balance between immune tolerance and immune aggression

... produced by statistical and time-series forecast models and reflects comprehensive information (e.g Brown and Rozeff, 1979; Fried and Givoly, 1982; O’Brien, 1988; and Alexander, 1995) However, ... stock brokers and financial analysts (Gurley and Shaw, 1960; Leland and Pyle, 1977) They argue that financial intermediaries can invest in wealth that they have special knowledge with and overcome ... positive and significant association between forecast dispersion and the traditional market-based risk measure (beta) and the accounting-based risk measure (earnings growth variability), and a negative...

Ngày tải lên: 08/11/2015, 17:09

... goals and plans of the novice user and, indirectly, the dialogue structure This is because the novice user does not have a good model of the task and is in the process of building one and because ... the task The verbal interaction between the user and the adviser is not just one of execution of plans and recognition of plans but rather one of situated actions and d e t e c t i o n a n d r ... imperfect understanding or as acknowledgement to verify understanding between the participants The notion of meta-plans allows us to account for the presence of clarification and acknowledgement...

Ngày tải lên: 21/02/2014, 20:20

... modifications; MAQ and SNM contributed human data and manuscript comment; SLY-C and APR were involved in data analysis, modelling and manuscript comment Acknowledgements Conclusion and Future Directions ... interests, and all authors have read and approved the manuscript Authors' contributions BJC wrote and researched the manuscript; MLA contributed by original thought, research, reasoning, writing and ... aetiology [31,32] Immune Cycling and Cancer Treatments Despite many attempts to stimulate the cancer patient's immune system for therapeutic benefit, results have been variable and often disappointing...

Ngày tải lên: 18/06/2014, 15:20

... believe it could help both physicians and patients, and even family carers to achieve a better understanding of the treatment outcomes of cancer patients and make appropriate decisions http://www.hqlo.com/content/7/1/102 ... on the relationship between quality of life data and survival duration The aim of this review was to examine the literature on the relationship between quality of life data and survival duration ... and Complementary Medicine (AMED) and Global Health databases to assess the existing knowledge about the relationship between quality of life data as 'prognostic' or 'predictive' indicators and...

Ngày tải lên: 18/06/2014, 19:20

... usual practice (standard of care) and followed over time using standardized methods and forms to make possible a valid and reliable description of case-mix, pattern of care and outcomes Subjects ... purposes) Health and Quality of Life Outcomes 2006, 4:7 http://www.hqlo.com/content/4/1/7 variance to analyze and separate the effects of treatments and time and test the interaction between the two, ... (pharmacological and non-pharmacological treatments) and relevant efficacy (analgesic and other patient-reported outcomes (PRO) outcomes such satisfaction, quality of life measures) and safety outcomes...

Ngày tải lên: 20/06/2014, 15:20

... Acquisition: From LC to LT Quality Control of Data and Algorithms: LC, GC, DV and CB Data Analysis and Interpretation: CB and LC Statistical analysis: DV and CB Manuscript preparation: LC, CB, CDN Manuscript ... data and clinical features were analyzed using descriptive methods Quantitative variables were summarized using mean and standard deviation Categorical variables were summarized as counts and ... patients with hematologic malignancies and solid tumors and we have shown that this technique may be efficacious and safe both in patients with acute leukemia and with solid tumors In addition, we...

Ngày tải lên: 09/08/2014, 03:22

... that the Th1/Th2 balance illustrated by the IL-4/IFN-γ and CD23/HLA-DR ratios was markedly different between LC and open cholecystectomy It was shown that down-regulation of the Th1 immune response ... and writing of the manuscript MN and NH assembled the data TM and YK performed the statistical analysis HI and HK performed the study of flowcytometry YN designed the study All authors read and ... duration of operation and operative blood loss for each procedure were 223 ± 55 and 267 ± 212 ml for gastric resection, 220 ± 71 and 325 ± 336 ml for colorectal resection, 365 ± 85 and 761 ± 759 ml...

Ngày tải lên: 09/08/2014, 04:21

... combination (Table 2, a) and then divided according to treatment regimen and analyzed separately (Table 2b and 2c) A total of 154 and 94 patients received treatment A (4.3 Gy *10) and B (2.5 Gy *20) ... both materials, and the top three accounted for 73.6%, 79.9% and 71.3% of the total number of represented chromosomes when analyzing cases and controls combined, only controls and only cases respectively ... VNK and ALBD designed the study - TT, LJ and PV genotyped the samples from the American Breast cancer patients - LJ and PV genotyped the samples from the Norwegian breast cancer patients and...

Ngày tải lên: 09/08/2014, 10:21

... nutritional supplements and herbal remedies, and its efficacy can be affected by vomiting and diarrhea, all of which are common in cancer patients Intolerance, hypersensitivity, and resistance to warfarin ... sites and modification of von Willebrand factor structure and function J Lab Clin Med 1992, 119:467-476 25 Rickles FR, Falanga A: Molecular basis for the relationship between thrombosis and cancer ... cancer patients The Kaplan-Meier survival estimates for 1, 2, and years after randomization were not different between the dalteparin and placebo groups (p = 0.19) However, in an analysis not planned...

Ngày tải lên: 10/08/2014, 22:20

... authors state that the manufacturer provided both the Phytalgic® and placebo capsules and that it claimed that they were identical and indistinguishable We argue, however, that it might be difficult ... Pfizer Inc (New York, NY, USA), Roche (Basel, Switzerland), sanofi-aventis (Paris, France), Scandinavian Clinical Nutrition (Stockholm, Sweden), and Wyeth (Madison, NJ, USA) Published: February 2010 ... N, BiermaZeinstra S, Brandt KD, Croft P, Doherty M, Dougados M, Hochberg M, Hunter DJ, Kwoh K, Lohmander LS, Tugwell P: OARSI recommendations for the management of hip and knee osteoarthritis,...

