autoimmune hemolytic anemias and drug induced immune hemolytic anemia

... http://www.jmedicalcasereports.com/content/5/1/156 Introduction Autoimmune hemolytic anemia (AIHA) is one of the most common causes of acquired hemolytic anemia The cause of AIHA remains idiopathic in 50% ... TD, Madueme HL, Wolf RC, Tefferi A: Rituximab for immune cytopenia in adults: idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and Evans syndrome Mayo Clin Proc 2003, 78:1340-1346 ... warm and cold autoimmune hemolytic anemia: complete recovery after courses of rituximab treatment Blood 2002, 99:3478-3479 Webster D, Ritchie B, Mant M: Prompt response to rituximab of severe hemolytic...

Ngày tải lên: 11/08/2014, 00:23

... tumors, and from vaccinated mice that did not develop tumors These two RNA pools were analyzed for T-cell and B-cell activation (SA Biosciences, cat # PAMM-053), and for T-cell anergy and immune ... Th-1-type immune response and in the activation of dendritic antigen-presenting cells (APC) We now report experimental evidence suggesting that, in addition to activating APC and a Th-1-type immune ... Th-1-type immune response, semi-allogeneic vaccines also inhibit tumor -induced immune tolerance and anergy Methods Cells and semi-allogeneic hybrids RAG cells are a non-reverting, 8-azaguanine-resistant...

Ngày tải lên: 18/06/2014, 15:20

... in childhood autoimmune hemolytic anemia Am J Pediatr Hematol Oncol 1983, 5:147-152 Petz LD, Garratty G: Management of autoimmune hemolytic anemias In Acquired Immune Hemolytic Anemias Edited ... treatment of refractory autoimmune hemolytic anemia in children Blood 2003, 101(10):3857-3861 Motto DG, Williams JA, Boxer LA: Rituximab for refractory childhood autoimmune hemolytic anemia Isr Med Assoc ... for refractory autoimmune hemolytic anemia Blood 2002, 100(10):704-706 Quartier P, Brethon B, Philippet P, Landman-Parker J, Le Deist F, Fischer A: Treatment of childhood autoimmune haemolytic...

Ngày tải lên: 11/08/2014, 17:21

... proinflammatory immune responses As possible markers of these changes in the immune system we investigated the proinflammatory cytokines IL-6 and TNF-a and measured the lymphocyte cell count Materials and ... Medicine and Toxicology 2010, 5:18 http://www.occup-med.com/content/5/1/18 deprivation and thereby an induction of proinflammatory immune responses [7-9] Cytokine levels correlate with fatique and ... disturbances and chronic sleep debt [1-6] To investigate the long-term influence of chronic sleep debt and circadian disruption on the immune system we compared cytokine production and lymphocytes...

Ngày tải lên: 20/06/2014, 00:20

... Bonaci-Nikolic BM, Nikolic MM, Andrejevic S, Zoric S, Bukilica M: Antineutrophil cytoplasmic antibodies (ANCA)-associated autoimmune diseases induced by antithyroid drugs: Comparison with idiopathic ... ANAs and antihistone antibodies as well as myeloperoxidase–ANCAs in such patients, the latter being likely to be caused by drug- induced damage directed at the neutrophils that process the drug ... propylthiouracilinduced vasculitis associated with anti-neutrophil cytoplasmic antibody (ANCA); review of literature Clin Nephrol 1997, 47: 336-340 Rubin RL: Autoantibody specificity in drug- induced lupus and...

Ngày tải lên: 09/08/2014, 07:20

... mg/dL; and undetectable serum haptoglobin Noninfectious causes of hemolytic anemia, including hemoglobinopathies (such as glucose-6-phosphate dehydrogenase deficiency), drug toxicity, autoimmune ... Morad AB: Infantile cytomegalovirus-associated autoimmune hemolytic anemia J Pediatr Hematol Oncol 2001, 23(5):318-320 Veldhius W, Janssen M, Kortlandt W, Van Houte A, Van De Ree M: Coombsnegative ... Gavazzi G, Leclercq P, Bouchard O, Bosseray A, Morand P, Micoud M: Association between primary cytomegalovirus infection and severe hemolytic anemia in an immunocompetent adult Eur J Clin Microbiol...

