b effects on t cell function
Characterization of CD137 ligand mediated human monocyte differentiation and their effects on t cell activities
Ngày tải lên :
10/09/2015, 15:54
... maturation status and effector functions of generated DCs, antigen loading and route of DC delivery Among these, the maturation status and effector functions will have the greatest impact on T cell ... on T cells Other than induction of T cell proliferation and differentiation, T cell interactions with myeloid cells have been shown to induce T cell apoptosis Several studies show that T cell ... ability to induce proliferation of naïve T cells CD137 not only induces monocyte to DC differentiation but also promotes DC maturation These DCs in turn inhibit development of regulatory T cells...
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Báo cáo y học: "Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis" doc
Ngày tải lên :
12/08/2014, 11:23
... of T- cell proliferation LG contributed to CIA induction and evaluation and to analysis of T- cell proliferation PM contributed to the design of the study and to manuscript preparation All authors ... co-cultures The addition of these inhibitors resulted in the abrogation of the inhibition of Tcell proliferation by wild-type MSCs (Figure 3e) The addition of the IDO inhibitor 1-methyl-DL-tryptophan ... with PBS 2% FCS, stained with the indicated antibodies for 30 minutes and washed twice with PBS 2% FCS For the biotin-conjugated antibody, a second staining step with streptavidin conjugated to...
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Alcohol’ s Effects on Female Reproductive Function pot
Ngày tải lên :
05/03/2014, 17:20
... cyclicity are complex In some situations, estrogen stimulates the hypothalamic–pituitary unit (Tang et al 1982); in other situations, it is inhibitory This short-term elevation in estradiol may be ... finding suggests the possibility that alcohol alters the repro ductive awakening and maturation that marks puberty Also, estrogen’s role in bone maturation raises the question of whether alcohol ... activated, leading to both sexual maturation and a growth spurt, via estrogen’s stimulatory effects on the GH–IGF axis Pubertal development is influenced not only by HPG and GH–IGF activities but...
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
Ngày tải lên :
18/06/2014, 16:20
... contribute to the onset of T1 D [53] These results suggest that an IL-2 functional deficiency in the target organ may disturb the positive feedback loop that controls Foxp3 stability, such that ... contribute to diabetes [69] Additionally, the T cells found in the blood, whether it be in their repertoire, function and state of activation, may not accurately reflect the status and behavior of their ... cell transplantation (HSCT) Studies in such patients indicate that Treg cells increase in response to the treatment, and that this effect seems to be increased with prolonged time of treatment [66]...
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Báo cáo y học: "Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ" potx
Ngày tải lên :
09/08/2014, 06:22
... in condition with Treg cells)/Radioactivity in condition without Treg cells) against the number of Treg cells R404 Arthritis Research & Therapy Vol No Kelchtermans et al Antibody administration ... [3H]TdR and harvested The suppressive activity of the Treg cells can be presented by plotting the percentage of inhibition (100 × (Radioactivity in condition without Treg cells – Radioactivity ... TGF-β-FW, TGA CGT CAC TGG AGT TGT ACG G; TGF-β-RV, GGT TCA TGT CAT GGA TGG TGC; TGFβ-TP, TTC AGC GCT CAC TGC TCT TGT GAC AG Probes were dual-labelled with 5'-FAM and 3'-TAMRA All primers and probes...
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Báo cáo y học: "Effects on heart pumping function when using foam and gauze for negative pressure wound therapy of sternotomy wounds" pptx
Ngày tải lên :
10/08/2014, 09:23
... problems with ingrowth of granulation tissue into gauze in NPWT [20] Before gauze is used for NPWT of sternotomy wounds, it is important to determine the effects on heart pumping function Hitherto, ... (CardioMed TraCe System, Medistim, Norway) was placed around the pulmonary artery to record the cardiac output The catheter was connected to a cardiac output monitor (Oximetrix 3, Abbot Laboratories, ... effects The reason for this cannot be deduced from the present study, but may be due to differences in the mechanical effects by the two materials on the heart [17] The decrease in heart rate when using...
