atomic spectrometry in biological and clinical analysis
báo cáo hóa học: " In vitro and in vivo pre-clinical analysis of a F(ab’)2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers" pot
... blood pharmacokinetics of 111 In- panitumumab F(ab’)2 was evaluated in tumor- and non-tumor-bearing mice following i.v and i.p administration In the absence of a tumor burden, i.v injected RIC demonstrated ... contributions KJW performed the in vitro and in vivo studies KEB and KG carried out radiolabelings TN performed PET imaging and analysis MWB synthesized the chelate and participated in the design of the ... following i.p injection of the panitumumab F(ab’)2 Imaging studies, g-scinitigraphy and PET, of the i.p tumor model using these two injection routes are pending Studies from this laboratory and...
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Báo cáo y học: "The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now" potx
... joint counts, the Simplified Disease Activity Index and the Clinical Disease Activity Index (reviewed in [9]) – have been shown useful for following disease activity and for serving as endpoints ... is recognition that clinical assessment (measuring and noting the change in index and the disease activity state attained) early in the course of therapy (3 to months after initiation of therapy) ... fragments Noncollagen and nonaggrecan proteins Cartilage oligomeric matrix protein Type I collagen Pyridinoline, deoxypyridinolin PYD, DPD Type I collagen C-terminal and N-terminal telopeptides CTX-I,...
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Báo cáo y học: "The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases" pot
... receptor chain with high affinity (1011/M) and slow off-rate, rendering it a useful and specific inhibitor in biologic systems Common γ-chain signalling cytokines – interleukin-15 and interleukin-21 ... considerable interest Recently described interleukin-12 superfamily members – interleukin-27 and interleukin-35 This cytokine superfamily has expanded recently and is of considerable interest in inflammatory ... implicated IL-15 in effector tissue pathology, including in psoriatic and inflammatory bowel disease models Clinical studies in humans have been undertaken using two distinct targeting approaches...
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Unraveling genomic instability in multiple myeloma mechanisms, biological and clinical implications
... 13% of patients In addition inactivating mutations of TRAF2, cIAP1/2, and CYLD were identified Chromosome translocations and amplifications resulting in activation of NFB inducing kinase (NIK) (Annunziata, ... activation in the remaining patients 1.2.5 Dysregulation of a Cyclin D gene: A unifying and early oncogenic event in MGUS and MM It has been proposed that dysregulation of a Cyclin D gene is a unifying, ... this is unclear Genomic instability in cancer is broadly categorized into mutational instability, e.g., microsatellite instability (MIN) and chromosome instability (CIN) CIN, characterized by unstable...
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analytical atomic spectrometry with flames and plasmas
... 25 soft 23, 223 line coincidence 193 line frequency 196 line pair 12 line pair selection 225 line pro®le 17, 74 line source 149 line spectrum 152 line width 157 line wing 202 linear dynamic range ... structure and hyper®ne structure, and also resonance broadening, resulting from the interaction between radiating and non-radiating atoms of the same species, and Stark broadening, resulting from interaction ... a and o and accordingly DnL and DnD can be determined and from the latter the gas kinetic temperature This is a measure of the kinetic energy of atoms and ions in the plasma Owing to the line...
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Cambridge Studies in Biological and Evolutionary Anthropology pot
... Paleodemography: looking back and thinking ahead xi xiii Reference samples: the first step in linking biology and age in the human skeleton 29 Aging through ... populations Looking back and thinking ahead 21 Princeton, NJ: Princeton University Press Coppa A, Cucina A, Chiarelli B, Luna Calderon F, and Mancinelli D (1995) Dental anthropology and paleodemography ... biology of the hominoid pelvis and its implications for the use of age-at-death indicators in the human skeleton In RR Paine (ed.): Integrating archaeological demography: in multidisciplinary approaches...