Ngày tải lên: 11/08/2014, 02:21

... of sotalol and verapamil in one case, acebutolol and meprobamate in two cases, propranolol, verapamil and betaxolol in one case, and various psychotropic drugs in one case; the single drug poisoning ... beta-blocker (BB), and membrane-stabilizing agent (MSA) poisoning This algorithm is based on series and case reports HR, heart rate; SBP, systolic blood pressure contractility Many cases of drug- induced ... antidepressants and chloroquine, while it can be underestimated for labetalol poisoning Therefore, in drug- induced cardiovascular shock with apparent refractoriness to conventional treatment, it is mandatory...

Ngày tải lên: 13/08/2014, 03:20

... injury and its pattern 1.2 Clinical outcomes of drug- induced liver injury 1.3 Mechanism of liver injury 1.3.1 General drug- induced liver injury mechanism 1.3.2 APAP -induced ... Ruenn Chai for his helps and inputs on the MSC-derived exosomes and also Judy Saw for her assistance in tocotrienols uptake assay The Laboratory of Liver Cancer and Drug- Induced Liver Diseases ... APAP- and H2O2 -induced in liver injury in vitro……… 112 4.3.1 Effect of T3 analogs on APAP and H2O2 -induced on cell death in TAMH cells 112 4.3.2 Effect of lower dosage of -T3 and...

Ngày tải lên: 09/09/2015, 11:21

... which is induced by Fas ligand (FasL), tumour necrosis factor alpha (TNFα) and TNF related apoptosis inducing ligand (TRAIL ) where these ligands bind to specific death domain receptors and induce ... from other DNA binding proteins, and a largely conserved C terminal domain which has sufficient variation to allow for ligand selectivity and possesses a ligand induced activation function called ... sumoylation, and phosphorylation have defined crucial roles in coactivator and corepressor activity and consequently on nuclear receptor function (Levine and Tjian, 2003) The concept that ligands act...

Ngày tải lên: 14/09/2015, 14:04

... animal models 34-36 and tryptophan depletion has been found to increase visually -induced nausea and dizziness in migraineurs Based on our results and the known effects of rizatriptan and serotonin, ... administering the drug, the technicians performing testing, and the subject were blinded to treatment assignment The Investigational Drug Service provided the unidentifiable drug in a container ... V+ and V- groups and between groups with and without visual motion sensitivity were performed using the Wilcoxon rank sum test Results Fourteen persons were identified as possible study candidates...

Ngày tải lên: 26/10/2012, 09:57

... United States, and Central Africa; B and C predominate in Asia; D is associated with southern Europe, the Middle East, and India; E is uniquely African; and F is found in Central and South America ... Not well standardized Can indicate and confirm emergence of antiviral resistance Wide variation in test sensitivities Direct marker and gold standard for HBV viral replication No gold standard among ... [1113], rising to more than 40% after two years, and increasing further to over 50% and 70% after years three and four, respectively [13] Increasing the drug dosage does not appear to substantially...

Ngày tải lên: 03/11/2012, 09:41

... gloves, and outer garments, and from raw product to processed product; (4) Maintenance of handwashing, hand sanitizing, and toilet facilities; (5) Protection of food, food packaging material, and ... September and 15, 1999, November 16 and 1, 1999, and February 2, 2000 FDA, DHHS, Hazard Analysis and Critical Control Point (HACCP); Procedures for the Safe and Sanitary Processing and Importing ... juice from a country that has an active memorandum of understanding (MOU) or similar agreement with the Food and Drug Administration, that covers the food and documents the equivalency or compliance...

Ngày tải lên: 25/10/2013, 21:20

... Reuter T.Y Diet induced models for obesity and type diabetes Drug discovery today: disease models Vol.4 (1) (2007) 124 D.N Lien et al / VNU Journal of Science, Natural Sciences and Technology ... insulin and key hepatic enzymes in experimental diabetes, Pharmaceutical Biology 40(3), (2002) 165 [8] N Brandstrup, JE Kirk, C Bruni, The hexokinase and phosphoglucoisomerase activities of aortic and ... diet (ND from NIHE), other fed with high fat diet (HFD) [4,5] and water ad libitum, for weeks 2.3 Development of HFD-fed and STZ -induced type diabetic mice After weeks of dietary manipulation,...

