atlat of x ray
Báo cáo y học: "Application of Small Angle X-ray Scattering (SAXS) for Differentiation between Normal and Cancerous Breast Tissue"
... using scattered X- rays. J Synchrotron Rad 2000; 7: 348-352. 8. Malden CH, Speller RD, et al. A CdZnTe array for the detection of explosives in baggage by energy dispersive X- ray diffraction ... of their diffraction profiles. 4. Discussion A noticeably shaper peak in the diffraction profile was obtained for adipose compared to other tissues. This is a result of the high levels of ... is expected different peak positions will exist for carcinoma and fibrocystic changes. Our results confirmed this expectation. The peak position of fibrocystic change was close to that of carcinoma....
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Tài liệu Characterization of the Polymorphic Behavior of an Organic Compound Using a Dynamic Thermal and X-ray Powder Diffraction Technique pptx
... melt.Figure 24. DSC of amorphous Form (sample 26)Figure 25. XRPD of amorphous Form (sample 26)Figure 26. DSC of mixture of hydrated Forms I and III (sample45).Figure 27. DSC of mixture of anhydrous ... 1.Detection of Mixtures of Polymorphs and Potential NewSolids Forms. By using the combined and dynamic DSC/XRPD, several mixtures of 1 disodium salt samples wereidentified, and the components of these ... apparently formed byrefluxing a mixture of Form I and Form IV or by refluxingForm VI in acetone. The proposed interconversions of thevarious polymorphs of 1 dicarboxylate disodium salt are givenin...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... pantoate-bound form of nPS using X- ray crystal-lography, as described below.Solution and refinement of the structure using X- ray crystallographyThe crystal structure of the pantoate–nPS complex wassolved ... in the vicinity exhibit highflexibility. Preliminary analysis of 15N relaxation datashows that residues 118–122 have a higher degree of flexibility than other ordered regions of the protein.Unfortunately, ... effects of one of the substrates, i.e. pantoate [8,9]. One of theinteresting features of the plant PSs is the presence of a conserved 24 residue insertion in the sequence [9].This sequence of amino...
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Tài liệu Báo cáo khoa học: Destabilization of psychrotrophic RNase HI in a localized fashion as revealed by mutational and X-ray crystallographic analyses pdf
... tomounting for X- ray diffraction.Structure determination and refinement X- Ray diffraction data sets of the 6·-RNase HI crystalwere collected at 100 K using synchrotron radiation at theBL44XU station ... structures of theseEc-RNase HI variants, the position of His124, whichcorresponds to His126 of So-RNase HI, varies for dif-ferent proteins, because of the intrinsic flexibility of theloop ... mechanism of So-RNase HIA combination of the six thermostabilizing mutationsincreases the stability of So-RNase HI by 28.8 CinTmand 27.0 kJặmol)1in DG(H2O). Five of the sixsubstituted...
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Tài liệu Báo cáo khoa học: Molecular determinants of ligand specificity in family 11 carbohydrate binding modules – an NMR, X-ray crystallography and computational chemistry approach doc
... thebinding of cellohexaose to CtCBM11. The STD-NMRspectrum of the hexasaccharide in a 20-fold excess overCtCBM11 is shown in Fig. 2 along with the cellohexa-ose reference spectrum. Comparison of both ... in the binding processFig. 2. STD-NMR of cellohexaose with CtCBM11. (A) Reference1H NMR cellohexaose spectrum. (B) STD spectra of the solution of cellohexaose (50 lM) with the protein (5 lM). ... allow determi-nation of the individual contributions of protons aH4a, bH3a, H4b-eand H5b-e to the binding.Fig. 3. Structure of cellohexaose. Relative degrees of saturation of the individual protons...