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Báo cáo y học: "Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints." potx
Ngày tải lên :
12/08/2014, 12:20
... in the blood days after the first transfer, but some T cells emerged in the circulation with time This was most likely due to homeostatic expansion of the few T cells (’contaminants’ in the T- depleted ... consistent with the observation that FTY720 inhibits T- cell egress from lymphoid organs but has no significant impact on the occupancy of these organs by T cells [20,21] As expected, the T- cell ... initiate inflammation but that continuous in vivo production of autoAbs by B cells (probably in a T cell- supported manner) is necessary for the perpetuation of the inflammatory process and establishment...
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TITANIUM DIOXIDE NANOMATERIALS EFFECTS ON ENDOTHELIAL CELL BARRIER INTEGRITY a CASE STUDY OF NANOMATERIALS INTERACTION WITH BIOLOGICAL SYSTEM
Ngày tải lên :
09/09/2015, 08:17
... of 5g/kg BW to be absorbed by the gastrointestinal tract The authors further suggested that the gastrointestinal absorption of NPs is facilitated by the Peyer’s patches, as evidenced by the high ... response to TiO2-NPs 2.4.1 Cytotoxicity Cell death or cytotoxicity is the most common TiO2-NPs induced biological effect to be reported This effect garners much attention due to the fact that death ... cytotoxicity and inflammation inducement on endothelial cells However, little work with the emphasis on understanding the interaction that manifest on function impairment of the endothelial cell...
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The accessory roles of lipopolysaccharide activated murine b cells in t cell polarization
Ngày tải lên :
14/09/2015, 08:27
... response 1.2.1 Th1 cells, Th2 cells and Th17 cells 1.2.2 Regulatory T cells (Treg) 1.2.3 Innate control of Th1/Th2 cell differentiation/polarization 1.2.4 Differentiation of CD4+ T- cell subsets by ... 1999) Stimulation of transfectant cell lines with TLR4/MD-2, but not TLR4 alone by LPS, results in the activation of the nuclear factor B (NF B) reporter gene Furthermore, cells with TLR4 alone ... CD4+ T cell subsets, and Chapter Introduction 22 determines their effector functions The influence of cytokines in the differentiation of CD4+ T cell subsets and the effect of CD4+ T cell subsets...
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Báo cáo khoa học: Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production pot
Ngày tải lên :
06/03/2014, 11:20
... enhanced Th -cell proliferation, the latter to a greater degree, suggesting a possible correlation between PRMT inhibition and T- cell proliferation, while MTA treatment inhibited T- cell proliferation ... arginine methylation in T- cell function, suggesting that PRMT inhibitors may be valuable for the treatment of autoimmune diseases As SAM is the methylation donor in the PRMT reaction, the use of ... co-engagement of the CD28 costimulatory receptor with the T- cell receptor increases PRMT activity and Vav1 methylation [5] Perturbation of PRMT activity through the use of methylation inhibitors leads to...
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Báo cáo hóa học: " Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies" doc
Ngày tải lên :
18/06/2014, 16:20
... at any timepoint, in line with previous data on altered Trp catabolism in cancer patients [24] In order to more accurately substantiate the assumption that pegfilgrastim alters the balance between ... with IL-12p75 [44] A report on post-transplantation immune functions in 43 patients receiving filgrastim has shown that cytokine administration delays the reconstitution of CD4+ T cells and blunts ... restrain the proliferation and function of diabetogenic T cells [31] It remains to be determined whether Treg recirculation and/or recruitment to sites of inflammation and tissue injury Bonanno...
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Báo cáo sinh học: "Shipping blood to a central laboratory in multicenter clinical trials: effect of ambient temperature on specimen temperature, and effects of temperature on mononuclear cell yield, viability and immunologic function" potx
Ngày tải lên :
18/06/2014, 19:20
... after overnight incubation [28] Regardless, we find that there is function in the PBMC that are viable after overnight incubation Incubation at 15 or 30°C is associated with comparable T cell function ... results It also is appropriate, in multicenter trials, to stratify patients by institution to control for systematic variations in temperature during shipping that may be encountered depending on ... cell function assessed by ELIspot assay to that seen with PBMC stored at RT Interestingly, we found that incubation at 30°C for periods up to 12 h was even associated with equivalent or better yields,...
