b — the added value of research infrastructures

... has proven the value of this approach in the empirical data of a large trial with a true treatment effect Earlier research has demonstrated that adjustment for strong predictors of outcome (covariate ... cut-off (a violation of the proportional odds assumption) A pragmatic approach is to focus more on the underlying concept of ‘shift analysis’, instead of emphasizing the formal assumptions of ... 1.43, P < 0.0001) Application of the proportional odds logistic regression model gave an estimated common odds ratio of 1.15 (95% CI 1.06 to 1.25) with a P -value of 0.0007 With the sliding dichotomy...

Ngày tải lên: 14/08/2014, 08:21

... was part of a larger research project entitled 'Investigating the added value of conjoint analysis for the evaluation of barriers and facilitators in implementation studies: the case of breast ... objective of our study was to investigate the complementary value of DCE for the evaluation of barriers and facilitators in implementation research To meet this objective we compared the results of ... This means that each of the profiles was combined with its 'foldover' profile A foldover profile includes the exact opposite attribute levels of the original profile and, therefore, ensures a...

Ngày tải lên: 11/08/2014, 05:21

... was part of a larger research project entitled 'Investigating the added value of conjoint analysis for the evaluation of barriers and facilitators in implementation studies: the case of breast ... objective of our study was to investigate the complementary value of DCE for the evaluation of barriers and facilitators in implementation research To meet this objective we compared the results of ... This means that each of the profiles was combined with its 'foldover' profile A foldover profile includes the exact opposite attribute levels of the original profile and, therefore, ensures a...

Ngày tải lên: 11/08/2014, 16:21

... performance of a bronchoalveolar lavage for culture, or start of or a change in antimicrobial therapy in case of unexpected infiltrates on the CXR; repositioning of tubes in case of malposition of orotracheal ... ultrasound of the thorax in case of pleural effusion on the CXR, start or change in medication (diuretics); insertion of a pleural drain; and repositioning of devices in the case of malposition of medical ... Table aAbsolute number of chest radiographs (% of all daily routine chest radiographs) bAbsolute number of patients (% of all patients with daily routine chest radiographs) of daily routine CXRs...

Ngày tải lên: 25/10/2012, 10:39

... Main result Main Theorem Let µ be the 5−fold convolution of the standard Cantor measure, then the lower extreme value of the local dimension of µ is α5 = | log 3.25 √ arccos 145 cos( log 427 √ 59 ... V.T.H Thanh et al / VNU Journal of Science, Mathematics - Physics 25 (2009) 57-68 65 From (13), (14) and (15), the assertion of the corollary follows 2.2 The proof of the main theorem Lemma Let ... (s3) are the values in Corollary From Lemma 2, Corollary and Proposition 2, we have Theorem Let µ is the 5−fold convolution of the standard Cantor measure, then the lower extreme value of the local...

Ngày tải lên: 13/02/2014, 03:20

Ngày tải lên: 14/02/2014, 21:20

... in 1994 at the Ministry of Commerce listed an export to North Korea of 5,000 “units” of rubber each valued at £1,000 in exchange for 2,800 “units” of steel and a quantity of machinery, tools, chemical ... cloth, and minerals valued at £5 million The pound sterling measurement apparently had nothing to with its London value Records of shipments to China of hundreds of tons of endangered animal ... build enough confidence in the riel to suppress the use of the U.S dollar and of gold as the prevailing means of exchange and stores of value Cambodia’s Economic Past It is important to know where...

Ngày tải lên: 16/02/2014, 11:20

... her value in terms of output, 14 For a description of the program, see http://www.teachforamerica.org/ Kane, Rockoff, and Staiger (2008) additionally provide some idea of the cost trade-off of ... Economic Value of Higher Teacher Quality Eric A Hanushek CALDER Working Paper No 56 December 2010 Abstract Most analyses of teacher quality end without any assessment of the economic value of altered ... evaluated in terms of the potential gains for students, implied by the economic value of 12 better performance Such evaluations, however, provide some idea of the social value of highly effective...

Ngày tải lên: 20/02/2014, 16:20

... Transportation of research animals is an essential component of the research enterprise The integrity and well-being of the animals being transported are necessary for the quality of the research and ... president of the National Academy of Sciences The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding ... by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public The Institute...

Ngày tải lên: 06/03/2014, 15:20

... residue in the A-chain of thrombin [1,2] Measurements of the pH dependence of both steady-state amidase activity and binding of the high-affinity inhibitor a-NAPAP showed pKa values of the catalytic ... and simultaneous analysis of the experimental data by grafit software allowed computation of the pKa values of the two groups both in the free and substrate-bound species of thrombin forms, along ... sets of NAPAP inhibition of d-Phe-Pip-ArgpNA hydrolysis at each pH value, the steady-state velocity of cleavage of seven substrate concentrations (0.5–32 lm) Urea-induced denaturation curves of...

Ngày tải lên: 07/03/2014, 12:20

... of such works of art that perception of Ideas is more readily available even to lesser minds Therefore, the epistemic value of a work of art is that it smoothens the contemplation of the Idea it ... works of art Thus, not only is art epistemically significant, but is also the source of the profoundest type of knowledge How plausible is all of this when applied to a particular work of art? ... account of the epistemic value of art largely intact My proposal can be best understood as a change of language in Schopenhauer's account of world as Will rather than some dramatic overhaul of its...