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Effective use of data mining technologies on biological and clinical data
... science and biology communities We would like to call this discovering biological knowledge in silico by data mining 1.2 Work and Contribution To make use of original biological and clinical data in ... which unifying principles in biology can be discerned [3] 1.1 Motivation At the beginning, the main role of bioinformatics was to create and maintain databases to store biological information, ... pressing task of bioinformatics has become to analyse and interpret various types of data, including nucleotide and amino acid sequences, protein structures, gene expression prolings and so on In...
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Investigation and application of liquid chromatography mass spectrometry in the analysis of polar, less volatile and thermal unstable organic pollutants in environmental and biological samples 6
... behavior in ultrapure water, drinking water, rain water, river water and seawater under various pH and irradiation sources (sunlight, darkness, indoor incandescent lighting and artificial UV lighting) ... Light intensity could prompt degradation significantly under mild alkaline conditions, while its influence was minor at higher pH (pH > 9) Furthermore, half-lives and degradation rates were obtained ... 2-isopropoxyphenol occurred in all tested biological samples under the applied MAE conditions and led to low recoveries The stability of propoxur under microwave irradiation was maintained as neither evaporation...
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Investigation and application of liquid chromatography mass spectrometry in the analysis of polar, less volatile and thermal unstable organic pollutants in environmental and biological samples 5
... power setting for the microwave heating This setting was proportional to the number of samples undergoing extraction during one run Furthermore, according to previous experience with MAE and intuition, ... variables (A, B, C and D), two-variable interaction, and the level setting values of the main variables applied to aquatic animals (goldfish and tortoises) and sea lettuce are displayed in Table 5-1 ... with a tuning solution (a mixture of caffeine, MRFA, and ultromark 1621) in both positive and negative ionization modes In order to ensure optimal tuning conditions, the propoxur standard was...
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Investigation and application of liquid chromatography mass spectrometry in the analysis of polar, less volatile and thermal unstable organic pollutants in environmental and biological samples 4
... 3) methanol 88 An interesting result observed from Fig 4-6 is that in the same solvent, the recovery increases in going from PAHs to PCBs, and then to triazines (i.e, increasing polarity of analyte) ... temperature 300°C; initial oven temperature 80°C for min, increased to 200°C at a rate of 25°C/min, then maintained at 200°C for min; a second ramp 230°C at rate of 5°C/min, increased to 280°C ... PCBs and triazines For example, the recoveries of triazines progressively improved with an increasing degree of moisture in the tested soil This can be explained by the high solubility of triazines...
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Investigation and application of liquid chromatography mass spectrometry in the analysis of polar, less volatile and thermal unstable organic pollutants in environmental and biological samples 3
... the K and t½ in each natural water sample K increases and t½ decreases accordingly when the light intensity increases in the order of darkness, indoor lighting and sunlight This indicates that ... Irradiation darkness indoor lighting a sunlight darkness indoor lighting a sunlight darkness indoor lighting a sunlight darkness indoor lighting a sunlight darkness indoor lighting a sunlight k (h ... different pH and irradiation sources (sunlight, darkness, indoor incandescent lighting and artificial UV light) by using LC-APCI-ITMS with selected ion monitoring mode; and (3) To investigate...
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Investigation and application of liquid chromatography mass spectrometry in the analysis of polar, less volatile and thermal unstable organic pollutants in environmental and biological samples 2
... (PCB-1242 and PCB-1248) were purchased as individual standard stock solutions containing a nominal concentration of 100 µg/ml in methanol from Ultra-Scientific Atrazine (purity 98%) and simazine (purity ... The instrument was initially tuned based on a mixture of caffeine, L-methionyl-arginyl-phenylananyl-alanine acetate·H2O and a mixture of perfluoroalkoxycyclotriphosphazenes in both positive and ... fresh running water and then rinsed with deionized water The fish samples were grinded in a mortar and pestle with liquid nitrogen until a homogenous fine powder was obtained In order to meet the...