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Báo cáo y học: "Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF-κB binding activity and TNF-α secretion of T cell" pot
Ngày tải lên :
09/08/2014, 03:24
... observation of differential effects only with total T cells, but not in CD4+ T cells, indicates a differential contribution of the CD4+ and CD8+ T- cell subpopulation and suggests that interactions between ... either cell depletion [2] or functional inactivation of T cells [3,4], although activation of T- cell functions has also been reported [5] These contrasting effects may explain the variability ... investigated as a model for MHC-dependent T- cell activation The antiCD4 mAbs moderately inhibited the proliferation of total spleen T cells, depending on the stimulator cell concentration (Supplementary...
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Báo cáo y học: "Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up" ppt
Ngày tải lên :
11/08/2014, 10:23
... rhGH treatment promotes the restoration of Tcell responses against HIV-1, a restoration that declines with cessation of treatment Since HIV-1+ patients commonly develop growth hormone abnormalities, ... points out the possibility that hormonal intervention with rhGH might be associated with both de novo generation of T lymphocytes (due to increased thymic output) [50,51] as well as increased function ... http://www.jibtherapies.com/content/6/1/7 Antibodies, flow cytometry and lymphocyte subset quantification Murine, anti-human monoclonal antibodies (mAb) to CD3, CD4, CD8 and CD45 (TetraOne, Beckman Coulter, High Wycombe,...
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Báo cáo sinh học: " Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" docx
Ngày tải lên :
14/08/2014, 19:22
... between immature and mature DCs, resulting in tolerogenic interaction with T cells in SIT We found that the combination of DNA vaccination with Fc and OVA had better effects onOVAinduced alterations ... allergen-DNA-targeted-DC may be useful in SIT and the restoration of Tregs played a key role in successful SIT Costimulatory molecules as potential targets contribute to the therapeutic intervention in ... OVA-Fc-pcDNA3.1 effects may be that Fc enhancing DC absorption is more powerful in stimulating the production of TH1 cytokine synthesis in naïve and memory T cells As an alternative to the administration...
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Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt
Ngày tải lên :
19/02/2014, 13:20
... in the b- turn region may be important in the inhibitory mechanism, in addition to the primary structure of the peptide To confirm our hypothesis that the b- turn structures are important for the ... inhibitory activities of the peptides, the structures of the cyclic peptides were determined by NMR The results proved that the stable b- turn conformation exists in the cyclic peptides The b- turn ... cyclization seemed to improve the activity of the peptide Thus, cyclization stabilizes the b- turn conformation in the peptide which may be necessary for biological activity exhibited by the peptides...
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Báo cáo khoa học: Surface-enhanced vibrational spectroscopy for probing transient interactions of proteins with biomimetic interfaces: electric field effects on structure, dynamics and function of cytochromec doc
Ngày tải lên :
22/03/2014, 16:20
... the orientation of the highest electron tunnelling probability This is the case in the low-field regime, as demonstrated by the comparison of the electron transfer and reorientation rate constants ... leading to a perturbation of the equilibrium at the initial potential The subsequent relaxation processes that restore thermodynamic equilibrium at the final potential may then be probed by SERR ... potential distribution at the membrane–solution interface (top) and at the electrode–SAM interface (bottom) wS, wD and Dw denote the surface potential, dipole potential and transmembrane potential,...
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báo cáo hóa học:" Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients" pot
Ngày tải lên :
18/06/2014, 15:20
... three patients out of twelve patients examined Though the number of patients in this study was too few to discuss the exact correlation, it is possible that the CTL induction efficiency might ... presenting cell Competing interests The authors declare that they have no competing interests Authors' contributions JK carried out the CTL induction, killing assays and drafted the manuscript TT ... at the interface between exon and exon 3, leading to insertion of an additional exon, termed exon 2B, in BIR domain Since BIR domain is a functional domain that is important for the anti-apoptotic...
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báo cáo hóa học:" Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy" potx
Ngày tải lên :
18/06/2014, 15:20
... interacts with CD4+ T cells We believe that this interaction might drive the inhibition of CD4+ T cell proliferation observed not only among PBMCs but also when pure CD4+ T cells were stimulated ... the fact that 3a-G1 inhibits CD4+ T cell proliferation without affecting NK cell one within PBMCs, we checked whether this activity could not be broadened to all T cells When stimulating T cell ... representation of γδ -T cells (data not shown) but we were never able to detect any NKT (Vα 24+) cell or CD8+ T cell expansion under our conditions In contrast, we found that a proportion of CD4+ T cells...
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