... This geometry minimized distortion of the signal due to incomplete alignment of F-actin filaments (B) shows the spectra of filaments of F-actin with three sorts of cross-links: (a) interstrand cross-links ... width of 23° at half maximum of the distribution (Fig 3) The second population of spin labels that was relatively disordered had a mean angle of 63 (±5)° with a full width at half maximum of 43° ... Burley RW, Seidel JC & Gergely J (1971) The stochiometry of the reaction of the spin labeling of F-actin and the effect of orientation of spin-labelled F-actin filaments Arch Biochem Biophys 146,...
Ngày tải lên: 16/03/2014, 13:20
... addition of small aliquots (1–5 lL) of a stock solution of the peptide to 0.5 mL of solution containing F-actin at a concentration of 2.5–4.0 mgÆmL)1 The broad signals of the spectrum of F-actin ... direct of evidence of sites of interaction and of conformational changes occurring in actin that are an important aspect of the regulatory process (Fig 10) They also imply that the role of tropomyosin ... activity Deletion of this loop region resulted in the loss of strong binding of myosin to actin [17] while a single amino acid residue change, ArgfiGln, in this loop region of the b-chain of human cardiac...
Ngày tải lên: 17/03/2014, 10:20
descartes and the puzzle of sensory representation feb 2010
... discusses ideas of secondary qualities in the context of his discussion of ideas of material things and the very proof of the existence of material things in Meditation Six assumes that ideas of sense ... by their mode of presentation of an object (or objective reality).12 (II) The mode of presentation provides an identifying description of the object (III) The mode of presentation of an idea determines ... think of abstract ideas as general and innate ways of conceiving of particular things Despite the presence of a few passages where Descartes seems to suggest that ideas of mathematics are ideas of...
Ngày tải lên: 10/06/2014, 21:37
báo cáo sinh học:" The course of specialization in public health in Rio de Janeiro, Brazil, from 1926 to 2006: lessons and challenges Monireh Obbadi" ppt
... Public Health of a group of professors from the university of Campinas, lead by Sergio Arouca, who became one of the leaders of the health reform movement in Brazil and a leading architect of the national ... documents: a) proof of identity; b) proof of completion of, or exemption from, military service; c) certification of vaccination against smallpox and typhoid; d) certification of physical and ... conclusion of their studies were expected to occupy the function of specialized public health inspectors in the federal offices of the National Department of Health (DNS) or in the state offices...
Ngày tải lên: 18/06/2014, 17:20
báo cáo hóa học: "On the identification of sensory information from mixed nerves by using single-channel cuff electrodes" pot
... humans However, the main goal of these studies was to identify the onset (and offset) of a specific neural activity, with the aim of triggering stimulation The aim of our work was to investigate ... filter with cutoff frequencies of 10 Hz and kHz), digitized at 20 kHz (PowerLab) and fed into a PC running Chart v5.5 (AD Instruments) Datasets consisted of ten applications of every type of stimuli ... increasing the number of stimuli to be identified on groups of two and three, until finding an acceptable percentage of classification The influence of different parts of the proposed signal...
Ngày tải lên: 19/06/2014, 08:20
Báo cáo y học: "vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study" pot
... clearly lower in patients of Turkish descent than in those of Dutch descent A total of 14 of the patients of Turkish descent had a vitamin B12 deficiency, as did patient of Dutch descent The patients ... shows that 4.85% of the patients of Turkish descent have atrophic gastritis, as 0% of the patients of Dutch descent Sizeable levels of vitamin B12 deficiency are observed in patients of Turkish descent ... average score of 31.76 (SD 7.95) The difference was not significant (P value 0.259) A total of 32 patients of Turkish descent had or comorbid psychiatric disorders, as did 10 of the patients of Dutch...
Ngày tải lên: 08/08/2014, 23:21
Báo cáo y học: "Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis" potx
... distribution of the cytokine profiles Indeed, an extensive study of longitudinal cytokine profiles in RA is complicated by the influence of disease phases and/or treatments [14], most of which affect ... advice, and Prof K von der Mark and Prof JR Kalden for generous support Dr S Kunkel is gratefully aknowledged for critical reading of the manuscript Prof F Emmrich, Prof R Bräuer, Prof RW Kinne, ... time (days) 6 time (days) Expression of mRNA of various cytokines in the synovial membrane of rats with AIA Expression of mRNA was assessed before the induction of antiAIA gen-induced arthritis (AIA)...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis" docx
... progression of arthritis Local cytokine responses were determined at the protein level by means of recently developed immunohistochemical techniques that enable discrimination of the localization of HMGB1 ... staining of cytoplasmic HMGB1 and of IL-1β was located in erosive parts of synovial tissue close to cartilage and bone undergoing destruction As opposed to expression of TNF, those of both cytoplasmic ... inflammation, with synovial expression of TNF and IL-1β preceding that of HMGB1 However, we did not observe a distinct, sequential order of appearance of Page of 10 (page number not for citation...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "Treatment of stasis dermatitis using aminaphtone: Development of Buffalo Hump in the course of antiretroviral therapy including raltegravir and unboosted atazanavir: a case report and review of the literature" pot
... increase of lipohypertrophy of the dorso-cervical region of the neck There was no localized accumulation of fat in her abdomen and in the submental region of her neck The hump in the back of her ... subcutaneous fat around the posterior aspect of the Page of neck (Figure 1) The results of DEXA confirmed these data Fasting lipid profile showed a total Cholesterol of 170 mg/dl, HDL-Cholesterol 42 mg/dl ... duration of use of protease inhibitors and longer duration of use of zidovudine [10] Palacios et al showed that Buffalo Hump was associated with treatment with saquinavir, indinavir, efavirenz, tenofovir...