Ngày tải lên: 07/03/2014, 17:20

... economic value of all three solar options considered here is high, higher than the marginal economic value of a flat block of power, in California at low levels of solar penetration This high value ... economic value of wind with increasing penetration is found to be, at least for low to medium penetrations of wind, largely a result of further reductions in capacity value The energy value of wind ... similar to the energy value of a flat block of power (and similar to the fuel and variable O&M cost of natural gas CCGT Table ES.1: Decomposition of the marginal economic value of variable generation...

Ngày tải lên: 08/03/2014, 06:20

... English language proficiency, lack of knowledge about the application process, and the cost of applying, which at $680 is higher than in most other OECD countries The Economic Value of Citizenship ... percent of immigrants, respectively, as of 2006 were naturalized.2 Part of this gap results from the substantial number of unauthorized immigrants in the United States About two-thirds of immigrants ... employer’s failure to accept qualifying documentation as proof of The Economic Value of Citizenship for Immigrants in the United States as a signal of better social and cultural integration, motivation,...

Ngày tải lên: 08/03/2014, 06:20

... within 500 feet of parks Assumed average value of a park Value of properties attributed to parks Effective annual residential tax rate Annual property tax capture from value of property due to ... atmosphere For instance, the externality value of a short ton of carbon monoxide is $870; the externality value of the same amount of sulfur dioxide is $1,500.) 13 PARK VALUE IN ACTION Cutting Air Pollution ... percent of home value Taking an average of this range yields the percent value that will be used until a park quality methodology can be established.) Once determined, the total assessed value of...

Ngày tải lên: 02/04/2014, 08:20

... mention in most studies of his life and work Like some shorter works of other noteworthy composers, Brahms’s small corpus of organ works often tends to be overlooked as a kind of oddity, hard to pigeonhole ... a little research time in Brahms’s world in Vienna A note of appreciation is due to Paul Peeters of Göteborg University, Stephen Pinel of the American Organ Archive, and Dr Uwe Pape of the University ... sources of information, I am particularly indebted to the excellent resources of the Music Division of the Mugar Library at Boston University, the Sibley Music Library of the Eastman School of Music,...

Ngày tải lên: 04/06/2014, 15:41

... to the NR with a cut-off value of 0.15 Results: We followed patients’ recovery for a median duration of 59 months An NR >0.15 was found in 23.1% of patients, and a median of 18 nodes were dissected ... number of involved nodes/number of excised nodes, has been suggested to address this discrepancy [4] Recent studies have shown the prognostic value of the NR and even proposed the possibility of ... used a value between 0.20 and 0.25 as a minimal cut-off threshold to distinguish risk groups, there is no consensus on which value is the most reliable [5-14] We used 0.15 as a cut-off value, ...

Ngày tải lên: 09/08/2014, 09:21

... evaluated area of the specimen This allowed the software to automatically quantitate not only the average intensity of each category, but also the relative area of these stains The products of the scoring ... heterogeneous, with a proportion of GBM samples demonstrating little to no expression of nestin [11,13-17] The clinical relevance of these varying expression patterns of nestin in GBM has not been ... significant Discussion Results The original RTOG TMA consisted of 156 GBM patients, of which, 153 were evaluable Of these, the total number of patients that comprised the low, intermediate, and high...

Ngày tải lên: 09/08/2014, 09:22

... number of SSc patients that are positive for PM/Scl aabs likely requires elucidation and further study Page of (page number not for citation purposes) The findings of Hanke and colleagues are of ... (especially the presence or absence of myositis) are needed for a consensus of the clinical value of PM/Scl, and especially of PM/Scl-75c, aabs Competing interests MM is employed at Dr Fooke Laboratorien ... this study was the lack of a detailed description of the recombinant PM/Scl-100 antigens that were produced in bacteria or insect cells (for example, purity or presence of a fusion-tag) In addition,...

Ngày tải lên: 09/08/2014, 13:22

... the presence of MRI erosions has a PPV of 50%, a NPV of 85%, a LR+ of 2.7 and a LR- of 0.5 for prediction of RA development [19] Tamai and colleagues studied the predictive value of MRI erosions ... Additionally, the predictive values of the SHS erosion score were investigated in a similar way, using different cut-off values (Table 3) In case of an erosion score of one ore more, 45% of UA patients developed ... the cut-off of having five or more erosive joints, the PPV was 73% As the 95% confidence interval (CI) were overlapping, it could not be concluded that the PPV of one of these cut-off values is...

Ngày tải lên: 09/08/2014, 14:22

... medical research [22] The accountability of RECs may be clarified in a number of ways: statutory codification of detailed standards; an enhanced model of self-regulation; accreditation of RECs; ... RECs; and certification of REC members Whether a single strategy or a combination of strategies is pursued, the goal should be to reinforce of the professionalism of human research review [23] in ... financial conflicts of interest N Engl J Med 1993, 329:573-576 Glass KC, Lemmens T: Conflict of interest and commercialization of biomedical research: what is the role of research ethics review...

Ngày tải lên: 12/08/2014, 18:21