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Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx
... structure of AII in solution with the X- ray structure of AII complexed to the Fab131 mAb. In Fig. 7A, asequence alignment is represented of the backbone of theconformational ensemble of AII in ... structures of AII to the fragment 3–6 of the X- ray structure of AII.Fig. 6. Structure of a representative folded conformer of AII showing the van der Waals contacts between the side-chains of residues ... yellow the side chains of Val3and Pro7) (a) with the the X- ray structure of AII in the Fab131–AII complex [30]3(b).Ó FEBS 2003 Comparison of the free and bound structure of angiotensin II (Eur....
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Tài liệu Báo cáo Y học: The solution structure and activation of visual arrestin studied by small-angle X-ray scattering pot
... range of 30150 lM(1.36.5 mgặmL)1), 90 lL of arrestin solutionwas mixed with 10 lLof10mMpeptide solution toyield a final peptide concentration of 1 mM. For higherconcentrations of arrestin ... phosphorylation of the C-terminus of R* and binding by arrestin. Phosphorylation somewhatdecreases the ability of R* to signal transducin. Rapid shut-off of R* signalling is then accomplished by binding of arrestin ... Because of the changing oligomeric state of arrestin in these experiments, Guinier analysis waspreferred over the use of the distance distributionfunction, which requires a prior estimation of the...
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Báo cáo khoa học: Determination of thioxylo-oligosaccharide binding to family 11 xylanases using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and X-ray crystallography pot
... 4,4II,4III,4IV-tetrathio-a-xylopentoside; TRX I, Trichodermareesei xylanase I; TRX II, Trichoderma reesei xylanase II; Xyl2, b-D-xylobiose; Xyl3, b-D-xylotriose; Xyl4, b-D-xylotetraose; Xyl5,b-D-xylopentaose; Xyl6, ... calorimetry of bothdomains decreased in the series b-d-xylohexaose(Xyl6) > b-d-xylopentaose (Xyl5) > b-d-xylotetraose(Xyl4) > b-d-xylotriose (Xyl3), with no detectableaffinity for b-d-xylobiose ... Param-eters of the measurement and refinement statistics for theCTX–S-Xyl5-Me complex are summarized in Table 4.Atomic co-ordinates for the crystal structures of TRX I,TRX II, CTX, and CTX–S-Xyl5-Me...
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Báo cáo khoa học: The effect of replacing the axial methionine ligand with a lysine residue in cytochrome c-550 from Paracoccus versutus assessed by X-ray crystallography and unfolding ppt
... concentrations of % 5 lmwere used. Peroxidase activity was assayed using hydrogenperoxide and guaiacol (O-methoxyphenol, Sigma). The syn-thesis of the fourfold oxidized product of guiacol, 3,3Â-di-methoxy-4,4Â-biphenoquinone ... unfolding of the M100K variant involvesthe breaking of the Lys-Nf-iron bond coupled with thedynamic process of ligand exchange. It thus seemslikely that the mechanism of release of the axial ... upon replacing the axial Met ligandwith a Lys in the M100K variant of cyt c-550 fromP. versutus. We describe three X- ray structures, one of the ferric wild type (wt) and two of the ferric M100Kvariant....
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Báo cáo khoa học: X-ray crystallography, CD and kinetic studies revealed the essence of the abnormal behaviors of the cytochrome b5 Phe35fiTyr mutant pdf
... Foundation of China. We are grateful to Prof. Li-Wen Niu,Prof. Mai-Kun Teng and Dr Xue-Yong Zhu of the University of Science and Technology of China for their support and help with the X- ray data ... chainconformation of this residue. The shift of the Ca atom of Tyr35 of the Phe35fiTyr mutant from that of Phe35 of thewild-type cyt b5is 0.21 A˚, within the error limit. The sidechain of Tyr35 of the ... structuralanalysis of bovine cytochrome b5at 1.5 A˚resolution. Acta Crys-tallogr. D52, 65–76.23. Xue, L.L. Wang, Y.H. Xie, Y. Yao, P. Wang, W.H. Qian, W.Huang, Z .X. Wu, J. & Xia. Z .X. (1999) Effect of...