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Investigation and application of liquid chromatography mass spectrometry in the analysis of polar, less volatile and thermal unstable organic pollutants in environmental and biological samples 1
... rapid and accurate molecular-mass determination for large proteins by means of ESI At present, APCI is commercially available and a growing interest in applications involving biological and environmental ... 1-3 Comparison of the boiling points of solvents in open and closed systems [64] Solvent Dichloromethane Boiling point (°C) in open system 39.8* Boiling point (°C) in closed system (175psi) 140 ... (ultrapure water, drinking water, rain water, seawater and river water), and irradiation sources (sunlight, darkness, indoor lighting and artificial UV lighting) on chemical degradation are investigated...
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ATOMIC ABSORPTION SPECTROMETRY IN WINE ANALYSIS – A REVIEW pot
... iron-induced oxidation Sources of lead in wine were inferred from systematic assay of grapes must and wine during winemaking It was found that Pb concentration in fermenting must vary during vinification ... contamination during post-fermentation processing, and sources include contact with nonstainless steel equipment and impurities in the fining agents and filter media [9, 10] In a model investigation, ... the main contamination source for elevated Pb content in wine [16] Cadmium levels have been determined during wine making in 21 locations in France During the alcoholic fermentation Cd elimination...
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elements and their compounds in the environment occurence analysis and biological relevance
... Contamination of the Environment 1117 Inorganic Tin 1117 Organic Tin 1118 Contamination of Food and Living organisms 1119 Uptake, Absorption and Elimination in Plants, Animals and Humans 1120 Tin and ... Products and Recycling 588 Distribution in the Environment, in Foods, and in Living Organisms 589 Uptake, Transport and Distribution, Metabolism and Elimination in Plants, Animals, and Humans ... Products and Recycling 620 Distribution in the Environment, in Foods, and in Living Organisms 621 Uptake, Transport and Distribution, Metabolism and Elimination in Plants, Animals, and Humans...
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Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx
... anti-inflammatory drug Clinical ulcers and bleeds Clinical ulcers and bleeds in the company clinical trial reports were as reported by investigators, and were not subjected to independent, blinded ... ordinal and interval scales is inadequate in relation to meta -analysis Ann Rheum Dis 2001, 60:349-352 Barden J: Meta -analysis to investigate methodological issues in clinical trials using pain ... extraction, analysis, and preparing the manuscript; SD with data extraction, analysis, and writing; GTM with planning, data extraction, analysis, and writing the manuscript; HJM with planning, analysis, ...
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Báo cáo y học: "The terrorist bomb explosions in Madrid, Spain – an analysis of the logistics, injuries sustained and clinical management of casualties treated at the closest hospital" potx
... one The incidence of critical injuries among survivors varies between 9% and 22% [2] Chest and abdominal injuries, including BLI, Available online http://ccforum.com/content/9/1/104 and traumatic ... 55% having open wounds, 31% having internal injuries, and 50% undergoing a procedure in the operating room [13] Also, the mortality rate was twofold higher than inpatient death following road ... head injuries was assessed as severe in 60%, moderate in 13% and mild in 27% of the critically ill patients Fractures to the base of the skull and brain contusions were the most common findings,...
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Báo cáo y học: "The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging" docx
... specifically, since the timing information pertains to individual planes within the 5D Image, a set of plane indexes would be included in the definition referring to a specific plane The timing information ... binary image data and all information regarding the image acquisition and processing, and any results generated during analysis In this way, all aspects of the data acquisition, processing, and ... advantage of its growing popularity in various unrelated fields - including a great deal of software written for XML, including databases, editing tools, and parsing libraries Finally, and perhaps most...
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Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations
... self-renew and differentiate In this thesis, the molecular and clinical significance of cancer stemcell markers and its related proteins in colorectal cancers were investigated Tissue microarray analysis ... metastatic adenocarcinoma as proposed by Fearon and Vogelstein (Fearon and Vogelstein, 1990) Figure A simplified working model of sporadic colorectal tumour development incorporating the CIN and CIMP pathways ... The MLH1 and MSH2 protein are essential in the mismatch repair machinery and mutations in MLH1 and MSH2 have been implicated in HNPCC (Boland et al., 1998) Many colorectal cancers with an intact...
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