Ngày tải lên: 11/08/2014, 00:22
Báo cáo khoa hoc:" Prospective Epidemiological Observations on the Course of the Disease in Fibromyalgia Patients" doc
... history 4.2% of the patients reported a dramatic onset of pain over a short period of time, 16.7% reported a slow progression of pain over a longer period of time, 54.2% reported flare-ups of pain ... certainty, as official records are often inaccessible, but they are estimated to amount to some 15–20% of the total costs in the field of Rheumatology [6] This represents 1.2% of the gross national ... extremes are noted under the heading Medium ± SEM General state of health assessment (very bad – very good) Assessment of lack of motivation (very frequent – more or less never) Contentment with...
Ngày tải lên: 11/08/2014, 08:20
Báo cáo y học: " Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33 000 women from the general population" ppt
... symptoms of the CAPE (Community Assessment of Psychic Experiences) questionnaire, a modified version of the Peters et al Delusions Inventory, [PDI; [22]]; which is based on the 9th edition of the ... weekly servings of fatty fish increased 25(OH)D by 45% in a population of Swedish women [35] Our results of the protective effect of fatty fish could in part be due to the content of vitamin D While ... surprisingly found that the effect of intermediate doses of EPA increased the levels of AA (an omega-6 PUFA) in the membrane of red cells, whereas higher doses of EPA did not, and the EPA-induced...
Ngày tải lên: 11/08/2014, 16:22
Báo cáo y học: "The course of untreated anxiety and depression, and determinants of poor one-year outcome: a one-year cohort study" ppt
... participant being 18 years of age and the oldest 65 Page of 10 Participants had an average of 12.0 years (sd 3.4 years) of education, ranging from to 18 years The majority of patients had a six-month ... course Apparently, receipt of and need for care are not independent of symptom severity in predicting the outcome of depression and anxiety Similarly, utilization of professional care appeared ... assessment (T0) Of these, 594 respondents (79.9%) participated in the one-year follow-up assessment (T1) Measures Dependent variables The dependent variables used in this study are severity of...
Ngày tải lên: 11/08/2014, 16:22
Báo cáo y học: "Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS" pot
... failure assessment (SOFA) score evaluation system of multiple organ dysfunction [12] Six organ systems are evaluated as a scale of 1–4 each The arithmetical sum of these six is the value of the SOFA ... between different groups of patients, eg for purposes of differential diagnosis, assessment of the severity of the disease and of systemic inflammation, including the severity of MODS, is mandatory ... concentrations of patients within four categories of the sepsis-related organ failure assessment (SOFA) score Indicated are median (l), 25/75 percentiles (box) and 10/90 percentiles (whisker) of CRP...
Ngày tải lên: 12/08/2014, 18:20
Báo cáo y học: "Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D" pps
... from both lung and spleens of infected animals indicating the presence of active infection (Fig 4) Recovery of fungus in the spleen provides evidence of dissemination of C posadasii to extra-pulmonary ... analyses of the data (t-test or ANOVA) were done using Prism Software (Graphpad Software, San Diego, CA) The p value
Ngày tải lên: 12/08/2014, 18:21
Báo cáo y học: "Prior mucosal exposure to heterologous cells alters the pathogenesis of cell-associated mucosal feline immunodeficiency virus challenge" docx
... at the time of this study, the data suggests that a reduction of the number of T-regulatory cells within the environment was associated with the development of an effector immune response Tregs ... response was enhanced without a detectable expansion of activated cells This may be related to the high percentage of activated cells normally present in the gut [52] Interestingly, the MLR response ... the design of the study SBK and MJB were responsible for the draft of the manuscript SBK performed most of experiments SEL performed flow cytometry experiments BA helped in isolation of Kumar et...
Ngày tải lên: 13/08/2014, 01:20
Báo cáo y học: " Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts" pdf
... and carriage of SNPs of molecules implicated in response to stimulation with LPS is not easy to discern as a variety of factors such as the time of blood sampling and the intensity of the infectious ... Department of Critical Care of the Evangelismos' General Hospital or in the second Department of Critical Care of the ATTIKON University Hospital of Athens, Greece All patients were over 18 years of ... Additional file Of the patients, 106 were carriers of only WT alleles; were carriers of only TLR4 SNP alleles; 41 were carriers of at least one TIRAP/Mal SNP allele; and were carriers of both TLR4...
Ngày tải lên: 13/08/2014, 20:22
Báo cáo y học: "Soluble triggering receptor on myeloid cells-1 is expressed in the course of non-infectious inflammation after traumatic lung contusion: a prospective cohort study" pptx
... disruption of the epithelial and endothelial cell lining of the lung, impairment of the alveolar-capillary barrier, an activation of the innate inflammatory response and subsequent recruitment of leukocytes, ... sepsis [5,6] The presence of sTREM-1 in bronchoalveolar fluid of mechanically ventilated patients is a strong predictor for the presence of pneumonia with a cut-off value of 230 pg/ml to predict ... quantification of the amount of lung contusion (area of high density of lung tissue), ventral and dorsal damage, and one or both sides affected Four classes of severity of lung contusion resulted:...
Ngày tải lên: 14/08/2014, 08:21
báo cáo khoa học: " Recent advances in the genetics of language impairment" docx
... versions of the FOXP2 gene, making it one of the most highly conserved genes found in comparisons of humanrodent genomes [38,39] Interestingly, analyses of primates demonstrated that two of these ... forms of language impairment Thus, as our understanding of downstream targets grows, so will our list of potential candidate genes for SLI The association of CNTNAP2 variations with an array of ... the etiology of typical forms of SLI [13,14], heterozygous disruptions of this gene (point mutations or chromosomal rearrange ments) invariably lead to syndromes that include aspects of verbal...
Ngày tải lên: 11/08/2014, 12:20