... pretreated with wortmannin (10 0 nM, 20 min) or LY294002 (10 lM, 20 min), PD98059 (10 lM, 30 min), GF109203X (1 lM, min) or pertussis toxin (PTX, 10 0 ngÆmL )1, 18 h) prior to addition of duodenase (30 nM)...

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Cardiovascular tolerance of healthy elderly subjects to weight-lifting exercises pptx

Ngày tải lên : 28/03/2014, 20:20

... (1. 8) 13 7.4 (1. 7) 78.4 (1. 5) 70.4 (1. 7) Seated Chest Press Exercise 200.6 (2.9) 12 7.4† (2.0) 10 5.5† (2.2) Rest Exercise 13 8.5 (1. 7) 78.3 (1. 6) 69.9 (2.0) 19 9.5 (2.7) 12 3.4 (1. 9) 10 2 .1 (2 .1) Values ... 71: 1 211 12 16, 19 81 13 K KITAMURA, C R JORGENSEN, F L GOBEL, H L TAYLOR, and Y WANG Hemodynamic correlates of myocardial oxygen consumption during upright exercise J Appl Physiol 32: 516 –522, 19 72 ... exercises of the strength test Bilateral Leg Press Bilateral Leg Extension Rest SAP (mm Hg) DAP (mm Hg) HR (min 1) Exercise Rest 13 8.2 (1. 6) 78.2 (1. 7) 69.3 (1. 6) 223.6* (3 .1) 13 9.6† (1. 9) 10 7.5* (1. 8)...

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Báo cáo khoa học: Adaptation to G93Asuperoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis The role of glutathione doc

Ngày tải lên : 29/03/2014, 23:20

... activity, which was 16 .44 ± 0. 31 nmolÆ min )1 mg )1 of protein, i.e 20% higher (P < 0. 01 by Student’s t-test) than that of tTA-40 cells (13 .96 ± 0.32 nmolÆmin )1 mg )1 of protein; mean ± SEM of four independent ... appears to also provide a tool to investigate the effects of chronic exposure to a small amount of G93ASOD1, as seen in the motor neurons of FALS1 patients To explain the different amounts of GSH ... oxidative and mitochondrial toxicity of mutant SOD1 [19 – 21] In this study, clones with different levels of expression of G93ASOD1 – lower or higher than murine SOD1 – were used to determine whether...

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báo cáo sinh học:" Equity-oriented toolkit for health technology assessment and knowledge translation: application to scaling up of training and education for health workers" pptx

Ngày tải lên : 18/06/2014, 17:20

... 26 References 10 11 12 13 14 15 Hongoro C, McPake B: How to bridge the gap in human resources for health Lancet 2004, 364 :14 51- 1456 Phiri M: Investing in human resources for health to attain the ... Equity-Oriented Toolkit offers tools that can be used to assess and monitor the recommendations from GHWA, from assessing the creation of a national planning authority to evaluating the outcomes of a new ... writing of the manuscript All authors reviewed and approved the final manuscript http://www.human-resources-health.com/content/7 /1/ 67 16 17 18 19 20 21 22 23 Acknowledgements We would like to thank...

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$báo cáo hóa học:" Representation to the Accident and Emergency department within 1-year of a fractured neck of femur" ppt$

báo cáo hóa học:" Representation to the Accident and Emergency department within 1-year of a fractured neck of femur" ppt

Ngày tải lên : 20/06/2014, 07:20

... Representation to the Accident and Emergency department within 1- year of a fractured neck of femur David J Bryson1, Scott Knapp1, Rory G Middleton1 , Murtuza Faizi1, Hardik Bhansali2, Chika E Uzoigwe1 Institutions: ... cause of admission (56.6% (16 1/284)) of which infection was the chief precipitant (28% (45 /16 1)) Cardiovascular pathology was implicated in 5.3% (15 /284) of admissions with five patients (1. 8%) ... and upon the resources of the NHS In 19 90 there were an estimated 1. 3 million hip fractures worldwide [1] With a population increasingly surviving into later decades of life this figure is set to...

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Calculus: An Integrated Approach to Functions and their Rates of Change, Preliminary Edition Part 1 pps

Ngày tải lên : 05/07/2014, 18:20

... discussion of systems of differential equations is also included The first few sections of Chapter 31 may easily be moved up to follow an introduction to integration and thereby be included at the end of ... reflection The first 16 chapters offer “Exploratory Problems.” These are integral to the text, and some are referred to in later sections Exploratory problems can be incorporated into the course in ... integrated approach to functions and their rates of change / by Robin Gottlieb.—Preliminary ed p cm ISBN 0-2 01- 70929-5 (alk paper) Calculus I Title QA303 G685 20 01 00-0 618 55 515 —dc 21 Copyright © 2002...

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Báo cáo y học: "Ethics of randomised controlled trials – not yet time to give up on equipoise Richard E Ashcroft" pps

Ngày tải lên : 09/08/2014, 01:24

... reason to give up on equipoise just yet 13 14 15 16 17 18 19 20 21 methods in health technology assessment: a review Health Technol Assess 2000, 4(38) :1- 1 21 Djulbegovic B, Hozo I: At what degree of ... Urbach P: The value of randomisation and control in clinical trials Stat Med 19 93, 12 :14 21- 14 41 10 Worrall J: What evidence in evidence-based medicine? Philos Sci 2002, 69:S 316 -S330 11 Kadane JB (Ed): ... Holland; 19 74 Freedman B: Equipoise and the ethics of clinical research New Engl J Med 19 87, 317 :14 1 -14 5 Miller PB, Weijer C: Rehabilitating equipoise Kennedy Inst Ethics J 2003, 13 :93 -11 8 Veatch...

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Báo cáo y học: "Insights into spatial configuration of a galactosylated epitope required to trigger arthritogenic T-cell receptors specific for the sugar moiety" ppsx

Ngày tải lên : 09/08/2014, 10:21

... mice, but also they were shown to modulate clinical symptoms of CIA in adoptive transfer experiments [15 ] or using T-cell vaccination protocols [14 ,16 ,17 ] Such regulatory effects suggests that these ... isolated from the lymph nodes of CII-immunized DBA /1 mice [15 ] All of the cells were cultured in RPMI 16 40 glutamax supplemented with antibiotics, × 10 -5 mol/l mercaptoethanol, 10 mmol/l HEPES, mmol/l ... design coordination and writing of the manuscript, and also interpretation and discussion of the data 12 13 14 15 16 17 Acknowledgements The authors are indebted to Drs Orly Amar and Alexandra...

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