assessment of response to treatment

... the potential to execute necrosis in response to treatments with glycolytic inhibitors In contrast, the bioenergetic signature directly correlates with the apoptotic response to 5-FU treatment Overall, ... activation of caspase (an apoptotic indicator) was observed following any of these above treatments in any of the cell lines tested (data not shown) Therefore, inhibition of the activity of glycolytic ... signature of a cell, which represents an index of the relative relevance of cellular energy provision pathways [9,11], and the potential to execute cell death in response to the metabolic inhibitors,...

Ngày tải lên: 18/06/2014, 19:20

... the potential to execute necrosis in response to treatments with glycolytic inhibitors In contrast, the bioenergetic signature directly correlates with the apoptotic response to 5-FU treatment Overall, ... activation of caspase (an apoptotic indicator) was observed following any of these above treatments in any of the cell lines tested (data not shown) Therefore, inhibition of the activity of glycolytic ... signature of a cell, which represents an index of the relative relevance of cellular energy provision pathways [9,11], and the potential to execute cell death in response to the metabolic inhibitors,...

Ngày tải lên: 20/06/2014, 03:20

... rheumatologist was unaware of the exact values of those composite scores Also, differences over time and the DAS28 response (no, moderate or good) and the ACR (American College of Rheumatology) response ... another week Evaluation of the response scores To evaluate categorical scores, we adapted the cut-off of the variable with the highest ranking (DAS28 at week 22) to the specificity of the categorical ... adapted the cut-off of the DAS28 at week 22 to a specificity of 64.2% (DAS28 = 4.01), we obtained a sensitivity of 80.0% (95% CI: 75.2–84.7) 'No DAS28 response' had a sensitivity of 46.7% (95%...

Ngày tải lên: 09/08/2014, 06:23

... in DAS28 of at least 1.2) [17] According to the EULAR response criteria, of the 33 patients had a poor response whereas 12 patients displayed a good response to treatment An overview of the patients' ... clinical response to treatment Finally, we investigated whether the treatment- induced changes in type I IFN response gene expression levels were associated with clinical response to treatment ... Differential regulation of interferon (IFN) response genes upon tumor necrosis factor (TNF) blockade and clinical response to treatment Figure Differential regulation of interferon (IFN) response genes...

Ngày tải lên: 12/08/2014, 11:22

... objective of this study is to investigate the symptomatology of bloating, the role of gastrointestinal transit and effect of tegaserod in non-diarrhea IBS patients with bloating In the first part of ... at least of the following symptoms: relieved with defecation associated with change in frequency of stools Associated with change in form of stools and two or more of the following symptoms: altered ... effect of psychological treatment in IBS A randomized, controlled trial of IBS patients with long-standing symptoms and no response to conventional medical treatment found psychotherapy superior to...

Ngày tải lên: 26/09/2015, 10:05

... discharged 6106 tons of organic matter (calculated from biochemical oxygen demand), 157 tons of phosphorus, 1184 tons of nitrogen and 67.6 tons of oil products in 1997 Because of lack of pre -treatment ... amount of heavy metals was registered In 1997 Kaunas wastewater contained 2.4 tons of chromium, 2.5 tons of copper, 0.4 tons of nickel and 12.8 tons of zinc Comparison of average concentration of ... biological wastewater treatment plant One of the main conclusions of the assessment of Kaunas efforts to reduce pollution in the Nemunas river is that there is a lack of integration of environmental...

Ngày tải lên: 23/03/2014, 00:20

... the prognosis of colorectal cancer and to guide treatment [8] P73 has long been recognized as central to the induction of apoptosis in response to DNA damage, a function thought to be critical ... expression of TAp73 and the presence/absence of K-Ras and B-Raf mutations in response to cetuximab supports their possible apoptotic function and helps to understand the action mechanism of this ... structural similarity to p53 and have been shown to share functions with the tumor suppressor gene p53, but their contributions to the inhibition of tumor formation or to the response to chemotherapy...

Ngày tải lên: 18/06/2014, 16:20

... predictive of response to both conventional cytotoxic and target therapy drugs [11] Platinum or platinum-based regimens are the treatment of choice in ovarian cancers, which remains the leading cause of ... The use of the re-induction therapy in peritoneal carcinomatosis underlines the importance of studying these patients in terms of preclinical evaluation for response to platinum-containing treatments ... a molecular profile of chemosensitivity to all the drugs used in the clinical treatment was generated for each tumor Patients were subdivided into responders 22.7 (6-39) Type of treatment Carboplatin/taxol...

Ngày tải lên: 18/06/2014, 19:20

... genetics of the hematological cell line panel was reviewed in relation to Aurora inhibition by GSK1070916 Expression profiles of Aurora A, B, and C were evaluated in terms of response to Aurora ... http://www.translational-medicine.com/content/9/1/110 Page of 10 Figure Response vs Chromosome Number Response profile of GSK1070916 for various hematological cell line tumor types (n = 45) Those cell lines that were responsive to treatment ... ease of measurement, low costs, and biological relevance as a negative predictor of response to Aurora inhibition, can be a powerful tool to enrich patients that can potentially respond to GSK1070916...

Ngày tải lên: 18/06/2014, 22:20

... measurement of sHLA in CSF would be most likely to reflect CNS disease activity Measurement of such a biological marker of disease activity could potentially serve as a monitor of response to immunomodulatory ... significant day -to- day fluctuation in this form of MS Furthermore, response to interferon beta, the most common form of immunomodulating therapy, can vary with only 30 to 40% of patients reported to have ... immunomodulatory treatment in MS However, a biological marker of disease activity, as well as response to therapy, must be reliable, noninvasive, and preferably of reasonable cost in order to be performed...