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Báo cáo Y học: Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues pdf
... the Met-turn andactive-site consensus HExxHxxGxxH sequence [15–17].Some organisms and mammalian tissues recently have beenreported to contain a number of multidomain proteins,which are related ... stereochemicalquality of protein structures. J. Appl. Cryst. 26, 283–291.43. Bode,W.,Reinemer,P.,Huber,R.,Kleine,T.,Schnierer,S.&Tschesche, H. (1994) The X- ray crystal structure of the catalyticdomain of ... Grams,F.,Reinemer,P.,Powers,J.C.,Kleine,T.,Pieper,M.,Tschesche, H., Huber, R. & Bode, W. (1995) X- ray structures of human neutrophil collagenase complexed with peptidehydroxamate and peptide thiol inhibitors. Implications forsubstrate...
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Báo cáo khoa học: An X-ray diffraction study of model membrane raft structures doc
... from a binary mixture of egg-PtdCho and pro-portions of cholesterol of $ 25 mole% (Fig. 5D). Theeffect of cholesterol on d-spacings of egg-PtdChobilayers is complex. The presence of only 10 mole%ABCDFig. ... ternarymixture apparently hinders formation of a gel phaseby brainSM in this mixture. Assignment of peak 1 to astructure of pure brainSM can also be excluded on thisevidence. The fit of peak ... Laboratory. The X- ray wave-length was 0.154 nm with a beam geometry of $ 0.2 · 0.5 mm in a mica sandwich cell with a surface of 2 · 5 mm and a path length of 0.5 mm. SimultaneousSAXS and WAXS intensities...
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Báo cáo khoa học: X-ray structure of peptidyl-prolyl cis–trans isomerase A from Mycobacterium tuberculosis potx
... rmsd of approxi-mately 1.6 A˚from that of Mt PpiA, when the C a atoms arecompared using a cut-off of 3.5 A˚(with 88% of the Casmatching). This is significantly larger than the r msd of 0.05 ... estimated kcat/Km of 2.0 Ã 106M)1ặs)1.The X- ray structure of PpiA was solved by molecular replace-ment, and r efined t o a resoluti on of 2.6 A˚with R and Rfreevalues of 21.3% and 22.9%, ... theCorrespondence to S. Mowbray, Department of Molecular Biology,Swedish University of Agricultural Sciences, Uppsala BiomedicalCenter, Box 590, SE-751 24 Uppsala, Sweden. Fax: +46 18 53 69 71,Tel.:...
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Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... zinc.XANES spectra of wild-type and mutantsAs shown in the following, the interpretation of the EXAFS of the mutant enzymes is confirmed by a comparativeanalysis of the zinc K-edge spectra (XANES ... Mta,methanol:coenzyme M methyltransferase; MtaA, protein subunit of Mta; XANES, X- ray absorption near edge structure; XAS, X- ray absorption spectroscopy.(Received November 2001, revised 15 February ... curve-fitting of unfiltered k space the in-housesoftwareSIMXwas used. By curve-fitting of various EXAFSspectra we found consistently that DE0refined to a value of % 9665 eV; this value has been fixed...
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Báo cáo khoa học: X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-b-D-galactopyranoside pdf
... 4990E-mail: mowbray@xray.bmc.uu.seWebsite: http://xray.bmc.uu.se/(Received 13 December 2008, revised 31January 2009, accepted 2 February 2009)doi:10.1111/j.1742-4658.2009.06945 .x Periplasmic ... Structure of the periplasmic glucose ⁄ galactose receptor of Salmonella typhimurium . Receptor 1 , 41–53.21 Zou JY, Flocco MM & Mowbray SL (1993) The 1.7 A˚refined X- ray structure of the periplasmic ... binding sites of the Escherichia coligalactose chemoreceptor protein. Science 242, 1290–1295.25 Flocco MM & Mowbray SL (1994) The 1.9 A˚ X- ray structure of a closed unliganded form of the periplasmicglucose...
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