Ngày tải lên: 12/02/2014, 17:20

... this mutant strain as described below) Body and organ weights as well as plasma parameters (Tables S2 and S3) were measured, and learning, memory and behavioral tests (Table S4) as well as histopathological ... Resistance to KK- and KK-Ay -induced genetic induced obesity in RMI1+/) mice To explore resistance to the development of obesity under other conditions, we generated KK-a ⁄ a and KK-Ay ⁄ a RMI1-deficient ... Matsushime, Masato Kobori, Jiro Hirosumi and Mr Tsutomu Higashiya at Astellas Pharma Inc., and Junko Kawano and Akemi Matsuoka at Trans Genic Inc for their helpful advice and support 12 References 13 Zhang...

Ngày tải lên: 16/02/2014, 09:20

... Chemical and Biological Defense DIA Drug Information Association DoD U.S Department of Defense E&T education and training FDA U.S Food and Drug Administration xix xx The Acquisition of Drugs and Biologics ... decentralized, and fragmented organizational system for drug and vaccine development This required us to understand the relation of different DoD organizations to CBW drug and biologics development and ... development and licensing capability Were DoD more effective in managing the drug development and licensing process, fewer candidate drugs and vaccines would be “parked” in IND status, and more...

Ngày tải lên: 17/02/2014, 11:20

... A prevailing issue in drug development is the attrition of new drug candidates Between 1995 and 2005, a total of 34 drugs were withdrawn from various markets (Table 1) and the reason for withdrawal ... investigational drug during drug development, Hy's Law falls short of constituting a "gold standard'" and validation of Hy's Law is much needed, chiefly with regards to its sensitivity and specificity ... hepatotoxicity Pharmacoepidemiology and Drug Safety 2006; 15: 241-243 [18] Faich GA, Moseley RH Troglitazone (Rezulin) and hepatic injury Pharmacoepidemi‐ ology and Drug Safety 2001; 10: 537-547 DOI:...

Ngày tải lên: 18/02/2014, 04:20

... chromatographic profiles for FprA and on incubation with and without urea on Superdex 200 H column at pH 7.0 and 25 °C Curves and represent profiles for FprA at pH 7.0 and that on incubation with M ... have studied the effect of GdmCl- and ureainduced changes in the structural and functional properties of FprA Time-dependent changes in the structural parameters and enzymatic activity of FprA at ... curve showing two distinct transitions between and 0.8 m and 0.8 and m GdmCl were observed (Fig 4B) These observations demonstrate that during GdmCl -induced denaturation of FprA the transition observed...

Ngày tải lên: 19/02/2014, 16:20

... lane 6, Glu-Pg- and mAb 34D3-treated cells Bands in lanes and correspond to forms I and II of plasmin(ogen) High molecular weight bands in lanes and correspond to mAb A10.2- and mAb 34D3-plasminogen ... Lys-plasmin(ogen) binding and activation These structural–functional transitions are determinant in the initiation and development of both fibrinolysis and cell detachment -induced apoptosis and may therefore ... evaluate their respective contribution to Gluand Lys-Pg binding and activation onto fibrin and cells, as well as their effects on fibrinolysis and on plasmin -induced cell apoptosis The LBS specificity...

Ngày tải lên: 20/02/2014, 01:20

... occurring mutations found as sequence polymorphisms and in drug resistance, with wild-type and five drug- resistant mutant PRs: M46L, V82A, I84V and L90M mutations that appeared together with the ... PR, and the respective S4 and S3 binding sites could accept a variety of residues [33,34,46] When compared to peptides having the same natural sequence background (peptides and 1, and 2, and ... it interacts with Arg8 and Glu21 through water molecules and makes hydrophobic interactions with Phe53, Pro81 and Val82 [26] P3 Arg could interact favorably with Asp29 and P1 Asn, which may contribute...

Ngày tải lên: 21/02/2014, 03:20

... protein and are relayed from the NBDs to the TMDs as a consequence of nucleotide binding and drug binding, respectively, thereby enabling active drug efflux by ABCB1 However, we are yet to understand ... changes are relayed between the TMD and NBD, and how they enable drug translocation Transmembrane helix (TM6) and transmembrane helix 12 (TM12) are likely candidates to effect coupling, given ... purchased from Lonza (Wokingham, UK) and Excell 405 from SAFC Biosciences (Andover, UK) CM, FM and BM were purchased from Molecular Probes (Leiden, The Netherlands) Site-directed mutagenesis of...

Ngày tải lên: 06/03/2014, 22:21