Ngày tải lên: 12/08/2014, 11:22

... admission (MPM II0) and at 24 hours (MPM II24) [23], and Acute Physiology and Chronic Health Evaluation (APACHE®; a registered trademark of Cerner Corporation, Kansas, MO, USA) versions II and III-J [19,24] ... Acute Physiology Score; SD, standard deviation; SE, standard error; SMR, standardized mortality rate Table Performance of each mortality prediction system for medical and emergency surgical patients ... discriminative ability (AUROC = 0.815) and MPM II0 the poorest (AUROC = 0.729), and all of the scores were poorly calibrated Statistically significant differences between observed and predicted mortality rates,...

Ngày tải lên: 12/08/2014, 20:20

... on the severity and duration of the obstruction [24] Thrombotic microangiopathy The association between thrombotic microangiopathy (TMA) and cancer was first described in 1973 and is now well ... cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α [25] Lastly, the association between TMA and BMT has been known since 1980 Although the prognosis has been described ... the only manifestation and others experiencing remissions [28] Typically, TMA starts to 12 months after BMT and is unresponsive to plasma therapy [29] Total body irradiation and graft-versus-host...

Ngày tải lên: 12/08/2014, 23:23

... collected and analyzed the data and reviewed and coordinated the study AS and MF collected and analyzed the data J-PB, J-LB, DB, and CF reviewed and coordinated the study All authors read and approved ... cTnI and NTproBNP have been found in patients with severe sepsis, and a good correlation between these two markers seems to indicate a relationship between the degree of myocyte damage and functional ... stay; and time from sepsis diagnosis to ICU admission and time from ICU admission to septic shock diagnosis and ICU mortality Early prognostic factors were defined as easy-to-collect, clinical and...

Ngày tải lên: 13/08/2014, 03:20

... ICU and hospital stay were (median (IQR)) 7.0 (10.3) days and 18.5 (23.6) days, respectively, without significant differences between neutropenic and non-neutropenic patients (P = 0.699 and P ... contributions PP, VCSD, MS and JIFS contributed to the study conception and design, carried out and participated in data analysis and drafted the manuscript VCSD, MS and JIFS participated in acquisition ... 0.111, respectively) The overall ICU and hospital mortality rates were 72.1% and 79.2%, respectively, without significant differences between study groups (P = 0.472 and P = 0.211, respectively) Most...

Ngày tải lên: 14/08/2014, 08:21

... Progression Free Survival (PFS: time between randomization and Page of progression or death from any cause) and the overall survival (OS: time between randomization and death for any cause) Secondary ... exists between the efficacy of bevacizumab and taxanes pretreatment (p = 0.96 and p = 0.45, respectively) This finding is consistent with the ECOG-2100 and AVADO previous release [14,15], and with ... PC, MM, CN, MR, PP, and GF participated in the trials recruitment and selection process; FCu, EB, VV, FP, AF and MM drafted and revised the manuscript; EB, PC, MM, MA, DG and FC did coordinate...

Ngày tải lên: 10/08/2014, 10:21

... sumoylation, and phosphorylation have defined crucial roles in coactivator and corepressor activity and consequently on nuclear receptor function (Levine and Tjian, 2003) The concept that ligands act ... cells, and estrogen related receptor in osteoblasts where NR4A2 activates the osteopontin promoter and this is repressed by ERRs, and NR4A1 and NR4A3 inhibited ERR mediated transactivation ERRs and ... induced by Fas ligand (FasL), tumour necrosis factor alpha (TNFα) and TNF related apoptosis inducing ligand (TRAIL ) where these ligands bind to specific death domain receptors and induce the formation...

Ngày tải lên: 14/09/2015, 14:04

... links the A and B domains shows significantly more homology between p107 and p130 than between p107/p130 and pRb This spacer region was shown to contain a p21-like sequence that can recruit and inhibit ... functions and interactions The difference in phosphorylation sites and kinases involved in the phosophorylation of these sites between p107 and p130 further support specific functions for p107 and p130 ... 1998; Ebenhard and Busslinger 1999) The interaction between these proteins is dependent on the large pocket (sub-domains A and B and the C-terminus) of the pRb protein family and a consensus...

Ngày tải lên: 25/10/2013, 21:20

... cisplatin and conformal radiotherapy, followed by surgery for esophageal cancer Cancer 2010, 116(17):4023-32 Burmeister BH, Smithers BM, Gebski V, Fitzgerald L, Simes RJ, Devitt P, Ackland S, Gotley ... D, Mayer R: Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781 J Clin Oncol 2008, 26(7):1086-92 ... alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial Lancet Oncol 2005, 6:659-668 Pereira B, Gourgou-Bourgade S,...

Ngày tải lên: 09/08/2014, 01:24

... months for the fourth and fifth years, and annually after years Chest X-ray and liver sonography were requested every months for the first years and annually for the fourth and fifth years Whole ... different between the groups, medial location being slightly higher in RT group (30% vs 25%) For the entire group, LRR and DM rates were 7% and 20%, respectively, and years actuarial DFS and OS ... BD, AO, BU, and KI Data analysis was done by RC, CU, NT and MS The manuscript was prepared by RC and AO Corrections and/ or improvements were suggested by CU, BD, MS, AO, SU, AS, VYC and ZK Major...

Ngày tải lên: 09/08/2014, 09:20