Ngày tải lên: 19/06/2014, 22:20

... predictive of response to both conventional cytotoxic and target therapy drugs [11] Platinum or platinum-based regimens are the treatment of choice in ovarian cancers, which remains the leading cause of ... The use of the re-induction therapy in peritoneal carcinomatosis underlines the importance of studying these patients in terms of preclinical evaluation for response to platinum-containing treatments ... a molecular profile of chemosensitivity to all the drugs used in the clinical treatment was generated for each tumor Patients were subdivided into responders 22.7 (6-39) Type of treatment Carboplatin/taxol...

Ngày tải lên: 20/06/2014, 04:20

... genetics of the hematological cell line panel was reviewed in relation to Aurora inhibition by GSK1070916 Expression profiles of Aurora A, B, and C were evaluated in terms of response to Aurora ... http://www.translational-medicine.com/content/9/1/110 Page of 10 Figure Response vs Chromosome Number Response profile of GSK1070916 for various hematological cell line tumor types (n = 45) Those cell lines that were responsive to treatment ... ease of measurement, low costs, and biological relevance as a negative predictor of response to Aurora inhibition, can be a powerful tool to enrich patients that can potentially respond to GSK1070916...

Ngày tải lên: 20/06/2014, 04:20

... the presence of residual disease and grading of pathological response to chemotherapy was done using MillerPayne criteria for assessment of response to chemotherapy [3] Miller-Payne response grade ... uniform methods of measurement and cut-off points to assess the potential value of 10 Abu-Farsakh H, Sneige N, Atkinson EN, Hortobagyi G: Pathologic Predictors of Tumor Response to Pre-operative ... along with feasibility to evaluate biomarkers of response to chemotherapy in these biopsies The correlation to response, if proven, would help clinicians to tailor chemotherapy to individual patients...

Ngày tải lên: 09/08/2014, 04:21

... into the error function E defined as: E= M N (Oij − yij )2 i=1 j=1 where M is the total number of tumor response patterns given as input to the network, N is the total number of output nodes of ... RT treatment In the present study, the post -treatment imaging was performed at day and day 9, and these time-points are Page of maybe not easily translated into clinical assessment of early treatment ... assessment of early treatment response However, in recent years, the use of imaging modalities for early-in -treatment response assessments, for example to weeks after initiation of therapy, has increased,...

Ngày tải lên: 09/08/2014, 09:20

... according to response to therapy Effects of adalimumab therapy on synovial gene expression profiles Next, we investigated the effects of adalimumab therapy on global gene expression profiles of synovial ... in FLSs by several cytokines, indicating that the absence of response could be due to the uncontrolled action of one or several of these cytokines Earlier studies failed to demonstrate any correlation ... expression of TNF-, IL-1, or other cytokines and clinical response to TNFblocking agents [33,34] However, the biological effect of a cytokine results not only from the presence of the cytokine itself,...

Ngày tải lên: 09/08/2014, 14:20

... where Y is the vector of observations, b is the vector of fixed effects (generations, generations × replicates and the regression of GFPR on litter size at weaning), a is the vector of additive genetic ... Records of GFPR and other traits were taken in generations 60 to 62 at 10 weeks of age on available lines (only replicates and were retained to generation 60) to check on the effects of relaxation of ... objective of the lines was to change the proportion of body fat, but without greatly changing lean mass [9, 14, 28] Selection was practised on the ratio of the gonadal fat pad weight to total body...

Ngày tải lên: 09/08/2014, 18:21

... the total population ten of each iT) sex = iT-!,/(l 1/4) = large If not, iT has to be calculated accordingly, taking account of the negative correlation, -1/(n - 1), of values of X - X of family ... number of individuals recorded of each sex, so X refers F the relationship of family members (r to the mean of one sex), r 1/2 for full-sib families), h heritability,t = intra-class correlation of ... There is, however, some confusion in the literature as to predicted rates of response to selection within families, which this note is intended to clarify There are actually two alternative selection...

Ngày tải lên: 09/08/2014, 18:22

... likely to adhere to treatment and thus, make more effort to influence the patient's adherence to treatment In such a fashion, SES could affect the patient's quality of life, the social life of the ... measurement of adherence [pills per dose, doses per day, days of treatment per week(s), respect of the exact time schedule of obtaining the medications, etc] and used different cutoff point of adherence ... (out of 17 studies reviewed); most significant findings refer to a positive association between levels of SES components and levels of adherence to antiretroviral treatment, although two of the...

Ngày tải lên: 13/08/2014, 06:20

... fishermen were found to be five times more likely to die of AIDS-related illnesses than farmers [13] Despite the high vulnerability to HIV infection of fisher community when compared to the general ... partners, duration of stay in the port areas, lack of condom use, and prevalence of sexual violence have been found to be associated with increased vulnerability of fishing communities to HIV infection ... including the history of the tens of thousands of refugees that are currently living in squalid conditions on the Bangladeshi side These refugees are comprised of large numbers of a Muslim minority,...

Ngày tải lên: 13/08/2014, 13:21

... presence of organic matter in AIRU feed water was investigated under dosage -response observations in multiple sets of laboratory reactors In case of simulated wastewater organic contaminations of 15 ... stirred to avoid any deposition of the particles in the upper tank Then, the raw water was fed to the sand filter reactor using a pump and hence the concentrations of arsenic and iron were similar to ... concentrations in stock solution and in other water samples were determined by using a total organic carbon analyzer (TOC-VCSH, Shimadzu), which allowed detection limit of 0.4 mg/L as TOC The value of pH...

Ngày tải lên: 05/09/2013, 09:38